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The map label for this gene is aroA

Identifier: 238920347

GI number: 238920347

Start: 2348917

End: 2350203

Strand: Reverse

Name: aroA

Synonym: NT01EI_2457

Alternate gene names: 238920347

Gene position: 2350203-2348917 (Counterclockwise)

Preceding gene: 238920348

Following gene: 238920346

Centisome position: 61.65

GC content: 63.25

Gene sequence:

>1287_bases
ATGTCGTCCGCCCTGACGTTACAACCCGTGCGCCGCTTTAGCGGCGAGATTAATCTGCCCGGCTCGAAAAGCGTTTCCAA
CCGCGCCCTGCTCCTGGCAGCGCAGGCCCGCGGCGTAACGCGGCTGCATAACCTGCTCGACAGCGACGATGTGCGCTACA
TGCTCGATGCCCTTAAGGCGCTGGGCGTGCGCTATCAGCTGTCGGACTGCCGCACCCGCTGCGAGGTGCAGGGACTCGGG
GGGACGCTGAGCGCCCACGGCGCGCTGACGCTGTTTCTGGGCAATGCCGGCACGGCGATGCGCCCGCTGGCGGCGGCGCT
CAGCCTGGGGCTACGCGATGTGATCCTGACCGGGGAGCCGCGCATGAAGGAGCGTCCGATCGCGCATCTGGTGACCGCCC
TGCGTCAGGGCGGTGCGCAGGTTGACTATCTGGAGAGCGATGGCTATCCGCCCGTACGTCTGCACGGCGGTTTTAACGGC
GGAGAGATCAGCGTTGACGGCTCGGTCTCCAGCCAGTTTCTGACCGCGCTGCTGATGGCGGCGCCGATGGCGGCAGAGGA
GACCCGTATCACCATTCTGGGAGAGCTGGTTTCCAAGCCCTATATCGCCATTACGCTGGCGATGATGCGGGCGTTCGGCG
TGGAGGTGGAGAATCACGCGTATCGCCATTTCGTGGTGCGGGGGGGGCAGGTCTATCAGGCTCCGAGCGACTATCTGGTC
GAAGGAGATGCATCCTCGGCGTCGTACTTTCTGGCCGGCGCAGCGATCGCCGGCGGTACCGTCCGGGTGACCGGAATTGG
GCGCCACAGCATGCAGGGGGATATTCACTTTGCCGATGTGCTGGAAAAAATGGGGGCGCAGGTCGAATGGGGGAATGACT
ATATCGCCTGCACCCGGGATAGCCTGCACGGCATCGATATGGATATGAATGCGATCCCCGATGCGGCGATGACCATCGCC
ACCACCGCGCTGTTTGCCAAAGGGCCGACGACTCTGCGCAATATTTACAATTGGCGTGTCAAGGAGACCGATCGCCTGGC
GGCAATGGCCAGTGAGCTGCGTAAGGTGGGTGCTGTGGTCGAGGAGGGGACGGACTTTCTGCGCATTGAGCCGCCCGCGC
AGCTGCAGGCGGCGCAGATTGCCACCTACAACGATCACCGCATGGCCATGTGTTTTTCACTGGTGGCGTTGTCGGGCACG
CCGGTGACCATCTGTGACCCCGGTTGTACCGCAAAAACCTTTCCCGATTACTTTCGCCAGTTCTCCGCGCTGTGCCATCC
GCGCTAA

Upstream 100 bases:

>100_bases
TCGCATAGTGACAGCGTTCAACAAAAACGGTACAAAAATACCCTTAACAGGAAGCGCGGCCATGATGGCAGCGCTGTTTG
CCCAGCAGGAGTGATTTAGC

Downstream 100 bases:

>100_bases
GCCGCATTAGGATTTTATCTGTAAAGCCGGCGTAGACGTACGCCGGCTTTTTGCTATCCGATTGCACCGCCCTGCAGTGC
AGGCAATCGTTTGGGGTTCG

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSSALTLQPVRRFSGEINLPGSKSVSNRALLLAAQARGVTRLHNLLDSDDVRYMLDALKALGVRYQLSDCRTRCEVQGLG
GTLSAHGALTLFLGNAGTAMRPLAAALSLGLRDVILTGEPRMKERPIAHLVTALRQGGAQVDYLESDGYPPVRLHGGFNG
GEISVDGSVSSQFLTALLMAAPMAAEETRITILGELVSKPYIAITLAMMRAFGVEVENHAYRHFVVRGGQVYQAPSDYLV
EGDASSASYFLAGAAIAGGTVRVTGIGRHSMQGDIHFADVLEKMGAQVEWGNDYIACTRDSLHGIDMDMNAIPDAAMTIA
TTALFAKGPTTLRNIYNWRVKETDRLAAMASELRKVGAVVEEGTDFLRIEPPAQLQAAQIATYNDHRMAMCFSLVALSGT
PVTICDPGCTAKTFPDYFRQFSALCHPR

Sequences:

