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The map label for this gene is mtr [H]

Identifier: 238920465

GI number: 238920465

Start: 2469130

End: 2470380

Strand: Direct

Name: mtr [H]

Synonym: NT01EI_2576

Alternate gene names: 238920465

Gene position: 2469130-2470380 (Clockwise)

Preceding gene: 238920463

Following gene: 238920466

Centisome position: 64.77

GC content: 61.55

Gene sequence:

>1251_bases
ATGACCATGGAGCAGACCTTGACCCATTCGCTGCAACGCCCCTCCGTTCTGGGCGGCGCGATGATCATCGCCGGCACCGC
CGTCGGCGCCGGTATGTTTTCGATCCCTGTCGTCACCGCCGGCGTCTGGTTTAGCCTCTCCGTCGTGCTGCTGCTCGTCA
CCTGGGCCTGCATGTATCTGTCCGGTCTGATGATCCTGGAGAGCAACCTGCACTACCCGGCGGGCGCCAGCTTTCACACC
ATGGTCGGCGATCTGCTGGGGAAGGGATGGAACAGCGTCAACGGGCTGTCGATCGCCTTCGTGCTGTATATTTTGACCTA
CGCCTACATCTCCGCCGGCGGCTCCATCATCACCCATACCCTGGCGCCGCTGGCCGAGGTAGGGCAGCCGCTGGCCGGCG
GAGTCTTCGCCCTGCTGGTTGGCTTTATCGTCTGGCTGTCAACCCGCGCGGTCGATCGCCTGAGCACCATACTGATCGGC
GGAATGGTGATCACCTTCCTGCTGTCAACCGGTGACATGTTTACTCACGTCGACCGCGCGATCTTGTTTGACAGCGCGGA
TACCCAGGCGAACTACCTGCCCTACGCGCTGGCGGCGCTGCCCTATCTGCTGACGTCGTTCGGCTACCACGGCAACGTGC
CGGGGCTGGTTAAGTACTACAACAAAGACAGCCGCGCCGTGGTACGCAGCCTGCTGTACGGCACCCTGATCGCCCTGGTG
ATCTACATTTTTTGGCAGTACGTGATTCAGGGCAATATCAGCCGCGCCGCCTTCCGCCAGATCATCGCCGAAGGTGGCAA
TATCGGCAGCCTGCTCAAGCAGATGGGCAGCGTCGCCAGCGGCCCATTGGTCACACAGTTGCTGAACGCCTTCTCCTATA
TGGCGCTGGCCAGTTCGTTCCTCGGCGTCTCGCTGGGTCTGTTCGACTACATCGCGGATATGCTGCGCTTTGCGGATACC
CCGAGCGGACGGGCCAAAAGTGCACTGGCCACCTTTGTGCCGCCGACGATCGGGGCCCTGCTGTTCCCCAATGGCTTTTT
GTATGCCATCGGATTTGCCGGTCTGGCCGCAACGATCTGGGCGGTGATCGTCCCTGCGCTGATGGCGCACGCCAGCCGCC
GTCGCTTTCCACAAGCGAGCTATCGCGTCCCCGGCGGGACGGCGGTCATCATCCTGGTTATCGCCTTTGGCCTGCTTAAC
GCTGCAGCCCATATCCTCTCCCTGTTCAATCTGTTACCGATTTACCGCTAA

Upstream 100 bases:

>100_bases
CCATTTTTTTATTCACCATCCGTCTAAATAGTTTACTTTCCGCGCACGACGTCGTACCATTGAGCTAGTACACAAGAATT
ATACCCAGGAGCAACACCCT

Downstream 100 bases:

>100_bases
TGCCAGAGCGCCCTCTCCTACGGGGGCGCTTTTCCCCGCCGATCCGACTTTTTACACCGCCTCCCCTTGCCTGAACGGCA
GCGGGCGGGTAGTGTGTCGC

Product: tryptophan-specific transport protein

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTMEQTLTHSLQRPSVLGGAMIIAGTAVGAGMFSIPVVTAGVWFSLSVVLLLVTWACMYLSGLMILESNLHYPAGASFHT
MVGDLLGKGWNSVNGLSIAFVLYILTYAYISAGGSIITHTLAPLAEVGQPLAGGVFALLVGFIVWLSTRAVDRLSTILIG
GMVITFLLSTGDMFTHVDRAILFDSADTQANYLPYALAALPYLLTSFGYHGNVPGLVKYYNKDSRAVVRSLLYGTLIALV
IYIFWQYVIQGNISRAAFRQIIAEGGNIGSLLKQMGSVASGPLVTQLLNAFSYMALASSFLGVSLGLFDYIADMLRFADT
PSGRAKSALATFVPPTIGALLFPNGFLYAIGFAGLAATIWAVIVPALMAHASRRRFPQASYRVPGGTAVIILVIAFGLLN
AAAHILSLFNLLPIYR

Sequences:

>Translated_416_residues
MTMEQTLTHSLQRPSVLGGAMIIAGTAVGAGMFSIPVVTAGVWFSLSVVLLLVTWACMYLSGLMILESNLHYPAGASFHT
MVGDLLGKGWNSVNGLSIAFVLYILTYAYISAGGSIITHTLAPLAEVGQPLAGGVFALLVGFIVWLSTRAVDRLSTILIG
GMVITFLLSTGDMFTHVDRAILFDSADTQANYLPYALAALPYLLTSFGYHGNVPGLVKYYNKDSRAVVRSLLYGTLIALV
IYIFWQYVIQGNISRAAFRQIIAEGGNIGSLLKQMGSVASGPLVTQLLNAFSYMALASSFLGVSLGLFDYIADMLRFADT
PSGRAKSALATFVPPTIGALLFPNGFLYAIGFAGLAATIWAVIVPALMAHASRRRFPQASYRVPGGTAVIILVIAFGLLN
AAAHILSLFNLLPIYR
>Mature_415_residues
TMEQTLTHSLQRPSVLGGAMIIAGTAVGAGMFSIPVVTAGVWFSLSVVLLLVTWACMYLSGLMILESNLHYPAGASFHTM
VGDLLGKGWNSVNGLSIAFVLYILTYAYISAGGSIITHTLAPLAEVGQPLAGGVFALLVGFIVWLSTRAVDRLSTILIGG
MVITFLLSTGDMFTHVDRAILFDSADTQANYLPYALAALPYLLTSFGYHGNVPGLVKYYNKDSRAVVRSLLYGTLIALVI
YIFWQYVIQGNISRAAFRQIIAEGGNIGSLLKQMGSVASGPLVTQLLNAFSYMALASSFLGVSLGLFDYIADMLRFADTP
SGRAKSALATFVPPTIGALLFPNGFLYAIGFAGLAATIWAVIVPALMAHASRRRFPQASYRVPGGTAVIILVIAFGLLNA
AAHILSLFNLLPIYR

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789552, Length=412, Percent_Identity=57.5242718446602, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1790145, Length=408, Percent_Identity=44.3627450980392, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=34.7394540942928, Blast_Score=238, Evalue=7e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44339; Mature: 44208

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMEQTLTHSLQRPSVLGGAMIIAGTAVGAGMFSIPVVTAGVWFSLSVVLLLVTWACMYL
CCHHHHHHHHHCCCCHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLMILESNLHYPAGASFHTMVGDLLGKGWNSVNGLSIAFVLYILTYAYISAGGSIITHT
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
LAPLAEVGQPLAGGVFALLVGFIVWLSTRAVDRLSTILIGGMVITFLLSTGDMFTHVDRA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ILFDSADTQANYLPYALAALPYLLTSFGYHGNVPGLVKYYNKDSRAVVRSLLYGTLIALV
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHH
IYIFWQYVIQGNISRAAFRQIIAEGGNIGSLLKQMGSVASGPLVTQLLNAFSYMALASSF
HHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LGVSLGLFDYIADMLRFADTPSGRAKSALATFVPPTIGALLFPNGFLYAIGFAGLAATIW
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHH
AVIVPALMAHASRRRFPQASYRVPGGTAVIILVIAFGLLNAAAHILSLFNLLPIYR
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TMEQTLTHSLQRPSVLGGAMIIAGTAVGAGMFSIPVVTAGVWFSLSVVLLLVTWACMYL
CHHHHHHHHHCCCCHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLMILESNLHYPAGASFHTMVGDLLGKGWNSVNGLSIAFVLYILTYAYISAGGSIITHT
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
LAPLAEVGQPLAGGVFALLVGFIVWLSTRAVDRLSTILIGGMVITFLLSTGDMFTHVDRA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ILFDSADTQANYLPYALAALPYLLTSFGYHGNVPGLVKYYNKDSRAVVRSLLYGTLIALV
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHH
IYIFWQYVIQGNISRAAFRQIIAEGGNIGSLLKQMGSVASGPLVTQLLNAFSYMALASSF
HHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LGVSLGLFDYIADMLRFADTPSGRAKSALATFVPPTIGALLFPNGFLYAIGFAGLAATIW
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHH
AVIVPALMAHASRRRFPQASYRVPGGTAVIILVIAFGLLNAAAHILSLFNLLPIYR
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]