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The map label for this gene is tkt [H]

Identifier: 238917924

GI number: 238917924

Start: 2075869

End: 2077857

Strand: Reverse

Name: tkt [H]

Synonym: EUBELI_02011

Alternate gene names: 238917924

Gene position: 2077857-2075869 (Counterclockwise)

Preceding gene: 238917925

Following gene: 238917923

Centisome position: 96.91

GC content: 40.77

Gene sequence:

>1989_bases
ATGACTAATATCGATGAAATGTCAATTAATGCAATCAGAGTATTGTCAGCAGATGCAATTCAGAAGGCGAATTCAGGACA
TCCTGGACTTCCACTTGGAACTGCACCAACAGCTTATGAATTATGGACTAACCATATGAATTACAATCCTGCTGATCCTA
AGTGGGAGAATAGAGACAGATTCGTTCTTTCTGGCGGACATGGTTCAATGCTTCTTTACTCATTGTTCCATTTACTTGGA
ATTGGCAATCTTTCTTTAGATGATGTAAAGAATTTCAGACAGATGGGCTCAAAGACACCAGGACATCCAGAGTATGGTCA
TACAGTTGGTGTTGAAGCAACAACTGGACCTCTTGGACAGGGTATGGCTATGGCAGTAGGTATGGCTATGGCAGAAGCAC
ATCTTGCATCAGTATTTAATAAGGATGGATACAATGTAGTAGACCATTACACATATGTACTTGGTGGAGACGGCTGTATG
ATGGAAGGTATTTCATCAGAGTGTTTCTCACTTGCAGGAACATTAGGTCTTTCAAAGCTTATTGTATTCTATGATTCTAA
CAATATATCAATCGAAGGAAGCACAGATATTGCATTTACAGAAAATGTAATGAAGAGATTTGAAGCATTTGGCTTCCAGA
CAATCGAGGTTGCTGATGGCAATGATATCGAAGCTATAGGCAAGGCTATTGAAGAAGCTAAGGCTGATAAGGAAAGACCT
TCACTTATCAAGGTTAATACACTTATCGGATACGGTTGTCCTGCAAAGCAGGGTAAGGCAAGCGCACACGGTGAGCCTCT
TGGTATTGATAATGTTGCAGCACTTAAGGAAAATCTTAACTGGCCATGCAAGGGTGATTTTGAAGTACCACAGGAAGTAT
ATGACCATTATAAAGAGATAGCAGCAAGAATGGCTGAGCCAGAGAAAGAATGGAATAAGCTCTTTGCTGAATACTGTGAG
AAGTTCCCTGAGATGAAGGAACTCTGGGATAAATATTACAATGGATGTGATATGTCCGATTTATTCAATTCTGAGGAATA
CCTTGCGAAGCCAGAGAAGGCAGAAGCAACAAGAAGTTCAAGTGGAACAATTCTTAACATGATTAAGAATCTCATGCCTA
ACCTTATTGGTGGTTCAGCAGATTTAGCACCATCTAATAAGACTAACATGAAGGATGCAGGAGATTTCTCTAAGGAGAAT
TATGCAGGAACTAACCTTCACTTTGGTGTAAGAGAACAGGCTATGGCAGCAATTGGTAATGGACTTGCACTTCATGGTGG
ATTAAGACCATTCGTTGCAACATTCTTCGTATTCAGTGATTACACAAAGCCAATGGCAAGACTTACATCACTTATGAAGT
TACCAGTTGTATATGTATTCACACATGACAGTATCGGAGTTGGTGAGGACGGACCTACACATGAGCCAATCGAGCAGCTT
GCAGCATTCCGTTCAATGCCTGACTTCACAGTATTCAGACCATGTGACAGAACAGAGACAGCACTTGCATGGGAATATGC
TATTGAGTCTAAGGATGAGCCAACAGCATTAGTTCTTACAAGACAGAATCTTCCACAGATGGCAGGTTCATCTAAGGAAG
CACTCAAGGGTGCATATATTCTTGAGGATTCAGATAAAGAGACTCCAGATGGAATCATCATTGCAAGTGGTTCAGAAGTG
AACTTAGCTGTATCTGCAAAGGCAGAGCTTAAGAATGCAGGAATAGATGTAAGAGTAGTAAGTATGCCATCTATGGACGT
ATTCGAGAAGCAGTCAGATGAATACAAGGAATCAGTACTTCCTAAGAGTGTAAGAAAGAGAGTTGCAGTTGAAGCACTTT
CAGACTTTGGATGGTACAGATATGTAGGTCTTGACGGAAAGGTAATCTGCATGAAGACATTCGGAGCTTCAGGTCCGGCT
AACCAGTTATTCGAGCATTTCGGATTCACTGTAGAGAATGTAGTTAACACTGTTAAGAGTCTTTTCTAA

Upstream 100 bases:

>100_bases
AGAAGAGAAGCGAGAATGGTGATGTTATATTCTTGACAGAGGCAGACTTTAAAGACAGATAAAACTATATGCACAAATGT
GCTTACACAGGGAGGAAACT

Downstream 100 bases:

>100_bases
GATGATAGAATAATAAGAAAATTAATATAAAAAATCAGGGATTTCGGTTATTAAATATAACTGGAATCCCTGATTTTTTT
ATGTTGTCAAGTGCAGAATG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MTNIDEMSINAIRVLSADAIQKANSGHPGLPLGTAPTAYELWTNHMNYNPADPKWENRDRFVLSGGHGSMLLYSLFHLLG
IGNLSLDDVKNFRQMGSKTPGHPEYGHTVGVEATTGPLGQGMAMAVGMAMAEAHLASVFNKDGYNVVDHYTYVLGGDGCM
MEGISSECFSLAGTLGLSKLIVFYDSNNISIEGSTDIAFTENVMKRFEAFGFQTIEVADGNDIEAIGKAIEEAKADKERP
SLIKVNTLIGYGCPAKQGKASAHGEPLGIDNVAALKENLNWPCKGDFEVPQEVYDHYKEIAARMAEPEKEWNKLFAEYCE
KFPEMKELWDKYYNGCDMSDLFNSEEYLAKPEKAEATRSSSGTILNMIKNLMPNLIGGSADLAPSNKTNMKDAGDFSKEN
YAGTNLHFGVREQAMAAIGNGLALHGGLRPFVATFFVFSDYTKPMARLTSLMKLPVVYVFTHDSIGVGEDGPTHEPIEQL
AAFRSMPDFTVFRPCDRTETALAWEYAIESKDEPTALVLTRQNLPQMAGSSKEALKGAYILEDSDKETPDGIIIASGSEV
NLAVSAKAELKNAGIDVRVVSMPSMDVFEKQSDEYKESVLPKSVRKRVAVEALSDFGWYRYVGLDGKVICMKTFGASGPA
NQLFEHFGFTVENVVNTVKSLF

Sequences:

