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The map label for this gene is tyrP [H]

Identifier: 238920531

GI number: 238920531

Start: 2536610

End: 2537827

Strand: Direct

Name: tyrP [H]

Synonym: NT01EI_2643

Alternate gene names: 238920531

Gene position: 2536610-2537827 (Clockwise)

Preceding gene: 238920529

Following gene: 238920532

Centisome position: 66.54

GC content: 63.22

Gene sequence:

>1218_bases
GTGAGAAATCGTACAATTGGCAGTGTTTTTATCGTGGCAGGAACCACCATTGGCGCAGGGATGCTGGCGATGCCGCTGGC
CGCCGCCGGCGTCGGCTTTAGTACCACGCTGGTGATGCTGATCGGGCTGTGGGCGCTGATGTGCTACACGGCTCTGCTGA
TGGTCGAAGTCTACCAGCATGCCCCGGCCGATGAAGGGCTGGGCACCCTGGCCCGCCGCTATCTGGGGCGCCCCGGCCAA
TGGCTGGCCGGTATCAGCATGCTGTTCCTCATGTACGCGCTCACCGCGGCCTATATCAGCGGTGCCGGTGAGCTGTTGGC
CGCCAGCCTGGGACAGTGGCTGTCACTGTCGGTTTCACCGGCAGTGGGGGTGCTGCTGTTCACGCTGGCCGGTGGCACTA
TCGTCAGCGTCGGTACCCATTCGGTCGATCTGTTCAACCGCCTGCTGTTCAGCGCCAAAATCGTGCTGCTGGTGGTGATG
CTGACGCTGATGATGCCCCACATTCAGCATACCAACCTGCTCAGCATGCCGCTGGAAAAAGGGCTGGCGCTGTCGGCTAT
TCCGGTCATCTTTACCTCTTTTGGGTTCCACGGCAGCGTGCCGAGCATCGTCAGCTACATGAAAGGTGATATGCGCCGCC
TGCGGCTCATCTTCATTACCGGCAGTGCCATTCCGCTGCTGGCCTATATTTTCTGGCAGCTGGCCACCCTGGGCACCATC
AGCAACCACACCTTTCTCGGCCTGCTAGCGACCCATGCCGGACTGAACGGGCTGCTGCAGGCGGTACGTGCCGTGGTGGC
AGCGCCTCATGTCGAGCTGGCGGTGCATCTGTTCGCCGACCTGGCGCTGGCGACCTCGTTTCTTGGCGTGTCACTGGGGC
TATTTGACTATCTGGGCGATCTGTTCCAACGCCGCCGTAACGCCTCCGGGCGCTTGCAGACCGGCATTCTGACCTTTATT
CCGCCCCTGGCCTTTGCCCTGTTCTATCCGCAGGGATTCGTCATGGCGCTGGGCTACGCCGCCATCGCGCTGGCGGTGCT
GGCGCTGCTGCTGCCGGCGCTGCTGGTATGGCAAACCCGCCGTCGCCACGGCGGACTGCCCAACGGCTACCGGGTCGCCG
GCGGCCGCCCGCTGCTGTGGCTGGTGCTGCTGTGCGGTGTCGCAGTGATCGCCATACAGCTGTCAATCGCGGCGGGGCTC
TTGCCAGAGGTGGGATAA

Upstream 100 bases:

>100_bases
ATAAATAATTACATATGATGTAACGACAGTTTGACGATAGTGGTATTTTCCCGTACGCTGCCACAAAATAACTCCCTGGA
GCAGTAAAGCAGAGGAAAGC

Downstream 100 bases:

>100_bases
GGCAGTATGGTGAAACGATGAAAATTACACTGTCCCGCCTGATCCCCTTTCGCTGGTGGCGCCGTTTACTGCGGCGGCCC
GATACTGTGTTCTTCTGATT

Product: tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MRNRTIGSVFIVAGTTIGAGMLAMPLAAAGVGFSTTLVMLIGLWALMCYTALLMVEVYQHAPADEGLGTLARRYLGRPGQ
WLAGISMLFLMYALTAAYISGAGELLAASLGQWLSLSVSPAVGVLLFTLAGGTIVSVGTHSVDLFNRLLFSAKIVLLVVM
LTLMMPHIQHTNLLSMPLEKGLALSAIPVIFTSFGFHGSVPSIVSYMKGDMRRLRLIFITGSAIPLLAYIFWQLATLGTI
SNHTFLGLLATHAGLNGLLQAVRAVVAAPHVELAVHLFADLALATSFLGVSLGLFDYLGDLFQRRRNASGRLQTGILTFI
PPLAFALFYPQGFVMALGYAAIALAVLALLLPALLVWQTRRRHGGLPNGYRVAGGRPLLWLVLLCGVAVIAIQLSIAAGL
LPEVG

Sequences:

>Translated_405_residues
MRNRTIGSVFIVAGTTIGAGMLAMPLAAAGVGFSTTLVMLIGLWALMCYTALLMVEVYQHAPADEGLGTLARRYLGRPGQ
WLAGISMLFLMYALTAAYISGAGELLAASLGQWLSLSVSPAVGVLLFTLAGGTIVSVGTHSVDLFNRLLFSAKIVLLVVM
LTLMMPHIQHTNLLSMPLEKGLALSAIPVIFTSFGFHGSVPSIVSYMKGDMRRLRLIFITGSAIPLLAYIFWQLATLGTI
SNHTFLGLLATHAGLNGLLQAVRAVVAAPHVELAVHLFADLALATSFLGVSLGLFDYLGDLFQRRRNASGRLQTGILTFI
PPLAFALFYPQGFVMALGYAAIALAVLALLLPALLVWQTRRRHGGLPNGYRVAGGRPLLWLVLLCGVAVIAIQLSIAAGL
LPEVG
>Mature_405_residues
MRNRTIGSVFIVAGTTIGAGMLAMPLAAAGVGFSTTLVMLIGLWALMCYTALLMVEVYQHAPADEGLGTLARRYLGRPGQ
WLAGISMLFLMYALTAAYISGAGELLAASLGQWLSLSVSPAVGVLLFTLAGGTIVSVGTHSVDLFNRLLFSAKIVLLVVM
LTLMMPHIQHTNLLSMPLEKGLALSAIPVIFTSFGFHGSVPSIVSYMKGDMRRLRLIFITGSAIPLLAYIFWQLATLGTI
SNHTFLGLLATHAGLNGLLQAVRAVVAAPHVELAVHLFADLALATSFLGVSLGLFDYLGDLFQRRRNASGRLQTGILTFI
PPLAFALFYPQGFVMALGYAAIALAVLALLLPALLVWQTRRRHGGLPNGYRVAGGRPLLWLVLLCGVAVIAIQLSIAAGL
LPEVG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=406, Percent_Identity=75.1231527093596, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1789552, Length=386, Percent_Identity=32.3834196891192, Blast_Score=204, Evalue=9e-54,
Organism=Escherichia coli, GI1790145, Length=412, Percent_Identity=28.3980582524272, Blast_Score=189, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42991; Mature: 42991

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNRTIGSVFIVAGTTIGAGMLAMPLAAAGVGFSTTLVMLIGLWALMCYTALLMVEVYQH
CCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APADEGLGTLARRYLGRPGQWLAGISMLFLMYALTAAYISGAGELLAASLGQWLSLSVSP
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCH
AVGVLLFTLAGGTIVSVGTHSVDLFNRLLFSAKIVLLVVMLTLMMPHIQHTNLLSMPLEK
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHC
GLALSAIPVIFTSFGFHGSVPSIVSYMKGDMRRLRLIFITGSAIPLLAYIFWQLATLGTI
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHC
SNHTFLGLLATHAGLNGLLQAVRAVVAAPHVELAVHLFADLALATSFLGVSLGLFDYLGD
CCCHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFQRRRNASGRLQTGILTFIPPLAFALFYPQGFVMALGYAAIALAVLALLLPALLVWQTR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRHGGLPNGYRVAGGRPLLWLVLLCGVAVIAIQLSIAAGLLPEVG
HHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRNRTIGSVFIVAGTTIGAGMLAMPLAAAGVGFSTTLVMLIGLWALMCYTALLMVEVYQH
CCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APADEGLGTLARRYLGRPGQWLAGISMLFLMYALTAAYISGAGELLAASLGQWLSLSVSP
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCH
AVGVLLFTLAGGTIVSVGTHSVDLFNRLLFSAKIVLLVVMLTLMMPHIQHTNLLSMPLEK
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHC
GLALSAIPVIFTSFGFHGSVPSIVSYMKGDMRRLRLIFITGSAIPLLAYIFWQLATLGTI
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHC
SNHTFLGLLATHAGLNGLLQAVRAVVAAPHVELAVHLFADLALATSFLGVSLGLFDYLGD
CCCHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFQRRRNASGRLQTGILTFIPPLAFALFYPQGFVMALGYAAIALAVLALLLPALLVWQTR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRHGGLPNGYRVAGGRPLLWLVLLCGVAVIAIQLSIAAGLLPEVG
HHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]