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The map label for this gene is nth [H]

Identifier: 238917625

GI number: 238917625

Start: 1769424

End: 1770065

Strand: Reverse

Name: nth [H]

Synonym: EUBELI_01704

Alternate gene names: 238917625

Gene position: 1770065-1769424 (Counterclockwise)

Preceding gene: 238917626

Following gene: 238917624

Centisome position: 82.55

GC content: 42.21

Gene sequence:

>642_bases
ATGACTAAGAAAGAACTTGCTTTAGAGGTTATAAGAAGATTAAAGGCAGAATATCCGGATTCGGAGTGCAGCCTTGATTA
CGATGATGCCTGGAAACTGCTTGTAAGCGTAAGACTTGCGGCACAATGCACTGATGCAAGAGTAAATGTTGTGGTTAAGG
GGCTGTATGAGAAATATCCTGATATAGCATCACTTGCTGCAGCATCTCCGGAAGAGATTGAAAAGATTATAAGACCTTGT
GGTCTTGGAAAAAGCAAGGCAAAGGATATATGTGCATGTATGCGTATGCTTCATGAGCAGTATAACGATAAAGTTCCTGA
CAGCATGGAAGAATTATTAAAGCTTCCTGGAGTTGGAAGAAAGAGTGCCAATCTTATTATGGGTGATGTGTTCGGAAAGC
CGGCAATTGTTACAGATACACACTGTATAAGGCTTTGTAACAGAATAGGTCTTGTAAAAGACGAGAAAGAGCCTAAGAAG
GTTGAGATGGCATTGTGGAAGATAGTCCCGCCGGAAGAAGGAAGCGGATTGTGCCACAGGTTTGTAGACCACGGAAGAGA
AGTATGTACGGCGCGTACTACGCCGCATTGTGAAAGATGCTGCCTTAATGATATCTGCAAGAAAAATGGGATAAAAGTAT
GA

Upstream 100 bases:

>100_bases
AAGGGGAACAGGTTATCTTGTTGGCTGGATGATATTTGCGTGTGTATTGCTTCTTGCAATATTCGGAATTGCTAATTATA
AGAAGAAAGATGCGTAATCT

Downstream 100 bases:

>100_bases
TTGAATACGTATTTTTATTGTGGTAGTATCTTATTGTTGTTCATACTAATGAACAAAATGTATGGGAGGGGAACATGGAA
TTAAAACAGTTAATAAGAAA

Product: DNA-(apurinic or apyrimidinic site) lyase

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MTKKELALEVIRRLKAEYPDSECSLDYDDAWKLLVSVRLAAQCTDARVNVVVKGLYEKYPDIASLAAASPEEIEKIIRPC
GLGKSKAKDICACMRMLHEQYNDKVPDSMEELLKLPGVGRKSANLIMGDVFGKPAIVTDTHCIRLCNRIGLVKDEKEPKK
VEMALWKIVPPEEGSGLCHRFVDHGREVCTARTTPHCERCCLNDICKKNGIKV

Sequences:

>Translated_213_residues
MTKKELALEVIRRLKAEYPDSECSLDYDDAWKLLVSVRLAAQCTDARVNVVVKGLYEKYPDIASLAAASPEEIEKIIRPC
GLGKSKAKDICACMRMLHEQYNDKVPDSMEELLKLPGVGRKSANLIMGDVFGKPAIVTDTHCIRLCNRIGLVKDEKEPKK
VEMALWKIVPPEEGSGLCHRFVDHGREVCTARTTPHCERCCLNDICKKNGIKV
>Mature_212_residues
TKKELALEVIRRLKAEYPDSECSLDYDDAWKLLVSVRLAAQCTDARVNVVVKGLYEKYPDIASLAAASPEEIEKIIRPCG
LGKSKAKDICACMRMLHEQYNDKVPDSMEELLKLPGVGRKSANLIMGDVFGKPAIVTDTHCIRLCNRIGLVKDEKEPKKV
EMALWKIVPPEEGSGLCHRFVDHGREVCTARTTPHCERCCLNDICKKNGIKV

Specific function: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=178, Percent_Identity=29.2134831460674, Blast_Score=78, Evalue=5e-15,
Organism=Escherichia coli, GI1787920, Length=200, Percent_Identity=37.5, Blast_Score=136, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17554540, Length=183, Percent_Identity=30.0546448087432, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550361, Length=175, Percent_Identity=32.5714285714286, Blast_Score=91, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 23842; Mature: 23711

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
8.9 %Cys+Met (Translated Protein)
6.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKELALEVIRRLKAEYPDSECSLDYDDAWKLLVSVRLAAQCTDARVNVVVKGLYEKYP
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
DIASLAAASPEEIEKIIRPCGLGKSKAKDICACMRMLHEQYNDKVPDSMEELLKLPGVGR
CHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCC
KSANLIMGDVFGKPAIVTDTHCIRLCNRIGLVKDEKEPKKVEMALWKIVPPEEGSGLCHR
CCCCCHHHHHCCCCCEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHH
FVDHGREVCTARTTPHCERCCLNDICKKNGIKV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKKELALEVIRRLKAEYPDSECSLDYDDAWKLLVSVRLAAQCTDARVNVVVKGLYEKYP
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
DIASLAAASPEEIEKIIRPCGLGKSKAKDICACMRMLHEQYNDKVPDSMEELLKLPGVGR
CHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCC
KSANLIMGDVFGKPAIVTDTHCIRLCNRIGLVKDEKEPKKVEMALWKIVPPEEGSGLCHR
CCCCCHHHHHCCCCCEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHH
FVDHGREVCTARTTPHCERCCLNDICKKNGIKV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]