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The map label for this gene is uxaB [H]

Identifier: 238916839

GI number: 238916839

Start: 918148

End: 919650

Strand: Direct

Name: uxaB [H]

Synonym: EUBELI_00907

Alternate gene names: 238916839

Gene position: 918148-919650 (Clockwise)

Preceding gene: 238916836

Following gene: 238916840

Centisome position: 42.82

GC content: 39.32

Gene sequence:

>1503_bases
ATGCAGAGATTAAACAAGAGTATTACACATGCAGTTGACAGACCTGTTAAGGTTATGCAGTTCGGTGAGGGTAACTTCCT
TAGAGCATTCGTTGATTATATCTTCGATGTAACTAATGAGAAGACAGATTTCAACGGTGGTGTTGTTATCGTTAAGCCTA
TCGAGTTCGGTACACTTGAGAGATTCCATGATCAGGAATGCCAGTACACACTTCAGTTAAGAGGTTTTGTTGATGGAGAG
CCTAAGGAAATCACACGTCAGATTACATCAGTAGTAGATGCAGTTGCAGCTATTGAGGATTATGACAAGTACATTGAGTA
TGGTACAAGCGAGACTCTTAGATTCATCGTTTCTAATACAACAGAGGCTGGTATCGTATTTGACGAGACAGATAACGATC
CTAATGCACGTCCTCCTAAGACATACCCAGGAAAGCTTACACAGCTCCTTTACAAGAGATATCAGAAGTTCAACGGAGCA
GCTGATAAGGGACTTATCTTACTTCCATGTGAGCTTATCGCTGATAATGGTATTGAATTAAAGAAGTGCATCATGAAGTT
TATCGAGCTTTGGGGACTTGAAGATGGATTCAAGGATTGGGTTAACAATTACTGCTCATTCTGCCCAACACTCGTAGATA
GAATTGTTCCAGGATATCCAAGAGAAGACGCAGCTAAGCTTTGCGAGGAATGGGGATATGAGGATCAGCTTATCGACAGA
GCTGAAGTATTCGGTCTCTGGGTTGTAGAGAGTGATTCTAACCTTCCACTTGAGCAGCTTGAGAAGGAACTTCCATTTAA
GGAAGCTGGACTTAATGTAGTATTTACTAATGATCATCACCCATACAAGGAAAGAAAGGTTAGAATCCTTAACGGATCTC
ATACATCATTTGTATTAGCTTCATTCCTTGCTGGTAACGATAATGTAGAGAATTCTATGAAGGATCCTGTAATCAGAAAG
TACATGGAAGAGACACTTTACAACGAAGTTATTCCTACACTTTCACTTTCTAAGGAAGATTGCGAAGAGTTCGCTAAGGC
TGTTATCGACAGATTCCTTAACCCATTCGTAGATCATAGATTATTAAGCATTTCACTTAACTCAGTATCTAAGTGGGAAG
CTAGATGTTTACCTTCATTCTTAGGATATGTTAAGAAGTTTAACAAGCTTCCTAAGTACCTTACATTCTCTATCGCAGCA
CTTATGAGCTTCTATACATCACAGACAGAAGCTGAGTTCAACGGCGGTATTGTATTAAAGGGTAACAGAAACGGTGAAGA
GTACAATATTACAGATGATAAGGCTGTTCTTGATTTCTTCAGAGATAATTCAGGAAAGTCTGCTAAGGAATTCACACATG
CTTACTTAAGCAATACTAAGTTCTTCGGTGGCGAGGATCTTTCTAAGGTTCTTAACCTTGAAGAAGTTATTACTGAGTAC
ATCACAGATATCAGAGAAAGAGGTATGAGAGCAGTTGTTAATGATTTAGCTCTTGACGACTAA

Upstream 100 bases:

>100_bases
AAAGCGCTTACATGCACTTATTTACATACCATTTACTGGTTAATAATTAGGGACCGTTATCGTAAAACGGATTATTCCCA
ATGAAAAAAGGAGATTTAAG

Downstream 100 bases:

>100_bases
TTAACAGGCCCTTTGAGTGATTACAGAGCGGATGTTTTTATATTCATCCGCTCTTATTTAATATAATAATTAGAATTACA
AGGAGAATATATGCAGGATT

Product: altronate oxidoreductase

Products: NA

Alternate protein names: Tagaturonate dehydrogenase; Tagaturonate reductase [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MQRLNKSITHAVDRPVKVMQFGEGNFLRAFVDYIFDVTNEKTDFNGGVVIVKPIEFGTLERFHDQECQYTLQLRGFVDGE
PKEITRQITSVVDAVAAIEDYDKYIEYGTSETLRFIVSNTTEAGIVFDETDNDPNARPPKTYPGKLTQLLYKRYQKFNGA
ADKGLILLPCELIADNGIELKKCIMKFIELWGLEDGFKDWVNNYCSFCPTLVDRIVPGYPREDAAKLCEEWGYEDQLIDR
AEVFGLWVVESDSNLPLEQLEKELPFKEAGLNVVFTNDHHPYKERKVRILNGSHTSFVLASFLAGNDNVENSMKDPVIRK
YMEETLYNEVIPTLSLSKEDCEEFAKAVIDRFLNPFVDHRLLSISLNSVSKWEARCLPSFLGYVKKFNKLPKYLTFSIAA
LMSFYTSQTEAEFNGGIVLKGNRNGEEYNITDDKAVLDFFRDNSGKSAKEFTHAYLSNTKFFGGEDLSKVLNLEEVITEY
ITDIRERGMRAVVNDLALDD

Sequences:

>Translated_500_residues
MQRLNKSITHAVDRPVKVMQFGEGNFLRAFVDYIFDVTNEKTDFNGGVVIVKPIEFGTLERFHDQECQYTLQLRGFVDGE
PKEITRQITSVVDAVAAIEDYDKYIEYGTSETLRFIVSNTTEAGIVFDETDNDPNARPPKTYPGKLTQLLYKRYQKFNGA
ADKGLILLPCELIADNGIELKKCIMKFIELWGLEDGFKDWVNNYCSFCPTLVDRIVPGYPREDAAKLCEEWGYEDQLIDR
AEVFGLWVVESDSNLPLEQLEKELPFKEAGLNVVFTNDHHPYKERKVRILNGSHTSFVLASFLAGNDNVENSMKDPVIRK
YMEETLYNEVIPTLSLSKEDCEEFAKAVIDRFLNPFVDHRLLSISLNSVSKWEARCLPSFLGYVKKFNKLPKYLTFSIAA
LMSFYTSQTEAEFNGGIVLKGNRNGEEYNITDDKAVLDFFRDNSGKSAKEFTHAYLSNTKFFGGEDLSKVLNLEEVITEY
ITDIRERGMRAVVNDLALDD
>Mature_500_residues
MQRLNKSITHAVDRPVKVMQFGEGNFLRAFVDYIFDVTNEKTDFNGGVVIVKPIEFGTLERFHDQECQYTLQLRGFVDGE
PKEITRQITSVVDAVAAIEDYDKYIEYGTSETLRFIVSNTTEAGIVFDETDNDPNARPPKTYPGKLTQLLYKRYQKFNGA
ADKGLILLPCELIADNGIELKKCIMKFIELWGLEDGFKDWVNNYCSFCPTLVDRIVPGYPREDAAKLCEEWGYEDQLIDR
AEVFGLWVVESDSNLPLEQLEKELPFKEAGLNVVFTNDHHPYKERKVRILNGSHTSFVLASFLAGNDNVENSMKDPVIRK
YMEETLYNEVIPTLSLSKEDCEEFAKAVIDRFLNPFVDHRLLSISLNSVSKWEARCLPSFLGYVKKFNKLPKYLTFSIAA
LMSFYTSQTEAEFNGGIVLKGNRNGEEYNITDDKAVLDFFRDNSGKSAKEFTHAYLSNTKFFGGEDLSKVLNLEEVITEY
ITDIRERGMRAVVNDLALDD

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxaB subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994885, Length=503, Percent_Identity=40.3578528827038, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1788497, Length=497, Percent_Identity=23.5412474849095, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI1787823, Length=359, Percent_Identity=24.7910863509749, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1790779, Length=497, Percent_Identity=23.5412474849095, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6324401, Length=481, Percent_Identity=23.9085239085239, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320765, Length=481, Percent_Identity=23.9085239085239, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.58 [H]

Molecular weight: Translated: 57141; Mature: 57141

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRLNKSITHAVDRPVKVMQFGEGNFLRAFVDYIFDVTNEKTDFNGGVVIVKPIEFGTLE
CCHHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHH
RFHDQECQYTLQLRGFVDGEPKEITRQITSVVDAVAAIEDYDKYIEYGTSETLRFIVSNT
HHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
TEAGIVFDETDNDPNARPPKTYPGKLTQLLYKRYQKFNGAADKGLILLPCELIADNGIEL
CCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCCHH
KKCIMKFIELWGLEDGFKDWVNNYCSFCPTLVDRIVPGYPREDAAKLCEEWGYEDQLIDR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHH
AEVFGLWVVESDSNLPLEQLEKELPFKEAGLNVVFTNDHHPYKERKVRILNGSHTSFVLA
HHHEEEEEEECCCCCCHHHHHHHCCHHHCCCEEEEECCCCCHHHCEEEEECCCCHHHHHH
SFLAGNDNVENSMKDPVIRKYMEETLYNEVIPTLSLSKEDCEEFAKAVIDRFLNPFVDHR
HHHHCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCE
LLSISLNSVSKWEARCLPSFLGYVKKFNKLPKYLTFSIAALMSFYTSQTEAEFNGGIVLK
EEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
GNRNGEEYNITDDKAVLDFFRDNSGKSAKEFTHAYLSNTKFFGGEDLSKVLNLEEVITEY
CCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ITDIRERGMRAVVNDLALDD
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQRLNKSITHAVDRPVKVMQFGEGNFLRAFVDYIFDVTNEKTDFNGGVVIVKPIEFGTLE
CCHHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHH
RFHDQECQYTLQLRGFVDGEPKEITRQITSVVDAVAAIEDYDKYIEYGTSETLRFIVSNT
HHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
TEAGIVFDETDNDPNARPPKTYPGKLTQLLYKRYQKFNGAADKGLILLPCELIADNGIEL
CCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCCHH
KKCIMKFIELWGLEDGFKDWVNNYCSFCPTLVDRIVPGYPREDAAKLCEEWGYEDQLIDR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHH
AEVFGLWVVESDSNLPLEQLEKELPFKEAGLNVVFTNDHHPYKERKVRILNGSHTSFVLA
HHHEEEEEEECCCCCCHHHHHHHCCHHHCCCEEEEECCCCCHHHCEEEEECCCCHHHHHH
SFLAGNDNVENSMKDPVIRKYMEETLYNEVIPTLSLSKEDCEEFAKAVIDRFLNPFVDHR
HHHHCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCE
LLSISLNSVSKWEARCLPSFLGYVKKFNKLPKYLTFSIAALMSFYTSQTEAEFNGGIVLK
EEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
GNRNGEEYNITDDKAVLDFFRDNSGKSAKEFTHAYLSNTKFFGGEDLSKVLNLEEVITEY
CCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ITDIRERGMRAVVNDLALDD
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]