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The map label for this gene is serS [H]

Identifier: 238917966

GI number: 238917966

Start: 2129526

End: 2130815

Strand: Reverse

Name: serS [H]

Synonym: EUBELI_02056

Alternate gene names: 238917966

Gene position: 2130815-2129526 (Counterclockwise)

Preceding gene: 238917967

Following gene: 238917963

Centisome position: 99.38

GC content: 37.83

Gene sequence:

>1290_bases
ATGTTAGATTTAAAATTTGTCAGAGAAAACCCGGATATTGTTAAACAGAATATTAAGAATAAATTTCAGGACAGAAAGCT
TCCACTTGTAGATGAAGTTATTGAGCTTGATGCTAAGGCTCGTGCAACACAGACAGAAGCTGATGAATTAAGAGCAAACA
GAAATAAGCTTTCTAAGCAGATAGGTGCTCTTATGGCACAGGGCAAGAAGGAAGAGGCTGAGGCAGTTAAGGCACAGGTA
AGTGCAGATGCTGCAAAGCTTGCTGAATTAGAAGCTGATGAGAAGGAACTTAATGAGAAAATAACTAAGATAATGATGAC
TATTCCTAACATCATTGATCCTAGTGTGCCAATTGGTAAAGATGACAGTGAGAATGTTGAAATCGAGAAGTTTGGTGAGC
CTGTAGTTCCTGATTTTGAGGTTCCATATCATACAGATATTATGGAAAGATTCAACGGAATTGATATGGATGCAGCTGGT
AAGGTTGCTGGTAACGGTTTTTATTACCTTATGGGTGATATTGCAAGACTTCATTCAGCAATTATTTCATATGCAAGAGA
TTTCATGATTGACAGAGGATTCACATATTGTATTCCTCCTTATATGATAAGAAGTAATGTAGTTACTGGTGTTATGAGCT
TTGATGAAATGGATGCCATGATGTATAAGATAGAAGGTGAAGATCTTTATCTTATCGGAACAAGTGAACATTCAATGATT
GGTAAGTTTATTGACACAATTACACCAGAGGAAGAGCTTCCTAAGACACTTACAAGCTATTCTCCATGTTTCAGAAAAGA
GAAGGGTGCTCACGGTATCGAGGAAAGAGGTGTATATAGAATCCATCAGTTCGAGAAACAGGAAATGATTGTTGTCTGCA
AGCCAGAAGAAAGCAAAATGTGGTTTGATAAATTATGGAAGAATACAGTAGATTTCTTCAGAACAATGGATATTCCGGTA
AGAACACTTGAGTGCTGTTCAGGAGATTTAGCTGATCTTAAGGTTAAATCAATCGATGTTGAAGCATGGTCACCAAGACA
GAAGAAGTACTTCGAGGTTGGTTCATGCTCTAACTTAGGAGATGCTCAGGCTAGAAGACTTAAGATAAGAGTTCAGGGTA
AGGACAAGAATAAGTACTTTGCACATACTCTTAACAACACATGTGTTGCACCTCCAAGAATGCTTATTGCATTTCTTGAG
AACAACCTTCAGGCAGATGGAAGAGTACTTATTCCAGAAGCACTCCGTATGTACATGGGTGGAAAGACAGAATTAGTTCC
AGTTAAGTAA

Upstream 100 bases:

>100_bases
AAGATAAAATGTAATTGAAAATATACTAAAAAAGGTGCATAATAGCATTTGGTAAATTTGATAAAATAGTGTCAATTATA
GGACACGGAAATGAGGAGTA

Downstream 100 bases:

>100_bases
TAGGAATATTATATAATATTATAAAAAATGTGGATAAAACATATTAAATGAATATGCTTTATCCACATTTATTTTATATT
ATCCACAAATTTTGTGGATA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLDLKFVRENPDIVKQNIKNKFQDRKLPLVDEVIELDAKARATQTEADELRANRNKLSKQIGALMAQGKKEEAEAVKAQV
SADAAKLAELEADEKELNEKITKIMMTIPNIIDPSVPIGKDDSENVEIEKFGEPVVPDFEVPYHTDIMERFNGIDMDAAG
KVAGNGFYYLMGDIARLHSAIISYARDFMIDRGFTYCIPPYMIRSNVVTGVMSFDEMDAMMYKIEGEDLYLIGTSEHSMI
GKFIDTITPEEELPKTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPEESKMWFDKLWKNTVDFFRTMDIPV
RTLECCSGDLADLKVKSIDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVQGKDKNKYFAHTLNNTCVAPPRMLIAFLE
NNLQADGRVLIPEALRMYMGGKTELVPVK

Sequences:

>Translated_429_residues
MLDLKFVRENPDIVKQNIKNKFQDRKLPLVDEVIELDAKARATQTEADELRANRNKLSKQIGALMAQGKKEEAEAVKAQV
SADAAKLAELEADEKELNEKITKIMMTIPNIIDPSVPIGKDDSENVEIEKFGEPVVPDFEVPYHTDIMERFNGIDMDAAG
KVAGNGFYYLMGDIARLHSAIISYARDFMIDRGFTYCIPPYMIRSNVVTGVMSFDEMDAMMYKIEGEDLYLIGTSEHSMI
GKFIDTITPEEELPKTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPEESKMWFDKLWKNTVDFFRTMDIPV
RTLECCSGDLADLKVKSIDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVQGKDKNKYFAHTLNNTCVAPPRMLIAFLE
NNLQADGRVLIPEALRMYMGGKTELVPVK
>Mature_429_residues
MLDLKFVRENPDIVKQNIKNKFQDRKLPLVDEVIELDAKARATQTEADELRANRNKLSKQIGALMAQGKKEEAEAVKAQV
SADAAKLAELEADEKELNEKITKIMMTIPNIIDPSVPIGKDDSENVEIEKFGEPVVPDFEVPYHTDIMERFNGIDMDAAG
KVAGNGFYYLMGDIARLHSAIISYARDFMIDRGFTYCIPPYMIRSNVVTGVMSFDEMDAMMYKIEGEDLYLIGTSEHSMI
GKFIDTITPEEELPKTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPEESKMWFDKLWKNTVDFFRTMDIPV
RTLECCSGDLADLKVKSIDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVQGKDKNKYFAHTLNNTCVAPPRMLIAFLE
NNLQADGRVLIPEALRMYMGGKTELVPVK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=476, Percent_Identity=31.0924369747899, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI8923421, Length=414, Percent_Identity=30.4347826086957, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI225579074, Length=418, Percent_Identity=30.3827751196172, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=33.8747099767981, Blast_Score=259, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17539260, Length=468, Percent_Identity=32.9059829059829, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17542084, Length=334, Percent_Identity=31.1377245508982, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=451, Percent_Identity=33.7028824833703, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6321799, Length=415, Percent_Identity=30.3614457831325, Blast_Score=199, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24581334, Length=471, Percent_Identity=31.8471337579618, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI17737985, Length=338, Percent_Identity=32.2485207100592, Blast_Score=162, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48783; Mature: 48783

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKFVRENPDIVKQNIKNKFQDRKLPLVDEVIELDAKARATQTEADELRANRNKLSKQ
CCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHH
IGALMAQGKKEEAEAVKAQVSADAAKLAELEADEKELNEKITKIMMTIPNIIDPSVPIGK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
DDSENVEIEKFGEPVVPDFEVPYHTDIMERFNGIDMDAAGKVAGNGFYYLMGDIARLHSA
CCCCCCCHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHH
IISYARDFMIDRGFTYCIPPYMIRSNVVTGVMSFDEMDAMMYKIEGEDLYLIGTSEHSMI
HHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHCEEEEEECCCEEEEEECCCHHHH
GKFIDTITPEEELPKTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPEESKM
HHHHHCCCCHHHHHHHHHHCCHHHHHCCCCCCCHHCCCHHHHHCCCCCEEEEECCCCHHH
WFDKLWKNTVDFFRTMDIPVRTLECCSGDLADLKVKSIDVEAWSPRQKKYFEVGSCSNLG
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHCEEEEEECCCCCCCHHHEEECCCCCCCC
DAQARRLKIRVQGKDKNKYFAHTLNNTCVAPPRMLIAFLENNLQADGRVLIPEALRMYMG
CCCEEEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECHHHHHHHHC
GKTELVPVK
CCCEEEECC
>Mature Secondary Structure
MLDLKFVRENPDIVKQNIKNKFQDRKLPLVDEVIELDAKARATQTEADELRANRNKLSKQ
CCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHH
IGALMAQGKKEEAEAVKAQVSADAAKLAELEADEKELNEKITKIMMTIPNIIDPSVPIGK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
DDSENVEIEKFGEPVVPDFEVPYHTDIMERFNGIDMDAAGKVAGNGFYYLMGDIARLHSA
CCCCCCCHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHH
IISYARDFMIDRGFTYCIPPYMIRSNVVTGVMSFDEMDAMMYKIEGEDLYLIGTSEHSMI
HHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHCEEEEEECCCEEEEEECCCHHHH
GKFIDTITPEEELPKTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPEESKM
HHHHHCCCCHHHHHHHHHHCCHHHHHCCCCCCCHHCCCHHHHHCCCCCEEEEECCCCHHH
WFDKLWKNTVDFFRTMDIPVRTLECCSGDLADLKVKSIDVEAWSPRQKKYFEVGSCSNLG
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHCEEEEEECCCCCCCHHHEEECCCCCCCC
DAQARRLKIRVQGKDKNKYFAHTLNNTCVAPPRMLIAFLENNLQADGRVLIPEALRMYMG
CCCEEEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECHHHHHHHHC
GKTELVPVK
CCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA