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The map label for this gene is dld [H]

Identifier: 238919078

GI number: 238919078

Start: 1142746

End: 1144470

Strand: Direct

Name: dld [H]

Synonym: NT01EI_1147

Alternate gene names: 238919078

Gene position: 1142746-1144470 (Clockwise)

Preceding gene: 238919076

Following gene: 238919080

Centisome position: 29.98

GC content: 62.43

Gene sequence:

>1725_bases
ATGCCCTTTTCCCGCCCCGTCCCACCGGCCGAGATGCTGCTGTCCCAGCTGCGCGCCATCGCAGGTCCTTCCCGGGTGTT
AAGCGATACGCGCAAAACGGCGCGTTACTGTAAAGGCTTTCGCTCCGGTCAGGGCCGCGCGCTGGCCGTGGTGTTCCCCG
ACACGCTGCTGGCGATGTGGCGGATCTTCAAGGCCTGCGTCGAGGCCGATCGCATCATTCTGATGCAGGCGGCCAATACC
GGCCTGACCGAAGGGTCGGCCCCCAGCGGCGATGACTACGATCGCGAGCTGGTGATCATCAATACCCTGCGCCTGGGTGG
CGCCCAACTGCTGGGTGAGGGGCGTCAGGTGGTAGCATTGCCCGGCACCACCCTGTGGCAGCTTGAGCGATTGCTGAAGC
CACTGGGGCGGGAGCCCCATTCGGTGATCGGCTCCTCCTGTATCGGCGCCTCGGTAATCGGCGGTATTTGTAACAACTCC
GGCGGTGCGCTGGTGCAGCGTGGTCCGGCCTATACCGAAATGGCGCTGTATGGACGGGTCAATGAAAAAGGCGAGGCAGA
GCTGATCAACCATCTGGGCATTGCGCTGGGCGAGACGCCGGAGGCCATATTGGAGAACCTGTCCCTGCGGCGTTACAGCG
ATGCGGATGTTCAGCATGATACGCGCCGGGCCTCCGATCATCAGTATGCGCAGCGCGTCAGGGCGGTCGATGCCGCCACG
CCGGCCCGCTTTAATGCCGATGAACGGCGTCTGTTTGAGGCCTCCGGCTGTGCCGGAAAGCTGGCGGTGTTCGCCGTGCG
TCTGGATACCTTTCCTGCGGAGGCGCGCCAGCAGGTGTTTTATATCGGTACCGATCGGCCCCAGGTGCTGACCGGGCTGC
GGCGGCATATATTGAGCCACTTTACCCACCTGCCGGTGGCCGCGGAGTATCTGCATCGCGATACGTTTGATATCGCCGAG
CGCTACGGTAAAGATACCTTTTTGATGATCGAAAAGCTGGGGACAGACAGGATGCCGTTCTTCTTCAACCTGAAGGGGCG
GATCGACGCATGGGCAGCGCGTGTGCCGCTGCTGCCGTTCCACCCGGTCGATCGCGCGATGCAGGCGCTGAGCCGTCTGT
GGCCGGGGCATCTGCCGCCGCGCATCAGGCAGTACCGCGATCGCTATTCCCACCACCTGTTGCTGAAGATGGCCGGAGAG
GGGATCGAGGAGGCACAGCGGTGGCTGAGCGACTATTTTGCCCAGGCCGACGGCGACTTTTTTACCTGTACGCCGGAGGA
GGGGAACAAGGCATTTTTACATCGCTTTGCCGCCGCCGGGGCGGCGATACGCTATCAGGCGGTGCATGACCGGCAGGTCG
AAGATATTCTGGCGCTGGATATCGCCCTGCGGCGCAACGACACGCAGTGGTTTGAACAGTTGCCGCCGGAGCTGATGCAG
GATCTGTCGCACTGTCTGTACTATGGCCACTTTCTGTGTCACGTATTTCATCAGGACTATATCGTGCGCAAGGGGGCCGA
TGTGGCGGCGATTAAGGCGAAGATGCTGGCGCTGCTGGATGCGCGCGGCGCGGAGTACCCGGCGGAGCATAACGTGGGCC
ATCTCTACCGCGCCAAGCCGCAGCTTGAGGCCTTTTATCGTCATCAGGATCCCACCAATACCCTCAATCCCGGCATCGGC
AAGACCAGTAAGTGCCGCAGCTGGGGCTGCGACGGTGGCCACTAG

Upstream 100 bases:

>100_bases
GTGTTATTTGGTCTGCATTGTTATGTTTTTTATTTGTTAACTTTAGGCGTTAGACACTATGCTGGACGGCACCTGATTCT
GCCGTCACAGGAGTGATGCC

Downstream 100 bases:

>100_bases
GGCGTGTCCCGTAGCCGTGCGCGCCAGCGATGCTCACGACCCGTTACGCGATACGCCCTGGGCCAGCTTTTCATCCGCCG
GCGGACAGTACAGGCGGTGC

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: Respiratory D-lactate dehydrogenase [H]

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MPFSRPVPPAEMLLSQLRAIAGPSRVLSDTRKTARYCKGFRSGQGRALAVVFPDTLLAMWRIFKACVEADRIILMQAANT
GLTEGSAPSGDDYDRELVIINTLRLGGAQLLGEGRQVVALPGTTLWQLERLLKPLGREPHSVIGSSCIGASVIGGICNNS
GGALVQRGPAYTEMALYGRVNEKGEAELINHLGIALGETPEAILENLSLRRYSDADVQHDTRRASDHQYAQRVRAVDAAT
PARFNADERRLFEASGCAGKLAVFAVRLDTFPAEARQQVFYIGTDRPQVLTGLRRHILSHFTHLPVAAEYLHRDTFDIAE
RYGKDTFLMIEKLGTDRMPFFFNLKGRIDAWAARVPLLPFHPVDRAMQALSRLWPGHLPPRIRQYRDRYSHHLLLKMAGE
GIEEAQRWLSDYFAQADGDFFTCTPEEGNKAFLHRFAAAGAAIRYQAVHDRQVEDILALDIALRRNDTQWFEQLPPELMQ
DLSHCLYYGHFLCHVFHQDYIVRKGADVAAIKAKMLALLDARGAEYPAEHNVGHLYRAKPQLEAFYRHQDPTNTLNPGIG
KTSKCRSWGCDGGH

Sequences:

>Translated_574_residues
MPFSRPVPPAEMLLSQLRAIAGPSRVLSDTRKTARYCKGFRSGQGRALAVVFPDTLLAMWRIFKACVEADRIILMQAANT
GLTEGSAPSGDDYDRELVIINTLRLGGAQLLGEGRQVVALPGTTLWQLERLLKPLGREPHSVIGSSCIGASVIGGICNNS
GGALVQRGPAYTEMALYGRVNEKGEAELINHLGIALGETPEAILENLSLRRYSDADVQHDTRRASDHQYAQRVRAVDAAT
PARFNADERRLFEASGCAGKLAVFAVRLDTFPAEARQQVFYIGTDRPQVLTGLRRHILSHFTHLPVAAEYLHRDTFDIAE
RYGKDTFLMIEKLGTDRMPFFFNLKGRIDAWAARVPLLPFHPVDRAMQALSRLWPGHLPPRIRQYRDRYSHHLLLKMAGE
GIEEAQRWLSDYFAQADGDFFTCTPEEGNKAFLHRFAAAGAAIRYQAVHDRQVEDILALDIALRRNDTQWFEQLPPELMQ
DLSHCLYYGHFLCHVFHQDYIVRKGADVAAIKAKMLALLDARGAEYPAEHNVGHLYRAKPQLEAFYRHQDPTNTLNPGIG
KTSKCRSWGCDGGH
>Mature_573_residues
PFSRPVPPAEMLLSQLRAIAGPSRVLSDTRKTARYCKGFRSGQGRALAVVFPDTLLAMWRIFKACVEADRIILMQAANTG
LTEGSAPSGDDYDRELVIINTLRLGGAQLLGEGRQVVALPGTTLWQLERLLKPLGREPHSVIGSSCIGASVIGGICNNSG
GALVQRGPAYTEMALYGRVNEKGEAELINHLGIALGETPEAILENLSLRRYSDADVQHDTRRASDHQYAQRVRAVDAATP
ARFNADERRLFEASGCAGKLAVFAVRLDTFPAEARQQVFYIGTDRPQVLTGLRRHILSHFTHLPVAAEYLHRDTFDIAER
YGKDTFLMIEKLGTDRMPFFFNLKGRIDAWAARVPLLPFHPVDRAMQALSRLWPGHLPPRIRQYRDRYSHHLLLKMAGEG
IEEAQRWLSDYFAQADGDFFTCTPEEGNKAFLHRFAAAGAAIRYQAVHDRQVEDILALDIALRRNDTQWFEQLPPELMQD
LSHCLYYGHFLCHVFHQDYIVRKGADVAAIKAKMLALLDARGAEYPAEHNVGHLYRAKPQLEAFYRHQDPTNTLNPGIGK
TSKCRSWGCDGGH

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=556, Percent_Identity=69.7841726618705, Blast_Score=825, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 64217; Mature: 64086

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFSRPVPPAEMLLSQLRAIAGPSRVLSDTRKTARYCKGFRSGQGRALAVVFPDTLLAMW
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHH
RIFKACVEADRIILMQAANTGLTEGSAPSGDDYDRELVIINTLRLGGAQLLGEGRQVVAL
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEHHCCHHHHCCCCEEEEE
PGTTLWQLERLLKPLGREPHSVIGSSCIGASVIGGICNNSGGALVQRGPAYTEMALYGRV
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHCCC
NEKGEAELINHLGIALGETPEAILENLSLRRYSDADVQHDTRRASDHQYAQRVRAVDAAT
CCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHCCC
PARFNADERRLFEASGCAGKLAVFAVRLDTFPAEARQQVFYIGTDRPQVLTGLRRHILSH
CCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
FTHLPVAAEYLHRDTFDIAERYGKDTFLMIEKLGTDRMPFFFNLKGRIDAWAARVPLLPF
HHCCCHHHHHHHCCHHHHHHHHCCCCEEEHHHCCCCCCCEEEEECCCHHHHHHHCCCCCC
HPVDRAMQALSRLWPGHLPPRIRQYRDRYSHHLLLKMAGEGIEEAQRWLSDYFAQADGDF
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEHHHHHCCCHHHHHHHHHHHHHHCCCCE
FTCTPEEGNKAFLHRFAAAGAAIRYQAVHDRQVEDILALDIALRRNDTQWFEQLPPELMQ
EEECCCCCCHHHHHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHH
DLSHCLYYGHFLCHVFHQDYIVRKGADVAAIKAKMLALLDARGAEYPAEHNVGHLYRAKP
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCH
QLEAFYRHQDPTNTLNPGIGKTSKCRSWGCDGGH
HHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCC
>Mature Secondary Structure 
PFSRPVPPAEMLLSQLRAIAGPSRVLSDTRKTARYCKGFRSGQGRALAVVFPDTLLAMW
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHH
RIFKACVEADRIILMQAANTGLTEGSAPSGDDYDRELVIINTLRLGGAQLLGEGRQVVAL
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEHHCCHHHHCCCCEEEEE
PGTTLWQLERLLKPLGREPHSVIGSSCIGASVIGGICNNSGGALVQRGPAYTEMALYGRV
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHCCC
NEKGEAELINHLGIALGETPEAILENLSLRRYSDADVQHDTRRASDHQYAQRVRAVDAAT
CCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHCCC
PARFNADERRLFEASGCAGKLAVFAVRLDTFPAEARQQVFYIGTDRPQVLTGLRRHILSH
CCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
FTHLPVAAEYLHRDTFDIAERYGKDTFLMIEKLGTDRMPFFFNLKGRIDAWAARVPLLPF
HHCCCHHHHHHHCCHHHHHHHHCCCCEEEHHHCCCCCCCEEEEECCCHHHHHHHCCCCCC
HPVDRAMQALSRLWPGHLPPRIRQYRDRYSHHLLLKMAGEGIEEAQRWLSDYFAQADGDF
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEHHHHHCCCHHHHHHHHHHHHHHCCCCE
FTCTPEEGNKAFLHRFAAAGAAIRYQAVHDRQVEDILALDIALRRNDTQWFEQLPPELMQ
EEECCCCCCHHHHHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHH
DLSHCLYYGHFLCHVFHQDYIVRKGADVAAIKAKMLALLDARGAEYPAEHNVGHLYRAKP
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCH
QLEAFYRHQDPTNTLNPGIGKTSKCRSWGCDGGH
HHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6386470; 3882663; 9278503; 10944213 [H]