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The map label for this gene is accC1 [H]

Identifier: 238917647

GI number: 238917647

Start: 1793334

End: 1794620

Strand: Reverse

Name: accC1 [H]

Synonym: EUBELI_01726

Alternate gene names: 238917647

Gene position: 1794620-1793334 (Counterclockwise)

Preceding gene: 238917648

Following gene: 238917646

Centisome position: 83.7

GC content: 40.64

Gene sequence:

>1287_bases
ATGGATGTAGAAACCGTAATTGTATATTCAACAGCAGATAAGGATTCACTTGCTGTTATGGCAGCAGACAAGGCAGTTTG
CATTGGACCGGCAAAGGCGGCTGAAAGTTATCTTAATCAGGATGCGATAATAGAAACAGCAATACTGACAGGGTGTGAGG
CAGTCCACCCTGGTTATGGCTTTCTGTCTGAGAATGCTGCATTTGCAAGAAAATGTGAGGAGAACAATCTTATATTTATA
GGACCATCAGCAGACATAATAAGCAGCATGGGAGATAAACAGTCGGCAAGGCAGCTTATGATTGAATGCGGGGTTCCGGT
TGTACCAGGTTCTGATGGTCTGGTTGCAACAGCAGAGGAAGCAGCACACATTGCAGAAAAAATTGGTTATCCGGTACTTA
TTAAAGCGTCAGCTGGAGGCGGTGGAAAAGGAATGCGCAAGGCATTCAGCAGAGAAGATATAGAAAATGCATTTGAAACC
GCTAAGAGTGAAGCTAAAGCTGCATTTGGCAACGATGATATGTACATAGAGAAGCTGATAATCAATCCACGGCATATTGA
GATACAGATTCTTGCAGATAAATATGGCAATACAATATATCTTGGAGAACGTGACTGTTCAATCCAGCGTAATAATCAGA
AGCTTTTAGAGGAAGCTCCGAGTGCAAGATTATGTAAAGATCAGCGGACAGTCATGGGAGAGACTGCAGTAAGAGCTGCG
AAAGCAGCAGGATATTATAGTGCAGGAACTGTTGAATTTGTTGTGAATGAACAGGGTGACTACTATTTTATAGAGATGAA
TACGAGAATACAGGTTGAACATCCGGTAACTGAGCAGGTTACAGGAATTGACCTTATAAGAGAACAGATAAGAATAGCTG
CCGGAATGAAGCTTAATATCACTCAGGAAGATACATGTGTCAATGGACATGCAATTGAGTGCAGAATAAATGCGGCTACA
CCGGGAGTTATTAAATTCTTACATTTTCCAGATGGTTATGGAGTAAGAGTTGAGAGCCATCTTTTTGAAGGTTATGAAGT
GAGTCCGTTTTATGATTCAATGATTGCCAAGATTATAGTGACTGGAAGCAGCAGACTTGAGGCGGTAAGACGATTAAGAA
GAGCTCTTGAGGAACTGATAATTGAAGGAGTTAAGACTAACAGAGAGTTCATGCATCTTCTTACATATCATAAGGATTTT
ATAAGAGGAAATTACAATACAGGTTTCTGGGAGAAGAATCATACCGAAATTGAAAAGTGGCTTAAGGAAGGAATTACAGT
TAAATGA

Upstream 100 bases:

>100_bases
TTGTAATCCTTAATTAACGGAGGTAGCAGAAGTGTTTAAGAGAATACTGATAGCAAACCGTGGTGAAATAGCGTTAAGGA
TAATCAGATGCTGCCGTGAG

Downstream 100 bases:

>100_bases
ATATCAATGACATTTTCTTAAAGCGTAAGAAAAGGTGGGGTATTATCAACAGATTAAGGGATAGTGAGGAACAGGCAGAC
GGAAGCCTTACACCATCAAG

Product: biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MDVETVIVYSTADKDSLAVMAADKAVCIGPAKAAESYLNQDAIIETAILTGCEAVHPGYGFLSENAAFARKCEENNLIFI
GPSADIISSMGDKQSARQLMIECGVPVVPGSDGLVATAEEAAHIAEKIGYPVLIKASAGGGGKGMRKAFSREDIENAFET
AKSEAKAAFGNDDMYIEKLIINPRHIEIQILADKYGNTIYLGERDCSIQRNNQKLLEEAPSARLCKDQRTVMGETAVRAA
KAAGYYSAGTVEFVVNEQGDYYFIEMNTRIQVEHPVTEQVTGIDLIREQIRIAAGMKLNITQEDTCVNGHAIECRINAAT
PGVIKFLHFPDGYGVRVESHLFEGYEVSPFYDSMIAKIIVTGSSRLEAVRRLRRALEELIIEGVKTNREFMHLLTYHKDF
IRGNYNTGFWEKNHTEIEKWLKEGITVK

Sequences:

>Translated_428_residues
MDVETVIVYSTADKDSLAVMAADKAVCIGPAKAAESYLNQDAIIETAILTGCEAVHPGYGFLSENAAFARKCEENNLIFI
GPSADIISSMGDKQSARQLMIECGVPVVPGSDGLVATAEEAAHIAEKIGYPVLIKASAGGGGKGMRKAFSREDIENAFET
AKSEAKAAFGNDDMYIEKLIINPRHIEIQILADKYGNTIYLGERDCSIQRNNQKLLEEAPSARLCKDQRTVMGETAVRAA
KAAGYYSAGTVEFVVNEQGDYYFIEMNTRIQVEHPVTEQVTGIDLIREQIRIAAGMKLNITQEDTCVNGHAIECRINAAT
PGVIKFLHFPDGYGVRVESHLFEGYEVSPFYDSMIAKIIVTGSSRLEAVRRLRRALEELIIEGVKTNREFMHLLTYHKDF
IRGNYNTGFWEKNHTEIEKWLKEGITVK
>Mature_428_residues
MDVETVIVYSTADKDSLAVMAADKAVCIGPAKAAESYLNQDAIIETAILTGCEAVHPGYGFLSENAAFARKCEENNLIFI
GPSADIISSMGDKQSARQLMIECGVPVVPGSDGLVATAEEAAHIAEKIGYPVLIKASAGGGGKGMRKAFSREDIENAFET
AKSEAKAAFGNDDMYIEKLIINPRHIEIQILADKYGNTIYLGERDCSIQRNNQKLLEEAPSARLCKDQRTVMGETAVRAA
KAAGYYSAGTVEFVVNEQGDYYFIEMNTRIQVEHPVTEQVTGIDLIREQIRIAAGMKLNITQEDTCVNGHAIECRINAAT
PGVIKFLHFPDGYGVRVESHLFEGYEVSPFYDSMIAKIIVTGSSRLEAVRRLRRALEELIIEGVKTNREFMHLLTYHKDF
IRGNYNTGFWEKNHTEIEKWLKEGITVK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=422, Percent_Identity=48.8151658767773, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI65506442, Length=422, Percent_Identity=48.8151658767773, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI295821183, Length=422, Percent_Identity=48.8151658767773, Blast_Score=390, Evalue=1e-109,
Organism=Homo sapiens, GI116805327, Length=426, Percent_Identity=44.8356807511737, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI106049528, Length=426, Percent_Identity=42.9577464788732, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI106049295, Length=426, Percent_Identity=42.9577464788732, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI106049292, Length=426, Percent_Identity=42.9577464788732, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI38679960, Length=451, Percent_Identity=31.2638580931264, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI38679977, Length=451, Percent_Identity=31.2638580931264, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI38679967, Length=451, Percent_Identity=31.2638580931264, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI38679974, Length=451, Percent_Identity=31.2638580931264, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI38679971, Length=451, Percent_Identity=31.2638580931264, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI134142062, Length=449, Percent_Identity=31.4031180400891, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI18105007, Length=226, Percent_Identity=24.3362831858407, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789654, Length=420, Percent_Identity=52.3809523809524, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1786216, Length=240, Percent_Identity=25, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71987519, Length=426, Percent_Identity=46.9483568075117, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17567343, Length=426, Percent_Identity=44.6009389671362, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17562816, Length=435, Percent_Identity=42.5287356321839, Blast_Score=342, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI71997168, Length=437, Percent_Identity=33.4096109839817, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=437, Percent_Identity=33.4096109839817, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI133931226, Length=433, Percent_Identity=32.1016166281755, Blast_Score=208, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6319685, Length=416, Percent_Identity=42.0673076923077, Blast_Score=333, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6319695, Length=424, Percent_Identity=42.688679245283, Blast_Score=322, Evalue=9e-89,
Organism=Saccharomyces cerevisiae, GI6321376, Length=424, Percent_Identity=43.3962264150943, Blast_Score=305, Evalue=8e-84,
Organism=Saccharomyces cerevisiae, GI6323863, Length=463, Percent_Identity=30.6695464362851, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324343, Length=475, Percent_Identity=31.3684210526316, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24651757, Length=419, Percent_Identity=43.9140811455847, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24651759, Length=398, Percent_Identity=44.4723618090452, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI281363050, Length=433, Percent_Identity=44.5727482678984, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24652224, Length=433, Percent_Identity=44.5727482678984, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24652222, Length=433, Percent_Identity=44.5727482678984, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24652220, Length=433, Percent_Identity=44.5727482678984, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24652218, Length=433, Percent_Identity=44.5727482678984, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24652212, Length=433, Percent_Identity=44.5727482678984, Blast_Score=347, Evalue=7e-96,
Organism=Drosophila melanogaster, GI24652210, Length=433, Percent_Identity=44.5727482678984, Blast_Score=347, Evalue=7e-96,
Organism=Drosophila melanogaster, GI24652214, Length=433, Percent_Identity=44.5727482678984, Blast_Score=347, Evalue=7e-96,
Organism=Drosophila melanogaster, GI19921944, Length=433, Percent_Identity=44.5727482678984, Blast_Score=347, Evalue=7e-96,
Organism=Drosophila melanogaster, GI24652216, Length=433, Percent_Identity=44.5727482678984, Blast_Score=347, Evalue=7e-96,
Organism=Drosophila melanogaster, GI24586458, Length=443, Percent_Identity=30.9255079006772, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI161076409, Length=443, Percent_Identity=30.9255079006772, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI161076407, Length=443, Percent_Identity=30.9255079006772, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24586460, Length=443, Percent_Identity=30.9255079006772, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 47262; Mature: 47262

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVETVIVYSTADKDSLAVMAADKAVCIGPAKAAESYLNQDAIIETAILTGCEAVHPGYG
CCCEEEEEEEECCCCCEEEEECCCEEEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCC
FLSENAAFARKCEENNLIFIGPSADIISSMGDKQSARQLMIECGVPVVPGSDGLVATAEE
CCCCCCHHHHHCCCCCEEEECCCHHHHHHCCCHHHHHHHHHHCCCEECCCCCCCEEEHHH
AAHIAEKIGYPVLIKASAGGGGKGMRKAFSREDIENAFETAKSEAKAAFGNDDMYIEKLI
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
INPRHIEIQILADKYGNTIYLGERDCSIQRNNQKLLEEAPSARLCKDQRTVMGETAVRAA
ECCCEEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
KAAGYYSAGTVEFVVNEQGDYYFIEMNTRIQVEHPVTEQVTGIDLIREQIRIAAGMKLNI
HHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEC
TQEDTCVNGHAIECRINAATPGVIKFLHFPDGYGVRVESHLFEGYEVSPFYDSMIAKIIV
CCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCEEEEHHCCCCEECCHHHHHHHHHHEE
TGSSRLEAVRRLRRALEELIIEGVKTNREFMHLLTYHKDFIRGNYNTGFWEKNHTEIEKW
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
LKEGITVK
HHCCCCCC
>Mature Secondary Structure
MDVETVIVYSTADKDSLAVMAADKAVCIGPAKAAESYLNQDAIIETAILTGCEAVHPGYG
CCCEEEEEEEECCCCCEEEEECCCEEEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCC
FLSENAAFARKCEENNLIFIGPSADIISSMGDKQSARQLMIECGVPVVPGSDGLVATAEE
CCCCCCHHHHHCCCCCEEEECCCHHHHHHCCCHHHHHHHHHHCCCEECCCCCCCEEEHHH
AAHIAEKIGYPVLIKASAGGGGKGMRKAFSREDIENAFETAKSEAKAAFGNDDMYIEKLI
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
INPRHIEIQILADKYGNTIYLGERDCSIQRNNQKLLEEAPSARLCKDQRTVMGETAVRAA
ECCCEEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
KAAGYYSAGTVEFVVNEQGDYYFIEMNTRIQVEHPVTEQVTGIDLIREQIRIAAGMKLNI
HHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEC
TQEDTCVNGHAIECRINAATPGVIKFLHFPDGYGVRVESHLFEGYEVSPFYDSMIAKIIV
CCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCEEEEHHCCCCEECCHHHHHHHHHHEE
TGSSRLEAVRRLRRALEELIIEGVKTNREFMHLLTYHKDFIRGNYNTGFWEKNHTEIEKW
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
LKEGITVK
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]