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The map label for this gene is cyoE

Identifier: 238920117

GI number: 238920117

Start: 2137255

End: 2138145

Strand: Reverse

Name: cyoE

Synonym: NT01EI_2223

Alternate gene names: 238920117

Gene position: 2138145-2137255 (Counterclockwise)

Preceding gene: 238920118

Following gene: 238920116

Centisome position: 56.09

GC content: 53.65

Gene sequence:

>891_bases
ATGATTAAGCAATACCTGCTAGTCACTAAACCAGGCATTATTTTCGGCAACCTCATTTCTGTTGTTGGCGGATTTCTGCT
CGCGGCTAAAGGGATCATCGACTATCCCCTGTTTCTTGCGACTCTGGTGGGGGTCTCATTGGTTGTCGCGTCGGGTTGTG
TGTTTAACAACTACATCGATCGCGACATCGACAAGAAAATGGAGAGAACGAAGAATCGGGTGCTGGTGAAAGGGCTGATT
GCGCCGAGTGTTACCCTGATTTATGCGACCGTTCTGGGTATTGCGGGCTTTGTGTTGCTGTATATCGCGGCTAATCCGCT
GGCCATGTGGCTGGCCGTGATGGGGTTTGTGGTTTATGTCGGCGTTTACAGCCTGTACATGAAGCGCCACTCGGTCTATG
GCACGCTGATCGGTAGCTTGTCGGGTGCCGCACCGCCGGTCATCGGTTATTGTGCGGTCACCAACGCGTTCGATGCTGGT
GCGTTGATCCTGCTGGCTATCTTTAGCCTGTGGCAGATGCCACACTCTTATGCCATCGCCATCTTCCGCTTTAAAGATTA
CCAGGCGGCTGGCATTCCCGTGTTGCCAGTGGTGAAAGGCGTTTCCGTCGCCAAGAACCATATCACGCTCTACATCCTGG
CGTTTATGATCGCCACGCTGATGCTGGCCCTGGTGGGCTATGCCGGCTATAAGTACCTGATTGTTGCGGCGGTGGTGAGT
ATTTGGTGGCTGGGGATGGCGCTGCGTGGTTATAAGACCGAGAACGACAGCATCTGGGCGCGAAAACTGTTTGTGTTTTC
CATTGTCGCCATCACCTCCCTGAGCGTGATGATGTCGATTGACTTCAGCGTCAGCAGCGCGTCGCCAGCACTGCTGACCT
ACGTTTGGTAA

Upstream 100 bases:

>100_bases
TCACCGCTGTGATCATCGGTATCGTTGTTGTTGGCTCACTCTGGATTATGTACAACCTCAACATCAATATGATGGTCGAT
TAAGGGCTGAGTGGCGCGTG

Downstream 100 bases:

>100_bases
GTCAGTGTGTGGACAGACGCACTCAGGGCCACTTCTGTGAATGGATCGCGGATATAGCCAATGTTATTGGTTTATCACAA
TATTGTCGTATGCAGGGTGA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MIKQYLLVTKPGIIFGNLISVVGGFLLAAKGIIDYPLFLATLVGVSLVVASGCVFNNYIDRDIDKKMERTKNRVLVKGLI
APSVTLIYATVLGIAGFVLLYIAANPLAMWLAVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTNAFDAG
ALILLAIFSLWQMPHSYAIAIFRFKDYQAAGIPVLPVVKGVSVAKNHITLYILAFMIATLMLALVGYAGYKYLIVAAVVS
IWWLGMALRGYKTENDSIWARKLFVFSIVAITSLSVMMSIDFSVSSASPALLTYVW

Sequences:

>Translated_296_residues
MIKQYLLVTKPGIIFGNLISVVGGFLLAAKGIIDYPLFLATLVGVSLVVASGCVFNNYIDRDIDKKMERTKNRVLVKGLI
APSVTLIYATVLGIAGFVLLYIAANPLAMWLAVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTNAFDAG
ALILLAIFSLWQMPHSYAIAIFRFKDYQAAGIPVLPVVKGVSVAKNHITLYILAFMIATLMLALVGYAGYKYLIVAAVVS
IWWLGMALRGYKTENDSIWARKLFVFSIVAITSLSVMMSIDFSVSSASPALLTYVW
>Mature_296_residues
MIKQYLLVTKPGIIFGNLISVVGGFLLAAKGIIDYPLFLATLVGVSLVVASGCVFNNYIDRDIDKKMERTKNRVLVKGLI
APSVTLIYATVLGIAGFVLLYIAANPLAMWLAVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTNAFDAG
ALILLAIFSLWQMPHSYAIAIFRFKDYQAAGIPVLPVVKGVSVAKNHITLYILAFMIATLMLALVGYAGYKYLIVAAVVS
IWWLGMALRGYKTENDSIWARKLFVFSIVAITSLSVMMSIDFSVSSASPALLTYVW

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=172, Percent_Identity=36.6279069767442, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1786631, Length=296, Percent_Identity=83.4459459459459, Blast_Score=495, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71998235, Length=243, Percent_Identity=28.8065843621399, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325085, Length=194, Percent_Identity=27.8350515463918, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921064, Length=273, Percent_Identity=29.3040293040293, Blast_Score=114, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYOE_EDWI9 (C5BFX0)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002933632.1
- GeneID:   7961655
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2223
- OMA:   EPQLQHD
- ProtClustDB:   PRK04375
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32125; Mature: 32125

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1dad60a8)-; HASH(0x1cd33504)-; HASH(0x19bae6c4)-; HASH(0x1c7b51e0)-; HASH(0x1cc95294)-; HASH(0x1da3bf98)-; HASH(0x1dc0bf14)-; HASH(0x1db36384)-; HASH(0x1d2243e8)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQYLLVTKPGIIFGNLISVVGGFLLAAKGIIDYPLFLATLVGVSLVVASGCVFNNYID
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RDIDKKMERTKNRVLVKGLIAPSVTLIYATVLGIAGFVLLYIAANPLAMWLAVMGFVVYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTNAFDAGALILLAIFSLWQMPHSYAIA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHEEE
IFRFKDYQAAGIPVLPVVKGVSVAKNHITLYILAFMIATLMLALVGYAGYKYLIVAAVVS
EEEEECCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IWWLGMALRGYKTENDSIWARKLFVFSIVAITSLSVMMSIDFSVSSASPALLTYVW
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEECH
>Mature Secondary Structure
MIKQYLLVTKPGIIFGNLISVVGGFLLAAKGIIDYPLFLATLVGVSLVVASGCVFNNYID
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RDIDKKMERTKNRVLVKGLIAPSVTLIYATVLGIAGFVLLYIAANPLAMWLAVMGFVVYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTNAFDAGALILLAIFSLWQMPHSYAIA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHEEE
IFRFKDYQAAGIPVLPVVKGVSVAKNHITLYILAFMIATLMLALVGYAGYKYLIVAAVVS
EEEEECCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IWWLGMALRGYKTENDSIWARKLFVFSIVAITSLSVMMSIDFSVSSASPALLTYVW
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEECH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA