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The map label for this gene is coaBC [H]

Identifier: 238917086

GI number: 238917086

Start: 1168115

End: 1169308

Strand: Reverse

Name: coaBC [H]

Synonym: EUBELI_01156

Alternate gene names: 238917086

Gene position: 1169308-1168115 (Counterclockwise)

Preceding gene: 238917087

Following gene: 238917084

Centisome position: 54.53

GC content: 39.03

Gene sequence:

>1194_bases
ATGCTTAAGGGAAAGACAGTTGTTCTTGGAGTAACAGGCAGTATAGCAGCATATAAGATTGCTAATCTTGCAAGTATGCT
TGTAAAGAAGCATGCCAATGTGCATGTTATAATGACTGAGAATGCATGCAATTTTATTAATCCGATAACATTTGAGACAC
TTACAGGAAATAAGTGCTTAGTTGATACATTTGACAGAAACTTCCAGTTTAATGTTGAGCATGTCAGCCTTGCAAAGCTG
GCTGATATATTCCTTGTAGCACCTGCTTCGGCAGATGTAATAGGAAAGATTGCAAATGGGATAGCAGACGATATGCTGAC
TACAACAATTATGGCATGCAAATGTCCAAAGCTTATATCACCTGCGATGAACACTAATATGTTTACTAATCCTATAGTAC
AGGATAATCTTAAGAAATTAGAGCATTATGGATATGAAATTATCCAGCCTGACAGCGGATATCTTGCGTGTGGAGATACA
GGTGCGGGAAAGATGCCGTCGGAGCAGGTTCTTCTTAATTACATCTTAAGGACAATAGCTAAAGATAAGGATATGACCGG
AATTAAGCTTACAGTTACTGCAGGACCTACAAGAGAGAAGTTAGACCCTGTAAGATTCTTATCTAATAATTCCACTGGAA
AAATGGGATATGCAATTGCTAAGATGGCAATGCTTCGTGGAGCGGATGTAACACTTATATCAGGAAAAGTAAGCCTTGAG
CCGGTGCCATTTGTTAAGATGGTGGATATTGTTTCAGCAGAGGATATGTATAATGCAGTAATTAAGAGTGCTAAAGACGC
AGATATAATAATCAAGGCAGCAGCAGTTGCAGATTACAGACCGTCTGATGTAAGCGATGAAAAGATTAAGAAAAAAGATG
GTGATATGTCAATTCCTCTTGAGCGGACTAAAGATATAATCGGCACACTTGGAAGCAGTAAAAGAGATGGATTGTTCCTG
TGCGGATTCTCAATGGAAACAGAGCATATGCTTGACAATTCCAAGGTGAAGCTTACAAAGAAGAATCTTGATATGATAGT
GGCTAATAATGTCAAAGTGGCAGGAGCCGGATTTGGAACAGATACCAATGTGGTTACTGTTATTACTAAAGATGCAGTCG
AGGAGCTTCCTATGATGAGTAAGGAAGAGGTTGCTGACGCACTTCTTGACAGAATAATGAAAGCAAGACAATAA

Upstream 100 bases:

>100_bases
GAATAGAATTGAGACTGACCCTGCACTTCTTATAAGAGGTCTGAAATACATTTATGATAAAAATGTCTAGAAAGTGGCTG
AATAGGCGGGAGGAGATAAT

Downstream 100 bases:

>100_bases
TAATAAAAACAGGCTGCCGGTTAACTGGCAGCCTGTTTTGCTACATATCTTCGCCAAGTGCCTTGATTCTTCCGTAAGTA
CTTAAAAGATATAAGCCGGA

Product: phosphopantothenoylcysteine decarboxylase / phosphopantothenate-cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MLKGKTVVLGVTGSIAAYKIANLASMLVKKHANVHVIMTENACNFINPITFETLTGNKCLVDTFDRNFQFNVEHVSLAKL
ADIFLVAPASADVIGKIANGIADDMLTTTIMACKCPKLISPAMNTNMFTNPIVQDNLKKLEHYGYEIIQPDSGYLACGDT
GAGKMPSEQVLLNYILRTIAKDKDMTGIKLTVTAGPTREKLDPVRFLSNNSTGKMGYAIAKMAMLRGADVTLISGKVSLE
PVPFVKMVDIVSAEDMYNAVIKSAKDADIIIKAAAVADYRPSDVSDEKIKKKDGDMSIPLERTKDIIGTLGSSKRDGLFL
CGFSMETEHMLDNSKVKLTKKNLDMIVANNVKVAGAGFGTDTNVVTVITKDAVEELPMMSKEEVADALLDRIMKARQ

Sequences:

>Translated_397_residues
MLKGKTVVLGVTGSIAAYKIANLASMLVKKHANVHVIMTENACNFINPITFETLTGNKCLVDTFDRNFQFNVEHVSLAKL
ADIFLVAPASADVIGKIANGIADDMLTTTIMACKCPKLISPAMNTNMFTNPIVQDNLKKLEHYGYEIIQPDSGYLACGDT
GAGKMPSEQVLLNYILRTIAKDKDMTGIKLTVTAGPTREKLDPVRFLSNNSTGKMGYAIAKMAMLRGADVTLISGKVSLE
PVPFVKMVDIVSAEDMYNAVIKSAKDADIIIKAAAVADYRPSDVSDEKIKKKDGDMSIPLERTKDIIGTLGSSKRDGLFL
CGFSMETEHMLDNSKVKLTKKNLDMIVANNVKVAGAGFGTDTNVVTVITKDAVEELPMMSKEEVADALLDRIMKARQ
>Mature_397_residues
MLKGKTVVLGVTGSIAAYKIANLASMLVKKHANVHVIMTENACNFINPITFETLTGNKCLVDTFDRNFQFNVEHVSLAKL
ADIFLVAPASADVIGKIANGIADDMLTTTIMACKCPKLISPAMNTNMFTNPIVQDNLKKLEHYGYEIIQPDSGYLACGDT
GAGKMPSEQVLLNYILRTIAKDKDMTGIKLTVTAGPTREKLDPVRFLSNNSTGKMGYAIAKMAMLRGADVTLISGKVSLE
PVPFVKMVDIVSAEDMYNAVIKSAKDADIIIKAAAVADYRPSDVSDEKIKKKDGDMSIPLERTKDIIGTLGSSKRDGLFL
CGFSMETEHMLDNSKVKLTKKNLDMIVANNVKVAGAGFGTDTNVVTVITKDAVEELPMMSKEEVADALLDRIMKARQ

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=165, Percent_Identity=37.5757575757576, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI87082301, Length=395, Percent_Identity=40.5063291139241, Blast_Score=281, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI17560194, Length=170, Percent_Identity=34.1176470588235, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322762, Length=190, Percent_Identity=31.0526315789474, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24657262, Length=172, Percent_Identity=33.7209302325581, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43041; Mature: 43041

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGKTVVLGVTGSIAAYKIANLASMLVKKHANVHVIMTENACNFINPITFETLTGNKCL
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCEEE
VDTFDRNFQFNVEHVSLAKLADIFLVAPASADVIGKIANGIADDMLTTTIMACKCPKLIS
EEECCCCEEEEEHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHC
PAMNTNMFTNPIVQDNLKKLEHYGYEIIQPDSGYLACGDTGAGKMPSEQVLLNYILRTIA
CCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
KDKDMTGIKLTVTAGPTREKLDPVRFLSNNSTGKMGYAIAKMAMLRGADVTLISGKVSLE
CCCCCCCEEEEEECCCCHHHCCHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECEEECC
PVPFVKMVDIVSAEDMYNAVIKSAKDADIIIKAAAVADYRPSDVSDEKIKKKDGDMSIPL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCCCH
ERTKDIIGTLGSSKRDGLFLCGFSMETEHMLDNSKVKLTKKNLDMIVANNVKVAGAGFGT
HHHHHHHHHCCCCCCCCEEEEECCCCHHHHCCCCEEEEEECCCCEEEECCEEEEECCCCC
DTNVVTVITKDAVEELPMMSKEEVADALLDRIMKARQ
CCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKGKTVVLGVTGSIAAYKIANLASMLVKKHANVHVIMTENACNFINPITFETLTGNKCL
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCEEE
VDTFDRNFQFNVEHVSLAKLADIFLVAPASADVIGKIANGIADDMLTTTIMACKCPKLIS
EEECCCCEEEEEHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHC
PAMNTNMFTNPIVQDNLKKLEHYGYEIIQPDSGYLACGDTGAGKMPSEQVLLNYILRTIA
CCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
KDKDMTGIKLTVTAGPTREKLDPVRFLSNNSTGKMGYAIAKMAMLRGADVTLISGKVSLE
CCCCCCCEEEEEECCCCHHHCCHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECEEECC
PVPFVKMVDIVSAEDMYNAVIKSAKDADIIIKAAAVADYRPSDVSDEKIKKKDGDMSIPL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCCCH
ERTKDIIGTLGSSKRDGLFLCGFSMETEHMLDNSKVKLTKKNLDMIVANNVKVAGAGFGT
HHHHHHHHHCCCCCCCCEEEEECCCCHHHHCCCCEEEEEECCCCEEEECCEEEEECCCCC
DTNVVTVITKDAVEELPMMSKEEVADALLDRIMKARQ
CCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]