The gene/protein map for NC_012779 is currently unavailable.
Definition Edwardsiella ictaluri 93-146 chromosome, complete genome.
Accession NC_012779
Length 3,812,315

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The map label for this gene is pdxB

Identifier: 238920610

GI number: 238920610

Start: 2615195

End: 2616322

Strand: Reverse

Name: pdxB

Synonym: NT01EI_2722

Alternate gene names: 238920610

Gene position: 2616322-2615195 (Counterclockwise)

Preceding gene: 238920612

Following gene: 238920609

Centisome position: 68.63

GC content: 64.98

Gene sequence:

>1128_bases
ATGAAAATTGTGGTTGATGAAAATATGCCGTATGCCGAGGCGCTGTTTGGGCGTCTTGGCGAGGTAGTGGCCGTGCGGGG
CCGCCCGCTGCCCGCGGCCGCGTTGGTCGGGGCTGATGCGCTGATGGTGCGCTCAGTGACGACGGTCAATCAGGCATTGC
TGGCGGGGCAGCGCGTTCGCTTTGTCGGCACCGCCACCGCCGGTACCGATCATGTGGATACAGCCTGGCTGGCGCAGGCT
GGCATCGGCTTTTCCGCCGCCCCCGGCTGTAACGCCATTGCCGTGGTGGAGTATGTCTTTTCTGCCCTGATGCTGCTGGC
GGAGCGGGACGGTTTTGCGCTGCGCGATAAGACCGTGGGGATCGTCGGGGTTGGCAATGTGGGCAGCCGGTTGCAGCGCC
GCCTGACCGCGCTGGGGATCCGCACCCTGCTGTGCGATCCGCCGCGCGCCGATCGCGGTGATGACGAGCAGTTTCACAGT
CTGGCGGATTTACAGCGTGAGGCGGATATCATCACCTTCCATACGCCGCTGAACAAGAGCGGTCCCTATCGAACGCTGCA
CCTGGCCGATGCGGATTTTCTGCGCGGGCTGCCGCCGGGGCGGATCCTGATTAACGCCGGGCGCGGCGCCGTCGTCGACA
ATGCGGCGCTGCTGCAGGCGCTGGAGGCGGGGCAGGATCTGCGGGTGGTGCTGGATGTCTGGGAGCCGGAGCCGATGCTG
TCGCTGCCGCTGCTGGCCCGGGTGGACATCGCGACGCCGCACATCGCCGGATACAGCCTGGAGGGGAAAGCGCGCGGTAC
TACCCAGGTATTTGAGGCTTTCAGCACCTTCTTGGGACAGCCGCAGTCGGTGGTGCTGCCCTCCCTGTTACCGCCACCGC
CGGTCGCCAGCGTACGCATTCACGGTCATCCCGATCAGGCGATGCTCAAACGTCTGATGCATCTGGTGTATGATGTGCGC
CGTGATGATGTACCGCTGCGTCGCGTCGCTGCACAGGAGGGCGAATTCGATCGCCTGCGTAAACACTATCCGGCGCGCCG
CGAGTGGTCATCGCTGCAGGTACTGTGCGACGATTGCACCAGTGCCTCGCTGCTGACGGCGTTGGGTTTTGACGCCCGCG
TCGCCTGA

Upstream 100 bases:

>100_bases
TTTGGGGCGGGATGCTGTCGCTGCTGAGGTTAGGTGTCGCATGCATTTGGTGGCAGAATAATCCGTCCTGAATCTATGGT
GTAGCCGCAGGGGAGAGCAG

Downstream 100 bases:

>100_bases
TCAGACAATGGATGCTTATCGCCAGTGTACCCGGGAGGGGGACTGGCGATTTTTGATGGGCTATTGACAGGGACGGCGGC
GTAACCCGCTGTCCGGGAGA

Product: erythronate-4-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MKIVVDENMPYAEALFGRLGEVVAVRGRPLPAAALVGADALMVRSVTTVNQALLAGQRVRFVGTATAGTDHVDTAWLAQA
GIGFSAAPGCNAIAVVEYVFSALMLLAERDGFALRDKTVGIVGVGNVGSRLQRRLTALGIRTLLCDPPRADRGDDEQFHS
LADLQREADIITFHTPLNKSGPYRTLHLADADFLRGLPPGRILINAGRGAVVDNAALLQALEAGQDLRVVLDVWEPEPML
SLPLLARVDIATPHIAGYSLEGKARGTTQVFEAFSTFLGQPQSVVLPSLLPPPPVASVRIHGHPDQAMLKRLMHLVYDVR
RDDVPLRRVAAQEGEFDRLRKHYPARREWSSLQVLCDDCTSASLLTALGFDARVA

Sequences:

>Translated_375_residues
MKIVVDENMPYAEALFGRLGEVVAVRGRPLPAAALVGADALMVRSVTTVNQALLAGQRVRFVGTATAGTDHVDTAWLAQA
GIGFSAAPGCNAIAVVEYVFSALMLLAERDGFALRDKTVGIVGVGNVGSRLQRRLTALGIRTLLCDPPRADRGDDEQFHS
LADLQREADIITFHTPLNKSGPYRTLHLADADFLRGLPPGRILINAGRGAVVDNAALLQALEAGQDLRVVLDVWEPEPML
SLPLLARVDIATPHIAGYSLEGKARGTTQVFEAFSTFLGQPQSVVLPSLLPPPPVASVRIHGHPDQAMLKRLMHLVYDVR
RDDVPLRRVAAQEGEFDRLRKHYPARREWSSLQVLCDDCTSASLLTALGFDARVA
>Mature_375_residues
MKIVVDENMPYAEALFGRLGEVVAVRGRPLPAAALVGADALMVRSVTTVNQALLAGQRVRFVGTATAGTDHVDTAWLAQA
GIGFSAAPGCNAIAVVEYVFSALMLLAERDGFALRDKTVGIVGVGNVGSRLQRRLTALGIRTLLCDPPRADRGDDEQFHS
LADLQREADIITFHTPLNKSGPYRTLHLADADFLRGLPPGRILINAGRGAVVDNAALLQALEAGQDLRVVLDVWEPEPML
SLPLLARVDIATPHIAGYSLEGKARGTTQVFEAFSTFLGQPQSVVLPSLLPPPPVASVRIHGHPDQAMLKRLMHLVYDVR
RDDVPLRRVAAQEGEFDRLRKHYPARREWSSLQVLCDDCTSASLLTALGFDARVA

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily

Homologues:

Organism=Homo sapiens, GI23308577, Length=265, Percent_Identity=30.188679245283, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI6912396, Length=285, Percent_Identity=27.0175438596491, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI145580578, Length=272, Percent_Identity=25.7352941176471, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4557499, Length=272, Percent_Identity=25.7352941176471, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI61743967, Length=252, Percent_Identity=27.3809523809524, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4557497, Length=252, Percent_Identity=27.3809523809524, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI145580575, Length=272, Percent_Identity=25.7352941176471, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788660, Length=372, Percent_Identity=71.2365591397849, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1789279, Length=318, Percent_Identity=27.0440251572327, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787645, Length=204, Percent_Identity=26.4705882352941, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082289, Length=260, Percent_Identity=28.8461538461538, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=267, Percent_Identity=26.2172284644195, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=27.82874617737, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=327, Percent_Identity=27.5229357798165, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=166, Percent_Identity=28.9156626506024, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=275, Percent_Identity=23.6363636363636, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574286, Length=264, Percent_Identity=27.6515151515151, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI19921140, Length=268, Percent_Identity=27.2388059701493, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24646446, Length=256, Percent_Identity=26.5625, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646448, Length=256, Percent_Identity=26.5625, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646452, Length=256, Percent_Identity=26.5625, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646450, Length=256, Percent_Identity=26.5625, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI62472511, Length=256, Percent_Identity=26.5625, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI45552429, Length=282, Percent_Identity=24.822695035461, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24585514, Length=282, Percent_Identity=24.822695035461, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574282, Length=282, Percent_Identity=24.822695035461, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574284, Length=282, Percent_Identity=24.822695035461, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45551003, Length=282, Percent_Identity=24.822695035461, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXB_EDWI9 (C5B8N0)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002934125.1
- GeneID:   7959932
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2722
- OMA:   SAPGCNA
- ProtClustDB:   CLSK2813416
- GO:   GO:0005737
- HAMAP:   MF_01825
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10996:SF4

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C

EC number: =1.1.1.290

Molecular weight: Translated: 40521; Mature: 40521

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 208-208 ACT_SITE 237-237 ACT_SITE 254-254 BINDING 45-45 BINDING 66-66 BINDING 146-146 BINDING 175-175 BINDING 232-232 BINDING 257-257 BINDING 258-258

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MKIVVDENMPYAEALFGRLGEVVAVRGRPLPAAALVGADALMVRSVTTVNQALLAGQRVR
CEEEEECCCCHHHHHHHHHCCEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCEEE
FVGTATAGTDHVDTAWLAQAGIGFSAAPGCNAIAVVEYVFSALMLLAERDGFALRDKTVG
EEEECCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCEE
IVGVGNVGSRLQRRLTALGIRTLLCDPPRADRGDDEQFHSLADLQREADIITFHTPLNKS
EEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCC
GPYRTLHLADADFLRGLPPGRILINAGRGAVVDNAALLQALEAGQDLRVVLDVWEPEPML
CCEEEEEECCHHHHHCCCCCEEEEECCCCCEEHHHHHHHHHHCCCCEEEEEEECCCCCCC
SLPLLARVDIATPHIAGYSLEGKARGTTQVFEAFSTFLGQPQSVVLPSLLPPPPVASVRI
CCCHHEEEECCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEE
HGHPDQAMLKRLMHLVYDVRRDDVPLRRVAAQEGEFDRLRKHYPARREWSSLQVLCDDCT
ECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHCCC
SASLLTALGFDARVA
CHHHHHHHCCCCCCC
>Mature Secondary Structure
MKIVVDENMPYAEALFGRLGEVVAVRGRPLPAAALVGADALMVRSVTTVNQALLAGQRVR
CEEEEECCCCHHHHHHHHHCCEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCEEE
FVGTATAGTDHVDTAWLAQAGIGFSAAPGCNAIAVVEYVFSALMLLAERDGFALRDKTVG
EEEECCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCEE
IVGVGNVGSRLQRRLTALGIRTLLCDPPRADRGDDEQFHSLADLQREADIITFHTPLNKS
EEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCC
GPYRTLHLADADFLRGLPPGRILINAGRGAVVDNAALLQALEAGQDLRVVLDVWEPEPML
CCEEEEEECCHHHHHCCCCCEEEEECCCCCEEHHHHHHHHHHCCCCEEEEEEECCCCCCC
SLPLLARVDIATPHIAGYSLEGKARGTTQVFEAFSTFLGQPQSVVLPSLLPPPPVASVRI
CCCHHEEEECCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEE
HGHPDQAMLKRLMHLVYDVRRDDVPLRRVAAQEGEFDRLRKHYPARREWSSLQVLCDDCT
ECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHCCC
SASLLTALGFDARVA
CHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA