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The map label for this gene is uxaA [H]

Identifier: 238916840

GI number: 238916840

Start: 919741

End: 921228

Strand: Direct

Name: uxaA [H]

Synonym: EUBELI_00908

Alternate gene names: 238916840

Gene position: 919741-921228 (Clockwise)

Preceding gene: 238916839

Following gene: 238916841

Centisome position: 42.89

GC content: 40.39

Gene sequence:

>1488_bases
ATGCAGGATTTTATTAAGATTAATAAAGATGATAATGTTGCTGTAGCATTAAAGCCTATTGCTAAAGGCACAACTCTTAA
TGTTGCAGGAATTGATGTGACAACTGTAGAAGATATTCCACAGGGACACAAGTTTGTAATTAAGGCTATCAAGAATGGTG
ATCCGGTTATCAAATATGGTTTCAGAATTGGATTTGCACAGGCTGATATTCCGGTTGGAGCATGGGTTCATACTCATAAC
TTAAAGACTGGTCTTGGCGAATTACTTGAATATACTTATGAACCAGAGGGACATAAGGATGTTGAGCCTACTGAGCCAGC
TTATTTCGATGGATATATGAGAGAGAACGGCAAGGTTGGTGTCCGTAACGAAGTATGGATTGTTCCTACAGTTGGATGCG
TTAACTCAATTGCAAGAGCAATTGAAGCAACAGCAAGAGCTAACAAGCCAGAAGGAGTAGATGAAGTAGTTGCATTTACT
CATCCATATGGATGTTCACAGACAACAGAAGATCAGGAGAATACAAGAAAGATTCTTGCTGATTTAATTAATCATCCTAA
TGCAGGTGCAGTTCTTGTACTTGGTCTTGGATGTGAGAACAGCCGTATTGAAGTTCTTAAGGATTATATCGGAGAGGTTA
ATCCAGACAGAGTTAAGTTCCTTCAGGTTCAGGATGTTGAGAACGAGCAGGAAGAAGCAGAGAAGCTTATGAACGAGCTT
ATGGCTTATGCTGCTACATTTAAGCGTGAAAAGGTTAATGCAAAGGAACTTATCATTGGTATGAAGTGTGGTGGTTCTGA
TGGATTATCAGGTATCACAGCTAATCCAACAGTTGGTCTTTTCTCAGATATGCTTGTATCTAAGGGTGGTACAACTATCC
TTACAGAAGTTCCAGAGATGTTCGGTGCTGAGACAATTCTTATGAACAGATGTGCTAACAAGGAACTCTTCGAGAAGACA
GTTCACCTTATTAATGACTTTAAGGAATACTTCATTAAGAATGGTCAGGAGATTTACGAGAATCCATCTCCAGGAAACAA
GGATGGTGGTATCACAACTCTTGAGGACAAGTCTTTAGGATGTACACAGAAGTCAGGAAGCTCATTAGTAAAGGGTGTTC
TTGCATATGCAGAGCCAGTTAATACTAAGGGGCTTAATCTTCTCAGCGCACCTGGTAACGACCTTGTTGCTGCAACAGCT
TGTGCAGCTTCAGGTGCACAGATGGTTCTTTTCACAACTGGACGTGGAACACCATTTGCATCACCGGTTCCTACAGTTAA
GATTGCAACTAATTCAAGACTTGCAGGAAATAAGGGCAACTGGATTGACTTCAATGCAGGAAGAATTGTTACAGATGATC
TTCCACTTGAAGATGCAGCTAAGGAACTTTTCCAGCTTGTATTAGATGTTGCTTCTGGTAAGAAGGTTAAGGCTGAGATA
GCAGGATTCCATGATCTTGCAATCTTTAAGCAGGGTGTAACTTTATAA

Upstream 100 bases:

>100_bases
TGACGACTAATTAACAGGCCCTTTGAGTGATTACAGAGCGGATGTTTTTATATTCATCCGCTCTTATTTAATATAATAAT
TAGAATTACAAGGAGAATAT

Downstream 100 bases:

>100_bases
TTGCTTGCTATAATGATATTTTTCTAAGATGTCGGTTATAGTTTTATAGAAGAATTTTAATAATTGGGGGTTTATAAAAG
CCTGCCAAATGTATCATAAA

Product: altronate hydrolase

Products: NA

Alternate protein names: Altronic acid hydratase [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MQDFIKINKDDNVAVALKPIAKGTTLNVAGIDVTTVEDIPQGHKFVIKAIKNGDPVIKYGFRIGFAQADIPVGAWVHTHN
LKTGLGELLEYTYEPEGHKDVEPTEPAYFDGYMRENGKVGVRNEVWIVPTVGCVNSIARAIEATARANKPEGVDEVVAFT
HPYGCSQTTEDQENTRKILADLINHPNAGAVLVLGLGCENSRIEVLKDYIGEVNPDRVKFLQVQDVENEQEEAEKLMNEL
MAYAATFKREKVNAKELIIGMKCGGSDGLSGITANPTVGLFSDMLVSKGGTTILTEVPEMFGAETILMNRCANKELFEKT
VHLINDFKEYFIKNGQEIYENPSPGNKDGGITTLEDKSLGCTQKSGSSLVKGVLAYAEPVNTKGLNLLSAPGNDLVAATA
CAASGAQMVLFTTGRGTPFASPVPTVKIATNSRLAGNKGNWIDFNAGRIVTDDLPLEDAAKELFQLVLDVASGKKVKAEI
AGFHDLAIFKQGVTL

Sequences:

>Translated_495_residues
MQDFIKINKDDNVAVALKPIAKGTTLNVAGIDVTTVEDIPQGHKFVIKAIKNGDPVIKYGFRIGFAQADIPVGAWVHTHN
LKTGLGELLEYTYEPEGHKDVEPTEPAYFDGYMRENGKVGVRNEVWIVPTVGCVNSIARAIEATARANKPEGVDEVVAFT
HPYGCSQTTEDQENTRKILADLINHPNAGAVLVLGLGCENSRIEVLKDYIGEVNPDRVKFLQVQDVENEQEEAEKLMNEL
MAYAATFKREKVNAKELIIGMKCGGSDGLSGITANPTVGLFSDMLVSKGGTTILTEVPEMFGAETILMNRCANKELFEKT
VHLINDFKEYFIKNGQEIYENPSPGNKDGGITTLEDKSLGCTQKSGSSLVKGVLAYAEPVNTKGLNLLSAPGNDLVAATA
CAASGAQMVLFTTGRGTPFASPVPTVKIATNSRLAGNKGNWIDFNAGRIVTDDLPLEDAAKELFQLVLDVASGKKVKAEI
AGFHDLAIFKQGVTL
>Mature_495_residues
MQDFIKINKDDNVAVALKPIAKGTTLNVAGIDVTTVEDIPQGHKFVIKAIKNGDPVIKYGFRIGFAQADIPVGAWVHTHN
LKTGLGELLEYTYEPEGHKDVEPTEPAYFDGYMRENGKVGVRNEVWIVPTVGCVNSIARAIEATARANKPEGVDEVVAFT
HPYGCSQTTEDQENTRKILADLINHPNAGAVLVLGLGCENSRIEVLKDYIGEVNPDRVKFLQVQDVENEQEEAEKLMNEL
MAYAATFKREKVNAKELIIGMKCGGSDGLSGITANPTVGLFSDMLVSKGGTTILTEVPEMFGAETILMNRCANKELFEKT
VHLINDFKEYFIKNGQEIYENPSPGNKDGGITTLEDKSLGCTQKSGSSLVKGVLAYAEPVNTKGLNLLSAPGNDLVAATA
CAASGAQMVLFTTGRGTPFASPVPTVKIATNSRLAGNKGNWIDFNAGRIVTDDLPLEDAAKELFQLVLDVASGKKVKAEI
AGFHDLAIFKQGVTL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789475, Length=494, Percent_Identity=52.2267206477733, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI1789516, Length=512, Percent_Identity=34.375, Blast_Score=245, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.7 [H]

Molecular weight: Translated: 53389; Mature: 53389

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDFIKINKDDNVAVALKPIAKGTTLNVAGIDVTTVEDIPQGHKFVIKAIKNGDPVIKYG
CCCCEEECCCCCEEEEEEECCCCCEEEEECCEEEEHHHCCCCCCEEHEECCCCCCEEEEE
FRIGFAQADIPVGAWVHTHNLKTGLGELLEYTYEPEGHKDVEPTEPAYFDGYMRENGKVG
EEEEEEECCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCCC
VRNEVWIVPTVGCVNSIARAIEATARANKPEGVDEVVAFTHPYGCSQTTEDQENTRKILA
CCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCHHHHHEEECCCCCCCCCCCHHHHHHHHH
DLINHPNAGAVLVLGLGCENSRIEVLKDYIGEVNPDRVKFLQVQDVENEQEEAEKLMNEL
HHHCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
MAYAATFKREKVNAKELIIGMKCGGSDGLSGITANPTVGLFSDMLVSKGGTTILTEVPEM
HHHHHHHHHHCCCHHHEEEEEECCCCCCCCCEECCCCHHHHHHHHHHCCCCEEEHHHHHH
FGAETILMNRCANKELFEKTVHLINDFKEYFIKNGQEIYENPSPGNKDGGITTLEDKSLG
HCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCEEEECCCCCC
CTQKSGSSLVKGVLAYAEPVNTKGLNLLSAPGNDLVAATACAASGAQMVLFTTGRGTPFA
CCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEHHHHCCCCEEEEEECCCCCCCC
SPVPTVKIATNSRLAGNKGNWIDFNAGRIVTDDLPLEDAAKELFQLVLDVASGKKVKAEI
CCCCEEEEECCCCCCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEHHH
AGFHDLAIFKQGVTL
CCHHHHHHHHCCCCC
>Mature Secondary Structure
MQDFIKINKDDNVAVALKPIAKGTTLNVAGIDVTTVEDIPQGHKFVIKAIKNGDPVIKYG
CCCCEEECCCCCEEEEEEECCCCCEEEEECCEEEEHHHCCCCCCEEHEECCCCCCEEEEE
FRIGFAQADIPVGAWVHTHNLKTGLGELLEYTYEPEGHKDVEPTEPAYFDGYMRENGKVG
EEEEEEECCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCCC
VRNEVWIVPTVGCVNSIARAIEATARANKPEGVDEVVAFTHPYGCSQTTEDQENTRKILA
CCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCHHHHHEEECCCCCCCCCCCHHHHHHHHH
DLINHPNAGAVLVLGLGCENSRIEVLKDYIGEVNPDRVKFLQVQDVENEQEEAEKLMNEL
HHHCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
MAYAATFKREKVNAKELIIGMKCGGSDGLSGITANPTVGLFSDMLVSKGGTTILTEVPEM
HHHHHHHHHHCCCHHHEEEEEECCCCCCCCCEECCCCHHHHHHHHHHCCCCEEEHHHHHH
FGAETILMNRCANKELFEKTVHLINDFKEYFIKNGQEIYENPSPGNKDGGITTLEDKSLG
HCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCEEEECCCCCC
CTQKSGSSLVKGVLAYAEPVNTKGLNLLSAPGNDLVAATACAASGAQMVLFTTGRGTPFA
CCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEHHHHCCCCEEEEEECCCCCCCC
SPVPTVKIATNSRLAGNKGNWIDFNAGRIVTDDLPLEDAAKELFQLVLDVASGKKVKAEI
CCCCEEEEECCCCCCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEHHH
AGFHDLAIFKQGVTL
CCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]