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The map label for this gene is sdaC [H]

Identifier: 238919639

GI number: 238919639

Start: 1692630

End: 1693913

Strand: Direct

Name: sdaC [H]

Synonym: NT01EI_1740

Alternate gene names: 238919639

Gene position: 1692630-1693913 (Clockwise)

Preceding gene: 238919638

Following gene: 238919645

Centisome position: 44.4

GC content: 56.31

Gene sequence:

>1284_bases
ATGACCGTACTTTCCACTGATGTCGGGCAAAACGCCGGTACGCGGCTGTCCCGCTGGAATAAAAACGATACTGTCTGGAT
GTTTGGACTGTATGCCACCGCCGTGGGGGCGGGGACGCTATTTTTACCGATTAACGCCGGCCTGAACGGGCCGCTGGTGC
TAATCCTGATGGCGCTGCTGGCTTACCCGCTGACTTACTTACCCCACCGGGCGCTGTGCCGTCTGGTGCTGTCCGGCAGC
CGTCGCGATGGCGATATTACCGATGTGGTAGAGGAGCACTTTGGCACACTGGCAGGAAAGGGGATTATGGTACTGTATTT
ACTGGCATTTTTTCCTATCGTGCTGGTTTACAGCATCTCTATTGCCAATGCGCTGGAGAGCTTTTTGATCAATCAGTTTC
ATGTGGCGCCGCCGTCGCGCCTGTGGCTGAGCTTTGGCGTGGTCGCTCTGTTGGCGCTGATCCTGCGCACTGGGCGAGAG
GCTATTGTGGCCGCCATGGGGGTGCTGGTATTTCCGCTGATCCTGTTTTTAATGGGGATCTCGCTGTACCTGATCCCGTA
CTGGCAACCTGCGCATTTCTTTTCCGGGCTGGGGCAGACCTCTCTGGGCGATCCCGCGCTGTGGCGTTCGCTGTGGCTGG
CGGTGCCAGTGATGGTGTTTTCGTTTAGTCATGCGCCGATCATCTCCTCGTTTGCCTCCAGTCAGCGTCAGCTGTATGGC
GAGCAGGCGGAGCGCCGCTGCGCACGCATTATGCGCTATAGTTATATTATGATTTGCGTCAGTATCCTTTTCTTCGTCTT
TAGCTGTGTGATGAGTCTGTCCCATGCGGATATGCTGGCCGCGAGGGAGCAGAATATTACCGTGCTGTCGAGCCTGGCCA
ACCGTTTCGCCAACCCGCTGATTGCCTATCTGGGACCGGTGATGGCGATCCTCGCAATGTCCAAGTCTTATCTGGGGACC
TCGCTGGGAGTGACGGAAGGAGCCACCAGCCTGATTGACGGTGTATTTCGCAGCGTGGGGCGCTCTGTCTCTTCTCAGGT
GACTAGCCGTATTGCGGCGATCGTGCTGTTTCTCGTGACCTGGCTGGTGACCTATCAAAACCCGAGCGCGCTGCACATTA
TTGAGACGGTCAGCGGGCCGCTGATTGCGGTGATCCTGTTTATTTTGCCCATGTACGCTATTCATCGCATCCCTGCGATG
CGCAAGTACCGTTCACCCAGCAACCCCTTCGTACTGTTTATAGGGCTGATTGCACTCTCTGCACTGGTGTACAGCCTACT
GTAA

Upstream 100 bases:

>100_bases
TGTTACCAAGGTAATGCCGCGTCGGCAGGGGGCAGTGTTCCGGGCAGAACAGGATGTCTGCATGAGCCTATCGTCCGTAT
AAACAAGGTATGACGAATTA

Downstream 100 bases:

>100_bases
CGCCGGGTTAAGCGTGCGAATGCCAGAAAACACAACGCCCGCACAGTGCGGGCGTTGTGTCATCGTCAGGGCGCTATCGA
TGGGGTTAGGCCGTTGCTGT

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTVLSTDVGQNAGTRLSRWNKNDTVWMFGLYATAVGAGTLFLPINAGLNGPLVLILMALLAYPLTYLPHRALCRLVLSGS
RRDGDITDVVEEHFGTLAGKGIMVLYLLAFFPIVLVYSISIANALESFLINQFHVAPPSRLWLSFGVVALLALILRTGRE
AIVAAMGVLVFPLILFLMGISLYLIPYWQPAHFFSGLGQTSLGDPALWRSLWLAVPVMVFSFSHAPIISSFASSQRQLYG
EQAERRCARIMRYSYIMICVSILFFVFSCVMSLSHADMLAAREQNITVLSSLANRFANPLIAYLGPVMAILAMSKSYLGT
SLGVTEGATSLIDGVFRSVGRSVSSQVTSRIAAIVLFLVTWLVTYQNPSALHIIETVSGPLIAVILFILPMYAIHRIPAM
RKYRSPSNPFVLFIGLIALSALVYSLL

Sequences:

>Translated_427_residues
MTVLSTDVGQNAGTRLSRWNKNDTVWMFGLYATAVGAGTLFLPINAGLNGPLVLILMALLAYPLTYLPHRALCRLVLSGS
RRDGDITDVVEEHFGTLAGKGIMVLYLLAFFPIVLVYSISIANALESFLINQFHVAPPSRLWLSFGVVALLALILRTGRE
AIVAAMGVLVFPLILFLMGISLYLIPYWQPAHFFSGLGQTSLGDPALWRSLWLAVPVMVFSFSHAPIISSFASSQRQLYG
EQAERRCARIMRYSYIMICVSILFFVFSCVMSLSHADMLAAREQNITVLSSLANRFANPLIAYLGPVMAILAMSKSYLGT
SLGVTEGATSLIDGVFRSVGRSVSSQVTSRIAAIVLFLVTWLVTYQNPSALHIIETVSGPLIAVILFILPMYAIHRIPAM
RKYRSPSNPFVLFIGLIALSALVYSLL
>Mature_426_residues
TVLSTDVGQNAGTRLSRWNKNDTVWMFGLYATAVGAGTLFLPINAGLNGPLVLILMALLAYPLTYLPHRALCRLVLSGSR
RDGDITDVVEEHFGTLAGKGIMVLYLLAFFPIVLVYSISIANALESFLINQFHVAPPSRLWLSFGVVALLALILRTGREA
IVAAMGVLVFPLILFLMGISLYLIPYWQPAHFFSGLGQTSLGDPALWRSLWLAVPVMVFSFSHAPIISSFASSQRQLYGE
QAERRCARIMRYSYIMICVSILFFVFSCVMSLSHADMLAAREQNITVLSSLANRFANPLIAYLGPVMAILAMSKSYLGTS
LGVTEGATSLIDGVFRSVGRSVSSQVTSRIAAIVLFLVTWLVTYQNPSALHIIETVSGPLIAVILFILPMYAIHRIPAMR
KYRSPSNPFVLFIGLIALSALVYSLL

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=412, Percent_Identity=51.2135922330097, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1789211, Length=411, Percent_Identity=42.5790754257908, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1789504, Length=441, Percent_Identity=39.2290249433107, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1789961, Length=407, Percent_Identity=24.8157248157248, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693183, Length=431, Percent_Identity=22.969837587007, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46765; Mature: 46634

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLSTDVGQNAGTRLSRWNKNDTVWMFGLYATAVGAGTLFLPINAGLNGPLVLILMALL
CCEECCCCCCCCCCHHHCCCCCCCEEEHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
AYPLTYLPHRALCRLVLSGSRRDGDITDVVEEHFGTLAGKGIMVLYLLAFFPIVLVYSIS
HHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
IANALESFLINQFHVAPPSRLWLSFGVVALLALILRTGREAIVAAMGVLVFPLILFLMGI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
SLYLIPYWQPAHFFSGLGQTSLGDPALWRSLWLAVPVMVFSFSHAPIISSFASSQRQLYG
HHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EQAERRCARIMRYSYIMICVSILFFVFSCVMSLSHADMLAAREQNITVLSSLANRFANPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IAYLGPVMAILAMSKSYLGTSLGVTEGATSLIDGVFRSVGRSVSSQVTSRIAAIVLFLVT
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLVTYQNPSALHIIETVSGPLIAVILFILPMYAIHRIPAMRKYRSPSNPFVLFIGLIALS
HHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHH
ALVYSLL
HHHHHHC
>Mature Secondary Structure 
TVLSTDVGQNAGTRLSRWNKNDTVWMFGLYATAVGAGTLFLPINAGLNGPLVLILMALL
CEECCCCCCCCCCHHHCCCCCCCEEEHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
AYPLTYLPHRALCRLVLSGSRRDGDITDVVEEHFGTLAGKGIMVLYLLAFFPIVLVYSIS
HHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
IANALESFLINQFHVAPPSRLWLSFGVVALLALILRTGREAIVAAMGVLVFPLILFLMGI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
SLYLIPYWQPAHFFSGLGQTSLGDPALWRSLWLAVPVMVFSFSHAPIISSFASSQRQLYG
HHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EQAERRCARIMRYSYIMICVSILFFVFSCVMSLSHADMLAAREQNITVLSSLANRFANPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IAYLGPVMAILAMSKSYLGTSLGVTEGATSLIDGVFRSVGRSVSSQVTSRIAAIVLFLVT
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLVTYQNPSALHIIETVSGPLIAVILFILPMYAIHRIPAMRKYRSPSNPFVLFIGLIALS
HHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHH
ALVYSLL
HHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]