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The map label for this gene is pepD [H]

Identifier: 238917133

GI number: 238917133

Start: 1217116

End: 1218558

Strand: Reverse

Name: pepD [H]

Synonym: EUBELI_01205

Alternate gene names: 238917133

Gene position: 1218558-1217116 (Counterclockwise)

Preceding gene: 238917134

Following gene: 238917132

Centisome position: 56.83

GC content: 38.18

Gene sequence:

>1443_bases
ATGAGTAACAACATTTTAGCAGATTTACAGCCACAGGCTGTCTTTAAATATTTTGAACAGATATGTGCAATTCCACATGG
TTCAGGCAATGTAAAGCAGATAAGTGATTATCTGTGTGAATTTGCACGCAAGAGAAATCTGTGGTTTAATCAGGACGAAA
GTTACAATGTGATAATAAAAAAGCCGGCAAGTAACTGTGAGAGCAAGGCTGCACCTGTTATTTTGCAGGGACATATTGAT
ATGGTTGCCGTCAAAACGAATGATAAGGTTAAAGATATGGAAAAAGAAGGTCTTGACCTGTATATAGATGATGGATATGT
CAAGGCTGACAGGACAACATTAGGTGCTGATGATGGAATTGCAGTTGCTTATGCACTTGCCATATTAGACAGCAAGGATG
TGTGTCATCCGCCGATTGAGGCTGTGTTTACAGTAGACGAGGAAATTGGAATGCTTGGTGCTGAGGCAATTAATACTGAT
TGTCTTGAAGGTAAAATTATGCTTAATATAGATTCTGAGGAGGAGGGGATATTCCTTTCAGGATGTGCTGGGGGAGCAAC
TTTAGAGGCTTCTTATCCATTGAAAAAATCGGATATTACAGGAACACAGATGTCTATTAAAATTAATGGCCTTACAAGTG
GACATTCTGGAACAGATATAATATGCCAGAGAGCTAATGCAAATATTCTGATGGGACGTCTTCTTTTTGCTGTTAAAGAA
TGTGTGAATATTGTAAGCATATCGGGTGGTGAAAAAGATAATTCTATAGCTCCATTTGCAAATGCGGTTATAATGACACA
GGAAGCAGATAAGGTTGCAGAGCTTCTTAATAATACTGCAAATGTTTTGAAAGATGAGTATTCGGTTACTGACCCACAGC
TTACCATCAAGGTGAATTGTGAATGTGAAGGCAGTGCTTTGGCATGTGATGATGTGACAACACAGATGCTTATAAATGTG
CTTAATTTTATACCTGATGGCGTTGTTAAGATGAGTAATGATATTAAGGGTCTGGTGCAGACTTCACTTAATCTGGGAGT
TACAGAGCTGGCTGAGAAAACATTTGCAGCAACCTACTTAATAAGGAGCAGTTCGCAGAGTGAAAAAGAATATCTTACTG
ATAAGGTTGGAAAAATGACTGAATATCTTGGTGGAACTTATGAACTTAAAGGTGTTTATCCGGCATGGGAATTTAAGAAG
AATTCAGCAATCAGGGATATGTTGTGTGAATCTTATAAGAGGCTTTTTGATAAAGAGGCATCTGTGGAAACAATGCATGC
AGGTGTTGAATGCGGTATCATGGCTGCCAAGATTGATGGTCTGGACTGTGTATCTTTTGGTCCTGATATAATTGATATTC
ATACTGTAAAAGAAAAACTGGATATTGCTTCGACACAAAGAATATGGGAGCTTATTCTGAATGTATTAAAGCAGCTTTCA
TAG

Upstream 100 bases:

>100_bases
ACGCATAATCCCACAGTATCCAGACAGTGAAACCCTGAGCCTCACGCCTGCACCACATATCCTGCCGTCCCATCACCACC
ACACCCAAAGGAGGTAAAAT

Downstream 100 bases:

>100_bases
TAAATAATTTAATAAAACTATATCTTGTATATGTCGTATTTGGCTGAATTTTTTTTGACGACGGGAAATCAACCGAATAC
GACATTTTATATACCGTTTA

Product: aminoacylhistidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSNNILADLQPQAVFKYFEQICAIPHGSGNVKQISDYLCEFARKRNLWFNQDESYNVIIKKPASNCESKAAPVILQGHID
MVAVKTNDKVKDMEKEGLDLYIDDGYVKADRTTLGADDGIAVAYALAILDSKDVCHPPIEAVFTVDEEIGMLGAEAINTD
CLEGKIMLNIDSEEEGIFLSGCAGGATLEASYPLKKSDITGTQMSIKINGLTSGHSGTDIICQRANANILMGRLLFAVKE
CVNIVSISGGEKDNSIAPFANAVIMTQEADKVAELLNNTANVLKDEYSVTDPQLTIKVNCECEGSALACDDVTTQMLINV
LNFIPDGVVKMSNDIKGLVQTSLNLGVTELAEKTFAATYLIRSSSQSEKEYLTDKVGKMTEYLGGTYELKGVYPAWEFKK
NSAIRDMLCESYKRLFDKEASVETMHAGVECGIMAAKIDGLDCVSFGPDIIDIHTVKEKLDIASTQRIWELILNVLKQLS

Sequences:

>Translated_480_residues
MSNNILADLQPQAVFKYFEQICAIPHGSGNVKQISDYLCEFARKRNLWFNQDESYNVIIKKPASNCESKAAPVILQGHID
MVAVKTNDKVKDMEKEGLDLYIDDGYVKADRTTLGADDGIAVAYALAILDSKDVCHPPIEAVFTVDEEIGMLGAEAINTD
CLEGKIMLNIDSEEEGIFLSGCAGGATLEASYPLKKSDITGTQMSIKINGLTSGHSGTDIICQRANANILMGRLLFAVKE
CVNIVSISGGEKDNSIAPFANAVIMTQEADKVAELLNNTANVLKDEYSVTDPQLTIKVNCECEGSALACDDVTTQMLINV
LNFIPDGVVKMSNDIKGLVQTSLNLGVTELAEKTFAATYLIRSSSQSEKEYLTDKVGKMTEYLGGTYELKGVYPAWEFKK
NSAIRDMLCESYKRLFDKEASVETMHAGVECGIMAAKIDGLDCVSFGPDIIDIHTVKEKLDIASTQRIWELILNVLKQLS
>Mature_479_residues
SNNILADLQPQAVFKYFEQICAIPHGSGNVKQISDYLCEFARKRNLWFNQDESYNVIIKKPASNCESKAAPVILQGHIDM
VAVKTNDKVKDMEKEGLDLYIDDGYVKADRTTLGADDGIAVAYALAILDSKDVCHPPIEAVFTVDEEIGMLGAEAINTDC
LEGKIMLNIDSEEEGIFLSGCAGGATLEASYPLKKSDITGTQMSIKINGLTSGHSGTDIICQRANANILMGRLLFAVKEC
VNIVSISGGEKDNSIAPFANAVIMTQEADKVAELLNNTANVLKDEYSVTDPQLTIKVNCECEGSALACDDVTTQMLINVL
NFIPDGVVKMSNDIKGLVQTSLNLGVTELAEKTFAATYLIRSSSQSEKEYLTDKVGKMTEYLGGTYELKGVYPAWEFKKN
SAIRDMLCESYKRLFDKEASVETMHAGVECGIMAAKIDGLDCVSFGPDIIDIHTVKEKLDIASTQRIWELILNVLKQLS

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=480, Percent_Identity=34.7916666666667, Blast_Score=305, Evalue=5e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52401; Mature: 52270

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNILADLQPQAVFKYFEQICAIPHGSGNVKQISDYLCEFARKRNLWFNQDESYNVIIK
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
KPASNCESKAAPVILQGHIDMVAVKTNDKVKDMEKEGLDLYIDDGYVKADRTTLGADDGI
CCCCCCCCCCCCEEEECCEEEEEEECCCCHHHHHHCCCEEEEECCEEEECCEECCCCCCH
AVAYALAILDSKDVCHPPIEAVFTVDEEIGMLGAEAINTDCLEGKIMLNIDSEEEGIFLS
HHHHHHHHHCCCCCCCCCCCEEEEECHHHCCCCHHHCCCCCCCCEEEEEECCCCCCEEEE
GCAGGATLEASYPLKKSDITGTQMSIKINGLTSGHSGTDIICQRANANILMGRLLFAVKE
ECCCCCEEEECCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHH
CVNIVSISGGEKDNSIAPFANAVIMTQEADKVAELLNNTANVLKDEYSVTDPQLTIKVNC
HHHEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEE
ECEGSALACDDVTTQMLINVLNFIPDGVVKMSNDIKGLVQTSLNLGVTELAEKTFAATYL
EECCCEEECHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHE
IRSSSQSEKEYLTDKVGKMTEYLGGTYELKGVYPAWEFKKNSAIRDMLCESYKRLFDKEA
EECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCC
SVETMHAGVECGIMAAKIDGLDCVSFGPDIIDIHTVKEKLDIASTQRIWELILNVLKQLS
CHHHHHCCCCCCEEEEEECCCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNNILADLQPQAVFKYFEQICAIPHGSGNVKQISDYLCEFARKRNLWFNQDESYNVIIK
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
KPASNCESKAAPVILQGHIDMVAVKTNDKVKDMEKEGLDLYIDDGYVKADRTTLGADDGI
CCCCCCCCCCCCEEEECCEEEEEEECCCCHHHHHHCCCEEEEECCEEEECCEECCCCCCH
AVAYALAILDSKDVCHPPIEAVFTVDEEIGMLGAEAINTDCLEGKIMLNIDSEEEGIFLS
HHHHHHHHHCCCCCCCCCCCEEEEECHHHCCCCHHHCCCCCCCCEEEEEECCCCCCEEEE
GCAGGATLEASYPLKKSDITGTQMSIKINGLTSGHSGTDIICQRANANILMGRLLFAVKE
ECCCCCEEEECCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHH
CVNIVSISGGEKDNSIAPFANAVIMTQEADKVAELLNNTANVLKDEYSVTDPQLTIKVNC
HHHEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEE
ECEGSALACDDVTTQMLINVLNFIPDGVVKMSNDIKGLVQTSLNLGVTELAEKTFAATYL
EECCCEEECHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHE
IRSSSQSEKEYLTDKVGKMTEYLGGTYELKGVYPAWEFKKNSAIRDMLCESYKRLFDKEA
EECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCC
SVETMHAGVECGIMAAKIDGLDCVSFGPDIIDIHTVKEKLDIASTQRIWELILNVLKQLS
CHHHHHCCCCCCEEEEEECCCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]