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The map label for this gene is kdc [H]

Identifier: 238919670

GI number: 238919670

Start: 1717472

End: 1719118

Strand: Direct

Name: kdc [H]

Synonym: NT01EI_1772

Alternate gene names: 238919670

Gene position: 1717472-1719118 (Clockwise)

Preceding gene: 238919668

Following gene: 238919674

Centisome position: 45.05

GC content: 58.23

Gene sequence:

>1647_bases
GTGTCTACAACGGTTATCGAATATGTGCTGTCACGGCTATATGATCTGGGAATTCATGACATTTTCGGCGTTCCGGGAGA
TTACGCTTTTCCGATTGAGGATGCCATCTGTGTGGACGAACGCCTACGCTGGATAGGCAACTGTAATGAGCTGAACGCCG
CCTATGCGGCCGATGCCTATGCCCGCACTCATGGGCTGGCGGCGCTGAGCACCACCTTTGGCGTGGGGGAGCTCAGTGCA
ATAAACGGCATCGCCGGCGCCTGCGCCGAGTCTGTTACGCTGTTTCATCTGGTCGGTATGCCGGCAAGCCATGTCCAGGC
AGCGGGGGCGTGTGTGCACCATACGCTGGGCAATGGCGATTTTACGTCGTTTTATGAGGCCACAGACTCCTTTGTCTGTG
CCCGTGCCATTCTGACGCCGGAAAACTGTATCGCAGAGACCGAGCGCCTGATCGAGGCGGCGCTGCGCTACCGTAAACCG
GTATATATGGGCTTCCCCAGCGATTATGCCATGATGCCGATCGTGGCGGACACCGCGCAGCCGGCAGCGGAGCCCGTCAG
CGATCCGCAGATCTTGAATGAGGTGATCGATGTTATCGCCGAGCGCCTGAATAACAGTGATAGCGTCTGCGCGCTGCCGG
GGATTTATCTGGTCCGCCACGGCGTACAGCAGGAGGCGACGGCGTTGATTGATGCCGCTAACCTGCCGTTTGCCACCATG
ATAATGGATAAGTGCGTGATCGATGAATCCCACCCGAACTACGTTGGAATGTATGTCGGCCAGCTGATGGACCAACGGGT
GCGCCAGTTTGTGGAGAGCAGCGATTGTGTACTGAAAATCGGCACTATTATGAGTGACTTGAACACCGGGGCGTACACCT
CGCACCTGGATGAGGCGCAGTGCATCAGCGTGGAGCCGACGTCGGTCCATATCGGTAAGTCGGTCTATGAAAACGTGTTG
ATGAAGGATGTGCTGAGTGGACTGATAGGCAGGGTCACCCGCAGGGCCCGCCGTCACGATATGCCGCCGGTACAGGGGAT
CCCCGTGGTGAGCGGCAGCGGCAAGCTGACCGCGGAGTACCTCTATTCACGCTGGCAGCAGATGCTGAAGCCGAACGATC
TGCTGGTGGCGGAGACCGGTACCACTTCCATGGGGCTGGCGTTTGCCAAGATGCCACAGGGCGCCATGTTTTATCAGCAG
ACCCTGTGGGGCTCCATCGGCTGGGCGACACCGGCGGCATTCGGTGTGGCGATGGCGGAGCCGGAGAAGCGCACCATTTT
GATCACCGGCGAAGGCTCGCACCAGATGACGGTACAGGAGATTGGCCAGTTCTATCGCTTTGGCTTGAAGCCGCTGATCT
TTGTTGTGAATAACGACGGCTATTTGGTCGAGCGTATGCTGTGCAAGGATGGTGATATCTATTACAACGATCTGACGCAG
TGGAACTACAGCCAACTGCCGGCGGGGCTGGGCTGCCGCGATTGGTTTACTGCCCGCGTGACCACCTGCGAGGCACTGGA
TGAGGCGATCCGCCATGCTGAAGCCGGTGACTGCGGCGCCTACATTGAAGTCGTAACCGATAAGTATGTCACCTCTGAGC
TGTTGGAGAAGCTGCACGGCGCGCTGACATCGCTCTACTCCGCCTGA

Upstream 100 bases:

