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The map label for this gene is galE [H]

Identifier: 238919228

GI number: 238919228

Start: 1302127

End: 1303131

Strand: Direct

Name: galE [H]

Synonym: NT01EI_1311

Alternate gene names: 238919228

Gene position: 1302127-1303131 (Clockwise)

Preceding gene: 238919227

Following gene: 238919229

Centisome position: 34.16

GC content: 58.41

Gene sequence:

>1005_bases
GTGACCGGCGGCGCCGGCTATATCGGTTCTCATACGGTGCTGGCGCTGCTGTCCCGTGGGGATGAGGTGGTAGTGCTGGA
TAACTTTGTCAACGCCTCTGTGCAGGCGCTGGCCCGGGTGGAGCAGATTTGTGACCGCCAACCCCACCTATACCGCGGTG
ATGTGCGCGATCGGGCGCTGCTGCAGCAGATTTTTGCACAGCACGTCATTAGCGATGTGATTCACTTCGCCGGTCTAAAG
GCCGTGGGTGAGTCGGTGGAAAAACCGCTTGAGTACTACGACAACAATGTCAGCGGTACGCTGGTGTTGCTGGAAGAGAT
GCGCCGCGCCGGCGTGCAGGGCTTTATCTTTAGCTCCTCGGCGACGGTGTATGGCGATCCGGAGTCAGTGCCGTTGACGG
AAAGCAGCCGTACCGGCGGGACGACCAACCCCTATGGCACCTCCAAGCTGATGGTCGAGCAGATCCTGCAGGATGTATCC
CGCGCTAGACCTGAGATGCGGATTACCGCGCTGCGCTACTTTAATCCGGTGGGAGCTCATCCATCGGGGCTTATCGGTGA
AGATCCCAACGGGATACCCAATAATCTGATCCCTTATGTTGCTCAGGTGGCGGTGGGAAAACTGGCCTGCCTGTCCATCT
TTGGCCATGATTATCCCACACAGGACGGCACCGGGGTACGCGACTATATTCACGTGATGGATCTGGCCACCGGCCACCTT
GCCGCACTCGATCGTCGCGATGAGGGGGCCAGCTATAAAGTGTATAACCTGGGGACGGGCGTCGGGTATTCTGTTTTGGA
TATCGTTGCCGCATTTGAGAGGTGCTCCGGGGTTACTATACCTTATCGCTTTGCACCGCGCCGCGCGGGTGATATCGCCG
AGTGTTGGTCCAATCCCGCCTTGGCGGCGCAAGAGTTGGGTTGGTGTGCGCAGTATGGTCTGGAGGCGATGATGACCGAT
ACCTGGCGCTGGCAGCAGAACAACCCGAATGGATACCAGGATTAA

Upstream 100 bases:

>100_bases
TGGGTTAAATCACTCTCAGCAGGGAGCGGCCTTTACCGCCTGGCTGCAGGATGTGCAGACGCGAATTGAATGATTCAGGG
TATTTAGCATGGCAATTTTA

Downstream 100 bases:

>100_bases
TTTTATTAACACAAAGGTATGTGATGAAGATAGCGATTAGCGGTACGGGCTACGTCGGCCTGTCCAATGGAATTTTGCTG
GCTCAGCATCATGAGGTGGT

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTGGAGYIGSHTVLALLSRGDEVVVLDNFVNASVQALARVEQICDRQPHLYRGDVRDRALLQQIFAQHVISDVIHFAGLK
AVGESVEKPLEYYDNNVSGTLVLLEEMRRAGVQGFIFSSSATVYGDPESVPLTESSRTGGTTNPYGTSKLMVEQILQDVS
RARPEMRITALRYFNPVGAHPSGLIGEDPNGIPNNLIPYVAQVAVGKLACLSIFGHDYPTQDGTGVRDYIHVMDLATGHL
AALDRRDEGASYKVYNLGTGVGYSVLDIVAAFERCSGVTIPYRFAPRRAGDIAECWSNPALAAQELGWCAQYGLEAMMTD
TWRWQQNNPNGYQD

Sequences:

>Translated_334_residues
MTGGAGYIGSHTVLALLSRGDEVVVLDNFVNASVQALARVEQICDRQPHLYRGDVRDRALLQQIFAQHVISDVIHFAGLK
AVGESVEKPLEYYDNNVSGTLVLLEEMRRAGVQGFIFSSSATVYGDPESVPLTESSRTGGTTNPYGTSKLMVEQILQDVS
RARPEMRITALRYFNPVGAHPSGLIGEDPNGIPNNLIPYVAQVAVGKLACLSIFGHDYPTQDGTGVRDYIHVMDLATGHL
AALDRRDEGASYKVYNLGTGVGYSVLDIVAAFERCSGVTIPYRFAPRRAGDIAECWSNPALAAQELGWCAQYGLEAMMTD
TWRWQQNNPNGYQD
>Mature_333_residues
TGGAGYIGSHTVLALLSRGDEVVVLDNFVNASVQALARVEQICDRQPHLYRGDVRDRALLQQIFAQHVISDVIHFAGLKA
VGESVEKPLEYYDNNVSGTLVLLEEMRRAGVQGFIFSSSATVYGDPESVPLTESSRTGGTTNPYGTSKLMVEQILQDVSR
ARPEMRITALRYFNPVGAHPSGLIGEDPNGIPNNLIPYVAQVAVGKLACLSIFGHDYPTQDGTGVRDYIHVMDLATGHLA
ALDRRDEGASYKVYNLGTGVGYSVLDIVAAFERCSGVTIPYRFAPRRAGDIAECWSNPALAAQELGWCAQYGLEAMMTDT
WRWQQNNPNGYQD

Specific function: By controlling the internal galactose concentration, it may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae [H]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=338, Percent_Identity=55.0295857988166, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI56118217, Length=338, Percent_Identity=55.0295857988166, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI189083684, Length=338, Percent_Identity=55.0295857988166, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI7657641, Length=270, Percent_Identity=26.2962962962963, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1786974, Length=334, Percent_Identity=56.8862275449102, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI48994969, Length=359, Percent_Identity=26.7409470752089, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788353, Length=360, Percent_Identity=25.2777777777778, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71982035, Length=341, Percent_Identity=52.4926686217009, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71982038, Length=343, Percent_Identity=52.1865889212828, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17568069, Length=272, Percent_Identity=26.1029411764706, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=49.2711370262391, Blast_Score=332, Evalue=4e-92,
Organism=Drosophila melanogaster, GI19923002, Length=342, Percent_Identity=53.5087719298246, Blast_Score=382, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36461; Mature: 36330

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGAGYIGSHTVLALLSRGDEVVVLDNFVNASVQALARVEQICDRQPHLYRGDVRDRAL
CCCCCCCCHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LQQIFAQHVISDVIHFAGLKAVGESVEKPLEYYDNNVSGTLVLLEEMRRAGVQGFIFSSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECC
ATVYGDPESVPLTESSRTGGTTNPYGTSKLMVEQILQDVSRARPEMRITALRYFNPVGAH
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCC
PSGLIGEDPNGIPNNLIPYVAQVAVGKLACLSIFGHDYPTQDGTGVRDYIHVMDLATGHL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHH
AALDRRDEGASYKVYNLGTGVGYSVLDIVAAFERCSGVTIPYRFAPRRAGDIAECWSNPA
HHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHCCCC
LAAQELGWCAQYGLEAMMTDTWRWQQNNPNGYQD
HHHHHHHHHHHHCHHHHHHCCEEEECCCCCCCCC
>Mature Secondary Structure 
TGGAGYIGSHTVLALLSRGDEVVVLDNFVNASVQALARVEQICDRQPHLYRGDVRDRAL
CCCCCCCHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LQQIFAQHVISDVIHFAGLKAVGESVEKPLEYYDNNVSGTLVLLEEMRRAGVQGFIFSSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECC
ATVYGDPESVPLTESSRTGGTTNPYGTSKLMVEQILQDVSRARPEMRITALRYFNPVGAH
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCC
PSGLIGEDPNGIPNNLIPYVAQVAVGKLACLSIFGHDYPTQDGTGVRDYIHVMDLATGHL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHH
AALDRRDEGASYKVYNLGTGVGYSVLDIVAAFERCSGVTIPYRFAPRRAGDIAECWSNPA
HHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHCCCC
LAAQELGWCAQYGLEAMMTDTWRWQQNNPNGYQD
HHHHHHHHHHHHCHHHHHHCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1956282; 7542800 [H]