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The map label for this gene is apt [H]

Identifier: 238916893

GI number: 238916893

Start: 978937

End: 979464

Strand: Direct

Name: apt [H]

Synonym: EUBELI_00962

Alternate gene names: 238916893

Gene position: 978937-979464 (Clockwise)

Preceding gene: 238916892

Following gene: 238916894

Centisome position: 45.66

GC content: 38.64

Gene sequence:

>528_bases
ATGAGTAAAAAAGTTGAAGATTATGTAAGAAGTATACCTGATTTCCCGGAACCGGGGATTATATTCAGGGATGTTACAAG
TGTTATCCAGAGTCCTGAGGGATTAAAGCTTGCAATAGACGGTCTTACAGATCTTATAGGGGATACAGAATTTGATGTTG
TAGTAGGACCAGAATCAAGAGGGTTTATATTTGGCGTTCCTGTTGCATATAATACCGGTAAGGGATTTGTTCCTGTAAGA
AAGAAGGGAAAGCTTCCGTGTGAGACTATATCAGCAGATTATGAACTTGAATATGGTACAGCTACTATAGAGATGCATAA
GGATGCGATTACTCCGGGACAGAAGGTTATTATTGTTGATGATCTGATTGCTACAGGCGGAACAACAGAAGCTATTATCA
AGCTTGTAGAAGAGCTTGGAGGAGAAGTAGTGAAAGTTCTTTTTCTTATGGAGCTTGAAGGACTTAAAGGAAGAGATAAG
ATTGCAGGATATGATGTCGAGTCAGTAATTAAATACCCAGGTAAATAA

Upstream 100 bases:

>100_bases
TTGTGTGTCTTATTGTGTAAAAAATGCTTTATTTAGGGCTTATAATATGATAAAATACTAAATATATTTGTGTGTCAAAA
CTAAGGAGGATATACACATT

Downstream 100 bases:

>100_bases
TTATTCGGGCTGCTTTATTATATAAAGCAGCCTTTTTAAGATTGATAACAGGAGGCAGATATGGGGACACCACATAATGA
AGCACAGACAGGAGATATAG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MSKKVEDYVRSIPDFPEPGIIFRDVTSVIQSPEGLKLAIDGLTDLIGDTEFDVVVGPESRGFIFGVPVAYNTGKGFVPVR
KKGKLPCETISADYELEYGTATIEMHKDAITPGQKVIIVDDLIATGGTTEAIIKLVEELGGEVVKVLFLMELEGLKGRDK
IAGYDVESVIKYPGK

Sequences:

>Translated_175_residues
MSKKVEDYVRSIPDFPEPGIIFRDVTSVIQSPEGLKLAIDGLTDLIGDTEFDVVVGPESRGFIFGVPVAYNTGKGFVPVR
KKGKLPCETISADYELEYGTATIEMHKDAITPGQKVIIVDDLIATGGTTEAIIKLVEELGGEVVKVLFLMELEGLKGRDK
IAGYDVESVIKYPGK
>Mature_174_residues
SKKVEDYVRSIPDFPEPGIIFRDVTSVIQSPEGLKLAIDGLTDLIGDTEFDVVVGPESRGFIFGVPVAYNTGKGFVPVRK
KGKLPCETISADYELEYGTATIEMHKDAITPGQKVIIVDDLIATGGTTEAIIKLVEELGGEVVKVLFLMELEGLKGRDKI
AGYDVESVIKYPGK

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=45.6140350877193, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=48, Blast_Score=124, Evalue=3e-29,
Organism=Escherichia coli, GI1786675, Length=173, Percent_Identity=50.2890173410405, Blast_Score=171, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=41.5204678362573, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=157, Percent_Identity=45.2229299363057, Blast_Score=121, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=166, Percent_Identity=31.9277108433735, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17136334, Length=172, Percent_Identity=47.093023255814, Blast_Score=146, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 18978; Mature: 18847

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKVEDYVRSIPDFPEPGIIFRDVTSVIQSPEGLKLAIDGLTDLIGDTEFDVVVGPESR
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEECHHHHHHCCCCEEEEECCCCC
GFIFGVPVAYNTGKGFVPVRKKGKLPCETISADYELEYGTATIEMHKDAITPGQKVIIVD
CEEEECCEEEECCCCCEEECCCCCCCHHCCCCCEEEECCEEEEEECCCCCCCCCEEEEEE
DLIATGGTTEAIIKLVEELGGEVVKVLFLMELEGLKGRDKIAGYDVESVIKYPGK
CEECCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCC
>Mature Secondary Structure 
SKKVEDYVRSIPDFPEPGIIFRDVTSVIQSPEGLKLAIDGLTDLIGDTEFDVVVGPESR
CCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEECHHHHHHCCCCEEEEECCCCC
GFIFGVPVAYNTGKGFVPVRKKGKLPCETISADYELEYGTATIEMHKDAITPGQKVIIVD
CEEEECCEEEECCCCCEEECCCCCCCHHCCCCCEEEECCEEEEEECCCCCCCCCEEEEEE
DLIATGGTTEAIIKLVEELGGEVVKVLFLMELEGLKGRDKIAGYDVESVIKYPGK
CEECCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA