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The map label for this gene is cobQ [H]

Identifier: 238919746

GI number: 238919746

Start: 1786283

End: 1787824

Strand: Direct

Name: cobQ [H]

Synonym: NT01EI_1850

Alternate gene names: 238919746

Gene position: 1786283-1787824 (Clockwise)

Preceding gene: 238919745

Following gene: 238919747

Centisome position: 46.86

GC content: 65.11

Gene sequence:

>1542_bases
ATGACCCTATCGATCATGATACAGGGCACCGCCTCGGACGCGGGGAAAAGCGTTTTGTGCGCCGGGCTGTGCCGGGTGTT
CTCCCGGGATGGCTACCGGGTGGCGCCGTTTAAGTCACAGAATATGGCGCTGAACTCCGGGATCACCGCCGACGGCGGCG
AGATGGGACGGGCGCAGATGATGCAGGTCGAGGCCGCCAACATCGCCCCGGACGTGCGGATGAACCCGATCCTGCTGAAG
CCCACCAGTGATTGTCATGCCCAGGTGGTGCTGATGGGACGGGTGCTGCAGGATATGGACGCCGTCCACTATCACCGCTA
TAAGCCCCGACTGTTAGAGCAGGTGGCGCAGGTTTACCGTGAGTTGGCCAGCCAGGTCGATATCATGGTGTTGGAGGGGG
CTGGCAGTCCGGCGGAGATCAATCTGCGCGATCGCGATATCGTCAATATGGGGATGGCGGAGAAGGTCGACGCGCCGGTG
CTGCTGGTGGCAGATATCGATCGCGGCGGTGTATTCGCCGCTATCTATGGCACACTGGCACTGTTGACGCCGCAGGAGCG
CGCGCGGGTCAAAGGAGTCATCATCAATAAGTTCCGCGGTGACTTCAGCCTGCTCACTCCGGGGCTGCGCCAGATAGAGT
CCCTTACCGGCGTGCCGGTGCTGGGGGTCCTACCGTGGCTGACGCTTGATTTGGATGACGAGGACGGCGTGGCGTTGCAG
CGCGGTAAGTACCGCCACGCAGAGGGGCGGGCACTGGAGATCGCGGTGCTGCAGCTCCCCTATATCGCCAACTTTACCGA
CTTCTCGCCGCTGAACGCCCAGCCGGACGTTACCCTGCGCTATATCACGGAGCACGATGAGATTGGCCGCCCGGACCTGC
TGATTCTGCCGGGCAGCAAAAGCACGCTGGCCGATCTGCGCTACCTGCGCGACAGCGGCCTGGCCCATCAGATCCTCTGC
GCCCGTCAGGCCGGTACGCCGATTCTGGGCATCTGCGGCGGCTACCAGATGCTGGGACGGCGGATCGTCGATGGCGTTGA
GTCGGCGCAGGCGGCCATGAGCGGCCTGGGGCTGCTGGACTGTGAAACCCGGTTTGCCCGGGAGAAAACCACCGCGCAGG
TGCGGGGCGAGGCTCTGGGCAGGTTGCCCGGTCCGTGGGCGGGGTGCAGTGCGATTCCGCTGGCGGGGTATGAGATCCAT
ATGGGGGTGACCCGGCGCGGCGCCGGATGTTCCCCGTTCTGCCGCCTGTTGTCGTCCAACGGGACGGCAGACGATCGGGA
GGAGGGCGCCATCAGTGCCGATGGTCTGGTGATGGGCACCTATCTGCATGGGCTGTTTGATACCCCGGTGCTAACGCGGG
CGCTGCTCGACGCGCTGCGCGAGCGTAAGGGGCTGGCGCCGGACGGTGGCCCGACCCTCAACTACTCCGCCTGGCGCGAG
CAGCAGTTTGACAGGCTGGCGGCGGCGCTGCGCGAACATGTGGACATCGCGCGGATCTATCAGCTGATGCGCGCCCACGC
GGGCGGGGCGCCGTCATCATGA

Upstream 100 bases:

>100_bases
GGTGTTTTATAAGGTAAACGACGATGAGAATGCGATGGTTCGGCGCCAGCGCTAACCCGGCCTTGACCGGCTGGCCGCCG
CGCGCCCTGGTGGAGGGAGA

Downstream 100 bases:

>100_bases
TGACGCGAACGGTATGCCCCGCATGACATTAACCTTAAGAGATACGTAACGATGACCCATTATGCACAGACGCTGGCGGA
GATCGTCGCCGCCATTCGTC

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTLSIMIQGTASDAGKSVLCAGLCRVFSRDGYRVAPFKSQNMALNSGITADGGEMGRAQMMQVEAANIAPDVRMNPILLK
PTSDCHAQVVLMGRVLQDMDAVHYHRYKPRLLEQVAQVYRELASQVDIMVLEGAGSPAEINLRDRDIVNMGMAEKVDAPV
LLVADIDRGGVFAAIYGTLALLTPQERARVKGVIINKFRGDFSLLTPGLRQIESLTGVPVLGVLPWLTLDLDDEDGVALQ
RGKYRHAEGRALEIAVLQLPYIANFTDFSPLNAQPDVTLRYITEHDEIGRPDLLILPGSKSTLADLRYLRDSGLAHQILC
ARQAGTPILGICGGYQMLGRRIVDGVESAQAAMSGLGLLDCETRFAREKTTAQVRGEALGRLPGPWAGCSAIPLAGYEIH
MGVTRRGAGCSPFCRLLSSNGTADDREEGAISADGLVMGTYLHGLFDTPVLTRALLDALRERKGLAPDGGPTLNYSAWRE
QQFDRLAAALREHVDIARIYQLMRAHAGGAPSS

Sequences:

>Translated_513_residues
MTLSIMIQGTASDAGKSVLCAGLCRVFSRDGYRVAPFKSQNMALNSGITADGGEMGRAQMMQVEAANIAPDVRMNPILLK
PTSDCHAQVVLMGRVLQDMDAVHYHRYKPRLLEQVAQVYRELASQVDIMVLEGAGSPAEINLRDRDIVNMGMAEKVDAPV
LLVADIDRGGVFAAIYGTLALLTPQERARVKGVIINKFRGDFSLLTPGLRQIESLTGVPVLGVLPWLTLDLDDEDGVALQ
RGKYRHAEGRALEIAVLQLPYIANFTDFSPLNAQPDVTLRYITEHDEIGRPDLLILPGSKSTLADLRYLRDSGLAHQILC
ARQAGTPILGICGGYQMLGRRIVDGVESAQAAMSGLGLLDCETRFAREKTTAQVRGEALGRLPGPWAGCSAIPLAGYEIH
MGVTRRGAGCSPFCRLLSSNGTADDREEGAISADGLVMGTYLHGLFDTPVLTRALLDALRERKGLAPDGGPTLNYSAWRE
QQFDRLAAALREHVDIARIYQLMRAHAGGAPSS
>Mature_512_residues
TLSIMIQGTASDAGKSVLCAGLCRVFSRDGYRVAPFKSQNMALNSGITADGGEMGRAQMMQVEAANIAPDVRMNPILLKP
TSDCHAQVVLMGRVLQDMDAVHYHRYKPRLLEQVAQVYRELASQVDIMVLEGAGSPAEINLRDRDIVNMGMAEKVDAPVL
LVADIDRGGVFAAIYGTLALLTPQERARVKGVIINKFRGDFSLLTPGLRQIESLTGVPVLGVLPWLTLDLDDEDGVALQR
GKYRHAEGRALEIAVLQLPYIANFTDFSPLNAQPDVTLRYITEHDEIGRPDLLILPGSKSTLADLRYLRDSGLAHQILCA
RQAGTPILGICGGYQMLGRRIVDGVESAQAAMSGLGLLDCETRFAREKTTAQVRGEALGRLPGPWAGCSAIPLAGYEIHM
GVTRRGAGCSPFCRLLSSNGTADDREEGAISADGLVMGTYLHGLFDTPVLTRALLDALRERKGLAPDGGPTLNYSAWREQ
QFDRLAAALREHVDIARIYQLMRAHAGGAPSS

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 55471; Mature: 55339

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSIMIQGTASDAGKSVLCAGLCRVFSRDGYRVAPFKSQNMALNSGITADGGEMGRAQM
CEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCEEECCCCCCCCCCCCCHHH
MQVEAANIAPDVRMNPILLKPTSDCHAQVVLMGRVLQDMDAVHYHRYKPRLLEQVAQVYR
EEEEHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ELASQVDIMVLEGAGSPAEINLRDRDIVNMGMAEKVDAPVLLVADIDRGGVFAAIYGTLA
HHHCCCCEEEEECCCCCCEEEECCCHHHCCCCHHHCCCCEEEEEECCCCCCHHHHHHHHH
LLTPQERARVKGVIINKFRGDFSLLTPGLRQIESLTGVPVLGVLPWLTLDLDDEDGVALQ
HCCCHHHHHCCEEEEECCCCCHHHHCHHHHHHHHHCCCCHHHHHCEEEEEECCCCCCEEC
RGKYRHAEGRALEIAVLQLPYIANFTDFSPLNAQPDVTLRYITEHDEIGRPDLLILPGSK
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCC
STLADLRYLRDSGLAHQILCARQAGTPILGICGGYQMLGRRIVDGVESAQAAMSGLGLLD
HHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEE
CETRFAREKTTAQVRGEALGRLPGPWAGCSAIPLAGYEIHMGVTRRGAGCSPFCRLLSSN
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECEECCCCCCCHHHHHHHCC
GTADDREEGAISADGLVMGTYLHGLFDTPVLTRALLDALRERKGLAPDGGPTLNYSAWRE
CCCCCCCCCCCCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
QQFDRLAAALREHVDIARIYQLMRAHAGGAPSS
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLSIMIQGTASDAGKSVLCAGLCRVFSRDGYRVAPFKSQNMALNSGITADGGEMGRAQM
EEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCEEECCCCCCCCCCCCCHHH
MQVEAANIAPDVRMNPILLKPTSDCHAQVVLMGRVLQDMDAVHYHRYKPRLLEQVAQVYR
EEEEHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ELASQVDIMVLEGAGSPAEINLRDRDIVNMGMAEKVDAPVLLVADIDRGGVFAAIYGTLA
HHHCCCCEEEEECCCCCCEEEECCCHHHCCCCHHHCCCCEEEEEECCCCCCHHHHHHHHH
LLTPQERARVKGVIINKFRGDFSLLTPGLRQIESLTGVPVLGVLPWLTLDLDDEDGVALQ
HCCCHHHHHCCEEEEECCCCCHHHHCHHHHHHHHHCCCCHHHHHCEEEEEECCCCCCEEC
RGKYRHAEGRALEIAVLQLPYIANFTDFSPLNAQPDVTLRYITEHDEIGRPDLLILPGSK
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCC
STLADLRYLRDSGLAHQILCARQAGTPILGICGGYQMLGRRIVDGVESAQAAMSGLGLLD
HHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEE
CETRFAREKTTAQVRGEALGRLPGPWAGCSAIPLAGYEIHMGVTRRGAGCSPFCRLLSSN
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECEECCCCCCCHHHHHHHCC
GTADDREEGAISADGLVMGTYLHGLFDTPVLTRALLDALRERKGLAPDGGPTLNYSAWRE
CCCCCCCCCCCCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
QQFDRLAAALREHVDIARIYQLMRAHAGGAPSS
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA