Click here to switch to the map view.

The map label for this gene is clcA [H]

Identifier: 238920975

GI number: 238920975

Start: 2994034

End: 2995398

Strand: Reverse

Name: clcA [H]

Synonym: NT01EI_3105

Alternate gene names: 238920975

Gene position: 2995398-2994034 (Counterclockwise)

Preceding gene: 238920981

Following gene: 238920974

Centisome position: 78.57

GC content: 59.56

Gene sequence:

>1365_bases
ATGCGCCGGGATAAAACGCCGCTTGCTACGTTGATCCTGGCGGCAATTGTGGGCACCCTGGCCGGTTTTATCGGGGTCGC
CTTTGAGCGCTGTGTTGACTGGGTGCAACAGCAGCGCCTGGCTGGTCTGGCAGAGGTCGCCAACTATTGGTTTATCGTCT
GGCCGGCGGCAATCCTCGGCTCTGCGTTGCTGGCCATGTGCGGCTACTATCTGGTGCGACGTTTTGCGCCAGAGGCCGGT
GGCTCCGGTATCCCGGAGATTGAGGGGGCGCTGGAGGATCTTCGCCCCGTTCGCTGGTGGCGGGTGATTCCGGTGAAATT
CATCGGTGGCCTGGGGACGCTGGGCGCCGGTATGGTGCTGGGGCGTGAAGGGCCTACGGTGCAGATGGGGGGTAACTTGG
GACAGATGGTGTATGACCTGTTCCGATTGCCCAAGCGCGATAATGAGACGCGCCATACGCTGCTGGCGACCGGTGCGGCT
GCGGGTCTGACGGCGGCATTCAATGCGCCGCTGGCCGGGATACTGTTCATCATTGAAGAGATGCGCCCGCAGTTCCACTA
TAGCCTGGTCTCCATCAAGGCGGTCTTCATCGGGGTGATCATGTCCTGCGTGGTGTTCCGTGTTTTTAACGGCGAACACT
CGGTGATTGAGGTAGGGCGTCTGGGTGTCGCGGAGATCAATACCCTGTGGCTCTATCTAGTGCTGGGCATGGTATTTGGT
ATCGTCGGCGTATTGTTTAACATGGGGGTCTTTCGCACCCAGGATATGTTTCAACGCATGCATGGCGGCAATTGGCGCAA
GCTGATGCTGATCGGCGCGGCGCTTGGCGGCCTGTGCGGTGCGCTGGGGCTTATTCAGCATGAGGCTGCAGGCGGCGGCT
TTGCCCTGATCCCGATCGCTGCTGAAGGCAACTACACTGTCGGCATGCTGCTGTTTATCTTTATTGCCCGTGTGGTGACG
ACACTACTGTGCTTTGGCTCTGGCGCGCCGGGCGGGATCTTTGCCCCAATGCTGGCGCTCGGGACATTGCTGGGTACGGC
ATTCGGCATGGCGGCCGCCTACCTGTTCCCACAATATGGCATCGTTCCGGGTACCTTCGCCATTGCCGGGATGGGGGCGC
TGTTTGCCGCCACGGTACGTGCGCCGCTGACAGGGATTGTTCTGGTGCTGGAGATGACTGATAACTATCAGCTTATTTTG
CCCATGATCATTACCTGTCTTGGCGCTACACTACTGGCGCAGTTTTTGGGTGGCAAACCGCTATACTCCCGTATTCTGGA
GCGTACCCTGCACCGCCAGATGCAGGAGCAGGAAGCCGTACAGAAACGGGCGGAGCAGAGTGGGCCGCAACCCACTAATA
CTTGA

Upstream 100 bases:

>100_bases
ACCAACTTTACTGACTGAACTGACTATGACTACGCAACAAGATCCTATCCCTCATCCGCTGACGCCCCGTCTGCGGCACA
GTGGCGTCCTGCGGCGGGTA

Downstream 100 bases:

>100_bases
ATGGATTACTCGGGTATTAGATAATCGCCCAATGAGTCAGTATGCCCTGGGCCAGGCGGCATTCTGATATGTACACTGAC
TGGAGCAATCAATGAGTGAT

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MRRDKTPLATLILAAIVGTLAGFIGVAFERCVDWVQQQRLAGLAEVANYWFIVWPAAILGSALLAMCGYYLVRRFAPEAG
GSGIPEIEGALEDLRPVRWWRVIPVKFIGGLGTLGAGMVLGREGPTVQMGGNLGQMVYDLFRLPKRDNETRHTLLATGAA
AGLTAAFNAPLAGILFIIEEMRPQFHYSLVSIKAVFIGVIMSCVVFRVFNGEHSVIEVGRLGVAEINTLWLYLVLGMVFG
IVGVLFNMGVFRTQDMFQRMHGGNWRKLMLIGAALGGLCGALGLIQHEAAGGGFALIPIAAEGNYTVGMLLFIFIARVVT
TLLCFGSGAPGGIFAPMLALGTLLGTAFGMAAAYLFPQYGIVPGTFAIAGMGALFAATVRAPLTGIVLVLEMTDNYQLIL
PMIITCLGATLLAQFLGGKPLYSRILERTLHRQMQEQEAVQKRAEQSGPQPTNT

Sequences:

>Translated_454_residues
MRRDKTPLATLILAAIVGTLAGFIGVAFERCVDWVQQQRLAGLAEVANYWFIVWPAAILGSALLAMCGYYLVRRFAPEAG
GSGIPEIEGALEDLRPVRWWRVIPVKFIGGLGTLGAGMVLGREGPTVQMGGNLGQMVYDLFRLPKRDNETRHTLLATGAA
AGLTAAFNAPLAGILFIIEEMRPQFHYSLVSIKAVFIGVIMSCVVFRVFNGEHSVIEVGRLGVAEINTLWLYLVLGMVFG
IVGVLFNMGVFRTQDMFQRMHGGNWRKLMLIGAALGGLCGALGLIQHEAAGGGFALIPIAAEGNYTVGMLLFIFIARVVT
TLLCFGSGAPGGIFAPMLALGTLLGTAFGMAAAYLFPQYGIVPGTFAIAGMGALFAATVRAPLTGIVLVLEMTDNYQLIL
PMIITCLGATLLAQFLGGKPLYSRILERTLHRQMQEQEAVQKRAEQSGPQPTNT
>Mature_454_residues
MRRDKTPLATLILAAIVGTLAGFIGVAFERCVDWVQQQRLAGLAEVANYWFIVWPAAILGSALLAMCGYYLVRRFAPEAG
GSGIPEIEGALEDLRPVRWWRVIPVKFIGGLGTLGAGMVLGREGPTVQMGGNLGQMVYDLFRLPKRDNETRHTLLATGAA
AGLTAAFNAPLAGILFIIEEMRPQFHYSLVSIKAVFIGVIMSCVVFRVFNGEHSVIEVGRLGVAEINTLWLYLVLGMVFG
IVGVLFNMGVFRTQDMFQRMHGGNWRKLMLIGAALGGLCGALGLIQHEAAGGGFALIPIAAEGNYTVGMLLFIFIARVVT
TLLCFGSGAPGGIFAPMLALGTLLGTAFGMAAAYLFPQYGIVPGTFAIAGMGALFAATVRAPLTGIVLVLEMTDNYQLIL
PMIITCLGATLLAQFLGGKPLYSRILERTLHRQMQEQEAVQKRAEQSGPQPTNT

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557473, Length=460, Percent_Identity=25, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI189217923, Length=460, Percent_Identity=25, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI189217921, Length=460, Percent_Identity=25, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI153252026, Length=458, Percent_Identity=24.6724890829694, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI55770840, Length=462, Percent_Identity=23.8095238095238, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI55770838, Length=462, Percent_Identity=23.8095238095238, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786350, Length=446, Percent_Identity=69.2825112107623, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI87081943, Length=339, Percent_Identity=27.7286135693215, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532615, Length=483, Percent_Identity=22.9813664596273, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71985148, Length=503, Percent_Identity=24.6520874751491, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71985141, Length=503, Percent_Identity=24.6520874751491, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980828, Length=469, Percent_Identity=21.9616204690832, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71980824, Length=469, Percent_Identity=22.3880597014925, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17559050, Length=470, Percent_Identity=26.5957446808511, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980820, Length=474, Percent_Identity=22.5738396624473, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322500, Length=479, Percent_Identity=22.1294363256785, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24665008, Length=460, Percent_Identity=25.4347826086956, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45551566, Length=384, Percent_Identity=26.5625, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281361606, Length=451, Percent_Identity=23.059866962306, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161078208, Length=451, Percent_Identity=23.059866962306, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281361608, Length=451, Percent_Identity=23.059866962306, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573073, Length=451, Percent_Identity=23.059866962306, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573075, Length=451, Percent_Identity=23.059866962306, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573071, Length=451, Percent_Identity=23.059866962306, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 48713; Mature: 48713

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA