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The map label for this gene is dacC [H]

Identifier: 238920432

GI number: 238920432

Start: 2443168

End: 2444520

Strand: Reverse

Name: dacC [H]

Synonym: NT01EI_2543

Alternate gene names: 238920432

Gene position: 2444520-2443168 (Counterclockwise)

Preceding gene: 238920440

Following gene: 238920426

Centisome position: 64.12

GC content: 55.88

Gene sequence:

>1353_bases
ATGAATTACTTCTCGGCAGGCTTAGCCGCCGCGGTAATGGTGACGGTGGAGTCCGTTGCCCTGCCGATGGTCAGCATGTC
GGGTTGCATCAGGTGCGTTGCCCGGGGCAATGGCATATTATTTGATCATATGAATGGATACACTGGTCTTATCATGAAGA
ATCGTGCACTTACCGTTTTTATTCGCAGGCTAACGTTGGGTGCAAGCCTGTCTCTGGTTGCCTTACCGTTGCAGGCCGCC
GATCCGGCACCGCCGCAGGTCAATGCCAAGGCCTATATTCTGCTGGACTATGATAGCGGCCGGGTGTTGACGGAGGGCAA
CGCCGACGAGCGTCTGGATCCTGCCAGTCTGACCAAAATCATGGCCAGTTATGTTATCGGCCAGGCATTGAAGAGCGGTA
AGATCGCGCCCGGCGATATGGTGGTGGTTGGTAAGGATGCCTGGGCGACGGGAAATCCGCTGCTGCGCGGCTCTTCGCTG
ATGTTTCTAAAACCCGGCGATCGGGTGCCGGTTGCGGAGCTGAACCGCGGAGTGGTTATTCAGTCCGGCAATGACGCCAG
CATCGCGCTGGCAGATCACGTGGCCGGCAGTCAGGATACATTTGTCAACCTGATGAACCAGTACGTTAGTGCCTGGGGGC
TGAAAAATACCCATTTTCAGACCGTCCATGGCCTGGATTCCGAGGGACAGTACAGCTCAGCGCGGGATATGGCGCTGATT
AGCCAGCGCCTGATCGCCGATGTGCCGGATGAGTATCAGCTGAATAAAGAGAAGGAGTTTACCTTTAATAAGATCCGCCA
AATCAATCGCAACCGTCTGCTGTGGGACAGCAGTCTGAACGTGGACGGGGTGAAGACGGGATTTACCAGCGGCGCCGGAC
ATAACCTGGTCGCATCGGCTATAGATGGCCCCATGCGATTGATTTCGGTGGTGTTGGGTGCACCAACCGATCGGGTGCGG
TTTGATGAAAGTAAAAAGCTGTTGACCTGGGGCTTTCGCTTCTATGAAACCGTCACTCCGCTCAAGGTAGGTCAGCCTTT
TACCACCCAGAAAGTGTGGTACGGCGAGCGCCGCGAGGTACCGCTGGGCGTGGATAAAAGTGCCTCGGTCACCATTCCCC
GCGGACAGATGAAGGATCTTAAGGCCAGCTATACGCTGACGCAGTCGCAGCTGGAGGCGCCGCTGAAGAAGGGACAGGCT
GTGGGTACCATCGATTTTCAGCTTAACGGCAAAACCATTGAGCAGCGTCCGCTGGTGGTGTTGGAGGATGTGCCGGAGGC
TGGCTTTTTCGGCCGTATCATTGACTTTGTCATGCTGAAGTTGCACAGCCTGTTCGGCGGTTGGTTCGGCTAA

Upstream 100 bases:

>100_bases
AAAAGTGTGCCCCCGTCCACAATCATGCGTCAAGAAGTGTCGTTATGCTGAAAAAATCCCAGGGATTATGTTAATAGTCC
CGAGGAATGTCATAAAATTA

Downstream 100 bases:

>100_bases
GAGCGCCGAGCGCACCGCTTGTCGCATAAAAAAATGCCCGGCGTTGCCGGGCATTTCATTTATCAACGCTAATCCCCTCC
GATGGAGGGGATCGCGGTAG

Product: D-alanyl-D-alanine carboxypeptidase DacC

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MNYFSAGLAAAVMVTVESVALPMVSMSGCIRCVARGNGILFDHMNGYTGLIMKNRALTVFIRRLTLGASLSLVALPLQAA
DPAPPQVNAKAYILLDYDSGRVLTEGNADERLDPASLTKIMASYVIGQALKSGKIAPGDMVVVGKDAWATGNPLLRGSSL
MFLKPGDRVPVAELNRGVVIQSGNDASIALADHVAGSQDTFVNLMNQYVSAWGLKNTHFQTVHGLDSEGQYSSARDMALI
SQRLIADVPDEYQLNKEKEFTFNKIRQINRNRLLWDSSLNVDGVKTGFTSGAGHNLVASAIDGPMRLISVVLGAPTDRVR
FDESKKLLTWGFRFYETVTPLKVGQPFTTQKVWYGERREVPLGVDKSASVTIPRGQMKDLKASYTLTQSQLEAPLKKGQA
VGTIDFQLNGKTIEQRPLVVLEDVPEAGFFGRIIDFVMLKLHSLFGGWFG

Sequences:

>Translated_450_residues
MNYFSAGLAAAVMVTVESVALPMVSMSGCIRCVARGNGILFDHMNGYTGLIMKNRALTVFIRRLTLGASLSLVALPLQAA
DPAPPQVNAKAYILLDYDSGRVLTEGNADERLDPASLTKIMASYVIGQALKSGKIAPGDMVVVGKDAWATGNPLLRGSSL
MFLKPGDRVPVAELNRGVVIQSGNDASIALADHVAGSQDTFVNLMNQYVSAWGLKNTHFQTVHGLDSEGQYSSARDMALI
SQRLIADVPDEYQLNKEKEFTFNKIRQINRNRLLWDSSLNVDGVKTGFTSGAGHNLVASAIDGPMRLISVVLGAPTDRVR
FDESKKLLTWGFRFYETVTPLKVGQPFTTQKVWYGERREVPLGVDKSASVTIPRGQMKDLKASYTLTQSQLEAPLKKGQA
VGTIDFQLNGKTIEQRPLVVLEDVPEAGFFGRIIDFVMLKLHSLFGGWFG
>Mature_450_residues
MNYFSAGLAAAVMVTVESVALPMVSMSGCIRCVARGNGILFDHMNGYTGLIMKNRALTVFIRRLTLGASLSLVALPLQAA
DPAPPQVNAKAYILLDYDSGRVLTEGNADERLDPASLTKIMASYVIGQALKSGKIAPGDMVVVGKDAWATGNPLLRGSSL
MFLKPGDRVPVAELNRGVVIQSGNDASIALADHVAGSQDTFVNLMNQYVSAWGLKNTHFQTVHGLDSEGQYSSARDMALI
SQRLIADVPDEYQLNKEKEFTFNKIRQINRNRLLWDSSLNVDGVKTGFTSGAGHNLVASAIDGPMRLISVVLGAPTDRVR
FDESKKLLTWGFRFYETVTPLKVGQPFTTQKVWYGERREVPLGVDKSASVTIPRGQMKDLKASYTLTQSQLEAPLKKGQA
VGTIDFQLNGKTIEQRPLVVLEDVPEAGFFGRIIDFVMLKLHSLFGGWFG

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=365, Percent_Identity=72.3287671232877, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI1786851, Length=400, Percent_Identity=63.5, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI87082022, Length=385, Percent_Identity=46.4935064935065, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI87082054, Length=262, Percent_Identity=25.5725190839695, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 49016; Mature: 49016

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYFSAGLAAAVMVTVESVALPMVSMSGCIRCVARGNGILFDHMNGYTGLIMKNRALTVF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCEEEEEEECCHHEEH
IRRLTLGASLSLVALPLQAADPAPPQVNAKAYILLDYDSGRVLTEGNADERLDPASLTKI
HHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHHHH
MASYVIGQALKSGKIAPGDMVVVGKDAWATGNPLLRGSSLMFLKPGDRVPVAELNRGVVI
HHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCEECCEEEEECCCCCCCHHHCCCCEEE
QSGNDASIALADHVAGSQDTFVNLMNQYVSAWGLKNTHFQTVHGLDSEGQYSSARDMALI
ECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHH
SQRLIADVPDEYQLNKEKEFTFNKIRQINRNRLLWDSSLNVDGVKTGFTSGAGHNLVASA
HHHHHHCCCCHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHH
IDGPMRLISVVLGAPTDRVRFDESKKLLTWGFRFYETVTPLKVGQPFTTQKVWYGERREV
CCCHHHHHHHHHCCCCCCEEECCCCCEEEHHHHHHHHCCCCCCCCCCCCCEEECCCCCCC
PLGVDKSASVTIPRGQMKDLKASYTLTQSQLEAPLKKGQAVGTIDFQLNGKTIEQRPLVV
CCCCCCCCEEEECCCHHHHHHHHHEECHHHHHHHHHCCCEEEEEEEEECCCEECCCCEEE
LEDVPEAGFFGRIIDFVMLKLHSLFGGWFG
EECCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNYFSAGLAAAVMVTVESVALPMVSMSGCIRCVARGNGILFDHMNGYTGLIMKNRALTVF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCEEEEEEECCHHEEH
IRRLTLGASLSLVALPLQAADPAPPQVNAKAYILLDYDSGRVLTEGNADERLDPASLTKI
HHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHHHH
MASYVIGQALKSGKIAPGDMVVVGKDAWATGNPLLRGSSLMFLKPGDRVPVAELNRGVVI
HHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCEECCEEEEECCCCCCCHHHCCCCEEE
QSGNDASIALADHVAGSQDTFVNLMNQYVSAWGLKNTHFQTVHGLDSEGQYSSARDMALI
ECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHH
SQRLIADVPDEYQLNKEKEFTFNKIRQINRNRLLWDSSLNVDGVKTGFTSGAGHNLVASA
HHHHHHCCCCHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHH
IDGPMRLISVVLGAPTDRVRFDESKKLLTWGFRFYETVTPLKVGQPFTTQKVWYGERREV
CCCHHHHHHHHHCCCCCCEEECCCCCEEEHHHHHHHHCCCCCCCCCCCCCEEECCCCCCC
PLGVDKSASVTIPRGQMKDLKASYTLTQSQLEAPLKKGQAVGTIDFQLNGKTIEQRPLVV
CCCCCCCCEEEECCCHHHHHHHHHEECHHHHHHHHHCCCEEEEEEEEECCCEECCCCEEE
LEDVPEAGFFGRIIDFVMLKLHSLFGGWFG
EECCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]