>100_bases
AGGCGAATAGTACCACGACACTAATTTGGAGTCACTACCCAAAATACCATTTGAAATCGCTATTGCCTATTGAATTATCT
GATAAAGCGGGAGATTTATT

Downstream 100 bases:

>100_bases
GGCTTGGGCAGCGATCTGTCGGGTACCAGAGCTAGATATGCCCGCAGCTCGGCGACATCCTCAATGCCCAGCGGCAGGCG
GATGAGCTGGGAAAGGATAC

Product: indole-3-pyruvate decarboxylase

Products: aldehyde; CO2

Alternate protein names: KDC [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MSTTVIEYVLSRLYDLGIHDIFGVPGDYAFPIEDAICVDERLRWIGNCNELNAAYAADAYARTHGLAALSTTFGVGELSA
INGIAGACAESVTLFHLVGMPASHVQAAGACVHHTLGNGDFTSFYEATDSFVCARAILTPENCIAETERLIEAALRYRKP
VYMGFPSDYAMMPIVADTAQPAAEPVSDPQILNEVIDVIAERLNNSDSVCALPGIYLVRHGVQQEATALIDAANLPFATM
IMDKCVIDESHPNYVGMYVGQLMDQRVRQFVESSDCVLKIGTIMSDLNTGAYTSHLDEAQCISVEPTSVHIGKSVYENVL
MKDVLSGLIGRVTRRARRHDMPPVQGIPVVSGSGKLTAEYLYSRWQQMLKPNDLLVAETGTTSMGLAFAKMPQGAMFYQQ
TLWGSIGWATPAAFGVAMAEPEKRTILITGEGSHQMTVQEIGQFYRFGLKPLIFVVNNDGYLVERMLCKDGDIYYNDLTQ
WNYSQLPAGLGCRDWFTARVTTCEALDEAIRHAEAGDCGAYIEVVTDKYVTSELLEKLHGALTSLYSA

Sequences:

>Translated_548_residues
MSTTVIEYVLSRLYDLGIHDIFGVPGDYAFPIEDAICVDERLRWIGNCNELNAAYAADAYARTHGLAALSTTFGVGELSA
INGIAGACAESVTLFHLVGMPASHVQAAGACVHHTLGNGDFTSFYEATDSFVCARAILTPENCIAETERLIEAALRYRKP
VYMGFPSDYAMMPIVADTAQPAAEPVSDPQILNEVIDVIAERLNNSDSVCALPGIYLVRHGVQQEATALIDAANLPFATM
IMDKCVIDESHPNYVGMYVGQLMDQRVRQFVESSDCVLKIGTIMSDLNTGAYTSHLDEAQCISVEPTSVHIGKSVYENVL
MKDVLSGLIGRVTRRARRHDMPPVQGIPVVSGSGKLTAEYLYSRWQQMLKPNDLLVAETGTTSMGLAFAKMPQGAMFYQQ
TLWGSIGWATPAAFGVAMAEPEKRTILITGEGSHQMTVQEIGQFYRFGLKPLIFVVNNDGYLVERMLCKDGDIYYNDLTQ
WNYSQLPAGLGCRDWFTARVTTCEALDEAIRHAEAGDCGAYIEVVTDKYVTSELLEKLHGALTSLYSA
>Mature_547_residues
STTVIEYVLSRLYDLGIHDIFGVPGDYAFPIEDAICVDERLRWIGNCNELNAAYAADAYARTHGLAALSTTFGVGELSAI
NGIAGACAESVTLFHLVGMPASHVQAAGACVHHTLGNGDFTSFYEATDSFVCARAILTPENCIAETERLIEAALRYRKPV
YMGFPSDYAMMPIVADTAQPAAEPVSDPQILNEVIDVIAERLNNSDSVCALPGIYLVRHGVQQEATALIDAANLPFATMI
MDKCVIDESHPNYVGMYVGQLMDQRVRQFVESSDCVLKIGTIMSDLNTGAYTSHLDEAQCISVEPTSVHIGKSVYENVLM
KDVLSGLIGRVTRRARRHDMPPVQGIPVVSGSGKLTAEYLYSRWQQMLKPNDLLVAETGTTSMGLAFAKMPQGAMFYQQT
LWGSIGWATPAAFGVAMAEPEKRTILITGEGSHQMTVQEIGQFYRFGLKPLIFVVNNDGYLVERMLCKDGDIYYNDLTQW
NYSQLPAGLGCRDWFTARVTTCEALDEAIRHAEAGDCGAYIEVVTDKYVTSELLEKLHGALTSLYSA

Specific function: Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes [H]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=531, Percent_Identity=22.7871939736347, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081685, Length=525, Percent_Identity=21.9047619047619, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6321524, Length=526, Percent_Identity=36.5019011406844, Blast_Score=340, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6323073, Length=529, Percent_Identity=36.6729678638941, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6323163, Length=514, Percent_Identity=35.7976653696498, Blast_Score=316, Evalue=5e-87,
Organism=Saccharomyces cerevisiae, GI6320123, Length=516, Percent_Identity=33.1395348837209, Blast_Score=309, Evalue=8e-85,
Organism=Saccharomyces cerevisiae, GI6320588, Length=547, Percent_Identity=28.7020109689214, Blast_Score=213, Evalue=6e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: 4.1.1.1

Molecular weight: Translated: 59910; Mature: 59779

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTVIEYVLSRLYDLGIHDIFGVPGDYAFPIEDAICVDERLRWIGNCNELNAAYAADAY
CCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
ARTHGLAALSTTFGVGELSAINGIAGACAESVTLFHLVGMPASHVQAAGACVHHTLGNGD
HHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
FTSFYEATDSFVCARAILTPENCIAETERLIEAALRYRKPVYMGFPSDYAMMPIVADTAQ
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCEECCEEECCCC
PAAEPVSDPQILNEVIDVIAERLNNSDSVCALPGIYLVRHGVQQEATALIDAANLPFATM
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHCCHHHHHHHHHHCCCCHHHH
IMDKCVIDESHPNYVGMYVGQLMDQRVRQFVESSDCVLKIGTIMSDLNTGAYTSHLDEAQ
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCHHCCCCCCC
CISVEPTSVHIGKSVYENVLMKDVLSGLIGRVTRRARRHDMPPVQGIPVVSGSGKLTAEY
EEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHH
LYSRWQQMLKPNDLLVAETGTTSMGLAFAKMPQGAMFYQQTLWGSIGWATPAAFGVAMAE
HHHHHHHHCCCCCEEEEECCCCHHCHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHCCC
PEKRTILITGEGSHQMTVQEIGQFYRFGLKPLIFVVNNDGYLVERMLCKDGDIYYNDLTQ
CCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEHHHHHCCCCEEECCCCC
WNYSQLPAGLGCRDWFTARVTTCEALDEAIRHAEAGDCGAYIEVVTDKYVTSELLEKLHG
CCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALTSLYSA
HHHHHHCC
>Mature Secondary Structure 
STTVIEYVLSRLYDLGIHDIFGVPGDYAFPIEDAICVDERLRWIGNCNELNAAYAADAY
CHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
ARTHGLAALSTTFGVGELSAINGIAGACAESVTLFHLVGMPASHVQAAGACVHHTLGNGD
HHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
FTSFYEATDSFVCARAILTPENCIAETERLIEAALRYRKPVYMGFPSDYAMMPIVADTAQ
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCEECCEEECCCC
PAAEPVSDPQILNEVIDVIAERLNNSDSVCALPGIYLVRHGVQQEATALIDAANLPFATM
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHCCHHHHHHHHHHCCCCHHHH
IMDKCVIDESHPNYVGMYVGQLMDQRVRQFVESSDCVLKIGTIMSDLNTGAYTSHLDEAQ
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCHHCCCCCCC
CISVEPTSVHIGKSVYENVLMKDVLSGLIGRVTRRARRHDMPPVQGIPVVSGSGKLTAEY
EEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHH
LYSRWQQMLKPNDLLVAETGTTSMGLAFAKMPQGAMFYQQTLWGSIGWATPAAFGVAMAE
HHHHHHHHCCCCCEEEEECCCCHHCHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHCCC
PEKRTILITGEGSHQMTVQEIGQFYRFGLKPLIFVVNNDGYLVERMLCKDGDIYYNDLTQ
CCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEHHHHHCCCCEEECCCCC
WNYSQLPAGLGCRDWFTARVTTCEALDEAIRHAEAGDCGAYIEVVTDKYVTSELLEKLHG
CCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALTSLYSA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-oxo acid

Specific reaction: A 2-oxo acid = an aldehyde + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]