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The map label for this gene is nuoH

Identifier: 238920561

GI number: 238920561

Start: 2567145

End: 2568122

Strand: Reverse

Name: nuoH

Synonym: NT01EI_2673

Alternate gene names: 238920561

Gene position: 2568122-2567145 (Counterclockwise)

Preceding gene: 238920562

Following gene: 238920560

Centisome position: 67.36

GC content: 59.0

Gene sequence:

>978_bases
ATGAGCGTAATAACGCCGGATACGGTGGAGATCCTTCTCACCGTGCTGAAGGCTGTGGTGATCCTGCTGGTGGTGGTCAC
CTGCGGGGCCTTTATGAGCTTCGGTGAACGCCGTCTGCTGGGGCTGTTCCAGAACCGCTATGGGCCAAGTCGGGTCGGGT
GGGGCGGTTCGCTGCAGCTGGTGGCGGATATGATCAAGATGTTCTTCAAGGAGGACTGGGTTCCGCCGTTCACCGATCGC
CTGATCTTTACCCTGGCGCCGATGATCGCCTTCTGCTCGCTGCTGCTCTCGTTTGCCATCGTGCCGGTGGCGCCGGGCTG
GATGGGGGCCGACCTTAACATCGGCATCCTGTTTTTCCTGATGATGGCCGGGCTGGCGGTGTATGCGGTGCTGTTCGCCG
GCTGGTCGAGCAACAACAAATACTCTCTGCTGGGGGCGATGCGTGCCTCGGCACAGACCCTGAGCTACGAGGTGTTCCTG
GGTCTTTCGCTGATGGGGGTAGTGGCACAGGCCGGTTCCTTCAATATGCAGGTGATCGTCGATTCGCAGACCCATCTGTG
GAACATCATTCCGCAGTTCTTCGGCTTCCTGACCTTTATCATCGCCGGTGTCGCGGTGTGTCACCGTCACCCGTTCGACC
AGCCGGAGGCCGAACAGGAGCTGGCCGACGGCTACCATATCGAATACTCCGGGATGAAGTTCGGTCTGTTCTTCGTCGGT
GAATACATCGGTATCGTCACCATTTCAGCGCTGATCGTCACCCTGTTCTTCGGCGGCTGGCACGGGCCGTGGCTGCCGCC
GTTTATCTGGTTTGCCATCAAGACGGCGTTCTTTATGGTGATGTTTATTCTGGTACGCGCCTCCCTGCCGCGTCCCCGCT
ATGACCAGGTGATGGCCTTCGGCTGGCGTATTTGCCTGCCGTTGACGCTGATCAACCTGTTGGTCACGGCGGCTGTCATT
TTGTATCACGCTCAGTAA

Upstream 100 bases:

>100_bases
GCCGCCTGCAGCCGGGCCAGGTCGGTCTGCCGCTGGGTATGCCGGGGGTCGCGCCGGTGTTGAATGGCGTTAAAGTGGAT
TACATGCGGGAGGCTGCGGT

Downstream 100 bases:

>100_bases
AAGGGGTGAGTGTAACCATGACATTGAAAGAGTTAGTGGTTGGTTTCGGCACCCAAGTACGCAGCCTGTGGATGATAGGC
CTGCATGCTTTCGCCAAACG

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSVITPDTVEILLTVLKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPSRVGWGGSLQLVADMIKMFFKEDWVPPFTDR
LIFTLAPMIAFCSLLLSFAIVPVAPGWMGADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFL
GLSLMGVVAQAGSFNMQVIVDSQTHLWNIIPQFFGFLTFIIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVG
EYIGIVTISALIVTLFFGGWHGPWLPPFIWFAIKTAFFMVMFILVRASLPRPRYDQVMAFGWRICLPLTLINLLVTAAVI
LYHAQ

Sequences:

>Translated_325_residues
MSVITPDTVEILLTVLKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPSRVGWGGSLQLVADMIKMFFKEDWVPPFTDR
LIFTLAPMIAFCSLLLSFAIVPVAPGWMGADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFL
GLSLMGVVAQAGSFNMQVIVDSQTHLWNIIPQFFGFLTFIIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVG
EYIGIVTISALIVTLFFGGWHGPWLPPFIWFAIKTAFFMVMFILVRASLPRPRYDQVMAFGWRICLPLTLINLLVTAAVI
LYHAQ
>Mature_324_residues
SVITPDTVEILLTVLKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPSRVGWGGSLQLVADMIKMFFKEDWVPPFTDRL
IFTLAPMIAFCSLLLSFAIVPVAPGWMGADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFLG
LSLMGVVAQAGSFNMQVIVDSQTHLWNIIPQFFGFLTFIIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGE
YIGIVTISALIVTLFFGGWHGPWLPPFIWFAIKTAFFMVMFILVRASLPRPRYDQVMAFGWRICLPLTLINLLVTAAVIL
YHAQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=283, Percent_Identity=39.5759717314488, Blast_Score=195, Evalue=4e-50,
Organism=Escherichia coli, GI1788618, Length=325, Percent_Identity=89.5384615384615, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI1789077, Length=256, Percent_Identity=28.125, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_EDWI9 (C5B8I0)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002934076.1
- GeneID:   7961699
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2673
- OMA:   MSWLTPE
- ProtClustDB:   PRK06076
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 36169; Mature: 36037

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1c6f5930)-; HASH(0x1dc398e0)-; HASH(0x1e3bf754)-; HASH(0x1e8a70f8)-; HASH(0x1e42c7e4)-; HASH(0x1e1365f8)-; HASH(0x1e88e958)-; HASH(0x1c837430)-; HASH(0x1e948e78)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVITPDTVEILLTVLKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPSRVGWGGSLQL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
VADMIKMFFKEDWVPPFTDRLIFTLAPMIAFCSLLLSFAIVPVAPGWMGADLNIGILFFL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFLGLSLMGVVAQAGSFNMQVIV
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
DSQTHLWNIIPQFFGFLTFIIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEECCCEEHHHHHH
EYIGIVTISALIVTLFFGGWHGPWLPPFIWFAIKTAFFMVMFILVRASLPRPRYDQVMAF
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
GWRICLPLTLINLLVTAAVILYHAQ
HHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
SVITPDTVEILLTVLKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPSRVGWGGSLQL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH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HHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA