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The map label for this gene is serC

Identifier: 238920349

GI number: 238920349

Start: 2351283

End: 2352374

Strand: Reverse

Name: serC

Synonym: NT01EI_2459

Alternate gene names: 238920349

Gene position: 2352374-2351283 (Counterclockwise)

Preceding gene: 238920350

Following gene: 238920348

Centisome position: 61.7

GC content: 60.62

Gene sequence:

>1092_bases
ATGACTCAGGTTTATAATTTCTGCGCCGGACCAGCGATGCTGCCGGTAGAAGTACTGCGTCGGGCCGAACAGGAGCTGTG
TAACTGGCATGGACTGGGGACCTCGGTAATGGAGATCAGCCATCGGGGGGAGGCGTTTATGCAAGTGGCCGCCGAGGCTG
AGCAGGATCTGCGCGATTTACTCAAGGTGCCGGCGGATTACCGCATCCTGTTCTGTCACGGCGGTGCCCGCGGTCAGTTT
GCCGCGGTACCACTTAACCTGCTGGGTTCTGAGCGGACGGCCCGGGCCGACTATGCCGTCGGCGGCTACTGGGCGCAGAG
CGCGGCAAAAGAGGCGCAGCGGTACTGCAATCCCCATGCTATCGATATCGCCCAGCGCGTGGACGGTAAGCTGTCGATGA
AGCCCATGGCGCAGTGGGATCTGTTGGAAGAGAGCGCCTATCTGCACTACTGCCCGAATGAAACGATCGACGGCGTCACG
ATCGATGAGGAGCCTGACTTTGGCGATCGGGTGGTGGTGGCCGATATGTCTTCGACCATTCTCTCACGCCCTATCGACGT
GAGTCGCTATGGGCTTATCTACGCCGGTGCCCAGAAGAACGTCGGGCCTGCGGGGATCACGCTGGTGATCGTGCGGGAGG
ACCTGCTGGGGCGCGCGCGTAGGGAGATCCCGTCGATTTTAGATTATCAGGTATTGGTGGAAAGTGACTCCATGTTCAAC
ACGCCGCCGACCTTTGCCTGGTATCTGTCGGGAATGGTCTTCAAGTGGCTTAAAGAGCAGGGGGGGGTGAGCGAAATGGC
GCGCCGTAATCAGGCCAAGGCCGACCTGCTGTATCAGGCGATCGACGGCGGCGAGTTTTACCGCAACGATGTGGCGCCCG
CCAACCGTTCGCGGATGAACGTTCCGTTCCAGATGGTGGACAGCGCGCTGGATCCACTGTTTTGGGATGAGGCGCGAAAG
GCCGGGCTGCATGCGCTGAAAGGGCATAAGGTCGCCGGTGGTATGCGTGCCTCCATCTATAACGCCATGCCGCTGGCTGG
GGTGCAGGCGCTGGTGGCGTTTATGGCAGATTTCGCCCGCCGTCACGGTTGA

Upstream 100 bases:

>100_bases
GGCAGGTGATAACCGTTGCGGTGTCTGTTCAGCGGTGATACAACCAAGGGCCTGTCAACCAAACACCTACGGGTGCAATT
TAGCGAGAGCGGTGAGTGAC

Downstream 100 bases:

>100_bases
TTTTCTCCGCGTGACGCAGGTCCCGCATCTGCAGGGTTAATGAGATGGTAACCCCACCCTGCCAGCGGTGCGCTGGCAGG
GTGTTTTTCTTTTAGGAGAG

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTQVYNFCAGPAMLPVEVLRRAEQELCNWHGLGTSVMEISHRGEAFMQVAAEAEQDLRDLLKVPADYRILFCHGGARGQF
AAVPLNLLGSERTARADYAVGGYWAQSAAKEAQRYCNPHAIDIAQRVDGKLSMKPMAQWDLLEESAYLHYCPNETIDGVT
IDEEPDFGDRVVVADMSSTILSRPIDVSRYGLIYAGAQKNVGPAGITLVIVREDLLGRARREIPSILDYQVLVESDSMFN
TPPTFAWYLSGMVFKWLKEQGGVSEMARRNQAKADLLYQAIDGGEFYRNDVAPANRSRMNVPFQMVDSALDPLFWDEARK
AGLHALKGHKVAGGMRASIYNAMPLAGVQALVAFMADFARRHG

Sequences:

>Translated_363_residues
MTQVYNFCAGPAMLPVEVLRRAEQELCNWHGLGTSVMEISHRGEAFMQVAAEAEQDLRDLLKVPADYRILFCHGGARGQF
AAVPLNLLGSERTARADYAVGGYWAQSAAKEAQRYCNPHAIDIAQRVDGKLSMKPMAQWDLLEESAYLHYCPNETIDGVT
IDEEPDFGDRVVVADMSSTILSRPIDVSRYGLIYAGAQKNVGPAGITLVIVREDLLGRARREIPSILDYQVLVESDSMFN
TPPTFAWYLSGMVFKWLKEQGGVSEMARRNQAKADLLYQAIDGGEFYRNDVAPANRSRMNVPFQMVDSALDPLFWDEARK
AGLHALKGHKVAGGMRASIYNAMPLAGVQALVAFMADFARRHG
>Mature_362_residues
TQVYNFCAGPAMLPVEVLRRAEQELCNWHGLGTSVMEISHRGEAFMQVAAEAEQDLRDLLKVPADYRILFCHGGARGQFA
AVPLNLLGSERTARADYAVGGYWAQSAAKEAQRYCNPHAIDIAQRVDGKLSMKPMAQWDLLEESAYLHYCPNETIDGVTI
DEEPDFGDRVVVADMSSTILSRPIDVSRYGLIYAGAQKNVGPAGITLVIVREDLLGRARREIPSILDYQVLVESDSMFNT
PPTFAWYLSGMVFKWLKEQGGVSEMARRNQAKADLLYQAIDGGEFYRNDVAPANRSRMNVPFQMVDSALDPLFWDEARKA
GLHALKGHKVAGGMRASIYNAMPLAGVQALVAFMADFARRHG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=366, Percent_Identity=45.0819672131148, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI10863955, Length=361, Percent_Identity=40.1662049861496, Blast_Score=281, Evalue=1e-75,
Organism=Escherichia coli, GI1787136, Length=364, Percent_Identity=69.2307692307692, Blast_Score=540, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17506897, Length=363, Percent_Identity=38.8429752066116, Blast_Score=271, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6324758, Length=385, Percent_Identity=36.8831168831169, Blast_Score=235, Evalue=8e-63,
Organism=Drosophila melanogaster, GI21356589, Length=365, Percent_Identity=45.7534246575342, Blast_Score=324, Evalue=6e-89,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_EDWI9 (Q9X4H1)

Other databases:

- EMBL:   CP001600
- EMBL:   AF110153
- RefSeq:   YP_002933864.1
- GeneID:   7959191
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2459
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BRENDA:   2.6.1.52
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40210; Mature: 40079

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 42-42 BINDING 104-104 BINDING 155-155 BINDING 175-175 BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVYNFCAGPAMLPVEVLRRAEQELCNWHGLGTSVMEISHRGEAFMQVAAEAEQDLRDL
CCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHH
LKVPADYRILFCHGGARGQFAAVPLNLLGSERTARADYAVGGYWAQSAAKEAQRYCNPHA
HHCCCCEEEEEEECCCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCH
IDIAQRVDGKLSMKPMAQWDLLEESAYLHYCPNETIDGVTIDEEPDFGDRVVVADMSSTI
HHHHHHCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCEECCCCCCCCCEEEEEEHHHHH
LSRPIDVSRYGLIYAGAQKNVGPAGITLVIVREDLLGRARREIPSILDYQVLVESDSMFN
HHCCCCCCCCEEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCEEEEEECCCCCC
TPPTFAWYLSGMVFKWLKEQGGVSEMARRNQAKADLLYQAIDGGEFYRNDVAPANRSRMN
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCC
VPFQMVDSALDPLFWDEARKAGLHALKGHKVAGGMRASIYNAMPLAGVQALVAFMADFAR
CCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
RHG
HCC
>Mature Secondary Structure 
TQVYNFCAGPAMLPVEVLRRAEQELCNWHGLGTSVMEISHRGEAFMQVAAEAEQDLRDL
CCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHH
LKVPADYRILFCHGGARGQFAAVPLNLLGSERTARADYAVGGYWAQSAAKEAQRYCNPHA
HHCCCCEEEEEEECCCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCH
IDIAQRVDGKLSMKPMAQWDLLEESAYLHYCPNETIDGVTIDEEPDFGDRVVVADMSSTI
HHHHHHCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCEECCCCCCCCCEEEEEEHHHHH
LSRPIDVSRYGLIYAGAQKNVGPAGITLVIVREDLLGRARREIPSILDYQVLVESDSMFN
HHCCCCCCCCEEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCEEEEEECCCCCC
TPPTFAWYLSGMVFKWLKEQGGVSEMARRNQAKADLLYQAIDGGEFYRNDVAPANRSRMN
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCC
VPFQMVDSALDPLFWDEARKAGLHALKGHKVAGGMRASIYNAMPLAGVQALVAFMADFAR
CCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
RHG
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA