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The map label for this gene is thiD [H]

Identifier: 238917324

GI number: 238917324

Start: 1444779

End: 1445585

Strand: Reverse

Name: thiD [H]

Synonym: EUBELI_01399

Alternate gene names: 238917324

Gene position: 1445585-1444779 (Counterclockwise)

Preceding gene: 238917325

Following gene: 238917323

Centisome position: 67.42

GC content: 40.77

Gene sequence:

>807_bases
ATGAATACAGCATTAACAATAGCAGGAAGTGATTGCAGTGGTGGAGCAGGAATACAGGCAGACTTAAAAACATTTGCAGC
ACATAAGGTATATGGAATGTCAGCAATTACTGCCCTTACAGCACAGAATACTTTAGGAGTTACAGGAATATCGGAATCTT
CACCTGAATTTCTTAAGGCACAGCTTGATGCAATATTTACAGATATATATCCTGATGCAGTTAAGATAGGAATGGTTGCG
TCAAAGGAACTTATAGAAACAATAGCAGATGCGTTAATTACATATAAGGCAAGAAATATTGTTCTTGACCCAGTAATGGT
ATCAACAAGTGGAAGCAGACTTATTAAGGAAGATGCAGCAGAGGTTCTTAAAGAACGCCTGATGGTGCTTGCAGATGTTA
TTACACCTAATATTCCGGAGACAGAAGTGCTTACAGGAATGACTGTTGACAGTGCAGATTCAATGGAGAAAGCAGCAATA
AAGATATATGAGAATCTTAAATCAAAAGGAGGACATGCGGCTGTCTTAGTAAAAGGAGGACATGCTGTTCATACGGCTAA
CGACTGTCTGTGTGTAGATGGCAGAATAGTGTGGCTTAATGGGGAGAGAGTTGATAATCCTAACACACATGGAACTGGCT
GTACATTGTCATCAGCCATTGCAGCTAATCTTGCACAGGGATTATCAATAGAAGAAAGTGTGAAGGCAGCTAAAGAGTAC
CTGACAGGTGCGTTGAAAGCAGGGCTTAATCTTGGAAGCGGCAGTGGCCCGCTTGACCATACATACTGGCTTGATATTAA
TAAGTAG

Upstream 100 bases:

>100_bases
TAACCTCGGTGCTTTTTTTGTGCGGGCAGCGATGAGAGAAAACATGGAAAGTTCACAGTCGTGCGGGAAGCGATGAGAAT
AGATGTAGAAAGGAAATTAT

Downstream 100 bases:

>100_bases
TAGAAGGAGAGACAGATGGACAGCTTCTTATATAGTATAAATGCAACGGTACCAATATTTTTAGTTATGATAGTTGGCTG
GGTAATAAAGCAGATTGGCG

Product: hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MNTALTIAGSDCSGGAGIQADLKTFAAHKVYGMSAITALTAQNTLGVTGISESSPEFLKAQLDAIFTDIYPDAVKIGMVA
SKELIETIADALITYKARNIVLDPVMVSTSGSRLIKEDAAEVLKERLMVLADVITPNIPETEVLTGMTVDSADSMEKAAI
KIYENLKSKGGHAAVLVKGGHAVHTANDCLCVDGRIVWLNGERVDNPNTHGTGCTLSSAIAANLAQGLSIEESVKAAKEY
LTGALKAGLNLGSGSGPLDHTYWLDINK

Sequences:

>Translated_268_residues
MNTALTIAGSDCSGGAGIQADLKTFAAHKVYGMSAITALTAQNTLGVTGISESSPEFLKAQLDAIFTDIYPDAVKIGMVA
SKELIETIADALITYKARNIVLDPVMVSTSGSRLIKEDAAEVLKERLMVLADVITPNIPETEVLTGMTVDSADSMEKAAI
KIYENLKSKGGHAAVLVKGGHAVHTANDCLCVDGRIVWLNGERVDNPNTHGTGCTLSSAIAANLAQGLSIEESVKAAKEY
LTGALKAGLNLGSGSGPLDHTYWLDINK
>Mature_268_residues
MNTALTIAGSDCSGGAGIQADLKTFAAHKVYGMSAITALTAQNTLGVTGISESSPEFLKAQLDAIFTDIYPDAVKIGMVA
SKELIETIADALITYKARNIVLDPVMVSTSGSRLIKEDAAEVLKERLMVLADVITPNIPETEVLTGMTVDSADSMEKAAI
KIYENLKSKGGHAAVLVKGGHAVHTANDCLCVDGRIVWLNGERVDNPNTHGTGCTLSSAIAANLAQGLSIEESVKAAKEY
LTGALKAGLNLGSGSGPLDHTYWLDINK

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=266, Percent_Identity=42.1052631578947, Blast_Score=187, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6324997, Length=280, Percent_Identity=36.7857142857143, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6325378, Length=286, Percent_Identity=32.5174825174825, Blast_Score=146, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324517, Length=284, Percent_Identity=35.5633802816901, Blast_Score=136, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28030; Mature: 28030

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTALTIAGSDCSGGAGIQADLKTFAAHKVYGMSAITALTAQNTLGVTGISESSPEFLKA
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHH
QLDAIFTDIYPDAVKIGMVASKELIETIADALITYKARNIVLDPVMVSTSGSRLIKEDAA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCEEEECCCCHHHHHHHH
EVLKERLMVLADVITPNIPETEVLTGMTVDSADSMEKAAIKIYENLKSKGGHAAVLVKGG
HHHHHHHHHHHHHHCCCCCCHHHEECCEECCCHHHHHHHHHHHHHHHCCCCCEEEEEECC
HAVHTANDCLCVDGRIVWLNGERVDNPNTHGTGCTLSSAIAANLAQGLSIEESVKAAKEY
EEEEECCCEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
LTGALKAGLNLGSGSGPLDHTYWLDINK
HHHHHHHCCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MNTALTIAGSDCSGGAGIQADLKTFAAHKVYGMSAITALTAQNTLGVTGISESSPEFLKA
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHH
QLDAIFTDIYPDAVKIGMVASKELIETIADALITYKARNIVLDPVMVSTSGSRLIKEDAA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCEEEECCCCHHHHHHHH
EVLKERLMVLADVITPNIPETEVLTGMTVDSADSMEKAAIKIYENLKSKGGHAAVLVKGG
HHHHHHHHHHHHHHCCCCCCHHHEECCEECCCHHHHHHHHHHHHHHHCCCCCEEEEEECC
HAVHTANDCLCVDGRIVWLNGERVDNPNTHGTGCTLSSAIAANLAQGLSIEESVKAAKEY
EEEEECCCEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
LTGALKAGLNLGSGSGPLDHTYWLDINK
HHHHHHHCCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]