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The map label for this gene is moaE [H]

Identifier: 238920525

GI number: 238920525

Start: 2531604

End: 2532056

Strand: Reverse

Name: moaE [H]

Synonym: NT01EI_2637

Alternate gene names: 238920525

Gene position: 2532056-2531604 (Counterclockwise)

Preceding gene: 238920526

Following gene: 238920524

Centisome position: 66.42

GC content: 66.67

Gene sequence:

>453_bases
ATGCAGGATACCCAGATTGTCGTCAGTGCCGCCCCCTTTTCCGTCGCCGAACAGTATCAGTGGCTGGCGCAGCGGGATGA
GGACGGGGCGGTAGTGACCTTCAGCGGCAAGGTGCGCAACCATAACCTGGGCGATGACGTCAGCGCGCTGACCCTGGAGC
ACTATCCGGGTATGACGGAGAAGGCGCTGGCGGAGATCGTCGCGCTGGCGCGCCGCCGCTGGCCGCTGGGGCGCATCGCG
GTGTATCACCGCGTCGGGCCGATGTTTCCCGGTGAGGAGATCGTGTTTGTCGGGGTGACCAGCGCGCACCGCGGCATGGC
CTTTGAGGCGGCGGAGTTCATCATGGACTACCTGAAGACCCGCGCTCCTTTCTGGAAGCGGGAGACCTCGGAGGGGGCCG
ATCGCTGGGTCGATGCCCGCGACAGCGATCGCCAGGCGGCCGAGCGCTGGTAG

Upstream 100 bases:

>100_bases
AAGCTGTTGGCCGCTGTGAATCAGACCATGGCGCCCTTCGACCACCCGCTGCAGGACGGTGACGAGGTAGCCTTTTTCCC
ACCGGTGACCGGAGGCTGAG

Downstream 100 bases:

>100_bases
CGCCGATACGCAGCGAATGCCGCTGACGTGGATTTCCCGCCGGAGCTGGCCTATAACTGTGGTGATTATCCGTGGATAAA
AGGAGTCGGGATCATGGCAG

Product: molybdopterin guanine dinucleotide biosynthesis protein MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MQDTQIVVSAAPFSVAEQYQWLAQRDEDGAVVTFSGKVRNHNLGDDVSALTLEHYPGMTEKALAEIVALARRRWPLGRIA
VYHRVGPMFPGEEIVFVGVTSAHRGMAFEAAEFIMDYLKTRAPFWKRETSEGADRWVDARDSDRQAAERW

Sequences:

>Translated_150_residues
MQDTQIVVSAAPFSVAEQYQWLAQRDEDGAVVTFSGKVRNHNLGDDVSALTLEHYPGMTEKALAEIVALARRRWPLGRIA
VYHRVGPMFPGEEIVFVGVTSAHRGMAFEAAEFIMDYLKTRAPFWKRETSEGADRWVDARDSDRQAAERW
>Mature_150_residues
MQDTQIVVSAAPFSVAEQYQWLAQRDEDGAVVTFSGKVRNHNLGDDVSALTLEHYPGMTEKALAEIVALARRRWPLGRIA
VYHRVGPMFPGEEIVFVGVTSAHRGMAFEAAEFIMDYLKTRAPFWKRETSEGADRWVDARDSDRQAAERW

Specific function: Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=108, Percent_Identity=37.037037037037, Blast_Score=87, Evalue=6e-18,
Organism=Escherichia coli, GI1787003, Length=150, Percent_Identity=75.3333333333333, Blast_Score=241, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17509279, Length=101, Percent_Identity=38.6138613861386, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356259, Length=137, Percent_Identity=35.7664233576642, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 16984; Mature: 16984

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDTQIVVSAAPFSVAEQYQWLAQRDEDGAVVTFSGKVRNHNLGDDVSALTLEHYPGMTE
CCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHEEHHCCCCCCH
KALAEIVALARRRWPLGRIAVYHRVGPMFPGEEIVFVGVTSAHRGMAFEAAEFIMDYLKT
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
RAPFWKRETSEGADRWVDARDSDRQAAERW
CCCCCCCCCCCCHHHHCCCCCCCHHHHHCC
>Mature Secondary Structure
MQDTQIVVSAAPFSVAEQYQWLAQRDEDGAVVTFSGKVRNHNLGDDVSALTLEHYPGMTE
CCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHEEHHCCCCCCH
KALAEIVALARRRWPLGRIAVYHRVGPMFPGEEIVFVGVTSAHRGMAFEAAEFIMDYLKT
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
RAPFWKRETSEGADRWVDARDSDRQAAERW
CCCCCCCCCCCCHHHHCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8361352; 8905232; 9278503; 8514782; 11135669 [H]