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The map label for this gene is guaB [H]

Identifier: 238916465

GI number: 238916465

Start: 527873

End: 529333

Strand: Direct

Name: guaB [H]

Synonym: EUBELI_00522

Alternate gene names: 238916465

Gene position: 527873-529333 (Clockwise)

Preceding gene: 238916464

Following gene: 238916466

Centisome position: 24.62

GC content: 41.34

Gene sequence:

>1461_bases
ATGGGTAAAATTATTGGTGAAGGCATTACATTTGACGACGTACTTTTAGTTCCACAGTATTCAGAAGTAACACCTAATAT
GATTGACCTCTCAACACAGCTCACTAAGAATATTAAACTTAACATTCCTTTAATGAGTGCAGGTATGGACACAGTTACAG
AACACAGAATGGCAATCGCAATGGCTAGACAGGGCGGTATTGGTATTATTCATAAGAATATGTCAGTAGAAGCTCAGGCA
GAAGAAGTAGACAAGGTTAAGCGTTCAGAGAATGGTGTTATCACAGACCCATTTTTCTTACATCCAGATAATACATTACA
GGAAGCTAATGACCTTATGGGCAAGTTCAGAATTTCCGGAGTACCTATCACAGATGATAATGGCAAGCTTGTCGGTATCA
TTACTAACAGAGACCTTAAGTTTGAGGAGCATTTTGAAAGACCAATCAAGGAGTGCATGACAAGCGAGAATCTTATCACT
GCTCCTGTTGGAACAACTCTTGAAGAAGCCAAGAAGATATTAGGAAAGGCAAGAAAAGAGAAGCTGCCTATCGTTGATGA
CGATTATAAGTTAAGAGGACTTATCACAATCAAGGATATTGAGAAGAGCGTTAAGTATCCATCTTCAGCACATGATTCAC
AGGGCAGACTTCTTGCAGGTGCTGCTGTTGGTATTACAGCTAATGTTATGGAAAGAGTACAGGCTCTTGTTAATGCAAAT
GTTGACTGTATCGTTATTGATTCAGCTCACGGACATTCTAAGAATATTATTACAACTCTTAAGGAGATTAAGTCAGCATT
CCCTGATCTTCAGGTTATTGCCGGTAATATTGCAACAGGTGCAGCTGCCAAGGCTCTTTGTGAGGCTGGTGTAGATGCTG
TTAAGGTTGGTATCGGACCTGGTTCTATCTGTACAACAAGAGTTGTTGCAGGTATTGGTGTACCACAGGTTACAGCCGTT
ATGGACGCTTATGCAGAGGCTAAGAAGTATGGTATTCCTGTAATTGCTGATGGTGGTATCAAGTATTCAGGAGATATCGT
TAAGGCTATCGCAGCAGGTGGTAATGTCTGCATGTTAGGAAGCCTTCTTGCAGGTTGTGATGAGGCTCCTGGTACATTCG
AGTTATTCCAGGGAAGAAAGTACAAGGTATACAGAGGAATGGGGTCTATCGCTGCCATGGAAAACGGAAGCAAGGACAGA
TATTTCCAGACTGGTGCAAAGAAGCTTGTTCCAGAGGGTGTTGAAGGACGTGTTGCTTATAAGGGACTTGTTGAAGATAC
TATCTTCCAGCTTATGGGTGGACTTCGTTCAGGTATGGGATATTGTGGAGCACCTACAATTCCAGTACTTCAGGAAACAG
CTCAGTTTATTAAGATGTCTTCAGCAGCTTTAAGAGAGAGTCATCCACATGATATTCATATCACAAAGGAAGCTCCTAAC
TATTCAGTTGAGGATAAGTAA

Upstream 100 bases:

>100_bases
GACTAAGCTGTCAGATACTTGTAGAAACATCCGGATTAATTTATTTATTCGGATTTTTTCTATATATTAAAACACAACAG
AAAGCGAGGATTTTAGCAAA

Downstream 100 bases:

>100_bases
TTAATCAGGAATGAAATTTACATCCGGGCAGCAATAACTGTCCGGGTGTTTTTTTTCAGAAGCACAATGTAAATTCTTCT
CAAATTATTGATATTGATTA

Product: malate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH; Superoxide-inducible protein 12; SOI12 [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MGKIIGEGITFDDVLLVPQYSEVTPNMIDLSTQLTKNIKLNIPLMSAGMDTVTEHRMAIAMARQGGIGIIHKNMSVEAQA
EEVDKVKRSENGVITDPFFLHPDNTLQEANDLMGKFRISGVPITDDNGKLVGIITNRDLKFEEHFERPIKECMTSENLIT
APVGTTLEEAKKILGKARKEKLPIVDDDYKLRGLITIKDIEKSVKYPSSAHDSQGRLLAGAAVGITANVMERVQALVNAN
VDCIVIDSAHGHSKNIITTLKEIKSAFPDLQVIAGNIATGAAAKALCEAGVDAVKVGIGPGSICTTRVVAGIGVPQVTAV
MDAYAEAKKYGIPVIADGGIKYSGDIVKAIAAGGNVCMLGSLLAGCDEAPGTFELFQGRKYKVYRGMGSIAAMENGSKDR
YFQTGAKKLVPEGVEGRVAYKGLVEDTIFQLMGGLRSGMGYCGAPTIPVLQETAQFIKMSSAALRESHPHDIHITKEAPN
YSVEDK

Sequences:

>Translated_486_residues
MGKIIGEGITFDDVLLVPQYSEVTPNMIDLSTQLTKNIKLNIPLMSAGMDTVTEHRMAIAMARQGGIGIIHKNMSVEAQA
EEVDKVKRSENGVITDPFFLHPDNTLQEANDLMGKFRISGVPITDDNGKLVGIITNRDLKFEEHFERPIKECMTSENLIT
APVGTTLEEAKKILGKARKEKLPIVDDDYKLRGLITIKDIEKSVKYPSSAHDSQGRLLAGAAVGITANVMERVQALVNAN
VDCIVIDSAHGHSKNIITTLKEIKSAFPDLQVIAGNIATGAAAKALCEAGVDAVKVGIGPGSICTTRVVAGIGVPQVTAV
MDAYAEAKKYGIPVIADGGIKYSGDIVKAIAAGGNVCMLGSLLAGCDEAPGTFELFQGRKYKVYRGMGSIAAMENGSKDR
YFQTGAKKLVPEGVEGRVAYKGLVEDTIFQLMGGLRSGMGYCGAPTIPVLQETAQFIKMSSAALRESHPHDIHITKEAPN
YSVEDK
>Mature_485_residues
GKIIGEGITFDDVLLVPQYSEVTPNMIDLSTQLTKNIKLNIPLMSAGMDTVTEHRMAIAMARQGGIGIIHKNMSVEAQAE
EVDKVKRSENGVITDPFFLHPDNTLQEANDLMGKFRISGVPITDDNGKLVGIITNRDLKFEEHFERPIKECMTSENLITA
PVGTTLEEAKKILGKARKEKLPIVDDDYKLRGLITIKDIEKSVKYPSSAHDSQGRLLAGAAVGITANVMERVQALVNANV
DCIVIDSAHGHSKNIITTLKEIKSAFPDLQVIAGNIATGAAAKALCEAGVDAVKVGIGPGSICTTRVVAGIGVPQVTAVM
DAYAEAKKYGIPVIADGGIKYSGDIVKAIAAGGNVCMLGSLLAGCDEAPGTFELFQGRKYKVYRGMGSIAAMENGSKDRY
FQTGAKKLVPEGVEGRVAYKGLVEDTIFQLMGGLRSGMGYCGAPTIPVLQETAQFIKMSSAALRESHPHDIHITKEAPNY
SVEDK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=481, Percent_Identity=43.035343035343, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=42.9166666666667, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI34328930, Length=480, Percent_Identity=42.9166666666667, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI156616279, Length=480, Percent_Identity=42.9166666666667, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=42.9166666666667, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI217035152, Length=489, Percent_Identity=42.3312883435583, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=42.0833333333333, Blast_Score=348, Evalue=9e-96,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=39.7916666666667, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI50541956, Length=360, Percent_Identity=29.7222222222222, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI50541954, Length=242, Percent_Identity=36.7768595041322, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI50541952, Length=242, Percent_Identity=36.7768595041322, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI50541948, Length=242, Percent_Identity=36.7768595041322, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI156104880, Length=237, Percent_Identity=37.1308016877637, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=55.5555555555556, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1786293, Length=223, Percent_Identity=35.8744394618834, Blast_Score=145, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=499, Percent_Identity=37.6753507014028, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=40.521327014218, Blast_Score=274, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI17560440, Length=258, Percent_Identity=32.9457364341085, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6323585, Length=481, Percent_Identity=40.3326403326403, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6322012, Length=481, Percent_Identity=39.2931392931393, Blast_Score=332, Evalue=6e-92,
Organism=Saccharomyces cerevisiae, GI6323464, Length=481, Percent_Identity=40.7484407484407, Blast_Score=330, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=382, Percent_Identity=37.9581151832461, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=38.7931034482759, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=42.9460580912863, Blast_Score=354, Evalue=9e-98,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=42.9460580912863, Blast_Score=354, Evalue=9e-98,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=42.8246013667426, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52017; Mature: 51885

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIIGEGITFDDVLLVPQYSEVTPNMIDLSTQLTKNIKLNIPLMSAGMDTVTEHRMAIA
CCCCCCCCCCCCCEEEECCHHHCCCCCEEHHHHHCCCEEEECEEECCCCHHHHHHHHHHE
MARQGGIGIIHKNMSVEAQAEEVDKVKRSENGVITDPFFLHPDNTLQEANDLMGKFRISG
ECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEECCCEEECCCCHHHHHHHHHHHEEECC
VPITDDNGKLVGIITNRDLKFEEHFERPIKECMTSENLITAPVGTTLEEAKKILGKARKE
EEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
KLPIVDDDYKLRGLITIKDIEKSVKYPSSAHDSQGRLLAGAAVGITANVMERVQALVNAN
CCCCCCCCCEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCC
VDCIVIDSAHGHSKNIITTLKEIKSAFPDLQVIAGNIATGAAAKALCEAGVDAVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCC
GSICTTRVVAGIGVPQVTAVMDAYAEAKKYGIPVIADGGIKYSGDIVKAIAAGGNVCMLG
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCCEEEHH
SLLAGCDEAPGTFELFQGRKYKVYRGMGSIAAMENGSKDRYFQTGAKKLVPEGVEGRVAY
HHHHCCCCCCCCHHHHCCCEEEEEECCCCEEECCCCCCCHHHHHCHHHHCCCCCCCCEEH
KGLVEDTIFQLMGGLRSGMGYCGAPTIPVLQETAQFIKMSSAALRESHPHDIHITKEAPN
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
YSVEDK
CCCCCC
>Mature Secondary Structure 
GKIIGEGITFDDVLLVPQYSEVTPNMIDLSTQLTKNIKLNIPLMSAGMDTVTEHRMAIA
CCCCCCCCCCCCEEEECCHHHCCCCCEEHHHHHCCCEEEECEEECCCCHHHHHHHHHHE
MARQGGIGIIHKNMSVEAQAEEVDKVKRSENGVITDPFFLHPDNTLQEANDLMGKFRISG
ECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEECCCEEECCCCHHHHHHHHHHHEEECC
VPITDDNGKLVGIITNRDLKFEEHFERPIKECMTSENLITAPVGTTLEEAKKILGKARKE
EEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
KLPIVDDDYKLRGLITIKDIEKSVKYPSSAHDSQGRLLAGAAVGITANVMERVQALVNAN
CCCCCCCCCEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCC
VDCIVIDSAHGHSKNIITTLKEIKSAFPDLQVIAGNIATGAAAKALCEAGVDAVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCC
GSICTTRVVAGIGVPQVTAVMDAYAEAKKYGIPVIADGGIKYSGDIVKAIAAGGNVCMLG
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCCEEEHH
SLLAGCDEAPGTFELFQGRKYKVYRGMGSIAAMENGSKDRYFQTGAKKLVPEGVEGRVAY
HHHHCCCCCCCCHHHHCCCEEEEEECCCCEEECCCCCCCHHHHHCHHHHCCCCCCCCEEH
KGLVEDTIFQLMGGLRSGMGYCGAPTIPVLQETAQFIKMSSAALRESHPHDIHITKEAPN
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
YSVEDK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1979163; 7584024; 9384377; 9298659 [H]