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The map label for this gene is manY [H]

Identifier: 238919621

GI number: 238919621

Start: 1675389

End: 1676189

Strand: Reverse

Name: manY [H]

Synonym: NT01EI_1720

Alternate gene names: 238919621

Gene position: 1676189-1675389 (Counterclockwise)

Preceding gene: 238919622

Following gene: 238919620

Centisome position: 43.97

GC content: 57.93

Gene sequence:

>801_bases
ATGGAGATTACCACTCTTCAGATTGTGCTGATATTTATCGTGGCATGTATTGCGGGGATGGGTTCTATCCTCGATGAGTT
TCAGTTCCACCGCCCGCTGGTCGCCTGTACCCTGATCGGTATCGTGCTCGGCGATATGAAGACCGGTATTATCATCGGGG
GTACCCTGGAGATGATCGCCCTGGGCTGGATGAACATCGGTGCCGCCGTCGCACCCGATGCCGCCCTGGCCTCCATCATC
TCAACCATCCTGGTCATCGCTGGCGGCCAGAGTATCGGCGCCGGTATCGCGCTGGCGATCCCGCTGGCTGCTGCCGGTCA
GGTATTGACCATCATCGTACGTACCATCACCGTGGGCTTCCAGCATGCCGCTGACGGTGCCGCTGAGCGCGGGGATCTGC
GCGCCATATCTTACCTGCACTGCTCCGCCCTGCTGCTACAGGCAATGCGCATCGCCATTCCGGCCGTTATCGTTGCCGTC
TCCGTCGGTACCGATGCCGTGCACTCCATGCTGAGCGCCATTCCTGAGGTCGTCACCACCGGTCTGGGTATCGCAGGCGG
AATGATCGTCGTTGTCGGTTACGCCATGGTCATCAACATGATGCGTGCCGGCTATCTGATGCCGTTCTTCTACCTGGGCT
TTGTCACCGCCGCGTTCACCAACTTCAACCTAGTTGCATTGGGTGTATTGGGTCTGGTTATGGCCATCCTGTATATCCAG
CTCAGCCCGAAATACAACAAGGCACAGGTGGTACAGTCCGCTGCCAACGGCAATAACGATCTCGACAACGAACTGGACTA
A

Upstream 100 bases:

>100_bases
ATCCGCGTCTGAAGATGATGGACCTTATCAGCAAGATGAACTGATATGCCGTAAGGCATTGATTTAAATAACTAAGATAT
TTGGTCAAAGGAGAAGTACA

Downstream 100 bases:

>100_bases
GAGAGAAGGTGAGAAAAATGGTTGATACGACTTCATCTGTAACCCCACATCAGGGTGAGAAGAGACTGACCGCTGGCGAT
ATTCGCGGTGTATTCCTGCG

Product: fructose permease iic component (p28)

Products: protein histidine; sugar phosphate; D-glucosamine-6-phosphate [Cytoplasm]; pyruvate; glucose-6-phosphate [Cytoplasm]; N-acetyl-D-glucosamine-6-phosphate [Cytoplasm]; mannose-6-phosphate [Cytoplasm]; fructose-6-phosphate [Cytoplasm] [C]

Alternate protein names: EII-P-Man; EIIC-Man; PTS system mannose-specific EIIC component [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MEITTLQIVLIFIVACIAGMGSILDEFQFHRPLVACTLIGIVLGDMKTGIIIGGTLEMIALGWMNIGAAVAPDAALASII
STILVIAGGQSIGAGIALAIPLAAAGQVLTIIVRTITVGFQHAADGAAERGDLRAISYLHCSALLLQAMRIAIPAVIVAV
SVGTDAVHSMLSAIPEVVTTGLGIAGGMIVVVGYAMVINMMRAGYLMPFFYLGFVTAAFTNFNLVALGVLGLVMAILYIQ
LSPKYNKAQVVQSAANGNNDLDNELD

Sequences:

>Translated_266_residues
MEITTLQIVLIFIVACIAGMGSILDEFQFHRPLVACTLIGIVLGDMKTGIIIGGTLEMIALGWMNIGAAVAPDAALASII
STILVIAGGQSIGAGIALAIPLAAAGQVLTIIVRTITVGFQHAADGAAERGDLRAISYLHCSALLLQAMRIAIPAVIVAV
SVGTDAVHSMLSAIPEVVTTGLGIAGGMIVVVGYAMVINMMRAGYLMPFFYLGFVTAAFTNFNLVALGVLGLVMAILYIQ
LSPKYNKAQVVQSAANGNNDLDNELD
>Mature_266_residues
MEITTLQIVLIFIVACIAGMGSILDEFQFHRPLVACTLIGIVLGDMKTGIIIGGTLEMIALGWMNIGAAVAPDAALASII
STILVIAGGQSIGAGIALAIPLAAAGQVLTIIVRTITVGFQHAADGAAERGDLRAISYLHCSALLLQAMRIAIPAVIVAV
SVGTDAVHSMLSAIPEVVTTGLGIAGGMIVVVGYAMVINMMRAGYLMPFFYLGFVTAAFTNFNLVALGVLGLVMAILYIQ
LSPKYNKAQVVQSAANGNNDLDNELD

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system i

COG id: COG3715

COG function: function code G; Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-4 domain [H]

Homologues:

Organism=Escherichia coli, GI1788121, Length=266, Percent_Identity=86.4661654135338, Blast_Score=413, Evalue=1e-117,
Organism=Escherichia coli, GI1789528, Length=262, Percent_Identity=26.7175572519084, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004700
- InterPro:   IPR018404 [H]

Pfam domain/function: PF03609 EII-Sor [H]

EC number: NA

Molecular weight: Translated: 27513; Mature: 27513

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS51106 PTS_EIIC_TYPE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N p -phosphohistidine; sugar; phosphoenolpyruvate; glucosamine [Periplasm]; phosphoenolpyruvate; beta-D-glucose [Periplasm]; N-acetyl-D-glucosamine [Periplasm]; mannose [Periplasm]; fructose [Periplasm] [C]

Specific reaction: protein N p -phosphohistidine + sugar = protein histidine + sugar phosphate phosphoenolpyruvate + glucosamine [Periplasm] = D-glucosamine-6-phosphate [Cytoplasm] + pyruvate phosphoenolpyruvate + beta-D-glucose [Periplasm] = glucose-6-phosphate [Cytoplasm]

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]