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The map label for this gene is tabA [H]

Identifier: 238916881

GI number: 238916881

Start: 967509

End: 968789

Strand: Direct

Name: tabA [H]

Synonym: EUBELI_00950

Alternate gene names: 238916881

Gene position: 967509-968789 (Clockwise)

Preceding gene: 238916880

Following gene: 238916882

Centisome position: 45.12

GC content: 38.72

Gene sequence:

>1281_bases
ATGAGTAAGAAAAAGACATTTGTTACACTTGAACAGCTTAAGGAAATCGACAAGACATATCCGACTCCTTATCATCTCTA
TGATGAGAAGGGAATCAGAGAGAACGCTAAGAGATTAAAGGAAGCATTCTCATGGAATAAAGGTTATAGAGAGTATTTTG
CTGTGAAGGCTACTCCTAATCCATATATTTTAAAGATATTAAAGGATTATGGCTGCGGTGTTGACTGTGCATCTATGGCA
GAGCTTATGATGGGTTACGCTCTTGATTATAAGCCGGAAGAGATTATGTTCTCATCTAATGATACTCCTGCGGAAGAGTA
TGCATATGCTAATGAGATAGGTGCTACTATTAATCTTGATGATATTACTCATATTGAGTTTCTTGATAAGATATTAGACG
GTAAGTTTCCTGAAACAATGAGCTGCCGTTACAATCCGGGCGGATATTTCCAGCTTGGAACATCTATTATGGATAATCCT
GGTGATGCCAAGTATGGTATGACACATGACCAGATTATTGAAGCATTTAAGATATTAAAGAGCAAGGGGGTTAAGCATTT
TGGTATCCATTCATTCCTTGCAAGTAATACAGTATCTAATGAATATTATCCGACACTTGCCAAGATTTTATTCGAGCTTG
CAGTTGAGTTAAGAGACAAGACTGGAGCAGATATTAAATTTGTAAACCTTTCAGGCGGTGTTGGTGTTGCCTACAAGCCA
GAACAGGAGCCTAACGATATTGCAGTTATCGGTGAAGGAGTACATAAGGTATATGATGAGGTTCTTGGTGCGGCTGGAAT
GGGTGATGTTGCAATTTATACAGAGCTTGGAAGATTTATGCTTGCTCCATATGGCTGTCTTGTAACTAAGGCAATTCATG
AGAAGCATATCTATAAGGAATACATCGGAGTTGATGCATGTGCATCTAACCTTATGCGTCCGGCGATCTATGGTGCATAT
CATCATATTACTGTTGCGGGTAAGGAAGATGCACCTTGCGACCATAAGTATGATGTTACAGGTTCTTTATGTGAGAACAG
TGATAAGTTCGCAATTGACAGAATGCTTCCTAAGATTGATATGGGTGATTATCTTATTATCCATGATACAGGAGCACACG
GTTTCTCTATGGGATACCAGTATAATGGAAAGTTAAGATCAGCAGAACTTCTTCTTAAGGAAGACGGCAGTGTCCAGATG
ATCAGACGAGCAGAGACAATCAAGGATTACTATGCTACATTTGATTTCTGTGATGCGTTGGATAAGTTGAATTTAAAATA
A

Upstream 100 bases:

>100_bases
ATAATATAGGATTTCTTACAGTGGCCTGACTATGCGTTGGTGCTGTGTGCGTGGGCTTGCGAAAGATTTTTAGAAATTCA
GCACAGAAACGAGGAAGATA

Downstream 100 bases:

>100_bases
ACGAGGTTTGATACATTGAAGAATTTAGGTTATATAGCAGGCGAAATTACAAAGGGAAAGAATCTTTCAGAAAATCTTTT
AAAGTATGGTAATGGAATGT

Product: diaminopimelate decarboxylase

Products: L-lysine; CO2

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSKKKTFVTLEQLKEIDKTYPTPYHLYDEKGIRENAKRLKEAFSWNKGYREYFAVKATPNPYILKILKDYGCGVDCASMA
ELMMGYALDYKPEEIMFSSNDTPAEEYAYANEIGATINLDDITHIEFLDKILDGKFPETMSCRYNPGGYFQLGTSIMDNP
GDAKYGMTHDQIIEAFKILKSKGVKHFGIHSFLASNTVSNEYYPTLAKILFELAVELRDKTGADIKFVNLSGGVGVAYKP
EQEPNDIAVIGEGVHKVYDEVLGAAGMGDVAIYTELGRFMLAPYGCLVTKAIHEKHIYKEYIGVDACASNLMRPAIYGAY
HHITVAGKEDAPCDHKYDVTGSLCENSDKFAIDRMLPKIDMGDYLIIHDTGAHGFSMGYQYNGKLRSAELLLKEDGSVQM
IRRAETIKDYYATFDFCDALDKLNLK

Sequences:

>Translated_426_residues
MSKKKTFVTLEQLKEIDKTYPTPYHLYDEKGIRENAKRLKEAFSWNKGYREYFAVKATPNPYILKILKDYGCGVDCASMA
ELMMGYALDYKPEEIMFSSNDTPAEEYAYANEIGATINLDDITHIEFLDKILDGKFPETMSCRYNPGGYFQLGTSIMDNP
GDAKYGMTHDQIIEAFKILKSKGVKHFGIHSFLASNTVSNEYYPTLAKILFELAVELRDKTGADIKFVNLSGGVGVAYKP
EQEPNDIAVIGEGVHKVYDEVLGAAGMGDVAIYTELGRFMLAPYGCLVTKAIHEKHIYKEYIGVDACASNLMRPAIYGAY
HHITVAGKEDAPCDHKYDVTGSLCENSDKFAIDRMLPKIDMGDYLIIHDTGAHGFSMGYQYNGKLRSAELLLKEDGSVQM
IRRAETIKDYYATFDFCDALDKLNLK
>Mature_425_residues
SKKKTFVTLEQLKEIDKTYPTPYHLYDEKGIRENAKRLKEAFSWNKGYREYFAVKATPNPYILKILKDYGCGVDCASMAE
LMMGYALDYKPEEIMFSSNDTPAEEYAYANEIGATINLDDITHIEFLDKILDGKFPETMSCRYNPGGYFQLGTSIMDNPG
DAKYGMTHDQIIEAFKILKSKGVKHFGIHSFLASNTVSNEYYPTLAKILFELAVELRDKTGADIKFVNLSGGVGVAYKPE
QEPNDIAVIGEGVHKVYDEVLGAAGMGDVAIYTELGRFMLAPYGCLVTKAIHEKHIYKEYIGVDACASNLMRPAIYGAYH
HITVAGKEDAPCDHKYDVTGSLCENSDKFAIDRMLPKIDMGDYLIIHDTGAHGFSMGYQYNGKLRSAELLLKEDGSVQMI
RRAETIKDYYATFDFCDALDKLNLK

Specific function: Involved in tabtoxin production and pathogenicity [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=420, Percent_Identity=28.3333333333333, Blast_Score=155, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24586472, Length=357, Percent_Identity=25.2100840336134, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: 4.1.1.20

Molecular weight: Translated: 47828; Mature: 47697

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKKTFVTLEQLKEIDKTYPTPYHLYDEKGIRENAKRLKEAFSWNKGYREYFAVKATPN
CCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCC
PYILKILKDYGCGVDCASMAELMMGYALDYKPEEIMFSSNDTPAEEYAYANEIGATINLD
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHEEECCCCCCHHHHHHHHHCCCEEECC
DITHIEFLDKILDGKFPETMSCRYNPGGYFQLGTSIMDNPGDAKYGMTHDQIIEAFKILK
CCHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCHHHCCCCCCCCCCCHHHHHHHHHHHH
SKGVKHFGIHSFLASNTVSNEYYPTLAKILFELAVELRDKTGADIKFVNLSGGVGVAYKP
HCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEECC
EQEPNDIAVIGEGVHKVYDEVLGAAGMGDVAIYTELGRFMLAPYGCLVTKAIHEKHIYKE
CCCCCCEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YIGVDACASNLMRPAIYGAYHHITVAGKEDAPCDHKYDVTGSLCENSDKFAIDRMLPKID
HHCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHCCCCCEEHHHHCCCCC
MGDYLIIHDTGAHGFSMGYQYNGKLRSAELLLKEDGSVQMIRRAETIKDYYATFDFCDAL
CCCEEEEECCCCCCEECCEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
DKLNLK
HHCCCC
>Mature Secondary Structure 
SKKKTFVTLEQLKEIDKTYPTPYHLYDEKGIRENAKRLKEAFSWNKGYREYFAVKATPN
CCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCC
PYILKILKDYGCGVDCASMAELMMGYALDYKPEEIMFSSNDTPAEEYAYANEIGATINLD
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHEEECCCCCCHHHHHHHHHCCCEEECC
DITHIEFLDKILDGKFPETMSCRYNPGGYFQLGTSIMDNPGDAKYGMTHDQIIEAFKILK
CCHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCHHHCCCCCCCCCCCHHHHHHHHHHHH
SKGVKHFGIHSFLASNTVSNEYYPTLAKILFELAVELRDKTGADIKFVNLSGGVGVAYKP
HCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEECC
EQEPNDIAVIGEGVHKVYDEVLGAAGMGDVAIYTELGRFMLAPYGCLVTKAIHEKHIYKE
CCCCCCEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YIGVDACASNLMRPAIYGAYHHITVAGKEDAPCDHKYDVTGSLCENSDKFAIDRMLPKID
HHCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHCCCCCEEHHHHCCCCC
MGDYLIIHDTGAHGFSMGYQYNGKLRSAELLLKEDGSVQMIRRAETIKDYYATFDFCDAL
CCCEEEEECCCCCCEECCEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
DKLNLK
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: D-Lysine; Pyridoxal 5'-phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1.7 {meso-2,6-diamininoheptanedioate}} [C]

Substrates: meso-2,6-diaminoheptanedioate

Specific reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2

General reaction: Decarboxylation [C]

Inhibitor: 2, 3-Diaminopropionic acid; Glutamic acid; L-Cystine; L-Lysine; Penicillamine [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1515668 [H]