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The map label for this gene is obg [H]

Identifier: 238916945

GI number: 238916945

Start: 1029022

End: 1030314

Strand: Reverse

Name: obg [H]

Synonym: EUBELI_01014

Alternate gene names: 238916945

Gene position: 1030314-1029022 (Counterclockwise)

Preceding gene: 238916946

Following gene: 238916944

Centisome position: 48.05

GC content: 39.91

Gene sequence:

>1293_bases
ATGTTTGCAGACAGAGTCCGCATTTTTATTAAATCCGGCAAGGGTGGAGATGGTCATGTAAGCTTCCGTAGAGAGCTTTA
TGTTCCTGCTGGCGGTCCTGATGGCGGCAATGGCGGTCATGGCGGAGATATTATTTTTATGGTCGATAAAGGCCTTAATA
CACTCGGTGATTTCAGACATAACAGCAAATATATTGCTGAAAGCGGCGAAGAAGGCGGCAAGAGAAGATGCACAGGTAAA
GATGGTGAAGACCTTATAATTAAAGTGCCTGAAGGAACTGTTATATATGATGATGAATCCGGTAAAGTTATTGCAGATAT
GTCTGGAGATAACCTTCAGGAAACTATTCTTAAAGGTGGCCGTGGTGGTAAAGGTAACATGAACTATGCTACATCTACCA
TGCAGGCTCCACAGTATGCACAGCCGGGACAGGATGCACAGGAATTATGGGTTCGTCTTGAACTTAAGGTTATTGCTGAT
GTTGGTCTTGTAGGATTCCCTAATGTTGGTAAATCAACATTTTTATCAAGAGTAACTAATGCAAGACCTAAGATTGCCAA
TTATCATTTCACAACACTTAATCCTAACCTTGGTGTTGTTGATCTTGATGGTGGTAAAGGTTTCGTTATTGCTGATATTC
CTGGTCTTATTGAGGGTGCATCAGAAGGTGTTGGTCTTGGACACCAGTTCTTACGTCATATTGAGAGAACTAAAGTCATT
ATTCATATTGTTGATGCAGCTTCAACTGAAGGCCGTGATCCTATAGCTGATATTAAGGCTATTAACAAAGAGCTTGAGAA
TTATAATCCTAAGCTTCTTGAAAGACCACAGGTTATAGCAGCTAATAAGATTGATGTTATATATGATGATGGCAGTGACC
CTGTACAGGCTATAAGAGATGCATTTGAGCCGGAAGGTATTAAGGTATATCCTATATCAGCTGTTACAGGACAGGGCGTT
AAAGAGCTGTTATACGCAGTCAGAACACTGCTTGATAACTTCAAGGACGAACCTGTATTATTTGAAAAAGAATTTGACTA
CGACGAGCTTATGGATAATCCTAACGAAAGCTTTGAAGTTTCTATTAACGAAGATGGCGTATACGTTGTCAACGGACCAA
AGATTGATAAAATGCTTGGTTATACTAACCTTGAATCTGAAAAGGGATTTGATTTCTTCCAGAAATTCATGAAGCGCTCA
GGTGTTCTTGATGAACTTGAGAAGCTTGGAATTGAGGAAGGCGATACAGTTATCGTTGGTGATTACCTTGAGTTTGATTA
CTATAAAGCATAA

Upstream 100 bases:

>100_bases
TTTTTAGCTCCAAGTCTTCGGATTTGGAGCTTTTTTCTTAATTTGTAAATGTTAATTCTAAACAGTTAACATAATTTAAA
TATAGAATGGAGGAAAGGTT

Downstream 100 bases:

