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The map label for this gene is cya [H]

Identifier: 238919418

GI number: 238919418

Start: 1479781

End: 1480974

Strand: Reverse

Name: cya [H]

Synonym: NT01EI_1512

Alternate gene names: 238919418

Gene position: 1480974-1479781 (Counterclockwise)

Preceding gene: 238919419

Following gene: 238919415

Centisome position: 38.85

GC content: 35.51

Gene sequence:

>1194_bases
ATGAAAATCGGATATGACCTTTCAGTAGTACTTCCTTGTCAGTACAGTAAGGAATTCGCAAAAAATAATGATCGGATTAG
TTGCGATGACGAGATGCAAATATTAATAAATTCCATTAAGGATAATACAGGGATAGCACATGAACATTTATTACCACTTC
AACGTCTAGCTAATGAAATAAATTGCATTATATCTTTCCGCCCCGTAGATAATTTGGCAACTGAGTTAATCGAATCAGGA
TATCCAACTAAAGGGTTTCATATTAAAGGGAAAAGTGCATCTTGGGGGCCTCAAACAGGATTTATCTGTGAGGAACAACG
CTTTAGTAAGCTGGAAGATGCACCTGTTGAATGTATAGACAATTTCAATCAACAAGTAAAACAATGTATAAGTGAAAGAC
ATGCTTTTTCTGTGGATTTGACGATAAACAAAAAACGGCTTAATACATTATTTGAAAAAGGGGTTATTGATGATATTTCT
GTTGAAAACACTAATGGAGTCCGTACTTTTAAAGCTCAAGGACCCAGCGGCAAATATTACTTTTTTGAAGCAAGAAAAAT
ATTAGACTCTAATGAGGAAGATTATCTTATATTAAATGAGAATAAACCGATTAGAGTCTTAGCACCGGAAATGAGTTCTA
AGGCATTCACTGCTGACTACGACCTGTTTATAGCTTCTCCACATATCAGTGATTTTGGCTCACAAGATAACTTACTTATT
CCTGATGTTGCACATAAAGTATTTCAGCATCGAGTGAACTCGTATCATAAAGAACTAACAACTAATCATGAGCTAATGCA
AGACTATTCTAACGCCGATAGTTTCTATAAGAACGAAGATCCTGATATTGGTAATGCATCAGCACGTGTCCGAATATTGA
TAGATTTAATTAATGCAACATTGGTCGGAGACGGTGAGAGGCTTGTGCATCATAGTATGGATTGTATCAACCCTGCCACG
GATTTGTCACTTAGTTATCCCGCAACCTTTGCATTGCCGATAAAAATAGGCCGATTTGATAAATTGTGCATTATTAACAA
CAATGATGAATTAAAAGAACTAATAAACGATGCCAGGAGTTCAGGATACTATATTAAAATAAATCCACTATGGGAAAAGG
AACTGGGTAAAATAGATTCTCAGAGATTTAAGGATGCGAAGGTTAAATTAGATCCGTTAACAAAACCGAGTTGA

Upstream 100 bases:

>100_bases
TCTGAAAATTACGAGGCCATGCTGCATTTTACCTGTGGTCTTATTGTCTGGAATAAAGTCCTATTGAAATAGGCTCTAAA
TCTATTTATGAGTGTTCGAC

Downstream 100 bases:

>100_bases
TTCGAATAACATCAATCCCCACATAGCAGGCATGACACGAAAAATCATCAGTAAGGACCCTGTACACGATTCTGTGTAAA
TGCCTTTTCTCAGAAGTGAC

Product: hypothetical protein

Products: NA

Alternate protein names: ATP pyrophosphate-lyase; Adenylyl cyclase; Anthrax edema toxin adenylate cyclase component; Edema factor; EF [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKIGYDLSVVLPCQYSKEFAKNNDRISCDDEMQILINSIKDNTGIAHEHLLPLQRLANEINCIISFRPVDNLATELIESG
YPTKGFHIKGKSASWGPQTGFICEEQRFSKLEDAPVECIDNFNQQVKQCISERHAFSVDLTINKKRLNTLFEKGVIDDIS
VENTNGVRTFKAQGPSGKYYFFEARKILDSNEEDYLILNENKPIRVLAPEMSSKAFTADYDLFIASPHISDFGSQDNLLI
PDVAHKVFQHRVNSYHKELTTNHELMQDYSNADSFYKNEDPDIGNASARVRILIDLINATLVGDGERLVHHSMDCINPAT
DLSLSYPATFALPIKIGRFDKLCIINNNDELKELINDARSSGYYIKINPLWEKELGKIDSQRFKDAKVKLDPLTKPS

Sequences:

>Translated_397_residues
MKIGYDLSVVLPCQYSKEFAKNNDRISCDDEMQILINSIKDNTGIAHEHLLPLQRLANEINCIISFRPVDNLATELIESG
YPTKGFHIKGKSASWGPQTGFICEEQRFSKLEDAPVECIDNFNQQVKQCISERHAFSVDLTINKKRLNTLFEKGVIDDIS
VENTNGVRTFKAQGPSGKYYFFEARKILDSNEEDYLILNENKPIRVLAPEMSSKAFTADYDLFIASPHISDFGSQDNLLI
PDVAHKVFQHRVNSYHKELTTNHELMQDYSNADSFYKNEDPDIGNASARVRILIDLINATLVGDGERLVHHSMDCINPAT
DLSLSYPATFALPIKIGRFDKLCIINNNDELKELINDARSSGYYIKINPLWEKELGKIDSQRFKDAKVKLDPLTKPS
>Mature_397_residues
MKIGYDLSVVLPCQYSKEFAKNNDRISCDDEMQILINSIKDNTGIAHEHLLPLQRLANEINCIISFRPVDNLATELIESG
YPTKGFHIKGKSASWGPQTGFICEEQRFSKLEDAPVECIDNFNQQVKQCISERHAFSVDLTINKKRLNTLFEKGVIDDIS
VENTNGVRTFKAQGPSGKYYFFEARKILDSNEEDYLILNENKPIRVLAPEMSSKAFTADYDLFIASPHISDFGSQDNLLI
PDVAHKVFQHRVNSYHKELTTNHELMQDYSNADSFYKNEDPDIGNASARVRILIDLINATLVGDGERLVHHSMDCINPAT
DLSLSYPATFALPIKIGRFDKLCIINNNDELKELINDARSSGYYIKINPLWEKELGKIDSQRFKDAKVKLDPLTKPS

Specific function: One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. EF is a calmodulin-dependent adenylyl cyclase that, when associated with PA, causes edema. EF is not toxic by itself and it is

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylyl cyclase class-2 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR003541
- InterPro:   IPR014781 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF07737 ATLF [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 45028; Mature: 45028

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGYDLSVVLPCQYSKEFAKNNDRISCDDEMQILINSIKDNTGIAHEHLLPLQRLANEI
CCCCCCEEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHE
NCIISFRPVDNLATELIESGYPTKGFHIKGKSASWGPQTGFICEEQRFSKLEDAPVECID
EEEEEECCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCEECHHHHHHCCCCHHHHHH
NFNQQVKQCISERHAFSVDLTINKKRLNTLFEKGVIDDISVENTNGVRTFKAQGPSGKYY
HHHHHHHHHHHHCCEEEEEEEECHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEE
FFEARKILDSNEEDYLILNENKPIRVLAPEMSSKAFTADYDLFIASPHISDFGSQDNLLI
EEEEHHHHCCCCCCEEEECCCCCEEEECCCCCCCEEECCCEEEEECCCCCCCCCCCCEEC
PDVAHKVFQHRVNSYHKELTTNHELMQDYSNADSFYKNEDPDIGNASARVRILIDLINAT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHCCCCCCCCCCCCCCEEEEEEEEHHHH
LVGDGERLVHHSMDCINPATDLSLSYPATFALPIKIGRFDKLCIINNNDELKELINDARS
EECCCHHHHHHHHHHCCCCCCCEECCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHC
SGYYIKINPLWEKELGKIDSQRFKDAKVKLDPLTKPS
CCEEEEECCCCHHHHCCHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure
MKIGYDLSVVLPCQYSKEFAKNNDRISCDDEMQILINSIKDNTGIAHEHLLPLQRLANEI
CCCCCCEEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHE
NCIISFRPVDNLATELIESGYPTKGFHIKGKSASWGPQTGFICEEQRFSKLEDAPVECID
EEEEEECCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCEECHHHHHHCCCCHHHHHH
NFNQQVKQCISERHAFSVDLTINKKRLNTLFEKGVIDDISVENTNGVRTFKAQGPSGKYY
HHHHHHHHHHHHCCEEEEEEEECHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEE
FFEARKILDSNEEDYLILNENKPIRVLAPEMSSKAFTADYDLFIASPHISDFGSQDNLLI
EEEEHHHHCCCCCCEEEECCCCCEEEECCCCCCCEEECCCEEEEECCCCCCCCCCCCEEC
PDVAHKVFQHRVNSYHKELTTNHELMQDYSNADSFYKNEDPDIGNASARVRILIDLINAT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHCCCCCCCCCCCCCCEEEEEEEEHHHH
LVGDGERLVHHSMDCINPATDLSLSYPATFALPIKIGRFDKLCIINNNDELKELINDARS
EECCCHHHHHHHHHHCCCCCCCEECCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHC
SGYYIKINPLWEKELGKIDSQRFKDAKVKLDPLTKPS
CCEEEEECCCCHHHHCCHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2906312; 3149607; 2834337; 10515943; 12004073; 12067380; 9398214; 11207582; 2114169; 11737637; 2108958; 1900429; 11553601; 10926933; 11807546; 8418825; 11544370 [H]