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The map label for this gene is rnd [H]

Identifier: 238919524

GI number: 238919524

Start: 1581702

End: 1582817

Strand: Direct

Name: rnd [H]

Synonym: NT01EI_1620

Alternate gene names: 238919524

Gene position: 1581702-1582817 (Clockwise)

Preceding gene: 238919523

Following gene: 238919528

Centisome position: 41.49

GC content: 59.95

Gene sequence:

>1116_bases
ATGCTAAAGTATCAGTTAATTACTTCCAGCAGCGCGCTGAAAGAGGTCTGTGAACGCGCCAGCGCCTGCCCTTATATCGC
GCTGGATACGGAGTTTGTCCGCACCCGTACCTATTATCCCCAGCTGGGGTTAGTGCAGCTGTATGACGGTGAGATGCTGT
CACTCATCGATCCGCTGACGATCTCCGACTGGCAACCGTTTGTCGATCTGCTGCGTAACCCACAGGTCGTCAAACTGTTG
CACGCCAGCAGCGAAGATCTGGAGGTCTTTCTGCATGACTTCCAGACTCTGCCTCAGCCGCTGATCGATACCCAGATCCT
GGCGGCCTTTAGCGGTCGTCCGCTTTCCAGCGGCTTTGCCGCCATGGTCAGCGCCTATCTGCAGGTCGATCTGGACAAGA
GCGAGTCGCGTACCGATTGGCTGGCCCGTCCGCTCAGCGAGCGCCAGTGTGACTATGCTGCGGCAGATGTCTATTACCTG
CTGCCGATGGCGCATAAGCTGCTGGCAGAGGTTGAGGCCTGCGGCTGGTTGCCGTCGGCACTCGATGAGTGTCAGGCTCT
GTGCCGCCGTCGCGCTGAAACAGCGGATCCTGCGCTGGTCTACCGGGAGATGACCAACGCCTGGCAGCTGCGTCCGCGTC
AGCTGGCCTGCCTGCAGCTGCTGGGTGAGTGGCGCCTGAATCAGGCCCGCGCCCGCGATATGGCGGTTAACTTTGTGGTG
CGTGAGGAGAGTCTGTGGCTGGTGGCACGCTATATGCCGGGATCGATGGCCGAGCTGAGTGAAATCGGTGTCAGCGGACC
AGAGATCCGTTATCACGGTAAGGCGCTGCTGGAGATCGTCGGACGCAGCGCTGCGCTGGAAGAGGCACAGCTACCGCCCA
CCGTTGGGCGTTTGATCGACCACCCGGGCTATAAACAGGCGTTTAAGTATATTAAGACGCTGGTGCAGCAGGTAGCGGAG
CAGCAGGGGCTGACGGCGGAGCTGTTGGCGTCTCGGCGCCAGATTAATCAGCTGTTGAGTGTGCACTGGCAGCTGAAGGC
GGAGCAGCCGGATCTGCTGAGCGGCTGGCGTGGTCAGCTGCTGGCCGATGGGCTGAATGACATGCTGAAAAAATAG

Upstream 100 bases:

>100_bases
GTGCGCCGGCGCGGCCGTCGGCGCACTGTTTTTTTGGGGCGGAATGAAATGATACCGCCCGTTCACGTTCTGCCGCGGCA
GGCGTTTTGATGAGATTATA

Downstream 100 bases:

>100_bases
CGTACACAGACGCTAAATAATAAAGACAGCCTTAGCGCTGCCTTTATTGTATTGGTGAGCTGAATTGTAGAATAAACCAA
AATTTATTCACTTTATCGGG

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MLKYQLITSSSALKEVCERASACPYIALDTEFVRTRTYYPQLGLVQLYDGEMLSLIDPLTISDWQPFVDLLRNPQVVKLL
HASSEDLEVFLHDFQTLPQPLIDTQILAAFSGRPLSSGFAAMVSAYLQVDLDKSESRTDWLARPLSERQCDYAAADVYYL
LPMAHKLLAEVEACGWLPSALDECQALCRRRAETADPALVYREMTNAWQLRPRQLACLQLLGEWRLNQARARDMAVNFVV
REESLWLVARYMPGSMAELSEIGVSGPEIRYHGKALLEIVGRSAALEEAQLPPTVGRLIDHPGYKQAFKYIKTLVQQVAE
QQGLTAELLASRRQINQLLSVHWQLKAEQPDLLSGWRGQLLADGLNDMLKK

Sequences:

>Translated_371_residues
MLKYQLITSSSALKEVCERASACPYIALDTEFVRTRTYYPQLGLVQLYDGEMLSLIDPLTISDWQPFVDLLRNPQVVKLL
HASSEDLEVFLHDFQTLPQPLIDTQILAAFSGRPLSSGFAAMVSAYLQVDLDKSESRTDWLARPLSERQCDYAAADVYYL
LPMAHKLLAEVEACGWLPSALDECQALCRRRAETADPALVYREMTNAWQLRPRQLACLQLLGEWRLNQARARDMAVNFVV
REESLWLVARYMPGSMAELSEIGVSGPEIRYHGKALLEIVGRSAALEEAQLPPTVGRLIDHPGYKQAFKYIKTLVQQVAE
QQGLTAELLASRRQINQLLSVHWQLKAEQPDLLSGWRGQLLADGLNDMLKK
>Mature_371_residues
MLKYQLITSSSALKEVCERASACPYIALDTEFVRTRTYYPQLGLVQLYDGEMLSLIDPLTISDWQPFVDLLRNPQVVKLL
HASSEDLEVFLHDFQTLPQPLIDTQILAAFSGRPLSSGFAAMVSAYLQVDLDKSESRTDWLARPLSERQCDYAAADVYYL
LPMAHKLLAEVEACGWLPSALDECQALCRRRAETADPALVYREMTNAWQLRPRQLACLQLLGEWRLNQARARDMAVNFVV
REESLWLVARYMPGSMAELSEIGVSGPEIRYHGKALLEIVGRSAALEEAQLPPTVGRLIDHPGYKQAFKYIKTLVQQVAE
QQGLTAELLASRRQINQLLSVHWQLKAEQPDLLSGWRGQLLADGLNDMLKK

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=263, Percent_Identity=27.7566539923954, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI50301240, Length=263, Percent_Identity=27.7566539923954, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788105, Length=372, Percent_Identity=63.1720430107527, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17531757, Length=258, Percent_Identity=25.968992248062, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=278, Percent_Identity=24.4604316546763, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI161078302, Length=264, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 41891; Mature: 41891

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKYQLITSSSALKEVCERASACPYIALDTEFVRTRTYYPQLGLVQLYDGEMLSLIDPLT
CCEEEEECCCHHHHHHHHHHCCCCEEEECHHHHHHHCCCCCCCEEEEECCCHHHHHCCCC
ISDWQPFVDLLRNPQVVKLLHASSEDLEVFLHDFQTLPQPLIDTQILAAFSGRPLSSGFA
CCCCHHHHHHHCCCCEEEHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHH
AMVSAYLQVDLDKSESRTDWLARPLSERQCDYAAADVYYLLPMAHKLLAEVEACGWLPSA
HHHHHHHHHCCCCCCCHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LDECQALCRRRAETADPALVYREMTNAWQLRPRQLACLQLLGEWRLNQARARDMAVNFVV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
REESLWLVARYMPGSMAELSEIGVSGPEIRYHGKALLEIVGRSAALEEAQLPPTVGRLID
ECCCEEEEEECCCCCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHC
HPGYKQAFKYIKTLVQQVAEQQGLTAELLASRRQINQLLSVHWQLKAEQPDLLSGWRGQL
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHCHHHHH
LADGLNDMLKK
HHHHHHHHHCC
>Mature Secondary Structure
MLKYQLITSSSALKEVCERASACPYIALDTEFVRTRTYYPQLGLVQLYDGEMLSLIDPLT
CCEEEEECCCHHHHHHHHHHCCCCEEEECHHHHHHHCCCCCCCEEEEECCCHHHHHCCCC
ISDWQPFVDLLRNPQVVKLLHASSEDLEVFLHDFQTLPQPLIDTQILAAFSGRPLSSGFA
CCCCHHHHHHHCCCCEEEHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHH
AMVSAYLQVDLDKSESRTDWLARPLSERQCDYAAADVYYLLPMAHKLLAEVEACGWLPSA
HHHHHHHHHCCCCCCCHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LDECQALCRRRAETADPALVYREMTNAWQLRPRQLACLQLLGEWRLNQARARDMAVNFVV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
REESLWLVARYMPGSMAELSEIGVSGPEIRYHGKALLEIVGRSAALEEAQLPPTVGRLID
ECCCEEEEEECCCCCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHC
HPGYKQAFKYIKTLVQQVAEQQGLTAELLASRRQINQLLSVHWQLKAEQPDLLSGWRGQL
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHCHHHHH
LADGLNDMLKK
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]