>Translated_662_residues
MTNIDEMSINAIRVLSADAIQKANSGHPGLPLGTAPTAYELWTNHMNYNPADPKWENRDRFVLSGGHGSMLLYSLFHLLG
IGNLSLDDVKNFRQMGSKTPGHPEYGHTVGVEATTGPLGQGMAMAVGMAMAEAHLASVFNKDGYNVVDHYTYVLGGDGCM
MEGISSECFSLAGTLGLSKLIVFYDSNNISIEGSTDIAFTENVMKRFEAFGFQTIEVADGNDIEAIGKAIEEAKADKERP
SLIKVNTLIGYGCPAKQGKASAHGEPLGIDNVAALKENLNWPCKGDFEVPQEVYDHYKEIAARMAEPEKEWNKLFAEYCE
KFPEMKELWDKYYNGCDMSDLFNSEEYLAKPEKAEATRSSSGTILNMIKNLMPNLIGGSADLAPSNKTNMKDAGDFSKEN
YAGTNLHFGVREQAMAAIGNGLALHGGLRPFVATFFVFSDYTKPMARLTSLMKLPVVYVFTHDSIGVGEDGPTHEPIEQL
AAFRSMPDFTVFRPCDRTETALAWEYAIESKDEPTALVLTRQNLPQMAGSSKEALKGAYILEDSDKETPDGIIIASGSEV
NLAVSAKAELKNAGIDVRVVSMPSMDVFEKQSDEYKESVLPKSVRKRVAVEALSDFGWYRYVGLDGKVICMKTFGASGPA
NQLFEHFGFTVENVVNTVKSLF
>Mature_661_residues
TNIDEMSINAIRVLSADAIQKANSGHPGLPLGTAPTAYELWTNHMNYNPADPKWENRDRFVLSGGHGSMLLYSLFHLLGI
GNLSLDDVKNFRQMGSKTPGHPEYGHTVGVEATTGPLGQGMAMAVGMAMAEAHLASVFNKDGYNVVDHYTYVLGGDGCMM
EGISSECFSLAGTLGLSKLIVFYDSNNISIEGSTDIAFTENVMKRFEAFGFQTIEVADGNDIEAIGKAIEEAKADKERPS
LIKVNTLIGYGCPAKQGKASAHGEPLGIDNVAALKENLNWPCKGDFEVPQEVYDHYKEIAARMAEPEKEWNKLFAEYCEK
FPEMKELWDKYYNGCDMSDLFNSEEYLAKPEKAEATRSSSGTILNMIKNLMPNLIGGSADLAPSNKTNMKDAGDFSKENY
AGTNLHFGVREQAMAAIGNGLALHGGLRPFVATFFVFSDYTKPMARLTSLMKLPVVYVFTHDSIGVGEDGPTHEPIEQLA
AFRSMPDFTVFRPCDRTETALAWEYAIESKDEPTALVLTRQNLPQMAGSSKEALKGAYILEDSDKETPDGIIIASGSEVN
LAVSAKAELKNAGIDVRVVSMPSMDVFEKQSDEYKESVLPKSVRKRVAVEALSDFGWYRYVGLDGKVICMKTFGASGPAN
QLFEHFGFTVENVVNTVKSLF

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=582, Percent_Identity=27.8350515463918, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI4507521, Length=582, Percent_Identity=27.8350515463918, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI133778974, Length=584, Percent_Identity=26.3698630136986, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI225637459, Length=582, Percent_Identity=23.5395189003436, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI225637463, Length=479, Percent_Identity=23.7995824634656, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI225637461, Length=483, Percent_Identity=24.223602484472, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI48994911, Length=671, Percent_Identity=49.9254843517139, Blast_Score=658, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=655, Percent_Identity=50.6870229007634, Blast_Score=649, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=693, Percent_Identity=25.974025974026, Blast_Score=172, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6325331, Length=663, Percent_Identity=48.7179487179487, Blast_Score=602, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6319593, Length=669, Percent_Identity=44.2451420029895, Blast_Score=552, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45551847, Length=675, Percent_Identity=26.6666666666667, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI45550715, Length=675, Percent_Identity=26.6666666666667, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24645119, Length=646, Percent_Identity=26.4705882352941, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24666278, Length=662, Percent_Identity=24.773413897281, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72449; Mature: 72318

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIDEMSINAIRVLSADAIQKANSGHPGLPLGTAPTAYELWTNHMNYNPADPKWENRDR
CCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCE
FVLSGGHGSMLLYSLFHLLGIGNLSLDDVKNFRQMGSKTPGHPEYGHTVGVEATTGPLGQ
EEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCC
GMAMAVGMAMAEAHLASVFNKDGYNVVDHYTYVLGGDGCMMEGISSECFSLAGTLGLSKL
CHHHHHHHHHHHHHHHHHHCCCCCEEEHEEEEEEECCCHHHCCCHHHHHHHHHHHCCEEE
IVFYDSNNISIEGSTDIAFTENVMKRFEAFGFQTIEVADGNDIEAIGKAIEEAKADKERP
EEEECCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCC
SLIKVNTLIGYGCPAKQGKASAHGEPLGIDNVAALKENLNWPCKGDFEVPQEVYDHYKEI
CEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
AARMAEPEKEWNKLFAEYCEKFPEMKELWDKYYNGCDMSDLFNSEEYLAKPEKAEATRSS
HHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHCCC
SGTILNMIKNLMPNLIGGSADLAPSNKTNMKDAGDFSKENYAGTNLHFGVREQAMAAIGN
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHCC
GLALHGGLRPFVATFFVFSDYTKPMARLTSLMKLPVVYVFTHDSIGVGEDGPTHEPIEQL
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHH
AAFRSMPDFTVFRPCDRTETALAWEYAIESKDEPTALVLTRQNLPQMAGSSKEALKGAYI
HHHHCCCCCEEECCCCCCCHHEEEEEHHCCCCCCCEEEEECCCCHHHCCCCHHHHCCEEE
LEDSDKETPDGIIIASGSEVNLAVSAKAELKNAGIDVRVVSMPSMDVFEKQSDEYKESVL
EECCCCCCCCCEEEECCCCEEEEEECHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHC
PKSVRKRVAVEALSDFGWYRYVGLDGKVICMKTFGASGPANQLFEHFGFTVENVVNTVKS
CHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHH
LF
HC
>Mature Secondary Structure 
TNIDEMSINAIRVLSADAIQKANSGHPGLPLGTAPTAYELWTNHMNYNPADPKWENRDR
CCCCCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCE
FVLSGGHGSMLLYSLFHLLGIGNLSLDDVKNFRQMGSKTPGHPEYGHTVGVEATTGPLGQ
EEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCC
GMAMAVGMAMAEAHLASVFNKDGYNVVDHYTYVLGGDGCMMEGISSECFSLAGTLGLSKL
CHHHHHHHHHHHHHHHHHHCCCCCEEEHEEEEEEECCCHHHCCCHHHHHHHHHHHCCEEE
IVFYDSNNISIEGSTDIAFTENVMKRFEAFGFQTIEVADGNDIEAIGKAIEEAKADKERP
EEEECCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCC
SLIKVNTLIGYGCPAKQGKASAHGEPLGIDNVAALKENLNWPCKGDFEVPQEVYDHYKEI
CEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
AARMAEPEKEWNKLFAEYCEKFPEMKELWDKYYNGCDMSDLFNSEEYLAKPEKAEATRSS
HHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHCCC
SGTILNMIKNLMPNLIGGSADLAPSNKTNMKDAGDFSKENYAGTNLHFGVREQAMAAIGN
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHCC
GLALHGGLRPFVATFFVFSDYTKPMARLTSLMKLPVVYVFTHDSIGVGEDGPTHEPIEQL
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHH
AAFRSMPDFTVFRPCDRTETALAWEYAIESKDEPTALVLTRQNLPQMAGSSKEALKGAYI
HHHHCCCCCEEECCCCCCCHHEEEEEHHCCCCCCCEEEEECCCCHHHCCCCHHHHCCEEE
LEDSDKETPDGIIIASGSEVNLAVSAKAELKNAGIDVRVVSMPSMDVFEKQSDEYKESVL
EECCCCCCCCCEEEECCCCEEEEEECHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHC
PKSVRKRVAVEALSDFGWYRYVGLDGKVICMKTFGASGPANQLFEHFGFTVENVVNTVKS
CHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHH
LF
HC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642 [H]