Click here to switch to the map view.

The map label for this gene is galK [H]

Identifier: 238920730

GI number: 238920730

Start: 2734740

End: 2735897

Strand: Direct

Name: galK [H]

Synonym: NT01EI_2843

Alternate gene names: 238920730

Gene position: 2734740-2735897 (Clockwise)

Preceding gene: 238920729

Following gene: 238920731

Centisome position: 71.73

GC content: 65.46

Gene sequence:

>1158_bases
ATGCGCCTCCATGACCTGATTGCCGTGACCCGTGATATATTTACCCGTGAGTTTGGCTATGTGCCGCTGCTGTGCGTGCA
GGCACCGGGACGGGTCAACCTGATCGGTGAACACACCGACTACAACGATGGCTTTGTACTGCCGTGCGCCATCGACTACC
AGACCGTTATCAGCTGTGCGCCGCGCAGCGATCGCCGGGTACGCGTCATCGCCGCCGACTACAACGGTCAGCAGGACAGC
TTCAGCCTCAATCAGCCCATCGACACCCGTGACGATATGATGTGGAGCAACTATGTCCGCGGGGTGATAAAACACCTGCA
GCAGCGCTGCGACGGCATCGGTGGTATCGATATGGTGATCAGCGGCAACGTACCGCAGGGGGCGGGACTCAGCTCCTCCG
CCTCGCTGGAGGTCGCCGTCGGCCAAGCGCTGCAGGCAGCGTATCAGCTGCCGCTGGACGGCGTCGCGCTGGCGCTCAAC
GGCCAGGAGGCGGAAAACCGCTTCGTCGGCTGCAACTGTGGCATCATGGATCAGCTGATCTCCGCCCTTGGACAGGCGCA
GCACGCCCTGTTGATCGACTGCCGCGCCCTGACCACCCGCGCGGTGCCGCTGCCGCCGGAGGCCGCGGTGGTGATCATCA
ACTCCAACGTCAAGCGCGGACTGGTCGACAGCGAATACAACACCCGCCGCCAGCAGTGCGAAGCGGCAGCGCGATTCTTT
GGCGTCGACGCCTTGCGCGACGTCACCCCGCAGCGCTTCGCCGCCGAGTCCCACGGGCTTCCGGCGCTGACCGTCCGCCG
CGCGCGCCACGTGATCAGCGAAAACCAGCGTACGCTGCAGGCGGCCGACGCGCTCGCCGCGGGCGATCTGGTGCTGATGG
GTGAGCTGATGGCGGCGTCCCACGCCTCCATGCGCGATGACTTCGCCATCACAGTTCCCCCCATCGATACCCTGGTCGGG
ATCGTCAAGGGGGTCATCGGCGATTGCGGCGGCGTGCGTATGACCGGCGGCGGATTCGGCGGCTGCGTCGTCGCACTGAT
ACCGCGGACTCTGGTCGAGCCGGTACGCGCCGCCGTCGCCCGTGACTACGCTGGCCGTACCGGCCTGAAGGAAACTTTTT
ACGTCTGTCAGCCCTCGGCGGGAGCCAGCGTATGCTAA

Upstream 100 bases:

>100_bases
GAAACCCAGCGCGATTTGACGCCGGAGCAGGCGGCCGAACGCCTGCGTGCCGTCAGCGACGTCCACTTTAGCCAAGCCTG
ATCCCGAGAGGAGAACACCC

Downstream 100 bases:

>100_bases
CCCCAGCGCCACAGTATGAGACCGCGCCGGACGGCGCCCCCTTTCAGTTCACCGCGCTGCACAACGCCCGGGGCAGCACG
CTGCTGCTGATGGACTGGGG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MRLHDLIAVTRDIFTREFGYVPLLCVQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRSDRRVRVIAADYNGQQDS
FSLNQPIDTRDDMMWSNYVRGVIKHLQQRCDGIGGIDMVISGNVPQGAGLSSSASLEVAVGQALQAAYQLPLDGVALALN
GQEAENRFVGCNCGIMDQLISALGQAQHALLIDCRALTTRAVPLPPEAAVVIINSNVKRGLVDSEYNTRRQQCEAAARFF
GVDALRDVTPQRFAAESHGLPALTVRRARHVISENQRTLQAADALAAGDLVLMGELMAASHASMRDDFAITVPPIDTLVG
IVKGVIGDCGGVRMTGGGFGGCVVALIPRTLVEPVRAAVARDYAGRTGLKETFYVCQPSAGASVC

Sequences:

>Translated_385_residues
MRLHDLIAVTRDIFTREFGYVPLLCVQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRSDRRVRVIAADYNGQQDS
FSLNQPIDTRDDMMWSNYVRGVIKHLQQRCDGIGGIDMVISGNVPQGAGLSSSASLEVAVGQALQAAYQLPLDGVALALN
GQEAENRFVGCNCGIMDQLISALGQAQHALLIDCRALTTRAVPLPPEAAVVIINSNVKRGLVDSEYNTRRQQCEAAARFF
GVDALRDVTPQRFAAESHGLPALTVRRARHVISENQRTLQAADALAAGDLVLMGELMAASHASMRDDFAITVPPIDTLVG
IVKGVIGDCGGVRMTGGGFGGCVVALIPRTLVEPVRAAVARDYAGRTGLKETFYVCQPSAGASVC
>Mature_385_residues
MRLHDLIAVTRDIFTREFGYVPLLCVQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRSDRRVRVIAADYNGQQDS
FSLNQPIDTRDDMMWSNYVRGVIKHLQQRCDGIGGIDMVISGNVPQGAGLSSSASLEVAVGQALQAAYQLPLDGVALALN
GQEAENRFVGCNCGIMDQLISALGQAQHALLIDCRALTTRAVPLPPEAAVVIINSNVKRGLVDSEYNTRRQQCEAAARFF
GVDALRDVTPQRFAAESHGLPALTVRRARHVISENQRTLQAADALAAGDLVLMGELMAASHASMRDDFAITVPPIDTLVG
IVKGVIGDCGGVRMTGGGFGGCVVALIPRTLVEPVRAAVARDYAGRTGLKETFYVCQPSAGASVC

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=390, Percent_Identity=44.6153846153846, Blast_Score=284, Evalue=8e-77,
Organism=Homo sapiens, GI48527957, Length=245, Percent_Identity=33.0612244897959, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4503897, Length=244, Percent_Identity=32.7868852459016, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1786972, Length=376, Percent_Identity=69.9468085106383, Blast_Score=544, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI71989053, Length=416, Percent_Identity=25.4807692307692, Blast_Score=98, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319494, Length=256, Percent_Identity=30.859375, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320212, Length=254, Percent_Identity=28.740157480315, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24661292, Length=403, Percent_Identity=27.7915632754342, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21355577, Length=403, Percent_Identity=27.7915632754342, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24661285, Length=403, Percent_Identity=27.7915632754342, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 41166; Mature: 41166

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLHDLIAVTRDIFTREFGYVPLLCVQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCA
CCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCEEEEEECCHHHHHCCC
PRSDRRVRVIAADYNGQQDSFSLNQPIDTRDDMMWSNYVRGVIKHLQQRCDGIGGIDMVI
CCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
SGNVPQGAGLSSSASLEVAVGQALQAAYQLPLDGVALALNGQEAENRFVGCNCGIMDQLI
ECCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCHHHHHH
SALGQAQHALLIDCRALTTRAVPLPPEAAVVIINSNVKRGLVDSEYNTRRQQCEAAARFF
HHHCCCCCEEEEEEHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
GVDALRDVTPQRFAAESHGLPALTVRRARHVISENQRTLQAADALAAGDLVLMGELMAAS
HHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHH
HASMRDDFAITVPPIDTLVGIVKGVIGDCGGVRMTGGGFGGCVVALIPRTLVEPVRAAVA
HCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHH
RDYAGRTGLKETFYVCQPSAGASVC
HHHCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MRLHDLIAVTRDIFTREFGYVPLLCVQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCA
CCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCEEEEEECCHHHHHCCC
PRSDRRVRVIAADYNGQQDSFSLNQPIDTRDDMMWSNYVRGVIKHLQQRCDGIGGIDMVI
CCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
SGNVPQGAGLSSSASLEVAVGQALQAAYQLPLDGVALALNGQEAENRFVGCNCGIMDQLI
ECCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCHHHHHH
SALGQAQHALLIDCRALTTRAVPLPPEAAVVIINSNVKRGLVDSEYNTRRQQCEAAARFF
HHHCCCCCEEEEEEHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
GVDALRDVTPQRFAAESHGLPALTVRRARHVISENQRTLQAADALAAGDLVLMGELMAAS
HHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHH
HASMRDDFAITVPPIDTLVGIVKGVIGDCGGVRMTGGGFGGCVVALIPRTLVEPVRAAVA
HCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHH
RDYAGRTGLKETFYVCQPSAGASVC
HHHCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA