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The map label for this gene is atzB [H]

Identifier: 238920333

GI number: 238920333

Start: 2333912

End: 2335282

Strand: Reverse

Name: atzB [H]

Synonym: NT01EI_2443

Alternate gene names: 238920333

Gene position: 2335282-2333912 (Counterclockwise)

Preceding gene: 238920334

Following gene: 238920330

Centisome position: 61.26

GC content: 64.99

Gene sequence:

>1371_bases
ATGCACACGAAGAAGACGCTGGTGATTAAGAATGCCGATCTGCTGGTCACGATGGATGACCGGCGCCGGGAGATCCGCGG
TGGCTGCATGCTGGTGGAGGGATGTCGTATTGTGGCGGTCGGCGGCAGCGAGCTGCTGGCCGCCGGCGCCGACGAGGAGC
TGGATCTGCGCGGGCACGTGGTGATCCCGGGGATGGTCAACACCCATCACCATATGTTCCAGACCCTGACGCGTGCGCTG
CCTGGCGCTCAGGACGCCGAGCTGTTCTCATGGCTGGAGACGCTGTACCCGGTATGGGGACGTCTGACGCCGGAGATGAT
TTATATCTCGGCCCAGACGGCGATGGCGGAGCTGATGCTCTCCGGCTGCACGACCTCCAGCGACCACCTGTACCTGTTTC
CCAACGGCTGTCGTCTGGATGACAGCATCGATGCGGCGCGTGAAATCGGTATGCGCTTTCACGCCTGTCGCGGCAGTATG
AGTCTGGGACGCAGCCGCGGTGGCCTGCCGCCCGATGCGCTGGTAGAGCGTGAGGAGGCGATTCTGGAGGATTCGCTGCG
GCTGATCCAGTCCTATCATGATGCGGCGCGCTTCAGCATGCTGCGGATCGCGCTGGCGCCTTGCTCCCCCTTTTCCGTCA
GTCGGGAGCTGATGAAAAAGAGCGCGCAGCTGGCGCGTCAGCACGGGGTCTCGCTGCATACCCATCTGGCGGAGAATGAT
AATGACGTCAGTTACAGTCAGCGCCACTTTGGTATGACTCCGGCGGAGTATGTGCGCGATCTGGGCTGGACTGGCCCGGA
CGTCTGGCATGCACACTGCGTGAAGCTGGATGCGCAGGGGATCGATCTGTTTGCCCGCACCCAGACCGGGGTCGCCCACT
GCCCATGCTCCAACATGCGTCTGGCGTCGGGGATCGCGCCGATCCGCCAGATGGTGGATGCCGGGGTGCCGGTCGGTATC
GGCGTGGATGGTTCGGCTTCTAACGACGGCAGCTCCCTGCTGGCCGAGGCGCGTCAGGCGATGCTGCTGCAGCGGGTGGC
CAGCGGGCCACAGGCCATGAGCGCGCGTGAGGCTCTGTGGCTGGCGACGCGGGGCGGGGCACAGGTCCTTAACCGTGACG
ACATCGGCGCGCTGGCGCCGGACATGGCGGCGGACTTTGTCGCCTTTGATCTGCGCGGCCTGGGCACCGCCGGCGCCCGT
CACGATCCGCTGGCAGCGCTGGTGTTCTGCAATCCGGGCAACGTGGCTCTCAGCGTGATCAATGGCCGGGTGGTGATCCG
CGACGGTCAGCTGCAGACGATCGATCTGTCGCAGGTGATCGCGACGCATAACCGCCTGAGCACGTTGCTGCTGCACCCCG
ATCCGCTGTAG

Upstream 100 bases:

>100_bases
GGTGTTCAGATGCCGTAGACCGCCGCTGGGGGCTATGGCACCGTTAAATCAGCCGCGGAGCGGCGCATAGCGGATGCGCT
CGCCTGCAGAGGGGAAAGCG

Downstream 100 bases:

>100_bases
TCCTAGCGGGCGCGCCACAGCCAGCGGCGGCACAGCAGGTAGGTCGTCGCCGGCAGCAGCAGCAGGCAGGCGGTGGCGGT
CAGCAGCGCCGTCGTGGTGC

Product: hydroxydechloroatrazine ethylaminohydrolase

Products: NA

Alternate protein names: Hydroxyatrazine hydrolase [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MHTKKTLVIKNADLLVTMDDRRREIRGGCMLVEGCRIVAVGGSELLAAGADEELDLRGHVVIPGMVNTHHHMFQTLTRAL
PGAQDAELFSWLETLYPVWGRLTPEMIYISAQTAMAELMLSGCTTSSDHLYLFPNGCRLDDSIDAAREIGMRFHACRGSM
SLGRSRGGLPPDALVEREEAILEDSLRLIQSYHDAARFSMLRIALAPCSPFSVSRELMKKSAQLARQHGVSLHTHLAEND
NDVSYSQRHFGMTPAEYVRDLGWTGPDVWHAHCVKLDAQGIDLFARTQTGVAHCPCSNMRLASGIAPIRQMVDAGVPVGI
GVDGSASNDGSSLLAEARQAMLLQRVASGPQAMSAREALWLATRGGAQVLNRDDIGALAPDMAADFVAFDLRGLGTAGAR
HDPLAALVFCNPGNVALSVINGRVVIRDGQLQTIDLSQVIATHNRLSTLLLHPDPL

Sequences:

>Translated_456_residues
MHTKKTLVIKNADLLVTMDDRRREIRGGCMLVEGCRIVAVGGSELLAAGADEELDLRGHVVIPGMVNTHHHMFQTLTRAL
PGAQDAELFSWLETLYPVWGRLTPEMIYISAQTAMAELMLSGCTTSSDHLYLFPNGCRLDDSIDAAREIGMRFHACRGSM
SLGRSRGGLPPDALVEREEAILEDSLRLIQSYHDAARFSMLRIALAPCSPFSVSRELMKKSAQLARQHGVSLHTHLAEND
NDVSYSQRHFGMTPAEYVRDLGWTGPDVWHAHCVKLDAQGIDLFARTQTGVAHCPCSNMRLASGIAPIRQMVDAGVPVGI
GVDGSASNDGSSLLAEARQAMLLQRVASGPQAMSAREALWLATRGGAQVLNRDDIGALAPDMAADFVAFDLRGLGTAGAR
HDPLAALVFCNPGNVALSVINGRVVIRDGQLQTIDLSQVIATHNRLSTLLLHPDPL
>Mature_456_residues
MHTKKTLVIKNADLLVTMDDRRREIRGGCMLVEGCRIVAVGGSELLAAGADEELDLRGHVVIPGMVNTHHHMFQTLTRAL
PGAQDAELFSWLETLYPVWGRLTPEMIYISAQTAMAELMLSGCTTSSDHLYLFPNGCRLDDSIDAAREIGMRFHACRGSM
SLGRSRGGLPPDALVEREEAILEDSLRLIQSYHDAARFSMLRIALAPCSPFSVSRELMKKSAQLARQHGVSLHTHLAEND
NDVSYSQRHFGMTPAEYVRDLGWTGPDVWHAHCVKLDAQGIDLFARTQTGVAHCPCSNMRLASGIAPIRQMVDAGVPVGI
GVDGSASNDGSSLLAEARQAMLLQRVASGPQAMSAREALWLATRGGAQVLNRDDIGALAPDMAADFVAFDLRGLGTAGAR
HDPLAALVFCNPGNVALSVINGRVVIRDGQLQTIDLSQVIATHNRLSTLLLHPDPL

Specific function: Catalyzes the deamination reaction of hydroxyatrazine to N-isopropylammelide (dihydroxy-isopropyl-atrazine). The enzyme is also capable of catalyzing some dechlorinating reactions [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=330, Percent_Identity=24.2424242424242, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1789249, Length=453, Percent_Identity=28.476821192053, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87082177, Length=450, Percent_Identity=23.7777777777778, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17540282, Length=385, Percent_Identity=24.4155844155844, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319963, Length=321, Percent_Identity=26.4797507788162, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24643849, Length=357, Percent_Identity=24.9299719887955, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.99.3 [H]

Molecular weight: Translated: 49360; Mature: 49360

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTKKTLVIKNADLLVTMDDRRREIRGGCMLVEGCRIVAVGGSELLAAGADEELDLRGHV
CCCCEEEEEECCCEEEEECHHHHHHCCCEEEEECCEEEEECCCHHEECCCCCCCCCCCCE
VIPGMVNTHHHMFQTLTRALPGAQDAELFSWLETLYPVWGRLTPEMIYISAQTAMAELML
EECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHH
SGCTTSSDHLYLFPNGCRLDDSIDAAREIGMRFHACRGSMSLGRSRGGLPPDALVEREEA
HCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHH
ILEDSLRLIQSYHDAARFSMLRIALAPCSPFSVSRELMKKSAQLARQHGVSLHTHLAEND
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
NDVSYSQRHFGMTPAEYVRDLGWTGPDVWHAHCVKLDAQGIDLFARTQTGVAHCPCSNMR
CCCCHHHHHCCCCHHHHHHHCCCCCCCHHEEEEEEEECCCCEEEEECCCCCEECCCCCCC
LASGIAPIRQMVDAGVPVGIGVDGSASNDGSSLLAEARQAMLLQRVASGPQAMSAREALW
HHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEE
LATRGGAQVLNRDDIGALAPDMAADFVAFDLRGLGTAGARHDPLAALVFCNPGNVALSVI
EEECCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEEE
NGRVVIRDGQLQTIDLSQVIATHNRLSTLLLHPDPL
CCEEEEECCCEEEEEHHHHHHHHHHHEEEEECCCCC
>Mature Secondary Structure
MHTKKTLVIKNADLLVTMDDRRREIRGGCMLVEGCRIVAVGGSELLAAGADEELDLRGHV
CCCCEEEEEECCCEEEEECHHHHHHCCCEEEEECCEEEEECCCHHEECCCCCCCCCCCCE
VIPGMVNTHHHMFQTLTRALPGAQDAELFSWLETLYPVWGRLTPEMIYISAQTAMAELML
EECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHH
SGCTTSSDHLYLFPNGCRLDDSIDAAREIGMRFHACRGSMSLGRSRGGLPPDALVEREEA
HCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHH
ILEDSLRLIQSYHDAARFSMLRIALAPCSPFSVSRELMKKSAQLARQHGVSLHTHLAEND
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
NDVSYSQRHFGMTPAEYVRDLGWTGPDVWHAHCVKLDAQGIDLFARTQTGVAHCPCSNMR
CCCCHHHHHCCCCHHHHHHHCCCCCCCHHEEEEEEEECCCCEEEEECCCCCEECCCCCCC
LASGIAPIRQMVDAGVPVGIGVDGSASNDGSSLLAEARQAMLLQRVASGPQAMSAREALW
HHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEE
LATRGGAQVLNRDDIGALAPDMAADFVAFDLRGLGTAGARHDPLAALVFCNPGNVALSVI
EEECCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEEE
NGRVVIRDGQLQTIDLSQVIATHNRLSTLLLHPDPL
CCEEEEECCCEEEEEHHHHHHHHHHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9055410 [H]