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The map label for this gene is cdr [H]

Identifier: 238919080

GI number: 238919080

Start: 1144980

End: 1146635

Strand: Direct

Name: cdr [H]

Synonym: NT01EI_1149

Alternate gene names: 238919080

Gene position: 1144980-1146635 (Clockwise)

Preceding gene: 238919078

Following gene: 238919081

Centisome position: 30.03

GC content: 64.43

Gene sequence:

>1656_bases
ATGAAAATCGTAATTGTCGGTGGGGTTGCCGGGGGCGCATCCGCCGCGGTCAGGGCCAGAAGGTTGTCTGAGACGGCGCA
GATCATCGTGCTGGAGCGCGGGGAGTATGCCTCGTTCGCCAACTGTGGCCTACCCTATCATATCGGCGGTGAAATCCCGC
AGCGCGATAGCCTGCTGTTGAAGACGCCGCAGGATTTTCGCCAGCGTTTCAATGTTGAGGTTCGGGTGCGCAACGAGGTA
CTGTCCATCGATCCCCAGGGAAAAAGCGTGGAGGTGCGCGATAGCGCCAGCGGGAAGACCTACCATGAGTCCTACGATCG
CCTGCTGCTGAGCAGCGGTGCCGCGCCGCTGGTGCCGCCGTTGCCGGGGGTGACAAGCCCGGGGGTATTTACCCTGCGCA
GCATTAACGATATGGATGCCATTCTGGCGCACATTGCGGCGCGGGCACCGCAGCATGCCACCGTGGTCGGTGGGGGCTTT
ATTGGTCTGGAGGTGGCCGAGGCACTGCATCAGCGTGGGCTGGCGGTCACCCTGCTGGAGATGGGCGCTCAGGTAATGAT
GCCGGTCGATGGCGAGATGGCGGTGCCGCTGCACCAGACGCTGCGCCGCCACGGGGTGGATCTGCGCCTGCAGACGGCGC
TGCAGGCGATCGCCGCCGACGGGGAGGGCATGGCCCTGACCCTGAGCGACGGCAGCGTGCTGCAGAGCGGGCTGGTGATC
ATGGCTATCGGAGTGAGGCCGGAAAGTCGCCTGGCACAGGATGCCGGCCTGGCGCTGGGCGCCAGTGGCGGTATTCGGGT
GGACAGCGGGATGCGCACTTCCGCGGTGGATATCTACGCGGTAGGCGACGCTGTTGAGGCGCCGCCCTTTGACGACGCCA
TGCCACTACTGGTTCCGCTGGCTGGGCCGGCCAACCGCCAGGGGCGCATTGCGGCCGATACCATGCTGGGGCGTGATAGC
CGCTACCGCGGTAGCCAGGCGGCGGCGGTGTGTAAGGTCTTTGATATGACCGTCGCCAGCGTGGGGCTGAGTGAGAAGCT
GCTGCAGCGCCAGCAGAGGGGCTATGAGAAGGTGTATGTGCATGGGTCTGACCACGCCGGCTACTACCCCCACGCGACGC
CCATCAGTCTGAAGCTGCTTTTCGATCCGGCCAACGGCGCCATTCTTGGCGCCCAGGCGATAGGCCAGGAGGGGGTCGAC
AAGCGCATTGATGTGATCTCTGTCGCCCAGCGCGCCGGGCTGAAGGTGGAGGATTTGGAACATCTGGAGCTGTGCTATGC
GCCGCCCTATAACAGCGCCCGGGATCTGGTCAATCAGGCGGGGATGTTGGCGGCCAACGTACGCTGCGGCGATACCGCGA
TTTGCCATGTCGCCGACGTACTGCAGCGCGATCCGGCGCGCCAGTGTCTGCTGGATATCCGCACCCCGCAGGAGCTGAAG
GCGCATGGAACCTATCCGCAGGCGCTGCACATCCCGCTGGATGCACTGCGCGAACGTCTGAATGAGCTACCGCGGGATAA
GGAGATCCTGATCGGCTGCCAGTCGGGTCTGCGGGGTCACGTGGCCTACCGCATTCTGCTTCAGCACGGCTTCCGTGCGC
GTAATCTGAGCGGGGGTTATATCACCTTTACACGGACGCTGGCGGTGCAGGACTAG

Upstream 100 bases:

>100_bases
TTATTTAATATTATATATTATTATATAATGATGAGGGGAAGCTGGCAACGCCGAGCCGGGTCGCTGCCGGTCTGATAATC
GGATTCGATGAGGTGAGCAG

Downstream 100 bases:

>100_bases
CGCGGCGCACCGGGATTGTCCTCCCGGCGGACGATCCCGGTGTAATATGAGCGCAGGGTGAAGTAAAAAGAGTGTTTTTT
CAATTAGTGTATTTACGCGA

Product: coenzyme A disulfide reductase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MKIVIVGGVAGGASAAVRARRLSETAQIIVLERGEYASFANCGLPYHIGGEIPQRDSLLLKTPQDFRQRFNVEVRVRNEV
LSIDPQGKSVEVRDSASGKTYHESYDRLLLSSGAAPLVPPLPGVTSPGVFTLRSINDMDAILAHIAARAPQHATVVGGGF
IGLEVAEALHQRGLAVTLLEMGAQVMMPVDGEMAVPLHQTLRRHGVDLRLQTALQAIAADGEGMALTLSDGSVLQSGLVI
MAIGVRPESRLAQDAGLALGASGGIRVDSGMRTSAVDIYAVGDAVEAPPFDDAMPLLVPLAGPANRQGRIAADTMLGRDS
RYRGSQAAAVCKVFDMTVASVGLSEKLLQRQQRGYEKVYVHGSDHAGYYPHATPISLKLLFDPANGAILGAQAIGQEGVD
KRIDVISVAQRAGLKVEDLEHLELCYAPPYNSARDLVNQAGMLAANVRCGDTAICHVADVLQRDPARQCLLDIRTPQELK
AHGTYPQALHIPLDALRERLNELPRDKEILIGCQSGLRGHVAYRILLQHGFRARNLSGGYITFTRTLAVQD

Sequences:

>Translated_551_residues
MKIVIVGGVAGGASAAVRARRLSETAQIIVLERGEYASFANCGLPYHIGGEIPQRDSLLLKTPQDFRQRFNVEVRVRNEV
LSIDPQGKSVEVRDSASGKTYHESYDRLLLSSGAAPLVPPLPGVTSPGVFTLRSINDMDAILAHIAARAPQHATVVGGGF
IGLEVAEALHQRGLAVTLLEMGAQVMMPVDGEMAVPLHQTLRRHGVDLRLQTALQAIAADGEGMALTLSDGSVLQSGLVI
MAIGVRPESRLAQDAGLALGASGGIRVDSGMRTSAVDIYAVGDAVEAPPFDDAMPLLVPLAGPANRQGRIAADTMLGRDS
RYRGSQAAAVCKVFDMTVASVGLSEKLLQRQQRGYEKVYVHGSDHAGYYPHATPISLKLLFDPANGAILGAQAIGQEGVD
KRIDVISVAQRAGLKVEDLEHLELCYAPPYNSARDLVNQAGMLAANVRCGDTAICHVADVLQRDPARQCLLDIRTPQELK
AHGTYPQALHIPLDALRERLNELPRDKEILIGCQSGLRGHVAYRILLQHGFRARNLSGGYITFTRTLAVQD
>Mature_551_residues
MKIVIVGGVAGGASAAVRARRLSETAQIIVLERGEYASFANCGLPYHIGGEIPQRDSLLLKTPQDFRQRFNVEVRVRNEV
LSIDPQGKSVEVRDSASGKTYHESYDRLLLSSGAAPLVPPLPGVTSPGVFTLRSINDMDAILAHIAARAPQHATVVGGGF
IGLEVAEALHQRGLAVTLLEMGAQVMMPVDGEMAVPLHQTLRRHGVDLRLQTALQAIAADGEGMALTLSDGSVLQSGLVI
MAIGVRPESRLAQDAGLALGASGGIRVDSGMRTSAVDIYAVGDAVEAPPFDDAMPLLVPLAGPANRQGRIAADTMLGRDS
RYRGSQAAAVCKVFDMTVASVGLSEKLLQRQQRGYEKVYVHGSDHAGYYPHATPISLKLLFDPANGAILGAQAIGQEGVD
KRIDVISVAQRAGLKVEDLEHLELCYAPPYNSARDLVNQAGMLAANVRCGDTAICHVADVLQRDPARQCLLDIRTPQELK
AHGTYPQALHIPLDALRERLNELPRDKEILIGCQSGLRGHVAYRILLQHGFRARNLSGGYITFTRTLAVQD

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=329, Percent_Identity=25.2279635258359, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI65787454, Length=329, Percent_Identity=25.2279635258359, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI226437568, Length=329, Percent_Identity=25.2279635258359, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI91199540, Length=387, Percent_Identity=23.7726098191214, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1789065, Length=277, Percent_Identity=31.4079422382672, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789765, Length=285, Percent_Identity=28.0701754385965, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788892, Length=250, Percent_Identity=31.6, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786307, Length=333, Percent_Identity=24.6246246246246, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI87082354, Length=356, Percent_Identity=23.876404494382, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789915, Length=330, Percent_Identity=25.4545454545455, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87081717, Length=251, Percent_Identity=27.8884462151394, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=266, Percent_Identity=24.0601503759398, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639257, Length=293, Percent_Identity=24.2320819112628, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281359715, Length=293, Percent_Identity=24.2320819112628, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI281359713, Length=293, Percent_Identity=24.2320819112628, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24639250, Length=293, Percent_Identity=24.2320819112628, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI18543267, Length=293, Percent_Identity=24.2320819112628, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24639252, Length=293, Percent_Identity=24.2320819112628, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24585130, Length=326, Percent_Identity=23.9263803680982, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358499, Length=373, Percent_Identity=24.3967828418231, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 58979; Mature: 58979

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVIVGGVAGGASAAVRARRLSETAQIIVLERGEYASFANCGLPYHIGGEIPQRDSLLL
CEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHCCCCCEECCCCCCCCCCEEE
KTPQDFRQRFNVEVRVRNEVLSIDPQGKSVEVRDSASGKTYHESYDRLLLSSGAAPLVPP
ECCHHHHHHCCEEEEEECEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
LPGVTSPGVFTLRSINDMDAILAHIAARAPQHATVVGGGFIGLEVAEALHQRGLAVTLLE
CCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEC
MGAQVMMPVDGEMAVPLHQTLRRHGVDLRLQTALQAIAADGEGMALTLSDGSVLQSGLVI
CCCEEEECCCCCEECCHHHHHHHCCCCEEHHHHHHHHHCCCCCEEEEECCCHHHHCCEEE
MAIGVRPESRLAQDAGLALGASGGIRVDSGMRTSAVDIYAVGDAVEAPPFDDAMPLLVPL
EEECCCCHHHHHHHCCEEEECCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEC
AGPANRQGRIAADTMLGRDSRYRGSQAAAVCKVFDMTVASVGLSEKLLQRQQRGYEKVYV
CCCCCCCCCEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEE
HGSDHAGYYPHATPISLKLLFDPANGAILGAQAIGQEGVDKRIDVISVAQRAGLKVEDLE
ECCCCCCCCCCCCCEEEEEEEECCCCCEEEHHHHCCCCCCHHHHHHHHHHHCCCCHHCCC
HLELCYAPPYNSARDLVNQAGMLAANVRCGDTAICHVADVLQRDPARQCLLDIRTPQELK
CEEEEECCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHEECCCCHHHH
AHGTYPQALHIPLDALRERLNELPRDKEILIGCQSGLRGHVAYRILLQHGFRARNLSGGY
HCCCCCCEEECCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCE
ITFTRTLAVQD
EEEEEEEEECC
>Mature Secondary Structure
MKIVIVGGVAGGASAAVRARRLSETAQIIVLERGEYASFANCGLPYHIGGEIPQRDSLLL
CEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHCCCCCEECCCCCCCCCCEEE
KTPQDFRQRFNVEVRVRNEVLSIDPQGKSVEVRDSASGKTYHESYDRLLLSSGAAPLVPP
ECCHHHHHHCCEEEEEECEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
LPGVTSPGVFTLRSINDMDAILAHIAARAPQHATVVGGGFIGLEVAEALHQRGLAVTLLE
CCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEC
MGAQVMMPVDGEMAVPLHQTLRRHGVDLRLQTALQAIAADGEGMALTLSDGSVLQSGLVI
CCCEEEECCCCCEECCHHHHHHHCCCCEEHHHHHHHHHCCCCCEEEEECCCHHHHCCEEE
MAIGVRPESRLAQDAGLALGASGGIRVDSGMRTSAVDIYAVGDAVEAPPFDDAMPLLVPL
EEECCCCHHHHHHHCCEEEECCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEC
AGPANRQGRIAADTMLGRDSRYRGSQAAAVCKVFDMTVASVGLSEKLLQRQQRGYEKVYV
CCCCCCCCCEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEE
HGSDHAGYYPHATPISLKLLFDPANGAILGAQAIGQEGVDKRIDVISVAQRAGLKVEDLE
ECCCCCCCCCCCCCEEEEEEEECCCCCEEEHHHHCCCCCCHHHHHHHHHHHCCCCHHCCC
HLELCYAPPYNSARDLVNQAGMLAANVRCGDTAICHVADVLQRDPARQCLLDIRTPQELK
CEEEEECCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHEECCCCHHHH
AHGTYPQALHIPLDALRERLNELPRDKEILIGCQSGLRGHVAYRILLQHGFRARNLSGGY
HCCCCCCEEECCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCE
ITFTRTLAVQD
EEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA