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The map label for this gene is lplA [H]

Identifier: 238919798

GI number: 238919798

Start: 1830313

End: 1831326

Strand: Direct

Name: lplA [H]

Synonym: NT01EI_1902

Alternate gene names: 238919798

Gene position: 1830313-1831326 (Clockwise)

Preceding gene: 238919797

Following gene: 238919812

Centisome position: 48.01

GC content: 61.05

Gene sequence:

>1014_bases
ATGACGCCGTTATCGCTTTTTATCTCCGATTCTCACGATCCCTGGTTCAATCTGGCGGTGGAAGAGTGCATCTTCCGCCA
GATGGATCCCGCACAGCGGGTTCTTTTCTTGTGGCGTAATGTCGATACGGTGGTGATTGGCCGCGCACAAAATCCCTGGC
GCGAGTGCAATACCCGTCGCATGGCGCAGGACGGCGTTAAACTGGCCCGGCGTAGCAGCGGCGGTGGCGCAGTGTTTCAC
GATCTGGGCAACAGCTGTTTTACCTTTATGGCCGGTAAGCCCGGCTATGATAAGCAGGTCTCCACAGGCATCATTCTTGC
TGCGCTGGCAGGGCTGGGAATGGATGTCCAGGCCAGCGGGCGCAACGATCTGGAGTTGGATACCCCGCAGGGAAGGCGCA
AAATTTCCGGTTCGGCCTACCGCGAGACCCAGGATCGCGGTTTTCATCACGGAACCCTGCTGCTGAATGCCAATCTGGGC
CGTCTGGCCGACTATCTGAACCCCGACCTGAAGAAGCTGCAGGCTAAGGGCATTGCCTCAGTGCGCGCGCGCGTCGCCAA
TCTGTCGGAGTGGGTTGCGGACATCAATCATACGCGTCTGTGCAATGCCATCGTCGAAGCCTTTTTTACCCATTACGGGC
AGCGGGTCGCACCGCAGCATATCTCGCTGCAGCATCTTCCGGATCTGCCCGGCTTTGCACAGCAGTTTCAGCGCCAGAGC
AGCTGGGCGTGGAACTATGGCCAGGCGCCCGACTTTAGCCATGTGATGGAGACGCGTTTTGACTGGGGCGGCGTGGAGCT
GCACTGCGAGGTGGCGCGGGGGACGATCGTCCGTGCCCGTCTGTTCAGCGATGCGTTGACGCCGGCGCCGCTTGAGGCGC
TGACCGTCGCACTGGCGGGCTGTCCCTATCAGGGAGAGGCGGTATCCCAGCGGGTGTTGGCGCAGGGAGGAGATGATACG
ACAGGGAGGATGATACCCCAGCTGGCGGCATGGCTGCGCCGCCAGCTGGCCTAG

Upstream 100 bases:

>100_bases
CCTACTGGCAGGCCCGGCGTCTATAGCCTCCGCTGCGGGCTCTTATCTGCGCAGTGGCAGTGCTATCATCATGACTTTAG
CTCAGTAAAAAGGCATGGTT

Downstream 100 bases:

>100_bases
GGCTGGCTACAGGCGCGTGTGCGCCTGGGGAAAGCGCGCCTTCAGCTGCGCGCGGGTCGGCGCACCGTCGGGGCCGGGCT
GGCTGACCACGCAGGCGGCG

Product: lipoate-protein ligase A

Products: NA

Alternate protein names: Lipoate--protein ligase [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTPLSLFISDSHDPWFNLAVEECIFRQMDPAQRVLFLWRNVDTVVIGRAQNPWRECNTRRMAQDGVKLARRSSGGGAVFH
DLGNSCFTFMAGKPGYDKQVSTGIILAALAGLGMDVQASGRNDLELDTPQGRRKISGSAYRETQDRGFHHGTLLLNANLG
RLADYLNPDLKKLQAKGIASVRARVANLSEWVADINHTRLCNAIVEAFFTHYGQRVAPQHISLQHLPDLPGFAQQFQRQS
SWAWNYGQAPDFSHVMETRFDWGGVELHCEVARGTIVRARLFSDALTPAPLEALTVALAGCPYQGEAVSQRVLAQGGDDT
TGRMIPQLAAWLRRQLA

Sequences:

>Translated_337_residues
MTPLSLFISDSHDPWFNLAVEECIFRQMDPAQRVLFLWRNVDTVVIGRAQNPWRECNTRRMAQDGVKLARRSSGGGAVFH
DLGNSCFTFMAGKPGYDKQVSTGIILAALAGLGMDVQASGRNDLELDTPQGRRKISGSAYRETQDRGFHHGTLLLNANLG
RLADYLNPDLKKLQAKGIASVRARVANLSEWVADINHTRLCNAIVEAFFTHYGQRVAPQHISLQHLPDLPGFAQQFQRQS
SWAWNYGQAPDFSHVMETRFDWGGVELHCEVARGTIVRARLFSDALTPAPLEALTVALAGCPYQGEAVSQRVLAQGGDDT
TGRMIPQLAAWLRRQLA
>Mature_336_residues
TPLSLFISDSHDPWFNLAVEECIFRQMDPAQRVLFLWRNVDTVVIGRAQNPWRECNTRRMAQDGVKLARRSSGGGAVFHD
LGNSCFTFMAGKPGYDKQVSTGIILAALAGLGMDVQASGRNDLELDTPQGRRKISGSAYRETQDRGFHHGTLLLNANLGR
LADYLNPDLKKLQAKGIASVRARVANLSEWVADINHTRLCNAIVEAFFTHYGQRVAPQHISLQHLPDLPGFAQQFQRQSS
WAWNYGQAPDFSHVMETRFDWGGVELHCEVARGTIVRARLFSDALTPAPLEALTVALAGCPYQGEAVSQRVLAQGGDDTT
GRMIPQLAAWLRRQLA

Specific function: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes [H]

COG id: COG0095

COG function: function code H; Lipoate-protein ligase A

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lplA family [H]

Homologues:

Organism=Homo sapiens, GI7706252, Length=270, Percent_Identity=37.037037037037, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI21729884, Length=270, Percent_Identity=37.037037037037, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI21729882, Length=270, Percent_Identity=37.037037037037, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI21729880, Length=270, Percent_Identity=37.037037037037, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI21729878, Length=270, Percent_Identity=37.037037037037, Blast_Score=159, Evalue=2e-39,
Organism=Escherichia coli, GI1790846, Length=333, Percent_Identity=65.1651651651652, Blast_Score=460, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71981909, Length=248, Percent_Identity=33.0645161290323, Blast_Score=121, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6322415, Length=190, Percent_Identity=31.5789473684211, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28573464, Length=322, Percent_Identity=30.1242236024845, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR005107
- InterPro:   IPR019491
- InterPro:   IPR004562 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB; PF10437 Lip_prot_lig_C [H]

EC number: =2.7.7.63 [H]

Molecular weight: Translated: 37354; Mature: 37223

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLSLFISDSHDPWFNLAVEECIFRQMDPAQRVLFLWRNVDTVVIGRAQNPWRECNTRR
CCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
MAQDGVKLARRSSGGGAVFHDLGNSCFTFMAGKPGYDKQVSTGIILAALAGLGMDVQASG
HHHHHHHHHHCCCCCCCHHHHCCCHHEEEECCCCCCCCHHHHHHHHHHHHHCCCCEECCC
RNDLELDTPQGRRKISGSAYRETQDRGFHHGTLLLNANLGRLADYLNPDLKKLQAKGIAS
CCCCEECCCCCCHHCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHCHHHHHHHHHHHHH
VRARVANLSEWVADINHTRLCNAIVEAFFTHYGQRVAPQHISLQHLPDLPGFAQQFQRQS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHC
SWAWNYGQAPDFSHVMETRFDWGGVELHCEVARGTIVRARLFSDALTPAPLEALTVALAG
CCCCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHC
CPYQGEAVSQRVLAQGGDDTTGRMIPQLAAWLRRQLA
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPLSLFISDSHDPWFNLAVEECIFRQMDPAQRVLFLWRNVDTVVIGRAQNPWRECNTRR
CCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
MAQDGVKLARRSSGGGAVFHDLGNSCFTFMAGKPGYDKQVSTGIILAALAGLGMDVQASG
HHHHHHHHHHCCCCCCCHHHHCCCHHEEEECCCCCCCCHHHHHHHHHHHHHCCCCEECCC
RNDLELDTPQGRRKISGSAYRETQDRGFHHGTLLLNANLGRLADYLNPDLKKLQAKGIAS
CCCCEECCCCCCHHCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHCHHHHHHHHHHHHH
VRARVANLSEWVADINHTRLCNAIVEAFFTHYGQRVAPQHISLQHLPDLPGFAQQFQRQS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHC
SWAWNYGQAPDFSHVMETRFDWGGVELHCEVARGTIVRARLFSDALTPAPLEALTVALAG
CCCCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHC
CPYQGEAVSQRVLAQGGDDTTGRMIPQLAAWLRRQLA
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA