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The map label for this gene is gnd [H]

Identifier: 238919237

GI number: 238919237

Start: 1312030

End: 1313445

Strand: Direct

Name: gnd [H]

Synonym: NT01EI_1320

Alternate gene names: 238919237

Gene position: 1312030-1313445 (Clockwise)

Preceding gene: 238919236

Following gene: 238919238

Centisome position: 34.42

GC content: 60.66

Gene sequence:

>1416_bases
ATGTCCAAGCAACAGATCGGTGTAGTGGGAATGGCGGTGATGGGGCGTAACCTGGCACTGAATATCGAAAGCCGTGGTTA
TAGCGTCTCTATCTTCAATCGCTCACCTGAGAAAACCGATGAGGTGATGGCGCAAAACCCGGGGCGGAAGCTGGTGCCAT
ACCATTCTGTGCAGGCGTTCGTGGCCTCGCTGGAGACACCGCGCCGCATTCTGCTGATGGTGAAGGCGGGTGAGGGGACA
GACAAGACCATCGCCTCTCTGACGCCCTATCTGGAGCCGGGAGACATCCTGATCGATGGTGGGAATACCTTCTTCCAGGA
TACCATCCGCCGCAACCGTGAGCTGTCGGCACAGGGCTTTAACTTTATCGGCACCGGGGTCTCCGGTGGTGAGGAGGGGG
CGCTGAAGGGGCCATCCATTATGCCCGGCGGGCAAAAGGCGGCCTATGAGCTGGTCGCGCCGATCCTGACGAAGATTGCC
GCCGTTGCCGAAGATGGTGAGGCCTGCGTGACCTATATCGGGCCGGACGGTGCCGGTCACTATGTGAAGATGGTACACAA
CGGTATCGAATACGGTGACATGCAGCTGATCGCCGAGGCCTACTCCCTGCTGAAGCATGCCGCCGGGATGCGCAACGACG
AGCTGGCTGCCACCTTTGCCGAATGGAATCGCGGCGAGCTGAGCAGCTACCTGATCGAGATCACCGCCGATATCTTCGCC
AAGAAAGATGACGAAGGGAATGATCTGGTCGACGTGATCCTGGACGAGGCGGCCAATAAAGGCACCGGCAAGTGGACCAG
CCAGAGCGCGCTGGATCTGGGGATCCCGCTGACGCTGATCACCGAATCCGTCTTTGCCCGCTATCTCTCCTCGCTGAAAG
CGCAGCGCGTGGCGGCCTCCCGGGTGCTGAGCGGCCCGCAGGCGCAGACGCTGCCGGCGGCAGAGCGCGCTGCTTTTGCC
GATAAGGTGCGCCGTGCCCTGTATCTGGGCAAGATTGTCTCCTATGCCCAGGGCTTCCAGCAGCTGAAGGCCGCCTCTGA
TGAATATGACTGGTCGCTGAACTTTGGCGAGATCGCCCGCATCTTCCGCGCCGGGTGCATTATCCGCGCCCAGTTCCTAC
AGAAGATCACCGATGCCTATGCCGAAAATCCGGCGCTGGCCAACCTGCTGCTGGCACCGTACTTTAAGGCCATCGCGGAT
GAGTATCAGCAGGCGCTGCGCGATGTGGTCTCCTACGCCGTACAGCAGGGGATCCCGGTACCGACCCTCTCTGCAGCGAT
TACCTATTACGACAGCTACCGCGCCGCGGTGCTGCCGGCCAACCTGATTCAGGCTCAGCGCGACTACTTTGGCGCCCACA
CCTACAAACGCACCGATCGGGAAGGGGTGTTCCATACCGAATGGCTGGCGGAGTAA

Upstream 100 bases:

>100_bases
CAGCAATCGATATCCCTGAAGTGCAAAGATGAGTTAACATATTACCCACAATTATGCTGTGCAGTGGGCACAGCCGGTAT
GTGTTACACAGGAGTTTGTC

Downstream 100 bases:

>100_bases
GCCAGCGGTCATACGTGAGTGACGTAATGATGCCAATCCGGGCCTGTGCCCGGATTTTTACTTTGTGGGGGAATTACCAA
GTAACGCCGCATCTTGTTGC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSPEKTDEVMAQNPGRKLVPYHSVQAFVASLETPRRILLMVKAGEGT
DKTIASLTPYLEPGDILIDGGNTFFQDTIRRNRELSAQGFNFIGTGVSGGEEGALKGPSIMPGGQKAAYELVAPILTKIA
AVAEDGEACVTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKHAAGMRNDELAATFAEWNRGELSSYLIEITADIFA
KKDDEGNDLVDVILDEAANKGTGKWTSQSALDLGIPLTLITESVFARYLSSLKAQRVAASRVLSGPQAQTLPAAERAAFA
DKVRRALYLGKIVSYAQGFQQLKAASDEYDWSLNFGEIARIFRAGCIIRAQFLQKITDAYAENPALANLLLAPYFKAIAD
EYQQALRDVVSYAVQQGIPVPTLSAAITYYDSYRAAVLPANLIQAQRDYFGAHTYKRTDREGVFHTEWLAE

Sequences:

>Translated_471_residues
MSKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSPEKTDEVMAQNPGRKLVPYHSVQAFVASLETPRRILLMVKAGEGT
DKTIASLTPYLEPGDILIDGGNTFFQDTIRRNRELSAQGFNFIGTGVSGGEEGALKGPSIMPGGQKAAYELVAPILTKIA
AVAEDGEACVTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKHAAGMRNDELAATFAEWNRGELSSYLIEITADIFA
KKDDEGNDLVDVILDEAANKGTGKWTSQSALDLGIPLTLITESVFARYLSSLKAQRVAASRVLSGPQAQTLPAAERAAFA
DKVRRALYLGKIVSYAQGFQQLKAASDEYDWSLNFGEIARIFRAGCIIRAQFLQKITDAYAENPALANLLLAPYFKAIAD
EYQQALRDVVSYAVQQGIPVPTLSAAITYYDSYRAAVLPANLIQAQRDYFGAHTYKRTDREGVFHTEWLAE
>Mature_470_residues
SKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSPEKTDEVMAQNPGRKLVPYHSVQAFVASLETPRRILLMVKAGEGTD
KTIASLTPYLEPGDILIDGGNTFFQDTIRRNRELSAQGFNFIGTGVSGGEEGALKGPSIMPGGQKAAYELVAPILTKIAA
VAEDGEACVTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKHAAGMRNDELAATFAEWNRGELSSYLIEITADIFAK
KDDEGNDLVDVILDEAANKGTGKWTSQSALDLGIPLTLITESVFARYLSSLKAQRVAASRVLSGPQAQTLPAAERAAFAD
KVRRALYLGKIVSYAQGFQQLKAASDEYDWSLNFGEIARIFRAGCIIRAQFLQKITDAYAENPALANLLLAPYFKAIADE
YQQALRDVVSYAVQQGIPVPTLSAAITYYDSYRAAVLPANLIQAQRDYFGAHTYKRTDREGVFHTEWLAE

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=51.9148936170213, Blast_Score=479, Evalue=1e-135,
Organism=Escherichia coli, GI1788341, Length=469, Percent_Identity=85.0746268656716, Blast_Score=826, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=49.2569002123142, Blast_Score=476, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6321695, Length=459, Percent_Identity=48.80174291939, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=49.5575221238938, Blast_Score=442, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24639279, Length=471, Percent_Identity=51.380042462845, Blast_Score=455, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51333; Mature: 51202

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSPEKTDEVMAQNPGRKLVPYHSVQAF
CCCCHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHH
VASLETPRRILLMVKAGEGTDKTIASLTPYLEPGDILIDGGNTFFQDTIRRNRELSAQGF
HHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCC
NFIGTGVSGGEEGALKGPSIMPGGQKAAYELVAPILTKIAAVAEDGEACVTYIGPDGAGH
CEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCH
YVKMVHNGIEYGDMQLIAEAYSLLKHAAGMRNDELAATFAEWNRGELSSYLIEITADIFA
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
KKDDEGNDLVDVILDEAANKGTGKWTSQSALDLGIPLTLITESVFARYLSSLKAQRVAAS
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RVLSGPQAQTLPAAERAAFADKVRRALYLGKIVSYAQGFQQLKAASDEYDWSLNFGEIAR
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
IFRAGCIIRAQFLQKITDAYAENPALANLLLAPYFKAIADEYQQALRDVVSYAVQQGIPV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTLSAAITYYDSYRAAVLPANLIQAQRDYFGAHTYKRTDREGVFHTEWLAE
CHHHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCC
>Mature Secondary Structure 
SKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSPEKTDEVMAQNPGRKLVPYHSVQAF
CCCHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHH
VASLETPRRILLMVKAGEGTDKTIASLTPYLEPGDILIDGGNTFFQDTIRRNRELSAQGF
HHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCC
NFIGTGVSGGEEGALKGPSIMPGGQKAAYELVAPILTKIAAVAEDGEACVTYIGPDGAGH
CEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCH
YVKMVHNGIEYGDMQLIAEAYSLLKHAAGMRNDELAATFAEWNRGELSSYLIEITADIFA
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
KKDDEGNDLVDVILDEAANKGTGKWTSQSALDLGIPLTLITESVFARYLSSLKAQRVAAS
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RVLSGPQAQTLPAAERAAFADKVRRALYLGKIVSYAQGFQQLKAASDEYDWSLNFGEIAR
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
IFRAGCIIRAQFLQKITDAYAENPALANLLLAPYFKAIADEYQQALRDVVSYAVQQGIPV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTLSAAITYYDSYRAAVLPANLIQAQRDYFGAHTYKRTDREGVFHTEWLAE
CHHHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042 [H]