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The map label for this gene is setB [H]

Identifier: 238920463

GI number: 238920463

Start: 2467380

End: 2468579

Strand: Direct

Name: setB [H]

Synonym: NT01EI_2574

Alternate gene names: 238920463

Gene position: 2467380-2468579 (Clockwise)

Preceding gene: 238920462

Following gene: 238920465

Centisome position: 64.72

GC content: 62.67

Gene sequence:

>1200_bases
ATGCTGACTTTTGCCCACCATCTTGCCCGGCGTTTACCCGATCGTACCGGCAGCGCCTTCCTGATCGTCGCTTTTCTGAC
CGGAATTGCCGGGGCGCTACAGACTCCGACGCTGAGCCTGTTTCTCTCAAGTCAGATTACCGGCAGCCCGCTGATGGTCG
GGCTGTTTTATACCGGCAGCGCGGTCATTGGCATCATCGTCAGCCAGTGGCTCGCCAACCTCTCCGATCGGCGCGGCGAT
CGTAAACAACTGATCCTGCTATGCTGCCTGCTGGGAGCACTGGGCTGCCTGCTGTTCGCCTACAACCGTAACTACTATCT
GCTGCTGATCGTCGGCGTCTGTCTGACCAGCTTTGGCTCCACCGCCAACCCGCAGATGTTTGCCCTGGCGCGGGAGTACG
CCGATCGCTGCGGCAAAGAGGCGGTGATGTTCAGCTCCGTACTGCGCGCGCAAATCTCCCTGGCCTGGGTGATTGGTCCA
CCGTTGGCCTTTGCCATGGCGCTGGGCTGGGGCTTTACCTTTATGTATCTGGCCGCCACCCTCACCTTTCTGCTGTGCGC
CGCCATTGTCTGGCGCTGGCTGCCGTCCATGCCGCGGACGGCAGAGACGCCACACGGCGGCACGCAGGCGCCGCGGCGTA
ATCGGCACCAGACCCTGCTGCTGCTGGCCTGCGCCACACTGATGTGGACCTGTAACAGCATGTACCTGATCAATATGCCG
CTGTATATCTGCGGCCAGCTGCAGCTGCCGGAGCGCCTGGCGGGTCTGATGATGGGAACTGCCGCCGGGCTGGAGATCCC
GACGATGCTGCTCGCCGGCGTCTATGCCGGACGGCTGGGAAAGCGGCGACTGATGCTCCTGGCGCTGATAGCCGGTCTGC
TGTTTTACGGCGGGCTGCTGTGGCTTACCCAGCCCTGGGCGCTGTTGGCCCTACAGCTGCTCAACGCGGTATTTATCGGT
ATTCTGGCCGGGATCGGCATGCTCTACTTTCAGGATCTGATGCCGGGACAGGCGGGTTCAGCCACGACGCTGTTCACCAC
CAGCGGACGTATCGGCTGGATCATCGCCGGCTCCGTGGCCGGTGCACTGGCCGAAATCTGGAGCTACGCATCCGTATTCC
CGGTGGCGCTGGTGATGCTGTTCATCGCCCTCGCCTGCCTGCTGCAGATAAAGCCGGATCGCCCGGCCGTAACGACGTAG

Upstream 100 bases:

>100_bases
TGGCGCAGATAAATATTGAAACCCCTTTTCATTTTAGAGAATTACCGGTAACATGCGCAGCGCATATCCCCTGACGCCCT
GACCCGATACCGGTTTTCTC

Downstream 100 bases:

>100_bases
AGCGGCTATCCGTCCGGCGCCGTCTCCTGCTCCAGATGCCGCAGATAGCCCAGGGCCGCTTCGCGGCTCTGTCCGCACAT
TTCAGCACAGGGTTTAAGTT

Product: sugar efflux transporter B

Products: lactose [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MLTFAHHLARRLPDRTGSAFLIVAFLTGIAGALQTPTLSLFLSSQITGSPLMVGLFYTGSAVIGIIVSQWLANLSDRRGD
RKQLILLCCLLGALGCLLFAYNRNYYLLLIVGVCLTSFGSTANPQMFALAREYADRCGKEAVMFSSVLRAQISLAWVIGP
PLAFAMALGWGFTFMYLAATLTFLLCAAIVWRWLPSMPRTAETPHGGTQAPRRNRHQTLLLLACATLMWTCNSMYLINMP
LYICGQLQLPERLAGLMMGTAAGLEIPTMLLAGVYAGRLGKRRLMLLALIAGLLFYGGLLWLTQPWALLALQLLNAVFIG
ILAGIGMLYFQDLMPGQAGSATTLFTTSGRIGWIIAGSVAGALAEIWSYASVFPVALVMLFIALACLLQIKPDRPAVTT

Sequences:

>Translated_399_residues
MLTFAHHLARRLPDRTGSAFLIVAFLTGIAGALQTPTLSLFLSSQITGSPLMVGLFYTGSAVIGIIVSQWLANLSDRRGD
RKQLILLCCLLGALGCLLFAYNRNYYLLLIVGVCLTSFGSTANPQMFALAREYADRCGKEAVMFSSVLRAQISLAWVIGP
PLAFAMALGWGFTFMYLAATLTFLLCAAIVWRWLPSMPRTAETPHGGTQAPRRNRHQTLLLLACATLMWTCNSMYLINMP
LYICGQLQLPERLAGLMMGTAAGLEIPTMLLAGVYAGRLGKRRLMLLALIAGLLFYGGLLWLTQPWALLALQLLNAVFIG
ILAGIGMLYFQDLMPGQAGSATTLFTTSGRIGWIIAGSVAGALAEIWSYASVFPVALVMLFIALACLLQIKPDRPAVTT
>Mature_399_residues
MLTFAHHLARRLPDRTGSAFLIVAFLTGIAGALQTPTLSLFLSSQITGSPLMVGLFYTGSAVIGIIVSQWLANLSDRRGD
RKQLILLCCLLGALGCLLFAYNRNYYLLLIVGVCLTSFGSTANPQMFALAREYADRCGKEAVMFSSVLRAQISLAWVIGP
PLAFAMALGWGFTFMYLAATLTFLLCAAIVWRWLPSMPRTAETPHGGTQAPRRNRHQTLLLLACATLMWTCNSMYLINMP
LYICGQLQLPERLAGLMMGTAAGLEIPTMLLAGVYAGRLGKRRLMLLALIAGLLFYGGLLWLTQPWALLALQLLNAVFIG
ILAGIGMLYFQDLMPGQAGSATTLFTTSGRIGWIIAGSVAGALAEIWSYASVFPVALVMLFIALACLLQIKPDRPAVTT

Specific function: Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Set transporter family [H]

Homologues:

Organism=Escherichia coli, GI1788495, Length=378, Percent_Identity=67.1957671957672, Blast_Score=496, Evalue=1e-142,
Organism=Escherichia coli, GI1790091, Length=384, Percent_Identity=58.8541666666667, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI48994875, Length=388, Percent_Identity=53.6082474226804, Blast_Score=392, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004750 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43197; Mature: 43197

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTFAHHLARRLPDRTGSAFLIVAFLTGIAGALQTPTLSLFLSSQITGSPLMVGLFYTGS
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCEEEEEHHHHH
AVIGIIVSQWLANLSDRRGDRKQLILLCCLLGALGCLLFAYNRNYYLLLIVGVCLTSFGS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCC
TANPQMFALAREYADRCGKEAVMFSSVLRAQISLAWVIGPPLAFAMALGWGFTFMYLAAT
CCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHH
LTFLLCAAIVWRWLPSMPRTAETPHGGTQAPRRNRHQTLLLLACATLMWTCNSMYLINMP
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECH
LYICGQLQLPERLAGLMMGTAAGLEIPTMLLAGVYAGRLGKRRLMLLALIAGLLFYGGLL
HHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLTQPWALLALQLLNAVFIGILAGIGMLYFQDLMPGQAGSATTLFTTSGRIGWIIAGSVA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEHHHHH
GALAEIWSYASVFPVALVMLFIALACLLQIKPDRPAVTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLTFAHHLARRLPDRTGSAFLIVAFLTGIAGALQTPTLSLFLSSQITGSPLMVGLFYTGS
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCEEEEEHHHHH
AVIGIIVSQWLANLSDRRGDRKQLILLCCLLGALGCLLFAYNRNYYLLLIVGVCLTSFGS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCC
TANPQMFALAREYADRCGKEAVMFSSVLRAQISLAWVIGPPLAFAMALGWGFTFMYLAAT
CCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHH
LTFLLCAAIVWRWLPSMPRTAETPHGGTQAPRRNRHQTLLLLACATLMWTCNSMYLINMP
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECH
LYICGQLQLPERLAGLMMGTAAGLEIPTMLLAGVYAGRLGKRRLMLLALIAGLLFYGGLL
HHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLTQPWALLALQLLNAVFIGILAGIGMLYFQDLMPGQAGSATTLFTTSGRIGWIIAGSVA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEHHHHH
GALAEIWSYASVFPVALVMLFIALACLLQIKPDRPAVTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactose [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: lactose [Cytoplasm] + Proton [Periplasm] = lactose [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 10209755; 10438463 [H]