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The map label for this gene is fnr [H]

Identifier: 238919859

GI number: 238919859

Start: 1892121

End: 1892879

Strand: Reverse

Name: fnr [H]

Synonym: NT01EI_1963

Alternate gene names: 238919859

Gene position: 1892879-1892121 (Counterclockwise)

Preceding gene: 238919873

Following gene: 238919858

Centisome position: 49.65

GC content: 51.65

Gene sequence:

>759_bases
ATGATTCCGGAAAAACGTGTCATTCGTCGTATCCAGTCTGGTGGTTGTGCGATCCACTGTCAGGATTGCAGCATCAGCCA
GCTGTGTATCCCGTTTACGCTTAATGAACATGAGCTGGGTCAGCTCGACAATATCATTGAGCGTAAAAAGCCGATTCAGA
AAGGTCAGGCGCTGTTTAAGGCGGGGGATGAACTGAAGTCGCTGTACGCGATCCGCTCCGGAACCATTAAGAGTTATACC
ATCACCGAGCAGGGCGATGAGCAGATCACTGCATTTCACCTGGCGGGTGATCTGGTGGGTTTTGATGCCATCGGCGCACA
GATACACCCCAGCTTTGCCCAGGCATTGGAAACCTCCATGGTGTGTGAGATCCCCTTTGAAACGCTGGACGACCTGTCCG
GTAAAATGCCCAGCCTGCGTCAGCAGATGATGCGCCTGATGAGCGGCGAAATTAAGGGCGATCAGGATATGATCTTACTG
CTGTCCAAGAAAAATGCAGAAGAGCGTCTGGCCGCCTTTATCTATAACCTGTCGCGGCGCTTTGCCCAGCGGGGCTTCTC
ACCGCGTGAATTCCGTCTTACCATGACCCGCGGCGATATCGGGAATTATCTTGGTCTGACGGTAGAGACGATTAGCCGTC
TGCTGGGACGCTTTCAGAAAAGTGATATTCTCAGCGTAAAGGGTAAGTATATCACTATTCAAGATATTGATGCGTTGGCC
AATCTGGCCGGTAATCCGCGTACACCTTGTGGTGAATGA

Upstream 100 bases:

>100_bases
CCTTAATTCGCATCCCCACATCTGGATCAACAATAGGGCTTATTATCCCCCATAAAAGATGTTAAAATTGACTGATATCA
ATATTATTTAGGCAACACCT

Downstream 100 bases:

>100_bases
GCGTTCGCTGCGAATTAAAGAAGACGGCCTGCGGGCCGTTTTTTATTGGTTACCCTCCTCACCCACCCCCCTAGATTATA
TTTTCTGATTTGTTGCTCGT

Product: fumarate/nitrate reduction transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MIPEKRVIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELGQLDNIIERKKPIQKGQALFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITAFHLAGDLVGFDAIGAQIHPSFAQALETSMVCEIPFETLDDLSGKMPSLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSDILSVKGKYITIQDIDALA
NLAGNPRTPCGE

Sequences:

>Translated_252_residues
MIPEKRVIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELGQLDNIIERKKPIQKGQALFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITAFHLAGDLVGFDAIGAQIHPSFAQALETSMVCEIPFETLDDLSGKMPSLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSDILSVKGKYITIQDIDALA
NLAGNPRTPCGE
>Mature_252_residues
MIPEKRVIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELGQLDNIIERKKPIQKGQALFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITAFHLAGDLVGFDAIGAQIHPSFAQALETSMVCEIPFETLDDLSGKMPSLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSDILSVKGKYITIQDIDALA
NLAGNPRTPCGE

Specific function: Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=248, Percent_Identity=92.741935483871, Blast_Score=472, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 28101; Mature: 28101

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00042 HTH_CRP_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPEKRVIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELGQLDNIIERKKPIQKGQALFK
CCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEQGDEQITAFHLAGDLVGFDAIGAQIHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHH
VCEIPFETLDDLSGKMPSLRQQMMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSRR
EEECCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSDILSVKGKYITIQDIDALA
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECHHHHH
NLAGNPRTPCGE
HCCCCCCCCCCC
>Mature Secondary Structure
MIPEKRVIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELGQLDNIIERKKPIQKGQALFK
CCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEQGDEQITAFHLAGDLVGFDAIGAQIHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHH
VCEIPFETLDDLSGKMPSLRQQMMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSRR
EEECCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSDILSVKGKYITIQDIDALA
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECHHHHH
NLAGNPRTPCGE
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]