Click here to switch to the map view.

The map label for this gene is clpA [H]

Identifier: 238920381

GI number: 238920381

Start: 2386859

End: 2389153

Strand: Reverse

Name: clpA [H]

Synonym: NT01EI_2491

Alternate gene names: 238920381

Gene position: 2389153-2386859 (Counterclockwise)

Preceding gene: 238920382

Following gene: 238920375

Centisome position: 62.67

GC content: 60.35

Gene sequence:

>2295_bases
ATGCTCAACCAAGAACTGGAACTCAGTCTCAACATGGCGTTCGCCAGAGCGCGCGAGCATCGACACGAGTTTATGACCGT
CGAGCACCTGCTGCTGGCGCTGTTGACGAACCCCGCGGCGCGGGAGGCGCTGGAGGCCTGTGCGGTGGATCTGGCGGCCC
TGCGCCAGGAGCTGGAGAGCTTTATCGAGCAGACTACGCCGTTGCTTCCCCAGGGGAACAGTGAGCGAGATACTCAGCCT
ACCCTGAGTTTTCAGCGGGTGCTGCAGCGGGCGGTTTTTCACGTGCAGTCTTCCGGGCGCAATGAGGTCAGCGGTGCCAA
TGTGCTGGTGGCCATCTTTAGCGAGCAGGAGTCCCAGGCAGCCTATCTGCTGCGTAAGCATGATGTTAGCCGTCTGGATA
TCGTCAATTTTATTTCTCACGGCACCCATAAGAACGAGTCTGGCCCGGCGGCGGGCGGTGGGTCGAACGATGCGCCTGGC
GGGAATGAGGCAGCGGCGGCCCCCGGCGGTGAAGAGCGGATGGAGAATTTCACCACCAACCTGAACCAGCTGGCGCGGGT
CGGCGGCATCGATCCGCTGATCGGTCGCGATCGTGAGCTGGAGCGCGCCATTCAGGTGCTGTGCCGTCGGCGTAAGAATA
ACCCGCTGCTGGTAGGGGAGTCCGGGGTGGGTAAAACCGCGATTGCGGAGGGGTTAGCCTGGCGCATCGTGCAGGGTGAA
GTACCAGAGGTGATGGCCAATTGCACCCTCTATTCGCTGGACATCGGCTCTCTGTTGGCCGGGACCAAGTACCGCGGCGA
CTTTGAGAAGCGCTTTAAGGCGCTGCTGAAGCAGTTGGAGCAGGACAGCGACAGCATCCTGTTTATCGATGAGATCCACA
CCATCATCGGCGCCGGGGCGGCGTCCGGTGGTCAGGTGGATGCCGCCAATCTGATCAAGCCGCTGCTGTCAGGAGGGCGC
ATTCGGGTGATCGGCTCGACCACCTATCAGGAGTTCAGCAATATTTTTGAAAAGGATCGTGCCCTGGCACGCCGGTTCCA
GAAGATCGACATTAATGAACCGAGCGCCGACGATACGGTGCAGATCCTCAACGGACTGAAGGCGAAGTATGAGGCGCACC
ACGATGTACGCTACACCGCCAAGGCCCTGCGCGCGGCGGTCGATCTGTCAGTGAAGTACATCAATGATCGCCACCTGCCG
GATAAGGCCATCGATGTCATCGACGAGGCCGGGGCCCGCAGTCGCCTGATGCCGGCGAGTCGGCGTAAGAAGACCATCAA
TGTGGCGGATATCGAGGCGGTGGTGGCCCGTATCGCGCGTATTCCGGAGAAAACCGTCTCCGCCAGCGACCGCGACGTGC
TGAAGAGCCTGGGCGATCGCCTGCGGATGCTGGTGTTTGGGCAGGATAAGGCCATCAGCGCGCTCACTGAGGCTATTAAG
ATGAGCCGCGCGGGGCTGAATCAGGACCACCGTCCGGTGGGAGCGTTCCTGTTTGCCGGGCCGACCGGCGTCGGCAAGAC
CGAGGTAACGGTACAGCTGGCCCGGGCGCTGGATATCCCGCTGCTGCGCTTTGATATGTCCGAGTATATGGAGCGGCATA
CGGTGAGCCGTCTGATCGGCGCCCCGCCGGGGTATGTTGGCTTTGATCAGGGCGGGCTGCTGACGGACGCGGTGATCAAG
AACCCTCACGCGGTGCTGCTGCTCGATGAGATCGAGAAGGCACACCCGGACGTCTTCAACCTGCTGCTGCAGGTGATGGA
TAACGGCACCCTGACCGATAATAATGGGCGTAAGGCGGACTTCCGCAACGTGATTCTGGTGATGACCACCAACGCTGGGG
TGCAGGAAACGCAGCGTAAGTCAATCGGTTTTAATTTGCAGGACAATAGCAGCGACGCGATGGAGGAGATCAGGCGGATC
TTTACGCCGGAGTTCCGTAACCGGCTGGATAACATCATCTGGTTTAACCATTTGTCGACGGAGATCATCCATCAGGTGGT
CGATAAATTTATCGTCGAACTGCAGGCACAGCTGGATGGCAAAGGCGTTTCACTGGAGGTCAGCGACGCCGCGCGCAACT
GGCTGGCGGAGCGTGGCTACGATCGTGCTATGGGGGCCAGACCGATGGCGCGGGTGATCCAGGATAACCTGAAAAAACCG
TTGGCTAATGAGCTGTTGTTCGGTGAGCTGGTCAACGGTGGCTCGGTCAGCGTTGACGTGGCCGAGGGTGATGCGACCCT
CAGTTACCGTTTTCGCAGCGCGCAGCAGCGCAAGGCCGAGGATGCGATGCACTGA

Upstream 100 bases:

>100_bases
GACCAAGGTGGCATTGATTAATCGCTACGCACGTGACAATGAACATCCGCTGCTGTGCACGCTGGAAAAAGCCTGACCGG
GTAACTGAAGGGAGGTGCCC

Downstream 100 bases:

>100_bases
CGTCATAGGTAGATACAGATAAAGGAAGAGCGCCGTAAGGCGCTCTTTTTTTACCGCCGGGAAAACAAACCGGCAGAATT
ACCCGTCTTGCCGCTGTCGG

Product: ATP-dependent Clp protease ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 764; Mature: 764

Protein sequence:

>764_residues
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLTNPAAREALEACAVDLAALRQELESFIEQTTPLLPQGNSERDTQP
TLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQAAYLLRKHDVSRLDIVNFISHGTHKNESGPAAGGGSNDAPG
GNEAAAAPGGEERMENFTTNLNQLARVGGIDPLIGRDRELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGE
VPEVMANCTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDSDSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSGGR
IRVIGSTTYQEFSNIFEKDRALARRFQKIDINEPSADDTVQILNGLKAKYEAHHDVRYTAKALRAAVDLSVKYINDRHLP
DKAIDVIDEAGARSRLMPASRRKKTINVADIEAVVARIARIPEKTVSASDRDVLKSLGDRLRMLVFGQDKAISALTEAIK
MSRAGLNQDHRPVGAFLFAGPTGVGKTEVTVQLARALDIPLLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIK
NPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVQETQRKSIGFNLQDNSSDAMEEIRRI
FTPEFRNRLDNIIWFNHLSTEIIHQVVDKFIVELQAQLDGKGVSLEVSDAARNWLAERGYDRAMGARPMARVIQDNLKKP
LANELLFGELVNGGSVSVDVAEGDATLSYRFRSAQQRKAEDAMH

Sequences:

>Translated_764_residues
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLTNPAAREALEACAVDLAALRQELESFIEQTTPLLPQGNSERDTQP
TLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQAAYLLRKHDVSRLDIVNFISHGTHKNESGPAAGGGSNDAPG
GNEAAAAPGGEERMENFTTNLNQLARVGGIDPLIGRDRELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGE
VPEVMANCTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDSDSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSGGR
IRVIGSTTYQEFSNIFEKDRALARRFQKIDINEPSADDTVQILNGLKAKYEAHHDVRYTAKALRAAVDLSVKYINDRHLP
DKAIDVIDEAGARSRLMPASRRKKTINVADIEAVVARIARIPEKTVSASDRDVLKSLGDRLRMLVFGQDKAISALTEAIK
MSRAGLNQDHRPVGAFLFAGPTGVGKTEVTVQLARALDIPLLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIK
NPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVQETQRKSIGFNLQDNSSDAMEEIRRI
FTPEFRNRLDNIIWFNHLSTEIIHQVVDKFIVELQAQLDGKGVSLEVSDAARNWLAERGYDRAMGARPMARVIQDNLKKP
LANELLFGELVNGGSVSVDVAEGDATLSYRFRSAQQRKAEDAMH
>Mature_764_residues
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLTNPAAREALEACAVDLAALRQELESFIEQTTPLLPQGNSERDTQP
TLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQAAYLLRKHDVSRLDIVNFISHGTHKNESGPAAGGGSNDAPG
GNEAAAAPGGEERMENFTTNLNQLARVGGIDPLIGRDRELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGE
VPEVMANCTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDSDSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSGGR
IRVIGSTTYQEFSNIFEKDRALARRFQKIDINEPSADDTVQILNGLKAKYEAHHDVRYTAKALRAAVDLSVKYINDRHLP
DKAIDVIDEAGARSRLMPASRRKKTINVADIEAVVARIARIPEKTVSASDRDVLKSLGDRLRMLVFGQDKAISALTEAIK
MSRAGLNQDHRPVGAFLFAGPTGVGKTEVTVQLARALDIPLLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIK
NPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVQETQRKSIGFNLQDNSSDAMEEIRRI
FTPEFRNRLDNIIWFNHLSTEIIHQVVDKFIVELQAQLDGKGVSLEVSDAARNWLAERGYDRAMGARPMARVIQDNLKKP
LANELLFGELVNGGSVSVDVAEGDATLSYRFRSAQQRKAEDAMH

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=330, Percent_Identity=31.8181818181818, Blast_Score=146, Evalue=6e-35,
Organism=Escherichia coli, GI1787109, Length=762, Percent_Identity=85.8267716535433, Blast_Score=1351, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=323, Percent_Identity=43.6532507739938, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6320464, Length=325, Percent_Identity=44.9230769230769, Blast_Score=288, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323002, Length=411, Percent_Identity=35.2798053527981, Blast_Score=242, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84162; Mature: 84162

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLTNPAAREALEACAVDLAALRQELES
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
FIEQTTPLLPQGNSERDTQPTLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQA
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHH
AYLLRKHDVSRLDIVNFISHGTHKNESGPAAGGGSNDAPGGNEAAAAPGGEERMENFTTN
HHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LNQLARVGGIDPLIGRDRELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGE
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCHHEEEECCC
VPEVMANCTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDSDSILFIDEIHTIIGAGA
HHHHHHCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCC
ASGGQVDAANLIKPLLSGGRIRVIGSTTYQEFSNIFEKDRALARRFQKIDINEPSADDTV
CCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
QILNGLKAKYEAHHDVRYTAKALRAAVDLSVKYINDRHLPDKAIDVIDEAGARSRLMPAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHCCCHHCCCCCH
RRKKTINVADIEAVVARIARIPEKTVSASDRDVLKSLGDRLRMLVFGQDKAISALTEAIK
HCCCCCCHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHEEEEECCCHHHHHHHHHHH
MSRAGLNQDHRPVGAFLFAGPTGVGKTEVTVQLARALDIPLLRFDMSEYMERHTVSRLIG
HHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
APPGYVGFDQGGLLTDAVIKNPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKAD
CCCCCCCCCCCCCCHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCC
FRNVILVMTTNAGVQETQRKSIGFNLQDNSSDAMEEIRRIFTPEFRNRLDNIIWFNHLST
CCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHEEEHHHHHH
EIIHQVVDKFIVELQAQLDGKGVSLEVSDAARNWLAERGYDRAMGARPMARVIQDNLKKP
HHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCH
LANELLFGELVNGGSVSVDVAEGDATLSYRFRSAQQRKAEDAMH
HHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLTNPAAREALEACAVDLAALRQELES
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
FIEQTTPLLPQGNSERDTQPTLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQA
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHH
AYLLRKHDVSRLDIVNFISHGTHKNESGPAAGGGSNDAPGGNEAAAAPGGEERMENFTTN
HHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LNQLARVGGIDPLIGRDRELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGE
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCHHEEEECCC
VPEVMANCTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDSDSILFIDEIHTIIGAGA
HHHHHHCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCC
ASGGQVDAANLIKPLLSGGRIRVIGSTTYQEFSNIFEKDRALARRFQKIDINEPSADDTV
CCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
QILNGLKAKYEAHHDVRYTAKALRAAVDLSVKYINDRHLPDKAIDVIDEAGARSRLMPAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHCCCHHCCCCCH
RRKKTINVADIEAVVARIARIPEKTVSASDRDVLKSLGDRLRMLVFGQDKAISALTEAIK
HCCCCCCHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHEEEEECCCHHHHHHHHHHH
MSRAGLNQDHRPVGAFLFAGPTGVGKTEVTVQLARALDIPLLRFDMSEYMERHTVSRLIG
HHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
APPGYVGFDQGGLLTDAVIKNPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKAD
CCCCCCCCCCCCCCHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCC
FRNVILVMTTNAGVQETQRKSIGFNLQDNSSDAMEEIRRIFTPEFRNRLDNIIWFNHLST
CCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHEEEHHHHHH
EIIHQVVDKFIVELQAQLDGKGVSLEVSDAARNWLAERGYDRAMGARPMARVIQDNLKKP
HHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCH
LANELLFGELVNGGSVSVDVAEGDATLSYRFRSAQQRKAEDAMH
HHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]