>100_bases
TAATAGGAGAGAATATATGACAAGCAAACAGAGAGCTTATTTAAAGGGTCTTGCAATGACAATGGATCCAATATTCCAGT
TTGGAAAGAACAGTCTTACT

Product: GTP-binding protein

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MFADRVRIFIKSGKGGDGHVSFRRELYVPAGGPDGGNGGHGGDIIFMVDKGLNTLGDFRHNSKYIAESGEEGGKRRCTGK
DGEDLIIKVPEGTVIYDDESGKVIADMSGDNLQETILKGGRGGKGNMNYATSTMQAPQYAQPGQDAQELWVRLELKVIAD
VGLVGFPNVGKSTFLSRVTNARPKIANYHFTTLNPNLGVVDLDGGKGFVIADIPGLIEGASEGVGLGHQFLRHIERTKVI
IHIVDAASTEGRDPIADIKAINKELENYNPKLLERPQVIAANKIDVIYDDGSDPVQAIRDAFEPEGIKVYPISAVTGQGV
KELLYAVRTLLDNFKDEPVLFEKEFDYDELMDNPNESFEVSINEDGVYVVNGPKIDKMLGYTNLESEKGFDFFQKFMKRS
GVLDELEKLGIEEGDTVIVGDYLEFDYYKA

Sequences:

>Translated_430_residues
MFADRVRIFIKSGKGGDGHVSFRRELYVPAGGPDGGNGGHGGDIIFMVDKGLNTLGDFRHNSKYIAESGEEGGKRRCTGK
DGEDLIIKVPEGTVIYDDESGKVIADMSGDNLQETILKGGRGGKGNMNYATSTMQAPQYAQPGQDAQELWVRLELKVIAD
VGLVGFPNVGKSTFLSRVTNARPKIANYHFTTLNPNLGVVDLDGGKGFVIADIPGLIEGASEGVGLGHQFLRHIERTKVI
IHIVDAASTEGRDPIADIKAINKELENYNPKLLERPQVIAANKIDVIYDDGSDPVQAIRDAFEPEGIKVYPISAVTGQGV
KELLYAVRTLLDNFKDEPVLFEKEFDYDELMDNPNESFEVSINEDGVYVVNGPKIDKMLGYTNLESEKGFDFFQKFMKRS
GVLDELEKLGIEEGDTVIVGDYLEFDYYKA
>Mature_430_residues
MFADRVRIFIKSGKGGDGHVSFRRELYVPAGGPDGGNGGHGGDIIFMVDKGLNTLGDFRHNSKYIAESGEEGGKRRCTGK
DGEDLIIKVPEGTVIYDDESGKVIADMSGDNLQETILKGGRGGKGNMNYATSTMQAPQYAQPGQDAQELWVRLELKVIAD
VGLVGFPNVGKSTFLSRVTNARPKIANYHFTTLNPNLGVVDLDGGKGFVIADIPGLIEGASEGVGLGHQFLRHIERTKVI
IHIVDAASTEGRDPIADIKAINKELENYNPKLLERPQVIAANKIDVIYDDGSDPVQAIRDAFEPEGIKVYPISAVTGQGV
KELLYAVRTLLDNFKDEPVLFEKEFDYDELMDNPNESFEVSINEDGVYVVNGPKIDKMLGYTNLESEKGFDFFQKFMKRS
GVLDELEKLGIEEGDTVIVGDYLEFDYYKA

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=335, Percent_Identity=40, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI111955139, Length=358, Percent_Identity=34.3575418994413, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI111955063, Length=251, Percent_Identity=36.2549800796813, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4557537, Length=121, Percent_Identity=36.3636363636364, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI58761500, Length=129, Percent_Identity=36.4341085271318, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=37.007874015748, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789574, Length=331, Percent_Identity=45.3172205438066, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1787454, Length=138, Percent_Identity=36.231884057971, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082120, Length=170, Percent_Identity=37.0588235294118, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790615, Length=179, Percent_Identity=30.1675977653631, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=331, Percent_Identity=36.8580060422961, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17552324, Length=321, Percent_Identity=29.9065420560748, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17509631, Length=161, Percent_Identity=29.8136645962733, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71981008, Length=118, Percent_Identity=36.4406779661017, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=35.5932203389831, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=165, Percent_Identity=40.6060606060606, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321612, Length=223, Percent_Identity=29.5964125560538, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=37.3015873015873, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20129375, Length=338, Percent_Identity=39.3491124260355, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24585318, Length=399, Percent_Identity=33.8345864661654, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI21356473, Length=117, Percent_Identity=36.7521367521368, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17981711, Length=118, Percent_Identity=36.4406779661017, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640873, Length=128, Percent_Identity=35.15625, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640877, Length=128, Percent_Identity=35.15625, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640875, Length=128, Percent_Identity=35.15625, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 47171; Mature: 47171

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFADRVRIFIKSGKGGDGHVSFRRELYVPAGGPDGGNGGHGGDIIFMVDKGLNTLGDFRH
CCCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHCC
NSKYIAESGEEGGKRRCTGKDGEDLIIKVPEGTVIYDDESGKVIADMSGDNLQETILKGG
CCCHHHCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCEEEECCCCCHHHHHHCCC
RGGKGNMNYATSTMQAPQYAQPGQDAQELWVRLELKVIADVGLVGFPNVGKSTFLSRVTN
CCCCCCCCEEHHCCCCCCCCCCCCCHHHHHEEEEEEEEEECCCCCCCCCCHHHHHHHHHC
ARPKIANYHFTTLNPNLGVVDLDGGKGFVIADIPGLIEGASEGVGLGHQFLRHIERTKVI
CCCCCCEEEEEEECCCCCEEEECCCCEEEEEECCHHHCCCCCCCCHHHHHHHHHHHCEEE
IHIVDAASTEGRDPIADIKAINKELENYNPKLLERPQVIAANKIDVIYDDGSDPVQAIRD
EEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCEEEECCEEEEECCCCCHHHHHHH
AFEPEGIKVYPISAVTGQGVKELLYAVRTLLDNFKDEPVLFEKEFDYDELMDNPNESFEV
HCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHCCCCCCEEE
SINEDGVYVVNGPKIDKMLGYTNLESEKGFDFFQKFMKRSGVLDELEKLGIEEGDTVIVG
EECCCCEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEE
DYLEFDYYKA
CCCCCCEECC
>Mature Secondary Structure
MFADRVRIFIKSGKGGDGHVSFRRELYVPAGGPDGGNGGHGGDIIFMVDKGLNTLGDFRH
CCCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHCC
NSKYIAESGEEGGKRRCTGKDGEDLIIKVPEGTVIYDDESGKVIADMSGDNLQETILKGG
CCCHHHCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCEEEECCCCCHHHHHHCCC
RGGKGNMNYATSTMQAPQYAQPGQDAQELWVRLELKVIADVGLVGFPNVGKSTFLSRVTN
CCCCCCCCEEHHCCCCCCCCCCCCCHHHHHEEEEEEEEEECCCCCCCCCCHHHHHHHHHC
ARPKIANYHFTTLNPNLGVVDLDGGKGFVIADIPGLIEGASEGVGLGHQFLRHIERTKVI
CCCCCCEEEEEEECCCCCEEEECCCCEEEEEECCHHHCCCCCCCCHHHHHHHHHHHCEEE
IHIVDAASTEGRDPIADIKAINKELENYNPKLLERPQVIAANKIDVIYDDGSDPVQAIRD
EEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCEEEECCEEEEECCCCCHHHHHHH
AFEPEGIKVYPISAVTGQGVKELLYAVRTLLDNFKDEPVLFEKEFDYDELMDNPNESFEV
HCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHCCCCCCEEE
SINEDGVYVVNGPKIDKMLGYTNLESEKGFDFFQKFMKRSGVLDELEKLGIEEGDTVIVG
EECCCCEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEE
DYLEFDYYKA
CCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA