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The map label for this gene is purC

Identifier: 238919131

GI number: 238919131

Start: 1195415

End: 1196128

Strand: Direct

Name: purC

Synonym: NT01EI_1202

Alternate gene names: 238919131

Gene position: 1195415-1196128 (Clockwise)

Preceding gene: 238919130

Following gene: 238919132

Centisome position: 31.36

GC content: 57.56

Gene sequence:

>714_bases
ATGCAAAAGCTCGCTGAGTTGTACCGCGGCAAGGCTAAAACAGTCTATACCACGGAGGATCCGGATCTGCTGATTCTGTC
GTTCCGCAACGATACGTCAGCCCTGGATGGCCAGCGCATTGAGCAGTTTGATCGCAAAGGTATGGTGAACAACAAGTTTA
ATCACTTCATCATGAGCAAGCTGGAGGCGGCCGGGATCCCGACGCAGATGGAGCGCCTGCTGTCCGATACCGATGCGCTG
GTGAAGAAGCTGGAGATGGTGCCGGTGGAGTGCGTGATCCGTAACCGCGCTGCTGGTTCGCTGGTGAAGCGTCTGGGCAT
TGAAGAGGGCATGCCGCTGAATCCGCCGCTGTTCGACCTGTTCCTGAAGAACGACGCCATGCACGATCCGATGGTCAATG
AATCCTACTGCCGTACCTTTGGCTGGGTCAGTGACGAGCATCTGGCGCAGATGAAGGCGCTGAGCTACCGCGCCAACGAG
GTGCTCAGCCAGCTGTTTGACGACGCCGGGCTGATCCTGGTGGACTTTAAGCTGGAGTTCGGTCTGTATAAGGGCCAAGT
CGTTCTGGGCGATGAGTTTTCGCCGGACGGCAGTCGCCTGTGGGATAAGACGACGCTGGCGAAGATGGATAAGGATCGTT
TCCGCCAGAATCTGGGCGGACTGATTGAGGCTTATGAAGAGGTGGCGCTCCGTCTGGGCGTGCCGCTCGACTGA

Upstream 100 bases:

>100_bases
TTTCTCTACGCAACCGTTTGGCTGGCCTATAATGGCCCGCATCCTGCGGCGCTGTCGCGCCCGAACGTTTCGGTTTGTTC
TTAACCTATGGAGTATACAA

Downstream 100 bases:

>100_bases
GCTGCGATGCGGGGAGCCGTGAAGCAACGGGGGTGATCGGCCCCCGTTGGCGTTATGGCGCCAGCCCGGCCATGACACTC
GTCTGTCCGCTGCCGGTGTC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MQKLAELYRGKAKTVYTTEDPDLLILSFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMSKLEAAGIPTQMERLLSDTDAL
VKKLEMVPVECVIRNRAAGSLVKRLGIEEGMPLNPPLFDLFLKNDAMHDPMVNESYCRTFGWVSDEHLAQMKALSYRANE
VLSQLFDDAGLILVDFKLEFGLYKGQVVLGDEFSPDGSRLWDKTTLAKMDKDRFRQNLGGLIEAYEEVALRLGVPLD

Sequences:

>Translated_237_residues
MQKLAELYRGKAKTVYTTEDPDLLILSFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMSKLEAAGIPTQMERLLSDTDAL
VKKLEMVPVECVIRNRAAGSLVKRLGIEEGMPLNPPLFDLFLKNDAMHDPMVNESYCRTFGWVSDEHLAQMKALSYRANE
VLSQLFDDAGLILVDFKLEFGLYKGQVVLGDEFSPDGSRLWDKTTLAKMDKDRFRQNLGGLIEAYEEVALRLGVPLD
>Mature_237_residues
MQKLAELYRGKAKTVYTTEDPDLLILSFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMSKLEAAGIPTQMERLLSDTDAL
VKKLEMVPVECVIRNRAAGSLVKRLGIEEGMPLNPPLFDLFLKNDAMHDPMVNESYCRTFGWVSDEHLAQMKALSYRANE
VLSQLFDDAGLILVDFKLEFGLYKGQVVLGDEFSPDGSRLWDKTTLAKMDKDRFRQNLGGLIEAYEEVALRLGVPLD

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=221, Percent_Identity=30.7692307692308, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI5453539, Length=221, Percent_Identity=30.7692307692308, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI119220559, Length=228, Percent_Identity=29.3859649122807, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI1788820, Length=237, Percent_Identity=86.0759493670886, Blast_Score=423, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17531275, Length=224, Percent_Identity=26.3392857142857, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI18860083, Length=222, Percent_Identity=29.7297297297297, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24583917, Length=247, Percent_Identity=27.5303643724696, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_EDWI9 (C5B7A4)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002932645.1
- ProteinModelPortal:   C5B7A4
- GeneID:   7960948
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_1202
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 26884; Mature: 26884

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLAELYRGKAKTVYTTEDPDLLILSFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMSK
CCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
LEAAGIPTQMERLLSDTDALVKKLEMVPVECVIRNRAAGSLVKRLGIEEGMPLNPPLFDL
HHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHH
FLKNDAMHDPMVNESYCRTFGWVSDEHLAQMKALSYRANEVLSQLFDDAGLILVDFKLEF
HCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
GLYKGQVVLGDEFSPDGSRLWDKTTLAKMDKDRFRQNLGGLIEAYEEVALRLGVPLD
CEEECEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQKLAELYRGKAKTVYTTEDPDLLILSFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMSK
CCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
LEAAGIPTQMERLLSDTDALVKKLEMVPVECVIRNRAAGSLVKRLGIEEGMPLNPPLFDL
HHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHH
FLKNDAMHDPMVNESYCRTFGWVSDEHLAQMKALSYRANEVLSQLFDDAGLILVDFKLEF
HCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
GLYKGQVVLGDEFSPDGSRLWDKTTLAKMDKDRFRQNLGGLIEAYEEVALRLGVPLD
CEEECEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA