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The map label for this gene is cueR [H]

Identifier: 238919070

GI number: 238919070

Start: 1137298

End: 1137711

Strand: Direct

Name: cueR [H]

Synonym: NT01EI_1140

Alternate gene names: 238919070

Gene position: 1137298-1137711 (Clockwise)

Preceding gene: 238919064

Following gene: 238919074

Centisome position: 29.83

GC content: 63.53

Gene sequence:

>414_bases
GTGAATATTAGTGAAGTGGCGAAAAAAACCGGCCTGAGCAGCAAGGCCATCCGCTTTTATGAAGAGAAAGGGCTGGTGAC
GCCGCCGCTGCGCGGGGAGAACGGCTATCGCCACTATGCGGCGACCCAGCTGGAGGAGCTGACGCTGCTGCGTCAGGCGC
GTCAGGTCGGCTTTACGCTGGAGGAGTGCCGGGAGCTGGTGGTGCTGTTCCACGACGAGCACCGCCACAGTGCCGAGGTA
AAACAGCGCACCCTGCAAAAGGTGGCGGAGATAGAGGTGCACATCCGCGATCTACAGGCGATGCGTGACCGGCTGGCGGC
ACTGGCACAGGCCTGCCCCGGCGACGACAGCGCCGATTGCCCGATCATTAACGATCTGGCCGGCTGCTGTCGCGGGGCGG
GGCACAGGGGATAA

Upstream 100 bases:

>100_bases
GGTTACGCTCAGGGTGCGGCGCGATAGCCTGCCGGTTGGCGTCCCCTTCAATTACGGTTAAGCTTAAACCTTCCCGCAAG
GTTAAGGTCAAGGGGGACGG

Downstream 100 bases:

>100_bases
CTTCCAGCGTGATGCCGCTGACGGCGCGCACCTGAACGCACTGTCCAGCGGGCAGATCCTGGGCACAGGTGACGCGCCAG
CTGCTGTCGCCGAGGCGCAG

Product: Cu(I)-responsive transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MNISEVAKKTGLSSKAIRFYEEKGLVTPPLRGENGYRHYAATQLEELTLLRQARQVGFTLEECRELVVLFHDEHRHSAEV
KQRTLQKVAEIEVHIRDLQAMRDRLAALAQACPGDDSADCPIINDLAGCCRGAGHRG

Sequences:

>Translated_137_residues
MNISEVAKKTGLSSKAIRFYEEKGLVTPPLRGENGYRHYAATQLEELTLLRQARQVGFTLEECRELVVLFHDEHRHSAEV
KQRTLQKVAEIEVHIRDLQAMRDRLAALAQACPGDDSADCPIINDLAGCCRGAGHRG
>Mature_137_residues
MNISEVAKKTGLSSKAIRFYEEKGLVTPPLRGENGYRHYAATQLEELTLLRQARQVGFTLEECRELVVLFHDEHRHSAEV
KQRTLQKVAEIEVHIRDLQAMRDRLAALAQACPGDDSADCPIINDLAGCCRGAGHRG

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=130, Percent_Identity=76.1538461538461, Blast_Score=206, Evalue=5e-55,
Organism=Escherichia coli, GI1789687, Length=127, Percent_Identity=36.2204724409449, Blast_Score=77, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15310; Mature: 15310

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISEVAKKTGLSSKAIRFYEEKGLVTPPLRGENGYRHYAATQLEELTLLRQARQVGFTL
CCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCH
EECRELVVLFHDEHRHSAEVKQRTLQKVAEIEVHIRDLQAMRDRLAALAQACPGDDSADC
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PIINDLAGCCRGAGHRG
CHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNISEVAKKTGLSSKAIRFYEEKGLVTPPLRGENGYRHYAATQLEELTLLRQARQVGFTL
CCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCH
EECRELVVLFHDEHRHSAEVKQRTLQKVAEIEVHIRDLQAMRDRLAALAQACPGDDSADC
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PIINDLAGCCRGAGHRG
CHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]