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The map label for this gene is rnz

Identifier: 238916344

GI number: 238916344

Start: 408443

End: 409357

Strand: Direct

Name: rnz

Synonym: EUBELI_00378

Alternate gene names: 238916344

Gene position: 408443-409357 (Clockwise)

Preceding gene: 238916343

Following gene: 238916345

Centisome position: 19.05

GC content: 42.3

Gene sequence:

>915_bases
ATGCTTGATGTATGTTTACTGGGAACCAGTGGCATGCTTCCCCTGCCGGGAAGATGGCTGACATCGCTTATGACACGTTA
CAACGGAAGCAGCCTGATGATAGATTGCGGAGAGGGAACACAGATAGCTGTTAAGCAGAAAGGATGGAGTTTTAATCCTA
TAGATGTTATCTGTTTCACACATTATCATGCTGATCATATAAGTGGTTTGCCGGGGCTTTTGCTCACAATAGGTAATTCT
GACAGAAAGAAGCCCTTAACTCTTGTAGGACCCAAGGGGCTTGGCAGGGTAGTTTCTTCGCTCAGGGTAATCGCACCAGA
GCTGCCATTTGAACTTAAGTTTATAGAACTTACGAATCAGCAGGAGCATTTGTCAATATGCGGATATGAGATAGATGCAT
TCAGGGTTAATCATGCTGTTATATGTTATGGGTATTCGATTAGTATTCCAAGAATAGGCAAGTTTGATGTAGAGAAGGCG
AAAGAACTTGGTATTCCGTGCAGCATGTGGAATAAACTGCAGCATGGAACAGCGGTTACAATAGATGATAAAGAATATAC
GCCGGATATGGTTATGGGGGCGGCAAGAAAAGGGCTTAAAGTAACATATTGTACAGATAGCAGGCCTGTTCAGATTATAT
CAGATAATGCTAAGGAATCAGATCTTTTCATATGTGAGGGTATGTATGGAGAGGATGGTAAGGAAGCTAAGGCAAAGGAA
TATAAGCATATGACCTTTACAGAAGCGGCACAGCTTGCAAAGAATGCGGATGTCAGGGAAATGTGGCTGACACATTATAG
TCCTTCACTTGTAAGACCTCAGGATTATGTTGATAAGGCAAGAAAGATATTCCCTGCTACAATAGCAGCTAATGATGGAA
GAACAGTTGAGTTGAAGTTTGACGATGAGGGTTAG

Upstream 100 bases:

>100_bases
AAACCAGTTGAGGACGCAGTAATAATGTCTAAAAATATTGGGTGAAATAATAGACTGCATAATATATATTGATGTATAAT
AACAGAAGGAGGTGCGATTA

Downstream 100 bases:

>100_bases
ATTATGAAAAAATACGGAAGGACGATAATTGTAATAGCAGTATTGGTTGCGTTGGGACTGGTGTATTACTATTACCTTGC
TAATAAGGATACAGGTAAAG

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLDVCLLGTSGMLPLPGRWLTSLMTRYNGSSLMIDCGEGTQIAVKQKGWSFNPIDVICFTHYHADHISGLPGLLLTIGNS
DRKKPLTLVGPKGLGRVVSSLRVIAPELPFELKFIELTNQQEHLSICGYEIDAFRVNHAVICYGYSISIPRIGKFDVEKA
KELGIPCSMWNKLQHGTAVTIDDKEYTPDMVMGAARKGLKVTYCTDSRPVQIISDNAKESDLFICEGMYGEDGKEAKAKE
YKHMTFTEAAQLAKNADVREMWLTHYSPSLVRPQDYVDKARKIFPATIAANDGRTVELKFDDEG

Sequences:

>Translated_304_residues
MLDVCLLGTSGMLPLPGRWLTSLMTRYNGSSLMIDCGEGTQIAVKQKGWSFNPIDVICFTHYHADHISGLPGLLLTIGNS
DRKKPLTLVGPKGLGRVVSSLRVIAPELPFELKFIELTNQQEHLSICGYEIDAFRVNHAVICYGYSISIPRIGKFDVEKA
KELGIPCSMWNKLQHGTAVTIDDKEYTPDMVMGAARKGLKVTYCTDSRPVQIISDNAKESDLFICEGMYGEDGKEAKAKE
YKHMTFTEAAQLAKNADVREMWLTHYSPSLVRPQDYVDKARKIFPATIAANDGRTVELKFDDEG
>Mature_304_residues
MLDVCLLGTSGMLPLPGRWLTSLMTRYNGSSLMIDCGEGTQIAVKQKGWSFNPIDVICFTHYHADHISGLPGLLLTIGNS
DRKKPLTLVGPKGLGRVVSSLRVIAPELPFELKFIELTNQQEHLSICGYEIDAFRVNHAVICYGYSISIPRIGKFDVEKA
KELGIPCSMWNKLQHGTAVTIDDKEYTPDMVMGAARKGLKVTYCTDSRPVQIISDNAKESDLFICEGMYGEDGKEAKAKE
YKHMTFTEAAQLAKNADVREMWLTHYSPSLVRPQDYVDKARKIFPATIAANDGRTVELKFDDEG

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=316, Percent_Identity=29.746835443038, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI87082078, Length=301, Percent_Identity=29.2358803986711, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_EUBE2 (C4Z309)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002929861.1
- ProteinModelPortal:   C4Z309
- GeneID:   7958146
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_00378
- OMA:   RICVTHF
- ProtClustDB:   PRK00055
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 33813; Mature: 33813

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVCLLGTSGMLPLPGRWLTSLMTRYNGSSLMIDCGEGTQIAVKQKGWSFNPIDVICFT
CEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCEEEEEEE
HYHADHISGLPGLLLTIGNSDRKKPLTLVGPKGLGRVVSSLRVIAPELPFELKFIELTNQ
EECHHHHCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCC
QEHLSICGYEIDAFRVNHAVICYGYSISIPRIGKFDVEKAKELGIPCSMWNKLQHGTAVT
CCEEEEECEEEEEEEECEEEEEEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHCCCCEEE
IDDKEYTPDMVMGAARKGLKVTYCTDSRPVQIISDNAKESDLFICEGMYGEDGKEAKAKE
ECCCCCCHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCCEEEEECCCCCCCCCCHHHH
YKHMTFTEAAQLAKNADVREMWLTHYSPSLVRPQDYVDKARKIFPATIAANDGRTVELKF
HHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHEEEEEECCCCCEEEEEE
DDEG
CCCC
>Mature Secondary Structure
MLDVCLLGTSGMLPLPGRWLTSLMTRYNGSSLMIDCGEGTQIAVKQKGWSFNPIDVICFT
CEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCEEEEEEE
HYHADHISGLPGLLLTIGNSDRKKPLTLVGPKGLGRVVSSLRVIAPELPFELKFIELTNQ
EECHHHHCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCC
QEHLSICGYEIDAFRVNHAVICYGYSISIPRIGKFDVEKAKELGIPCSMWNKLQHGTAVT
CCEEEEECEEEEEEEECEEEEEEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHCCCCEEE
IDDKEYTPDMVMGAARKGLKVTYCTDSRPVQIISDNAKESDLFICEGMYGEDGKEAKAKE
ECCCCCCHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCCEEEEECCCCCCCCCCHHHH
YKHMTFTEAAQLAKNADVREMWLTHYSPSLVRPQDYVDKARKIFPATIAANDGRTVELKF
HHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHEEEEEECCCCCEEEEEE
DDEG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA