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The map label for this gene is srrA [H]

Identifier: 238917107

GI number: 238917107

Start: 1190289

End: 1190966

Strand: Reverse

Name: srrA [H]

Synonym: EUBELI_01177

Alternate gene names: 238917107

Gene position: 1190966-1190289 (Counterclockwise)

Preceding gene: 238917108

Following gene: 238917106

Centisome position: 55.54

GC content: 36.58

Gene sequence:

>678_bases
ATGGATAAGATGAAGGTTTTAGTAGTAGATGATGAAAGCAGAATGAGAAAGCTTGTAAGTGATTTCCTTACAAGAAAAGG
ATATGCTGTTATTGAAGCGGCTGATGGTGTAGAAGCTGTAGATACATTTATGGAGAATAAAGATATTGCACTTATAATTC
TTGATGTTATGATGCCAAGAATGGATGGATGGGAAGTGTGCAGGCAGATAAGAAAGGATTCTAAAGTTCCTATTATAATG
CTTACAGCAAAGGGCGAGGAGATGGATGAACTACAAGGCTTTGAATGTGGAGCTGACGAATATATTGCCAAGCCATTTTC
ACCCAAGATACTTACAGCCAGAGTTGATGCAATTATAAGACGTGCATATGGTGTTGACAGCAACGAGATAATTGAGATTG
GTGGAATTACTATAGATAAAGCAGCACATATCGTTAAGATTGATGGTGAAGAGATAGAGTTAAGCTATAAGGAGTTTGAA
CTGCTTACTTATTTTGTTGAGAATAAAGGGCTTGCGTTGTCTAGAGAGAAGATTCTTAATAATGTATGGAATTATGATTA
CTATGGAGATGCAAGAACTATAGATACCCATGTTAAGAAATTAAGAAAGAAAATGGGTGAGAAGGGTGATTACATCAAGA
CAATCTGGGGTATGGGTTACAAGTTCATTGTTGACTGA

Upstream 100 bases:

>100_bases
AAGTAGTCATAATATAAATATATGAGCAGAGTACACATTTTAAACATATTTATCAGATAGTATATAGATAATTAATTCAC
CGTGAAAGTGAGGATTACAT

Downstream 100 bases:

>100_bases
TTCTGCGTATAAGGAAGGCAATTAAAGATGAAGATACATTCAATTAAGTTTAAGATTACACTTCTTCTGGTAGTTACTGT
TACATGTCTTGTGGCTATGC

Product: two-component system OmpR family response regulator ResD

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MDKMKVLVVDDESRMRKLVSDFLTRKGYAVIEAADGVEAVDTFMENKDIALIILDVMMPRMDGWEVCRQIRKDSKVPIIM
LTAKGEEMDELQGFECGADEYIAKPFSPKILTARVDAIIRRAYGVDSNEIIEIGGITIDKAAHIVKIDGEEIELSYKEFE
LLTYFVENKGLALSREKILNNVWNYDYYGDARTIDTHVKKLRKKMGEKGDYIKTIWGMGYKFIVD

Sequences:

>Translated_225_residues
MDKMKVLVVDDESRMRKLVSDFLTRKGYAVIEAADGVEAVDTFMENKDIALIILDVMMPRMDGWEVCRQIRKDSKVPIIM
LTAKGEEMDELQGFECGADEYIAKPFSPKILTARVDAIIRRAYGVDSNEIIEIGGITIDKAAHIVKIDGEEIELSYKEFE
LLTYFVENKGLALSREKILNNVWNYDYYGDARTIDTHVKKLRKKMGEKGDYIKTIWGMGYKFIVD
>Mature_225_residues
MDKMKVLVVDDESRMRKLVSDFLTRKGYAVIEAADGVEAVDTFMENKDIALIILDVMMPRMDGWEVCRQIRKDSKVPIIM
LTAKGEEMDELQGFECGADEYIAKPFSPKILTARVDAIIRRAYGVDSNEIIEIGGITIDKAAHIVKIDGEEIELSYKEFE
LLTYFVENKGLALSREKILNNVWNYDYYGDARTIDTHVKKLRKKMGEKGDYIKTIWGMGYKFIVD

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=38.5650224215247, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=37.6623376623377, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=35.1351351351351, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=35.1111111111111, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=35.4545454545455, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=32.7510917030568, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=31.3559322033898, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790860, Length=230, Percent_Identity=33.9130434782609, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=31.3636363636364, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=30.7017543859649, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=31.25, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=30.0448430493274, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=28.8288288288288, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=29.3103448275862, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788191, Length=123, Percent_Identity=34.9593495934959, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=124, Percent_Identity=34.6774193548387, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1788550, Length=125, Percent_Identity=28.8, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI145693157, Length=111, Percent_Identity=34.2342342342342, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25782; Mature: 25782

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKMKVLVVDDESRMRKLVSDFLTRKGYAVIEAADGVEAVDTFMENKDIALIILDVMMPR
CCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCEEEEEEEHHCCC
MDGWEVCRQIRKDSKVPIIMLTAKGEEMDELQGFECGADEYIAKPFSPKILTARVDAIIR
CCHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHH
RAYGVDSNEIIEIGGITIDKAAHIVKIDGEEIELSYKEFELLTYFVENKGLALSREKILN
HHHCCCCCCEEEECCEEECCCEEEEEECCCEEEEHHHHHHHHHHHHHCCCCEEHHHHHHH
NVWNYDYYGDARTIDTHVKKLRKKMGEKGDYIKTIWGMGYKFIVD
HHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEC
>Mature Secondary Structure
MDKMKVLVVDDESRMRKLVSDFLTRKGYAVIEAADGVEAVDTFMENKDIALIILDVMMPR
CCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCEEEEEEEHHCCC
MDGWEVCRQIRKDSKVPIIMLTAKGEEMDELQGFECGADEYIAKPFSPKILTARVDAIIR
CCHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHH
RAYGVDSNEIIEIGGITIDKAAHIVKIDGEEIELSYKEFELLTYFVENKGLALSREKILN
HHHCCCCCCEEEECCEEECCCEEEEEECCCEEEEHHHHHHHHHHHHHCCCCEEHHHHHHH
NVWNYDYYGDARTIDTHVKKLRKKMGEKGDYIKTIWGMGYKFIVD
HHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA