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The map label for this gene is proC [H]

Identifier: 238917047

GI number: 238917047

Start: 1126386

End: 1127183

Strand: Reverse

Name: proC [H]

Synonym: EUBELI_01117

Alternate gene names: 238917047

Gene position: 1127183-1126386 (Counterclockwise)

Preceding gene: 238917048

Following gene: 238917046

Centisome position: 52.57

GC content: 38.6

Gene sequence:

>798_bases
ATGGCTAAGATTGGTTTTATTGGAATGGGTAACATGGGATATGCAATGCTTAAAGGTGCTTTGGCAGCATTTTCACCATC
AGATATTATATTTTCATCACCAGACAGAGAAAAATGCGAAAGAATATCATCTGAGACATGCGTACGATTTGCAGAAAGTA
ATGCAGAGTGTGGCAATAATGCCAAGTATATTGTGCTTGCAGTAAAACCACAGATGTATCCAACAGTACTTAAGAATATT
GTCAATGTGGTAACAGAAGAAAGTGTTATTATATCAATTGCACCGGGAATTACTATTGCGTCTATAAAGAATGCTCTTGG
AAGCAACATAAGAGTTGTAAGAGCAATGCCTAATACACCTGCACTTATTGGAGAGGGAATGACAGGAGTATCATATAATA
TGACAGATTTTTCATTTGACGAAAGAGATGTTATTGATAAATTCTTTAATTCATTTGGAAAGGTTGTTTATGTTGATGAA
AAGCTTATGGATGGAATAGTGTGTGCAAGTGGCAGCTCGCCTGCCTATGTATATATGTTCATTGAGGCGATGGCGGATAG
CGTTGTAAAGTATGGAATAAAGAGAGATGACGCATATAAGCTGGTTGCCCAGACTGTCCTTGGTTCGGCAAAGATGGTAC
TTGAGTCAGGAGAACACCCGGCAGTACTTAAAGATAAAGTGTGTTCGCCTGGTGGAACAACAATTCAGGCTGTTTCTGCA
CTTGAAGAGAATGGTTTCAGAAATGCACTTATCAAAGCAACTGACGCCTGCTATGACAAATGTACAAGCATTAAGTAA

Upstream 100 bases:

>100_bases
TAATTAATATAAGCTTGCTTTTTATAAGCAAGCTTATTTAATAACTGGGTATATAATAATCAGATATTATATATCATGAT
ATAGTTGGGAGGATATACAT

Downstream 100 bases:

>100_bases
CATTTTTATATAGAAAGGCTGAATATGAAAGAACATATTAAAAGAGTGGATAGAATTCTTAAATATAAGGGTTCAATACT
TGATATATATACAGATGTTA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MAKIGFIGMGNMGYAMLKGALAAFSPSDIIFSSPDREKCERISSETCVRFAESNAECGNNAKYIVLAVKPQMYPTVLKNI
VNVVTEESVIISIAPGITIASIKNALGSNIRVVRAMPNTPALIGEGMTGVSYNMTDFSFDERDVIDKFFNSFGKVVYVDE
KLMDGIVCASGSSPAYVYMFIEAMADSVVKYGIKRDDAYKLVAQTVLGSAKMVLESGEHPAVLKDKVCSPGGTTIQAVSA
LEENGFRNALIKATDACYDKCTSIK

Sequences:

>Translated_265_residues
MAKIGFIGMGNMGYAMLKGALAAFSPSDIIFSSPDREKCERISSETCVRFAESNAECGNNAKYIVLAVKPQMYPTVLKNI
VNVVTEESVIISIAPGITIASIKNALGSNIRVVRAMPNTPALIGEGMTGVSYNMTDFSFDERDVIDKFFNSFGKVVYVDE
KLMDGIVCASGSSPAYVYMFIEAMADSVVKYGIKRDDAYKLVAQTVLGSAKMVLESGEHPAVLKDKVCSPGGTTIQAVSA
LEENGFRNALIKATDACYDKCTSIK
>Mature_264_residues
AKIGFIGMGNMGYAMLKGALAAFSPSDIIFSSPDREKCERISSETCVRFAESNAECGNNAKYIVLAVKPQMYPTVLKNIV
NVVTEESVIISIAPGITIASIKNALGSNIRVVRAMPNTPALIGEGMTGVSYNMTDFSFDERDVIDKFFNSFGKVVYVDEK
LMDGIVCASGSSPAYVYMFIEAMADSVVKYGIKRDDAYKLVAQTVLGSAKMVLESGEHPAVLKDKVCSPGGTTIQAVSAL
EENGFRNALIKATDACYDKCTSIK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=260, Percent_Identity=39.2307692307692, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI24797097, Length=260, Percent_Identity=38.0769230769231, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI24797095, Length=260, Percent_Identity=38.0769230769231, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI198041662, Length=257, Percent_Identity=35.408560311284, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI1786585, Length=260, Percent_Identity=47.6923076923077, Blast_Score=232, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=37.4531835205993, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17540664, Length=273, Percent_Identity=34.7985347985348, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6320861, Length=274, Percent_Identity=31.021897810219, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21358587, Length=271, Percent_Identity=38.0073800738007, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24648116, Length=267, Percent_Identity=34.8314606741573, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=42.0118343195266, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28489; Mature: 28358

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIGFIGMGNMGYAMLKGALAAFSPSDIIFSSPDREKCERISSETCVRFAESNAECGNN
CCEEEEEEECCCCHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
AKYIVLAVKPQMYPTVLKNIVNVVTEESVIISIAPGITIASIKNALGSNIRVVRAMPNTP
CEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCEEEEEECCCCC
ALIGEGMTGVSYNMTDFSFDERDVIDKFFNSFGKVVYVDEKLMDGIVCASGSSPAYVYMF
HHHCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCEEEECHHHHCCEEEECCCCCEEEEHH
IEAMADSVVKYGIKRDDAYKLVAQTVLGSAKMVLESGEHPAVLKDKVCSPGGTTIQAVSA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHH
LEENGFRNALIKATDACYDKCTSIK
HHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKIGFIGMGNMGYAMLKGALAAFSPSDIIFSSPDREKCERISSETCVRFAESNAECGNN
CEEEEEEECCCCHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
AKYIVLAVKPQMYPTVLKNIVNVVTEESVIISIAPGITIASIKNALGSNIRVVRAMPNTP
CEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCEEEEEECCCCC
ALIGEGMTGVSYNMTDFSFDERDVIDKFFNSFGKVVYVDEKLMDGIVCASGSSPAYVYMF
HHHCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCEEEECHHHHCCEEEECCCCCEEEEHH
IEAMADSVVKYGIKRDDAYKLVAQTVLGSAKMVLESGEHPAVLKDKVCSPGGTTIQAVSA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHH
LEENGFRNALIKATDACYDKCTSIK
HHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]