>Translated_428_residues
MSSALTLQPVRRFSGEINLPGSKSVSNRALLLAAQARGVTRLHNLLDSDDVRYMLDALKALGVRYQLSDCRTRCEVQGLG
GTLSAHGALTLFLGNAGTAMRPLAAALSLGLRDVILTGEPRMKERPIAHLVTALRQGGAQVDYLESDGYPPVRLHGGFNG
GEISVDGSVSSQFLTALLMAAPMAAEETRITILGELVSKPYIAITLAMMRAFGVEVENHAYRHFVVRGGQVYQAPSDYLV
EGDASSASYFLAGAAIAGGTVRVTGIGRHSMQGDIHFADVLEKMGAQVEWGNDYIACTRDSLHGIDMDMNAIPDAAMTIA
TTALFAKGPTTLRNIYNWRVKETDRLAAMASELRKVGAVVEEGTDFLRIEPPAQLQAAQIATYNDHRMAMCFSLVALSGT
PVTICDPGCTAKTFPDYFRQFSALCHPR
>Mature_427_residues
SSALTLQPVRRFSGEINLPGSKSVSNRALLLAAQARGVTRLHNLLDSDDVRYMLDALKALGVRYQLSDCRTRCEVQGLGG
TLSAHGALTLFLGNAGTAMRPLAAALSLGLRDVILTGEPRMKERPIAHLVTALRQGGAQVDYLESDGYPPVRLHGGFNGG
EISVDGSVSSQFLTALLMAAPMAAEETRITILGELVSKPYIAITLAMMRAFGVEVENHAYRHFVVRGGQVYQAPSDYLVE
GDASSASYFLAGAAIAGGTVRVTGIGRHSMQGDIHFADVLEKMGAQVEWGNDYIACTRDSLHGIDMDMNAIPDAAMTIAT
TALFAKGPTTLRNIYNWRVKETDRLAAMASELRKVGAVVEEGTDFLRIEPPAQLQAAQIATYNDHRMAMCFSLVALSGTP
VTICDPGCTAKTFPDYFRQFSALCHPR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=423, Percent_Identity=74.7044917257683, Blast_Score=634, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320332, Length=443, Percent_Identity=36.7945823927765, Blast_Score=249, Evalue=6e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_EDWI9 (Q9X4H2)

Other databases:

- EMBL:   AF110153
- EMBL:   CP001600
- RefSeq:   YP_002933862.1
- ProteinModelPortal:   Q9X4H2
- SMR:   Q9X4H2
- GeneID:   7959189
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2457
- OMA:   GADIEWG
- ProtClustDB:   CLSK2813323
- BRENDA:   2.5.1.19
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 46054; Mature: 45923

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSALTLQPVRRFSGEINLPGSKSVSNRALLLAAQARGVTRLHNLLDSDDVRYMLDALKA
CCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHH
LGVRYQLSDCRTRCEVQGLGGTLSAHGALTLFLGNAGTAMRPLAAALSLGLRDVILTGEP
HCCEEEHHHHHCEEEEECCCCEEECCCEEEEEECCCCCHHHHHHHHHHCCCCEEEECCCC
RMKERPIAHLVTALRQGGAQVDYLESDGYPPVRLHGGFNGGEISVDGSVSSQFLTALLMA
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCEEEECCCHHHHHHHHHHHH
APMAAEETRITILGELVSKPYIAITLAMMRAFGVEVENHAYRHFVVRGGQVYQAPSDYLV
CCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEEECCCCCEE
EGDASSASYFLAGAAIAGGTVRVTGIGRHSMQGDIHFADVLEKMGAQVEWGNDYIACTRD
ECCCCCCEEEEEEHEECCCEEEEEECCCCCCCCCCHHHHHHHHHCCEEEECCCEEEEECC
SLHGIDMDMNAIPDAAMTIATTALFAKGPTTLRNIYNWRVKETDRLAAMASELRKVGAVV
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EEGTDFLRIEPPAQLQAAQIATYNDHRMAMCFSLVALSGTPVTICDPGCTAKTFPDYFRQ
HCCCCEEEECCCCCCCHHEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHH
FSALCHPR
HHHHCCCC
>Mature Secondary Structure 
SSALTLQPVRRFSGEINLPGSKSVSNRALLLAAQARGVTRLHNLLDSDDVRYMLDALKA
CCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHH
LGVRYQLSDCRTRCEVQGLGGTLSAHGALTLFLGNAGTAMRPLAAALSLGLRDVILTGEP
HCCEEEHHHHHCEEEEECCCCEEECCCEEEEEECCCCCHHHHHHHHHHCCCCEEEECCCC
RMKERPIAHLVTALRQGGAQVDYLESDGYPPVRLHGGFNGGEISVDGSVSSQFLTALLMA
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCEEEECCCHHHHHHHHHHHH
APMAAEETRITILGELVSKPYIAITLAMMRAFGVEVENHAYRHFVVRGGQVYQAPSDYLV
CCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEEECCCCCEE
EGDASSASYFLAGAAIAGGTVRVTGIGRHSMQGDIHFADVLEKMGAQVEWGNDYIACTRD
ECCCCCCEEEEEEHEECCCEEEEEECCCCCCCCCCHHHHHHHHHCCEEEECCCEEEEECC
SLHGIDMDMNAIPDAAMTIATTALFAKGPTTLRNIYNWRVKETDRLAAMASELRKVGAVV
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EEGTDFLRIEPPAQLQAAQIATYNDHRMAMCFSLVALSGTPVTICDPGCTAKTFPDYFRQ
HCCCCEEEECCCCCCCHHEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHH
FSALCHPR
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA