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The map label for this gene is phoR [H]

Identifier: 238917774

GI number: 238917774

Start: 1918884

End: 1920311

Strand: Direct

Name: phoR [H]

Synonym: EUBELI_01855

Alternate gene names: 238917774

Gene position: 1918884-1920311 (Clockwise)

Preceding gene: 238917773

Following gene: 238917781

Centisome position: 89.49

GC content: 34.1

Gene sequence:

>1428_bases
TTGAAGGGCTTAAGTACACTGGGGAAGCACATTTTTTTATATATAGCTATATCCATTATAGGATTTATTATTGTATCTAC
TGTATGTTATAAAATTGATTACAAACGCATATACAACTATTATTCAGACAGATTATATCTTCAGGCCAATGAAATAGCCA
ATGAATATGCTCTTGATTATTTCAGTGAAACAAGGCTCCGCTCCATAGAACTTGAACTTCATTCCGTATCCGTGCTTAAT
GACACGCGTATTATTTTTATAACTCCGTCAGGTGATGTCATTCTTGATACTAACGACAGCACTAAAGATAAAAGCAATAA
TGATGAAAAGATATTATATTCTATTGAAGATTTTGACTATGGAGACCTTCACGGAAAACACGATATACTCTGGAATTTTT
ATAATTTGTTAAATGAACCGACACTGAGTGTTTTTGCTCCAATATCTAACTCCTTTGAAATAAAAGGTTATGTTGTAATT
AATATTCCTGATTCTGTAATCACAGACAGGGTTTATGATACATTTAACACTAACTACCTTACACTTATTATTACCCTTTT
CCTTTCAGCTTCTTTCCTCGGATTGTATTTCATTCAGGTTCATAAGCCAATCAAGGAAATCACAAAGGCAACAACTGAAT
ATGGTAAAGGTAATCTTTCTTATCATATCAAGCCAATGCTTAATGACGAAATAGGACGACTTGGAATGTCACTTGACTAT
ATGGCTTCCCAGCTTAATGAATCTGATAAGTTTCAGCAAAAATTCTTATCAAACATTTCTCATGATTTCAGGTCACCTCT
AACATCAATTAAAGGCTACTTAGAGGCAATACAGGACGGAACTATTCCTCCTGAAATGCTTGATAAATATATTGGTATCA
TGCTTTTTGAGACAGAACGTCTTACTAAGCTGACCAGCAACATACTTACACTTAACGAACTGGATCCTAAATCTGTATGC
CTTGATATAAGTGTATTTGACCTTAATTCTATAATCCGTCATACTGTTGAAACATTTGAAGGAACATGCAAGAAAAAAGG
CATTAAATTCAATATAACATATGCCAACAGCATACAAAATGTCAAGGCTGATAAAGGCAGAATACAACAGGTAATTTACA
ATCTTATTGACAATGCAATTAAGTTCAGCAAGGACGGCTCATATATTTATATTACCGTAAAAGAAAAGGGCGAGAAAGCT
CAGATATCCATAAAGGATACCGGCTGTGGAATTTCCAAAGAAGACATTGATAAAATCTGGGACAGATTCTATAAGTCAGA
TTCTTCAAGGGGACGTGATAAGAAAGGTTCCGGTCTTGGTCTTTCAATAACTAAGGAAGTTATTCAGGCACATGGTGAAA
ACATTGATGTTGTAAGTACTTTAGGTGTCGGAACAGAATTCATATTCACACTTGAACTTGCAAAATAA

Upstream 100 bases:

>100_bases
AGAAAATCAAGGATCATGTCCACTGGAATATTGAAACAGTATGGGGAATTGGTTACAAGTTCGTAACTAAATAAAAAGGG
CAGGACAAGGAGGCTTAATA

Downstream 100 bases:

>100_bases
AAAACACACGGACATGCATAACTTGTATGTCCGTGTGTTTTATTATTCCTTCCAGTTAAGTCTGTGAAGATGTCCCTCAC
AATTCATGTGTGAAAAATCA

Product: two-component system OmpR family phosphate regulon sensor histidine kinase PhoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKGLSTLGKHIFLYIAISIIGFIIVSTVCYKIDYKRIYNYYSDRLYLQANEIANEYALDYFSETRLRSIELELHSVSVLN
DTRIIFITPSGDVILDTNDSTKDKSNNDEKILYSIEDFDYGDLHGKHDILWNFYNLLNEPTLSVFAPISNSFEIKGYVVI
NIPDSVITDRVYDTFNTNYLTLIITLFLSASFLGLYFIQVHKPIKEITKATTEYGKGNLSYHIKPMLNDEIGRLGMSLDY
MASQLNESDKFQQKFLSNISHDFRSPLTSIKGYLEAIQDGTIPPEMLDKYIGIMLFETERLTKLTSNILTLNELDPKSVC
LDISVFDLNSIIRHTVETFEGTCKKKGIKFNITYANSIQNVKADKGRIQQVIYNLIDNAIKFSKDGSYIYITVKEKGEKA
QISIKDTGCGISKEDIDKIWDRFYKSDSSRGRDKKGSGLGLSITKEVIQAHGENIDVVSTLGVGTEFIFTLELAK

Sequences:

>Translated_475_residues
MKGLSTLGKHIFLYIAISIIGFIIVSTVCYKIDYKRIYNYYSDRLYLQANEIANEYALDYFSETRLRSIELELHSVSVLN
DTRIIFITPSGDVILDTNDSTKDKSNNDEKILYSIEDFDYGDLHGKHDILWNFYNLLNEPTLSVFAPISNSFEIKGYVVI
NIPDSVITDRVYDTFNTNYLTLIITLFLSASFLGLYFIQVHKPIKEITKATTEYGKGNLSYHIKPMLNDEIGRLGMSLDY
MASQLNESDKFQQKFLSNISHDFRSPLTSIKGYLEAIQDGTIPPEMLDKYIGIMLFETERLTKLTSNILTLNELDPKSVC
LDISVFDLNSIIRHTVETFEGTCKKKGIKFNITYANSIQNVKADKGRIQQVIYNLIDNAIKFSKDGSYIYITVKEKGEKA
QISIKDTGCGISKEDIDKIWDRFYKSDSSRGRDKKGSGLGLSITKEVIQAHGENIDVVSTLGVGTEFIFTLELAK
>Mature_475_residues
MKGLSTLGKHIFLYIAISIIGFIIVSTVCYKIDYKRIYNYYSDRLYLQANEIANEYALDYFSETRLRSIELELHSVSVLN
DTRIIFITPSGDVILDTNDSTKDKSNNDEKILYSIEDFDYGDLHGKHDILWNFYNLLNEPTLSVFAPISNSFEIKGYVVI
NIPDSVITDRVYDTFNTNYLTLIITLFLSASFLGLYFIQVHKPIKEITKATTEYGKGNLSYHIKPMLNDEIGRLGMSLDY
MASQLNESDKFQQKFLSNISHDFRSPLTSIKGYLEAIQDGTIPPEMLDKYIGIMLFETERLTKLTSNILTLNELDPKSVC
LDISVFDLNSIIRHTVETFEGTCKKKGIKFNITYANSIQNVKADKGRIQQVIYNLIDNAIKFSKDGSYIYITVKEKGEKA
QISIKDTGCGISKEDIDKIWDRFYKSDSSRGRDKKGSGLGLSITKEVIQAHGENIDVVSTLGVGTEFIFTLELAK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=27.6679841897233, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=29.6943231441048, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786783, Length=355, Percent_Identity=23.0985915492958, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=27.7310924369748, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789149, Length=244, Percent_Identity=28.6885245901639, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=27.6497695852535, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=27.0742358078603, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790861, Length=313, Percent_Identity=23.3226837060703, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=27.7533039647577, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI87081816, Length=233, Percent_Identity=29.1845493562232, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=24.2647058823529, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=27.4774774774775, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789403, Length=228, Percent_Identity=27.6315789473684, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788279, Length=287, Percent_Identity=26.4808362369338, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787894, Length=297, Percent_Identity=23.9057239057239, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87082128, Length=295, Percent_Identity=22.7118644067797, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=23.4042553191489, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53990; Mature: 53990

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLSTLGKHIFLYIAISIIGFIIVSTVCYKIDYKRIYNYYSDRLYLQANEIANEYALDY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHH
FSETRLRSIELELHSVSVLNDTRIIFITPSGDVILDTNDSTKDKSNNDEKILYSIEDFDY
HHHCCCEEEEEEEEEEEEECCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEEEECCCCC
GDLHGKHDILWNFYNLLNEPTLSVFAPISNSFEIKGYVVINIPDSVITDRVYDTFNTNYL
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEEECCHHHHHHHHHHCCCCCHH
TLIITLFLSASFLGLYFIQVHKPIKEITKATTEYGKGNLSYHIKPMLNDEIGRLGMSLDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCHHH
MASQLNESDKFQQKFLSNISHDFRSPLTSIKGYLEAIQDGTIPPEMLDKYIGIMLFETER
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCEEEEEHHH
LTKLTSNILTLNELDPKSVCLDISVFDLNSIIRHTVETFEGTCKKKGIKFNITYANSIQN
HHHHHHCCEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCC
VKADKGRIQQVIYNLIDNAIKFSKDGSYIYITVKEKGEKAQISIKDTGCGISKEDIDKIW
CCCHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHH
DRFYKSDSSRGRDKKGSGLGLSITKEVIQAHGENIDVVSTLGVGTEFIFTLELAK
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEECC
>Mature Secondary Structure
MKGLSTLGKHIFLYIAISIIGFIIVSTVCYKIDYKRIYNYYSDRLYLQANEIANEYALDY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHH
FSETRLRSIELELHSVSVLNDTRIIFITPSGDVILDTNDSTKDKSNNDEKILYSIEDFDY
HHHCCCEEEEEEEEEEEEECCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEEEECCCCC
GDLHGKHDILWNFYNLLNEPTLSVFAPISNSFEIKGYVVINIPDSVITDRVYDTFNTNYL
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEEECCHHHHHHHHHHCCCCCHH
TLIITLFLSASFLGLYFIQVHKPIKEITKATTEYGKGNLSYHIKPMLNDEIGRLGMSLDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCHHH
MASQLNESDKFQQKFLSNISHDFRSPLTSIKGYLEAIQDGTIPPEMLDKYIGIMLFETER
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCEEEEEHHH
LTKLTSNILTLNELDPKSVCLDISVFDLNSIIRHTVETFEGTCKKKGIKFNITYANSIQN
HHHHHHCCEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCC
VKADKGRIQQVIYNLIDNAIKFSKDGSYIYITVKEKGEKAQISIKDTGCGISKEDIDKIW
CCCHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHH
DRFYKSDSSRGRDKKGSGLGLSITKEVIQAHGENIDVVSTLGVGTEFIFTLELAK
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]