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The map label for this gene is yeiQ [H]

Identifier: 238920469

GI number: 238920469

Start: 2473684

End: 2475156

Strand: Direct

Name: yeiQ [H]

Synonym: NT01EI_2580

Alternate gene names: 238920469

Gene position: 2473684-2475156 (Clockwise)

Preceding gene: 238920466

Following gene: 238920475

Centisome position: 64.89

GC content: 61.85

Gene sequence:

>1473_bases
ATGAACAACCTCGCCAACTATACTTTAGCGGCCGACGTACAGCGCCCCACCTACGATCGCAGCGCCCTGAAATCCCGCCT
CGTGCACCTGGGATTTGGCGCATTTCATCGGGCTCATCAGGCGCTGCTTACCGACCGCGTGCTGAATAAGCTGGGCGGTG
ACTGGGGCTACTGTGAGATCAACCTGATCGGCGGTGAGACCCTGATCGAACAGCTGCGCCAGCAGGATCATCTGTACAGC
GTACTGGAGAAGGGCGCCAGTCATAATCAGGCCATCGTCATCGGTGCGGTACATGAGTCGCTGCATGCCACCCTCGACGG
TATCCACGCCGTGGTAGAAAAGATGGCCGAGCCGCAGGTGGCCATCGTCTCCCTGACGGTCACCGAAAAAGGTTATTGTA
TTGAGCCTGGCAGCGGTCGTCTGGATCTCAGCAACCCGCTGATTAAGGCCGATCTGGCGCATCCGCAGCAGCCGGCATCC
GCCCCCGGTGCAATTGTAGAGGCCCTGCGCCTGCGCTGCGAACGCGGCCTGCCGCCTTTTACCGTGCTCTCCTGCGACAA
CATTCCGGAAAACGGCCACGTGGTGAAAAATGCGGTGCTGGATCTGGCGCAGGCGCGCGATCCGCAGCTGGCGGCGTGGA
TCGCCGACAGCGTCACCTTCCCCAGTACCATGGTCGATCGCATCGTACCGGCGGTCACCGAGGAGACCCTGACCCAGATC
AGCGCGGCCCTTGGCGTCGATGACCCGTGCGGTATCGCCTGCGAACCCTTTATTCAGTGGGTGGTCGAGGATAACTTCGT
CGCCGGACGCCCCGAGTGGGAAGCCGTCGGCGCCGAGCTGGTCAGCGACGTACTGCCCTATGAAGAGATGAAGCTGCGCA
TGCTCAACGGCAGCCACTCTTTCCTGGCTTACCTGGGCTATCTGGCTGGCTATCAGCACATTAATGACTGTATGGAAGAT
TCCGCCTATCGCCAGAATGCCTATCGCCTGATGCTGCTGGAGCAGGCGCCAACCCTGAGCGTTAGCGGTGTCGATCTGGC
ACGCTATGCAGCGCTGCTGATCGAACGCTACAGTAATCCCTCCCTGAAACACCGCACCTGGCAGATAGCCATGGATGGAA
CCCAGAAGCTGCCGCAGCGAATGCTGGACTCCATTCGCTGGCATCTGGCCTACGGCAGCACCTTCCCCTGCCTGGCGCTG
GGCGTCGCGGGATGGATGCGCTATGTCGGCGGCACCGATGACGCAGGCCTGGCCATCGATGTCCGCGATCCGATGGCAGA
AACCCTGAAACAGTGCGTGGCTAACAGCGCTGATGGCGCGGAGCGTGTTCAGGCACTGCTGAGCGTCAGCGCAGTATTCG
GCGATGTGCTGCCGCAGGAGCCTCGCTTTGTCGAGGCGGTGAGCGCGGCCTACCTGTCGCTGATGCGCCAGGGCGCGGCC
CGTACCTGCGCCGCGCTGGCAAGTCAGGAATAA

Upstream 100 bases:

>100_bases
AGCCCTATCAGTAAGTGGTCTAACACCTTTTATGGCTATAGCAACGAAACAGGCCGCTGAAGGCGGCGCTGCTTCCGTCA
TCCATCAGATGGAGTTACGA

Downstream 100 bases:

>100_bases
TCCTGTCCCAACGCAGTCTGCCGCCCGACGGCGGTAGACTGCGGCGCACCCGACACGGGCGTACCCTTATCTCAAAGCTG
CCGTCGTCTCCAGCGGCACA

Product: D-mannonate oxidoreductase

Products: D-fructuronate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MNNLANYTLAADVQRPTYDRSALKSRLVHLGFGAFHRAHQALLTDRVLNKLGGDWGYCEINLIGGETLIEQLRQQDHLYS
VLEKGASHNQAIVIGAVHESLHATLDGIHAVVEKMAEPQVAIVSLTVTEKGYCIEPGSGRLDLSNPLIKADLAHPQQPAS
APGAIVEALRLRCERGLPPFTVLSCDNIPENGHVVKNAVLDLAQARDPQLAAWIADSVTFPSTMVDRIVPAVTEETLTQI
SAALGVDDPCGIACEPFIQWVVEDNFVAGRPEWEAVGAELVSDVLPYEEMKLRMLNGSHSFLAYLGYLAGYQHINDCMED
SAYRQNAYRLMLLEQAPTLSVSGVDLARYAALLIERYSNPSLKHRTWQIAMDGTQKLPQRMLDSIRWHLAYGSTFPCLAL
GVAGWMRYVGGTDDAGLAIDVRDPMAETLKQCVANSADGAERVQALLSVSAVFGDVLPQEPRFVEAVSAAYLSLMRQGAA
RTCAALASQE

Sequences:

>Translated_490_residues
MNNLANYTLAADVQRPTYDRSALKSRLVHLGFGAFHRAHQALLTDRVLNKLGGDWGYCEINLIGGETLIEQLRQQDHLYS
VLEKGASHNQAIVIGAVHESLHATLDGIHAVVEKMAEPQVAIVSLTVTEKGYCIEPGSGRLDLSNPLIKADLAHPQQPAS
APGAIVEALRLRCERGLPPFTVLSCDNIPENGHVVKNAVLDLAQARDPQLAAWIADSVTFPSTMVDRIVPAVTEETLTQI
SAALGVDDPCGIACEPFIQWVVEDNFVAGRPEWEAVGAELVSDVLPYEEMKLRMLNGSHSFLAYLGYLAGYQHINDCMED
SAYRQNAYRLMLLEQAPTLSVSGVDLARYAALLIERYSNPSLKHRTWQIAMDGTQKLPQRMLDSIRWHLAYGSTFPCLAL
GVAGWMRYVGGTDDAGLAIDVRDPMAETLKQCVANSADGAERVQALLSVSAVFGDVLPQEPRFVEAVSAAYLSLMRQGAA
RTCAALASQE
>Mature_490_residues
MNNLANYTLAADVQRPTYDRSALKSRLVHLGFGAFHRAHQALLTDRVLNKLGGDWGYCEINLIGGETLIEQLRQQDHLYS
VLEKGASHNQAIVIGAVHESLHATLDGIHAVVEKMAEPQVAIVSLTVTEKGYCIEPGSGRLDLSNPLIKADLAHPQQPAS
APGAIVEALRLRCERGLPPFTVLSCDNIPENGHVVKNAVLDLAQARDPQLAAWIADSVTFPSTMVDRIVPAVTEETLTQI
SAALGVDDPCGIACEPFIQWVVEDNFVAGRPEWEAVGAELVSDVLPYEEMKLRMLNGSHSFLAYLGYLAGYQHINDCMED
SAYRQNAYRLMLLEQAPTLSVSGVDLARYAALLIERYSNPSLKHRTWQIAMDGTQKLPQRMLDSIRWHLAYGSTFPCLAL
GVAGWMRYVGGTDDAGLAIDVRDPMAETLKQCVANSADGAERVQALLSVSAVFGDVLPQEPRFVEAVSAAYLSLMRQGAA
RTCAALASQE

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=479, Percent_Identity=64.9269311064718, Blast_Score=659, Evalue=0.0,
Organism=Escherichia coli, GI1787823, Length=481, Percent_Identity=62.1621621621622, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI1790779, Length=477, Percent_Identity=62.0545073375262, Blast_Score=593, Evalue=1e-170,
Organism=Escherichia coli, GI1790028, Length=286, Percent_Identity=28.3216783216783, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI48994885, Length=481, Percent_Identity=23.9085239085239, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324401, Length=479, Percent_Identity=39.6659707724426, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6320765, Length=479, Percent_Identity=39.6659707724426, Blast_Score=358, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: 1.1.1.57

Molecular weight: Translated: 53384; Mature: 53384

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLANYTLAADVQRPTYDRSALKSRLVHLGFGAFHRAHQALLTDRVLNKLGGDWGYCEI
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
NLIGGETLIEQLRQQDHLYSVLEKGASHNQAIVIGAVHESLHATLDGIHAVVEKMAEPQV
EEECHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCE
AIVSLTVTEKGYCIEPGSGRLDLSNPLIKADLAHPQQPASAPGAIVEALRLRCERGLPPF
EEEEEEEECCCEEECCCCCCEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCE
TVLSCDNIPENGHVVKNAVLDLAQARDPQLAAWIADSVTFPSTMVDRIVPAVTEETLTQI
EEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SAALGVDDPCGIACEPFIQWVVEDNFVAGRPEWEAVGAELVSDVLPYEEMKLRMLNGSHS
HHHHCCCCCCCCCHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHH
FLAYLGYLAGYQHINDCMEDSAYRQNAYRLMLLEQAPTLSVSGVDLARYAALLIERYSNP
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCHHHHHHHHHHHHCCCC
SLKHRTWQIAMDGTQKLPQRMLDSIRWHLAYGSTFPCLALGVAGWMRYVGGTDDAGLAID
CCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEE
VRDPMAETLKQCVANSADGAERVQALLSVSAVFGDVLPQEPRFVEAVSAAYLSLMRQGAA
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RTCAALASQE
HHHHHHHCCC
>Mature Secondary Structure
MNNLANYTLAADVQRPTYDRSALKSRLVHLGFGAFHRAHQALLTDRVLNKLGGDWGYCEI
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
NLIGGETLIEQLRQQDHLYSVLEKGASHNQAIVIGAVHESLHATLDGIHAVVEKMAEPQV
EEECHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCE
AIVSLTVTEKGYCIEPGSGRLDLSNPLIKADLAHPQQPASAPGAIVEALRLRCERGLPPF
EEEEEEEECCCEEECCCCCCEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCE
TVLSCDNIPENGHVVKNAVLDLAQARDPQLAAWIADSVTFPSTMVDRIVPAVTEETLTQI
EEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SAALGVDDPCGIACEPFIQWVVEDNFVAGRPEWEAVGAELVSDVLPYEEMKLRMLNGSHS
HHHHCCCCCCCCCHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHH
FLAYLGYLAGYQHINDCMEDSAYRQNAYRLMLLEQAPTLSVSGVDLARYAALLIERYSNP
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCHHHHHHHHHHHHCCCC
SLKHRTWQIAMDGTQKLPQRMLDSIRWHLAYGSTFPCLALGVAGWMRYVGGTDDAGLAID
CCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEE
VRDPMAETLKQCVANSADGAERVQALLSVSAVFGDVLPQEPRFVEAVSAAYLSLMRQGAA
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RTCAALASQE
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-mannonate; NAD+

Specific reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]