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The map label for this gene is ydhC [H]

Identifier: 238920010

GI number: 238920010

Start: 2034036

End: 2035205

Strand: Direct

Name: ydhC [H]

Synonym: NT01EI_2114

Alternate gene names: 238920010

Gene position: 2034036-2035205 (Clockwise)

Preceding gene: 238920008

Following gene: 238920011

Centisome position: 53.35

GC content: 62.39

Gene sequence:

>1170_bases
ATGCTGGGATACCTGGCCACCGATATGTATCTGCCCGCCTTTGGCGCCATGCGCCATGATCTGGGTGCCTCCGCTGGCGC
CATCAGCGCCAGCCTGAGCATCTTCCTGGCCGGCTTTGCCTTTGCACAGCTGCTGTGGGGGCCACTCTCCGATCGCATCG
GACGTAAGCCGGTTCTGCTGTTGGGACTGGGCATGTTCGCCCTGGCCTGCCTGGGTATGCTGTGGGTCGACAATACCACC
CAACTGCTGATCCTGCGCTTCGTTCAGGCCGTCGGGGTCTGCTCTGCGGCCGTCACCTGGCAGGCTTTGGTTATCGATCG
CTACAGCAAAGGGGTCGCCAACCGCGTCTTCGCCACGGTCATGCCATTGGTCGCCCTCTCGCCGGCGCTGGCACCGCTGC
TCGGTGCCTGGCTGCTCAACCATTTTGAATGGCAGGCCATCTTCGCCGTGCTGTTCGCCATCACCCTGCTGCTGATGATC
CCGACCCTGCGTCTGCAGGAGCACCGGGCAATGGCGAACCGTCAGACACCGAGCATCGGCTTTCTGCGTCTGATGCGTTC
CAACATCTTTAGCGGCAACGTACTGATCTACGCCGCCTGCTCCGCCGGTTTCTTCGCCTGGCTGACCGGTTCGCCCTTCA
TTCTGGGCGAGATGGGATATAGCCCGAACGATATCGGCCTGAGCTATGTGCCGCAGACCATCGCCTTCCTGCTGGGCGGC
TATGGCTGCCGGGCGCTGCTGAGTCGCATCGGCGGCACCCTGCTGCTGCCGTGGCTGCTGGTCATCTACTCACTGAGTAT
GCTGGCGATGCTGGTGATGGCCCTCAGCTACCAGCCCGGTCTGCTGGCGCTGCTGATACCGTTCTGCGTCATGGCGATGA
TGAACGGTGCCATCTATCCCATCGTGGTCGCCAGCGCTCTGACGCCCTTCCCGAACAACAGCGGCAAGGCGGCGGCACTG
CAGAATACGCTGCAGCTTGGCGTCTGCTTCCTGGCCAGCCTACTGGTGTCGGCACTGATCCACATACCGCTGCTGGCGAC
CTCCGCCATCATGGCCGGCACCATTCCGCTGGTTATGCTGGGGTATTGGCTCAAAAGTGACAGCGTCACAACAATCCTGG
AAAAACGCCGCGAACAGCAACGCGGTCAGCACGCTCTCTCCCGCCGCTGA

Upstream 100 bases:

>100_bases
TAAACTCTCCCCGTCACATTCTTTATCTGCAACATATTTATAACGAGTCAAAATAATGAGAAGTAAATCAGGTTTCATAA
TCTATCTGGCTGGCCTCAGT

Downstream 100 bases:

>100_bases
TTTCCACTCAGACGCACTGGAGTCTCCCGGTGCGTCTGGTGATGGCTCCTCCCTCCCTTGAGTCCATTTTCCAACCACTC
CCGTTCTATGCTGAACAGAA

Product: inner membrane transport protein YdhC

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MLGYLATDMYLPAFGAMRHDLGASAGAISASLSIFLAGFAFAQLLWGPLSDRIGRKPVLLLGLGMFALACLGMLWVDNTT
QLLILRFVQAVGVCSAAVTWQALVIDRYSKGVANRVFATVMPLVALSPALAPLLGAWLLNHFEWQAIFAVLFAITLLLMI
PTLRLQEHRAMANRQTPSIGFLRLMRSNIFSGNVLIYAACSAGFFAWLTGSPFILGEMGYSPNDIGLSYVPQTIAFLLGG
YGCRALLSRIGGTLLLPWLLVIYSLSMLAMLVMALSYQPGLLALLIPFCVMAMMNGAIYPIVVASALTPFPNNSGKAAAL
QNTLQLGVCFLASLLVSALIHIPLLATSAIMAGTIPLVMLGYWLKSDSVTTILEKRREQQRGQHALSRR

Sequences:

>Translated_389_residues
MLGYLATDMYLPAFGAMRHDLGASAGAISASLSIFLAGFAFAQLLWGPLSDRIGRKPVLLLGLGMFALACLGMLWVDNTT
QLLILRFVQAVGVCSAAVTWQALVIDRYSKGVANRVFATVMPLVALSPALAPLLGAWLLNHFEWQAIFAVLFAITLLLMI
PTLRLQEHRAMANRQTPSIGFLRLMRSNIFSGNVLIYAACSAGFFAWLTGSPFILGEMGYSPNDIGLSYVPQTIAFLLGG
YGCRALLSRIGGTLLLPWLLVIYSLSMLAMLVMALSYQPGLLALLIPFCVMAMMNGAIYPIVVASALTPFPNNSGKAAAL
QNTLQLGVCFLASLLVSALIHIPLLATSAIMAGTIPLVMLGYWLKSDSVTTILEKRREQQRGQHALSRR
>Mature_389_residues
MLGYLATDMYLPAFGAMRHDLGASAGAISASLSIFLAGFAFAQLLWGPLSDRIGRKPVLLLGLGMFALACLGMLWVDNTT
QLLILRFVQAVGVCSAAVTWQALVIDRYSKGVANRVFATVMPLVALSPALAPLLGAWLLNHFEWQAIFAVLFAITLLLMI
PTLRLQEHRAMANRQTPSIGFLRLMRSNIFSGNVLIYAACSAGFFAWLTGSPFILGEMGYSPNDIGLSYVPQTIAFLLGG
YGCRALLSRIGGTLLLPWLLVIYSLSMLAMLVMALSYQPGLLALLIPFCVMAMMNGAIYPIVVASALTPFPNNSGKAAAL
QNTLQLGVCFLASLLVSALIHIPLLATSAIMAGTIPLVMLGYWLKSDSVTTILEKRREQQRGQHALSRR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=367, Percent_Identity=65.3950953678474, Blast_Score=466, Evalue=1e-133,
Organism=Escherichia coli, GI1788509, Length=339, Percent_Identity=28.023598820059, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790794, Length=228, Percent_Identity=30.2631578947368, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1787065, Length=258, Percent_Identity=32.1705426356589, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082312, Length=340, Percent_Identity=28.5294117647059, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790146, Length=221, Percent_Identity=29.4117647058824, Blast_Score=78, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41972; Mature: 41972

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGYLATDMYLPAFGAMRHDLGASAGAISASLSIFLAGFAFAQLLWGPLSDRIGRKPVLL
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LGLGMFALACLGMLWVDNTTQLLILRFVQAVGVCSAAVTWQALVIDRYSKGVANRVFATV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MPLVALSPALAPLLGAWLLNHFEWQAIFAVLFAITLLLMIPTLRLQEHRAMANRQTPSIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
FLRLMRSNIFSGNVLIYAACSAGFFAWLTGSPFILGEMGYSPNDIGLSYVPQTIAFLLGG
HHHHHHHHCCCCCEEEEEEHHCCHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCC
YGCRALLSRIGGTLLLPWLLVIYSLSMLAMLVMALSYQPGLLALLIPFCVMAMMNGAIYP
CCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHH
IVVASALTPFPNNSGKAAALQNTLQLGVCFLASLLVSALIHIPLLATSAIMAGTIPLVML
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYWLKSDSVTTILEKRREQQRGQHALSRR
HHHHCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]