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The map label for this gene is sdaB [H]

Identifier: 238920431

GI number: 238920431

Start: 2441692

End: 2443059

Strand: Direct

Name: sdaB [H]

Synonym: NT01EI_2542

Alternate gene names: 238920431

Gene position: 2441692-2443059 (Clockwise)

Preceding gene: 238920430

Following gene: 238920433

Centisome position: 64.05

GC content: 60.23

Gene sequence:

>1368_bases
ATGATTAGCGTTTTTGATATTTATAAGATCGGCATTGGCCCATCCAGTTCCCATACCGTAGGGCCGATGAAGGCCGGTAA
GCAATTTTGCGATGACCTTATCGAAAAAGGTCTGCTAAACGACGTCACCCGCGTCGTTGTTGACGTTTATGGCTCCCTGT
CCCTCACCGGCAAGGGTCACCACACCGATCTGGCCATCATCATGGGGCTGGCCGGTAACCTGCCGGACAGCGTCGATATC
GACAGCATCCCCGTCTTCATCAAGGACGTAGAGACCCGCGGCCGTCTGCTGATGGCCAACGGCCAGCATGAGGTGGCGTT
CCCGCTGGAAAGCAGCATGAACTTCCACGAAGACAATCTGTCTCTGCATGAAAACGGTATGCGCATTACCGCGCTGGCCG
GTGATAAGGTGCTCTACAGCAAGACCTATTACTCTATCGGCGGCGGCTTTATCGTTGATGAAGAGCACTTTGGCCAGCAG
AGCAGTCAGCAGGTTGCCGTCCCGTACCCCTATAGCAGCGCTGCCGATCTGCAGCGTCACTGCAAAGAGTCCGGGCTCTC
CCTGTCCGGCCTGGTGATGCAAAATGAGCTAGCCCTGCACAGTAAGGATGAGATCGCGGCCCACTTCTCCCGGGTTTGGG
ACGTGATGCGTACCGGCATCGAGCGTGGCATCAACACCGAAGGCGTTCTGCCCGGGCCGCTGCGCGTACCGCGCCGAGCC
TCTGCCCTGCGCCGTATGCTGGTCACCAATGACAAGACCAGCGTCGATCCGATGGCCGTTGTCGACTGGATCAACATGTT
CGCCTTCGCAGTGAACGAAGAAAACGCCGCCGGCGGCCGCGTCGTTACCGCGCCGACCAACGGTGCCTGCGGGATCATCC
CCGCCGTTCTGGCCTACTACGATAAGTTTATTCGTGAGGTGAACGCCAACTCGTATACCCGCTACTTCCTGGCTTCCGGC
GTCATCGGTACGCTGTACAAGATGAACGCCTCCATCTCCGGCGCCGAAGTGGGCTGTCAGGGCGAGGTCGGGGTCGCCTG
CTCTATGGCCGCGGCCGGTCTGGCCGAGCTGTTGGGGGGCAGTCCGGCCCAGGTCTGCATGGCGGCTGAGATCGCCATGG
AGCATAACCTGGGGCTAACCTGCGACCCGGTCGCCGGCCAGGTTCAGGTACCGTGCATCGAGCGTAACGCCATCGCCGCC
GTCAAAGCGGTGAACGCGGCGCGTATGGCACTGCGCCGCACCAGCGATCCACGCGTCTGCCTGGATAAGGTTATCGAGAC
CATGTACGAAACTGGCAAGGACATGAACGCCAAGTACCGTGAGACCTCTCGCGGGGGCCTGGCGCTGAAAGTGCTCGCCT
GCGGCTAA

Upstream 100 bases:

>100_bases
AATAACAGTAACAGCCCGACCGGTGCGGCTTCCGCACCGGTCGTTTTTTTATCCTGGCAACAGTTTCAATTTCCAGCCTT
GATAAATCATTGGAGGCGAT

Downstream 100 bases:

>100_bases
GTCGGCCACTACCGCGATCCCCTCCATCGGAGGGGATTAGCGTTGATAAATGAAATGCCCGGCAACGCCGGGCATTTTTT
TATGCGACAAGCGGTGCGCT

Product: L-serine ammonia-lyase

Products: NA

Alternate protein names: SDH 2; L-serine deaminase 2; L-SD2 [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MISVFDIYKIGIGPSSSHTVGPMKAGKQFCDDLIEKGLLNDVTRVVVDVYGSLSLTGKGHHTDLAIIMGLAGNLPDSVDI
DSIPVFIKDVETRGRLLMANGQHEVAFPLESSMNFHEDNLSLHENGMRITALAGDKVLYSKTYYSIGGGFIVDEEHFGQQ
SSQQVAVPYPYSSAADLQRHCKESGLSLSGLVMQNELALHSKDEIAAHFSRVWDVMRTGIERGINTEGVLPGPLRVPRRA
SALRRMLVTNDKTSVDPMAVVDWINMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYYDKFIREVNANSYTRYFLASG
VIGTLYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGGSPAQVCMAAEIAMEHNLGLTCDPVAGQVQVPCIERNAIAA
VKAVNAARMALRRTSDPRVCLDKVIETMYETGKDMNAKYRETSRGGLALKVLACG

Sequences:

>Translated_455_residues
MISVFDIYKIGIGPSSSHTVGPMKAGKQFCDDLIEKGLLNDVTRVVVDVYGSLSLTGKGHHTDLAIIMGLAGNLPDSVDI
DSIPVFIKDVETRGRLLMANGQHEVAFPLESSMNFHEDNLSLHENGMRITALAGDKVLYSKTYYSIGGGFIVDEEHFGQQ
SSQQVAVPYPYSSAADLQRHCKESGLSLSGLVMQNELALHSKDEIAAHFSRVWDVMRTGIERGINTEGVLPGPLRVPRRA
SALRRMLVTNDKTSVDPMAVVDWINMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYYDKFIREVNANSYTRYFLASG
VIGTLYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGGSPAQVCMAAEIAMEHNLGLTCDPVAGQVQVPCIERNAIAA
VKAVNAARMALRRTSDPRVCLDKVIETMYETGKDMNAKYRETSRGGLALKVLACG
>Mature_455_residues
MISVFDIYKIGIGPSSSHTVGPMKAGKQFCDDLIEKGLLNDVTRVVVDVYGSLSLTGKGHHTDLAIIMGLAGNLPDSVDI
DSIPVFIKDVETRGRLLMANGQHEVAFPLESSMNFHEDNLSLHENGMRITALAGDKVLYSKTYYSIGGGFIVDEEHFGQQ
SSQQVAVPYPYSSAADLQRHCKESGLSLSGLVMQNELALHSKDEIAAHFSRVWDVMRTGIERGINTEGVLPGPLRVPRRA
SALRRMLVTNDKTSVDPMAVVDWINMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYYDKFIREVNANSYTRYFLASG
VIGTLYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGGSPAQVCMAAEIAMEHNLGLTCDPVAGQVQVPCIERNAIAA
VKAVNAARMALRRTSDPRVCLDKVIETMYETGKDMNAKYRETSRGGLALKVLACG

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1789161, Length=454, Percent_Identity=86.3436123348018, Blast_Score=829, Evalue=0.0,
Organism=Escherichia coli, GI1788116, Length=451, Percent_Identity=79.3791574279379, Blast_Score=754, Evalue=0.0,
Organism=Escherichia coli, GI48994925, Length=455, Percent_Identity=73.6263736263736, Blast_Score=678, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48783; Mature: 48783

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVFDIYKIGIGPSSSHTVGPMKAGKQFCDDLIEKGLLNDVTRVVVDVYGSLSLTGKGH
CCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
HTDLAIIMGLAGNLPDSVDIDSIPVFIKDVETRGRLLMANGQHEVAFPLESSMNFHEDNL
CCHHHEEEECCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCEEEEECCCCCCCCCCCC
SLHENGMRITALAGDKVLYSKTYYSIGGGFIVDEEHFGQQSSQQVAVPYPYSSAADLQRH
CEECCCEEEEEEECCEEEEEEEEEECCCCEEEEHHHCCCCCCCEEEECCCCCCHHHHHHH
CKESGLSLSGLVMQNELALHSKDEIAAHFSRVWDVMRTGIERGINTEGVLPGPLRVPRRA
HHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
SALRRMLVTNDKTSVDPMAVVDWINMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYY
HHHHHHHHCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DKFIREVNANSYTRYFLASGVIGTLYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGG
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPAQVCMAAEIAMEHNLGLTCDPVAGQVQVPCIERNAIAAVKAVNAARMALRRTSDPRVC
CHHHHHHHHHHHHHCCCCCEECCCCCCEECCEECCCHHHHHHHHHHHHHHHHCCCCCHHH
LDKVIETMYETGKDMNAKYRETSRGGLALKVLACG
HHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECC
>Mature Secondary Structure
MISVFDIYKIGIGPSSSHTVGPMKAGKQFCDDLIEKGLLNDVTRVVVDVYGSLSLTGKGH
CCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
HTDLAIIMGLAGNLPDSVDIDSIPVFIKDVETRGRLLMANGQHEVAFPLESSMNFHEDNL
CCHHHEEEECCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCEEEEECCCCCCCCCCCC
SLHENGMRITALAGDKVLYSKTYYSIGGGFIVDEEHFGQQSSQQVAVPYPYSSAADLQRH
CEECCCEEEEEEECCEEEEEEEEEECCCCEEEEHHHCCCCCCCEEEECCCCCCHHHHHHH
CKESGLSLSGLVMQNELALHSKDEIAAHFSRVWDVMRTGIERGINTEGVLPGPLRVPRRA
HHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
SALRRMLVTNDKTSVDPMAVVDWINMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYY
HHHHHHHHCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DKFIREVNANSYTRYFLASGVIGTLYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGG
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPAQVCMAAEIAMEHNLGLTCDPVAGQVQVPCIERNAIAAVKAVNAARMALRRTSDPRVC
CHHHHHHHHHHHHHCCCCCEECCCCCCEECCEECCCHHHHHHHHHHHHHHHHCCCCCHHH
LDKVIETMYETGKDMNAKYRETSRGGLALKVLACG
HHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8385012; 9278503 [H]