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The map label for this gene is mutS [H]

Identifier: 238916895

GI number: 238916895

Start: 980259

End: 981941

Strand: Direct

Name: mutS [H]

Synonym: EUBELI_00964

Alternate gene names: 238916895

Gene position: 980259-981941 (Clockwise)

Preceding gene: 238916894

Following gene: 238916896

Centisome position: 45.72

GC content: 35.95

Gene sequence:

>1683_bases
ATGACAGATACAGATTTAGAGATTATTGTTTTTGTACTGCTGGCTGTTGCAATCGGCGTGTATGTATGTGTAAGCAGCAG
TATTAAGCGGAAGAAGGCAGCGGAGAATACCATAAAGAAAGCGTGGGGCAAACGTGCTGTATACAAGGGAACAGATGAGA
GTTTTGAATATATATCGCATTATGCCAAAGGTAATCCGAGTGAATCTATGATTGATGATATAACATGGAATGATCTTGGC
ATGGATGAAGTATTTAAATGTATTAATAATACTAATTCATCTGTTGGACAGGAATATCTATATAAGATGTTAAGAGAACC
GGTTGCAGATGCAGAAAAGCTTCACGAACTGGACAGGCTTGCAGATGAATTCACAGCTAATGAAAAGGAAAGAATTACAA
TCCAGAAGATATTTATGAATATGGGAAAAAGCCGTAAGATTGCAGTTACAGATTATATCGGTTATATAATGGATATAGAG
CAGGGAAGTAATATTGTGCATTATCTTGCGTGGGTATTTCTTATAGCTTCAATTCTTGTTACGGTTCTTGTAACTCCGGT
GCTTGGAATATGGCTCATAATTGCGTCGGTAGCATTTTCAATAATTACTTATTACAAGTATAAGGCTAAGATTGAGAATT
ATTTCAAATGTATTAATGTTATTGTGAAAATGGCATCGGCATCTGAAGATATATGTGAAAGCAATATAAGTTTTCTTGAA
CCAGAGTGTAACAGGCTTAAAGAGATATTAAAGAGCTTTTCTAAAGTAACAAAAGGCTCATGGATGATTGAGTCAGGCAA
TGTTGATGGTTCAATCGGAGAGGTTGTACTTGATTATCTAAGAATGATAACGCACATGGATATTGTGAAGTTTAATAAGA
TGACAAAGCTTATAACTGCCAAAAGTGAGGATGCATATAACCTTGTAGATACACTTGGATTCATAGAGACATCAATTGCT
GTTGCATCATTCAGGGAAAGCCTGCCATTTTACTGTAAGCCTGAATTTATGGAGAATACTAATAACCTTAGTGTGAAAGA
AGTGTATCATCCGCTTATAGATAATCCTGTGTGCAATTCAATAACAACTAAAGGAAATGTTCTCCTTACAGGTTCTAATG
CTTCGGGTAAATCAACATTTTTAAAGACAATAGCAATCAACAGTATTCTGGCACAGACTATAGGAACAAGTCTTTCCAAA
GAATACATTGCTCCGGTATATAGGATATATTCTTCAATGGCATTAAGGGATGACCTTGCTAATTCAGACAGTTACTATAT
TGTTGAGATTAAGTCATTAAAGAGAATTCTTGATGCAGTTGGTAAAAAAGGTAGAACAGTTCTATGTTTTATTGATGAGG
TACTTCGTGGAACTAACACTGTTGAGAGAATTGCAGCATCATCAGAGATATTAAAGAATCTTAATACAGGCAGGGCGTTG
TGCTTTGCAGCAACACATGATATTGAGCTTACAACAATACTTAAGGACTGTTACAGCAACTATCATTTTCAGGAGGAAGT
TACTGAGGATGAGGTTAAGTTTGATTATAAGCTGTATGCCGGACCTGCAACAACAAGGAATGCAATCAAGCTTCTTAATG
TTATAGGGTATGATAAGAATATAATTAAGGGAGCCGAACAGCGTGCAATGCATTTCCTGACAGATGGAAACTGGAAATCT
TGA

Upstream 100 bases:

>100_bases
AGCTGTCAGCACAGGAGAGACAGACAGGATTTACTAAAATGATGGAGACAGCTCTTGAAACTGCAGTCAGATTGCAGAAT
AACAGGCAGATGGAGGCTTT

Downstream 100 bases:

>100_bases
TAAATGTTGTTGCTTGTGATATTATAAATTATTGCGAAGGCTTTTATTATAATTCGTGGAGGTAATAATATGGTTGGGTT
AGTCGGCGTACTCGTAGGTG

Product: DNA mismatch repair protein MSH4

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MTDTDLEIIVFVLLAVAIGVYVCVSSSIKRKKAAENTIKKAWGKRAVYKGTDESFEYISHYAKGNPSESMIDDITWNDLG
MDEVFKCINNTNSSVGQEYLYKMLREPVADAEKLHELDRLADEFTANEKERITIQKIFMNMGKSRKIAVTDYIGYIMDIE
QGSNIVHYLAWVFLIASILVTVLVTPVLGIWLIIASVAFSIITYYKYKAKIENYFKCINVIVKMASASEDICESNISFLE
PECNRLKEILKSFSKVTKGSWMIESGNVDGSIGEVVLDYLRMITHMDIVKFNKMTKLITAKSEDAYNLVDTLGFIETSIA
VASFRESLPFYCKPEFMENTNNLSVKEVYHPLIDNPVCNSITTKGNVLLTGSNASGKSTFLKTIAINSILAQTIGTSLSK
EYIAPVYRIYSSMALRDDLANSDSYYIVEIKSLKRILDAVGKKGRTVLCFIDEVLRGTNTVERIAASSEILKNLNTGRAL
CFAATHDIELTTILKDCYSNYHFQEEVTEDEVKFDYKLYAGPATTRNAIKLLNVIGYDKNIIKGAEQRAMHFLTDGNWKS

Sequences:

>Translated_560_residues
MTDTDLEIIVFVLLAVAIGVYVCVSSSIKRKKAAENTIKKAWGKRAVYKGTDESFEYISHYAKGNPSESMIDDITWNDLG
MDEVFKCINNTNSSVGQEYLYKMLREPVADAEKLHELDRLADEFTANEKERITIQKIFMNMGKSRKIAVTDYIGYIMDIE
QGSNIVHYLAWVFLIASILVTVLVTPVLGIWLIIASVAFSIITYYKYKAKIENYFKCINVIVKMASASEDICESNISFLE
PECNRLKEILKSFSKVTKGSWMIESGNVDGSIGEVVLDYLRMITHMDIVKFNKMTKLITAKSEDAYNLVDTLGFIETSIA
VASFRESLPFYCKPEFMENTNNLSVKEVYHPLIDNPVCNSITTKGNVLLTGSNASGKSTFLKTIAINSILAQTIGTSLSK
EYIAPVYRIYSSMALRDDLANSDSYYIVEIKSLKRILDAVGKKGRTVLCFIDEVLRGTNTVERIAASSEILKNLNTGRAL
CFAATHDIELTTILKDCYSNYHFQEEVTEDEVKFDYKLYAGPATTRNAIKLLNVIGYDKNIIKGAEQRAMHFLTDGNWKS
>Mature_559_residues
TDTDLEIIVFVLLAVAIGVYVCVSSSIKRKKAAENTIKKAWGKRAVYKGTDESFEYISHYAKGNPSESMIDDITWNDLGM
DEVFKCINNTNSSVGQEYLYKMLREPVADAEKLHELDRLADEFTANEKERITIQKIFMNMGKSRKIAVTDYIGYIMDIEQ
GSNIVHYLAWVFLIASILVTVLVTPVLGIWLIIASVAFSIITYYKYKAKIENYFKCINVIVKMASASEDICESNISFLEP
ECNRLKEILKSFSKVTKGSWMIESGNVDGSIGEVVLDYLRMITHMDIVKFNKMTKLITAKSEDAYNLVDTLGFIETSIAV
ASFRESLPFYCKPEFMENTNNLSVKEVYHPLIDNPVCNSITTKGNVLLTGSNASGKSTFLKTIAINSILAQTIGTSLSKE
YIAPVYRIYSSMALRDDLANSDSYYIVEIKSLKRILDAVGKKGRTVLCFIDEVLRGTNTVERIAASSEILKNLNTGRALC
FAATHDIELTTILKDCYSNYHFQEEVTEDEVKFDYKLYAGPATTRNAIKLLNVIGYDKNIIKGAEQRAMHFLTDGNWKS

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=295, Percent_Identity=29.8305084745763, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1789089, Length=232, Percent_Identity=27.5862068965517, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17534743, Length=234, Percent_Identity=30.3418803418803, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17508445, Length=313, Percent_Identity=26.517571884984, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17508447, Length=257, Percent_Identity=24.9027237354086, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319935, Length=233, Percent_Identity=28.755364806867, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320302, Length=186, Percent_Identity=29.5698924731183, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321109, Length=236, Percent_Identity=27.9661016949153, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321912, Length=272, Percent_Identity=27.9411764705882, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 63006; Mature: 62875

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTDLEIIVFVLLAVAIGVYVCVSSSIKRKKAAENTIKKAWGKRAVYKGTDESFEYISH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
YAKGNPSESMIDDITWNDLGMDEVFKCINNTNSSVGQEYLYKMLREPVADAEKLHELDRL
HHCCCCCHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEFTANEKERITIQKIFMNMGKSRKIAVTDYIGYIMDIEQGSNIVHYLAWVFLIASILV
HHHHCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHECCCCCHHHHHHHHHHHHHHHHH
TVLVTPVLGIWLIIASVAFSIITYYKYKAKIENYFKCINVIVKMASASEDICESNISFLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHCC
PECNRLKEILKSFSKVTKGSWMIESGNVDGSIGEVVLDYLRMITHMDIVKFNKMTKLITA
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KSEDAYNLVDTLGFIETSIAVASFRESLPFYCKPEFMENTNNLSVKEVYHPLIDNPVCNS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHCCCCCCCC
ITTKGNVLLTGSNASGKSTFLKTIAINSILAQTIGTSLSKEYIAPVYRIYSSMALRDDLA
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NSDSYYIVEIKSLKRILDAVGKKGRTVLCFIDEVLRGTNTVERIAASSEILKNLNTGRAL
CCCCEEEEEHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCCEE
CFAATHDIELTTILKDCYSNYHFQEEVTEDEVKFDYKLYAGPATTRNAIKLLNVIGYDKN
EEEEECCCHHHHHHHHHHHCCCCHHHCCHHHHEEEEEEEECCCCHHHHHHHHHHHCCCHH
IIKGAEQRAMHFLTDGNWKS
HHHCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TDTDLEIIVFVLLAVAIGVYVCVSSSIKRKKAAENTIKKAWGKRAVYKGTDESFEYISH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
YAKGNPSESMIDDITWNDLGMDEVFKCINNTNSSVGQEYLYKMLREPVADAEKLHELDRL
HHCCCCCHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEFTANEKERITIQKIFMNMGKSRKIAVTDYIGYIMDIEQGSNIVHYLAWVFLIASILV
HHHHCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHECCCCCHHHHHHHHHHHHHHHHH
TVLVTPVLGIWLIIASVAFSIITYYKYKAKIENYFKCINVIVKMASASEDICESNISFLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHCC
PECNRLKEILKSFSKVTKGSWMIESGNVDGSIGEVVLDYLRMITHMDIVKFNKMTKLITA
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KSEDAYNLVDTLGFIETSIAVASFRESLPFYCKPEFMENTNNLSVKEVYHPLIDNPVCNS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHCCCCCCCC
ITTKGNVLLTGSNASGKSTFLKTIAINSILAQTIGTSLSKEYIAPVYRIYSSMALRDDLA
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NSDSYYIVEIKSLKRILDAVGKKGRTVLCFIDEVLRGTNTVERIAASSEILKNLNTGRAL
CCCCEEEEEHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCCEE
CFAATHDIELTTILKDCYSNYHFQEEVTEDEVKFDYKLYAGPATTRNAIKLLNVIGYDKN
EEEEECCCHHHHHHHHHHHCCCCHHHCCHHHHEEEEEEEECCCCHHHHHHHHHHHCCCHH
IIKGAEQRAMHFLTDGNWKS
HHHCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA