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The map label for this gene is menE [H]

Identifier: 238916237

GI number: 238916237

Start: 302878

End: 304269

Strand: Direct

Name: menE [H]

Synonym: EUBELI_00271

Alternate gene names: 238916237

Gene position: 302878-304269 (Clockwise)

Preceding gene: 238916235

Following gene: 238916238

Centisome position: 14.13

GC content: 37.64

Gene sequence:

>1392_bases
ATGACAGATAAAAATACATTTTATAATATGTTAAAGAATAATGCGCAGAAACATCCGGACGCTGTGGCTGTCGTATATGA
TACGATGAAAGTTACTTATGCGAAGCTTTTTGATGATGTCACGAAAAAGGCATTGCATTTCCAGAAATTTGATGGCGAGA
GAATTGCAATATTCGGACAGGCTTCATACAGATGGATTGTTAATATGTTTGGAACAATAGTGGCAGGAAAGGATCTGGTT
CTTGTTGATTTCTTTCTTCCACATGATTCGAGAGTGGATCTTCTTAAGAAAACAGAGGTCAATTACACACTGACATCAAC
TAACCAGTATATTCTTTCAGATGAGAATTCTATTATTATATCAAGTGCAGAAAAGGATGATGTTGAAGGGCTGATATATG
ATGAGAATACCACAGAGGGAGATATCATAATGTTCACAGCAACAGCAGGTGAATGTGACAAACCGGTTGTTTTATCAGTG
GATAATATTCTTAATACAGCCACTGAAATAAGCAACAGAGTGGAATGTACAGAAGATGATATCGTGCTTGCACAGATTCC
TCTGCATAATGAATTTGGTCTTATATATAGTCTTATATGGCCGTTATGCTGTGGAGCTATGGTGTGTATAGGAAGAGGCT
TAAGACATATTGATGCAGACACTTATTATTACGATCCGACTATTCTTATAGGTACACCGTCTATGATTGATTATCTCAGG
GCTGTGAGTGGATTTAACAGTGAACTTAAAACTATCATAATAGGTGGTGCAAGCTGCCCATTCAGGCTTTTTGAGAATCT
GTGTGACAGTGACTTAAAGGTCTATAATATATATGGAACGACAGAGACATCGGGCTGTGTCGGAGTTAATGAGCTGTATG
ACGGTTCTTATACACTTTTTGACAAGGATGCGGTTACAATTGCTGAAGACGGAGAGATTCTTGTAAAAGGTCCATGTGTT
ATGAAAGGATATTACAAGGATGATGAAGCCAATAATAAAGTTTTAAAGGATGGAGTATATCATACAGGTGATTACGGACG
GATTAATAATGCAGGCAGACTTGTGTTATTACAGCGCAATCCTGATATTATACTGCTTCCTACAGGAGAGAAAATAAGCC
GTGTAAGAACTAATGAACAGATTACAGCTATTAACGGAGTTGCCGAAGGGTTCATTACATTTTACAATAACAGACTTACA
GCGATTATTGTACCTATTGATAAGGGAGCAACAGAGGATATATTCAAGCGCCGGATTGATAAGTATAATGAGAAAAAGGG
ATACCGCTGGGAGATTCAGAAGATTGTGTTAAGGAAAGAGCCTTTGCCAAGAAATGCTGATGGAACTGTTGATGAGGATG
CGGTGTGTGAGTTTATAGAAAAGATTAAATAA

Upstream 100 bases:

>100_bases
ATCATTATACAATAACAGTGTTGGCATTTTCTACGCTAAATGCTATAATTTTTTATATTTGATGCAGGATTTATGACTAT
TTTTAGAAACGGAGAAAATC

Downstream 100 bases:

>100_bases
TAATGGAGAAAGAATTGGAATTTAGTGCGGATTATTTTAAGACAGAAGTGAGGGATGGCTTTGAGATTCCGGCAATGATG
AAGCGTGCATGGGCTGCACA

Product: fatty-acyl-CoA synthase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTDKNTFYNMLKNNAQKHPDAVAVVYDTMKVTYAKLFDDVTKKALHFQKFDGERIAIFGQASYRWIVNMFGTIVAGKDLV
LVDFFLPHDSRVDLLKKTEVNYTLTSTNQYILSDENSIIISSAEKDDVEGLIYDENTTEGDIIMFTATAGECDKPVVLSV
DNILNTATEISNRVECTEDDIVLAQIPLHNEFGLIYSLIWPLCCGAMVCIGRGLRHIDADTYYYDPTILIGTPSMIDYLR
AVSGFNSELKTIIIGGASCPFRLFENLCDSDLKVYNIYGTTETSGCVGVNELYDGSYTLFDKDAVTIAEDGEILVKGPCV
MKGYYKDDEANNKVLKDGVYHTGDYGRINNAGRLVLLQRNPDIILLPTGEKISRVRTNEQITAINGVAEGFITFYNNRLT
AIIVPIDKGATEDIFKRRIDKYNEKKGYRWEIQKIVLRKEPLPRNADGTVDEDAVCEFIEKIK

Sequences:

>Translated_463_residues
MTDKNTFYNMLKNNAQKHPDAVAVVYDTMKVTYAKLFDDVTKKALHFQKFDGERIAIFGQASYRWIVNMFGTIVAGKDLV
LVDFFLPHDSRVDLLKKTEVNYTLTSTNQYILSDENSIIISSAEKDDVEGLIYDENTTEGDIIMFTATAGECDKPVVLSV
DNILNTATEISNRVECTEDDIVLAQIPLHNEFGLIYSLIWPLCCGAMVCIGRGLRHIDADTYYYDPTILIGTPSMIDYLR
AVSGFNSELKTIIIGGASCPFRLFENLCDSDLKVYNIYGTTETSGCVGVNELYDGSYTLFDKDAVTIAEDGEILVKGPCV
MKGYYKDDEANNKVLKDGVYHTGDYGRINNAGRLVLLQRNPDIILLPTGEKISRVRTNEQITAINGVAEGFITFYNNRLT
AIIVPIDKGATEDIFKRRIDKYNEKKGYRWEIQKIVLRKEPLPRNADGTVDEDAVCEFIEKIK
>Mature_462_residues
TDKNTFYNMLKNNAQKHPDAVAVVYDTMKVTYAKLFDDVTKKALHFQKFDGERIAIFGQASYRWIVNMFGTIVAGKDLVL
VDFFLPHDSRVDLLKKTEVNYTLTSTNQYILSDENSIIISSAEKDDVEGLIYDENTTEGDIIMFTATAGECDKPVVLSVD
NILNTATEISNRVECTEDDIVLAQIPLHNEFGLIYSLIWPLCCGAMVCIGRGLRHIDADTYYYDPTILIGTPSMIDYLRA
VSGFNSELKTIIIGGASCPFRLFENLCDSDLKVYNIYGTTETSGCVGVNELYDGSYTLFDKDAVTIAEDGEILVKGPCVM
KGYYKDDEANNKVLKDGVYHTGDYGRINNAGRLVLLQRNPDIILLPTGEKISRVRTNEQITAINGVAEGFITFYNNRLTA
IIVPIDKGATEDIFKRRIDKYNEKKGYRWEIQKIVLRKEPLPRNADGTVDEDAVCEFIEKIK

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Caenorhabditis elegans, GI17558820, Length=376, Percent_Identity=24.468085106383, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI32563687, Length=343, Percent_Identity=24.4897959183673, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 52038; Mature: 51907

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKNTFYNMLKNNAQKHPDAVAVVYDTMKVTYAKLFDDVTKKALHFQKFDGERIAIFGQ
CCCCHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
ASYRWIVNMFGTIVAGKDLVLVDFFLPHDSRVDLLKKTEVNYTLTSTNQYILSDENSIII
CCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEECCCCEEEECCCEEEEECCCEEEE
SSAEKDDVEGLIYDENTTEGDIIMFTATAGECDKPVVLSVDNILNTATEISNRVECTEDD
ECCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCC
IVLAQIPLHNEFGLIYSLIWPLCCGAMVCIGRGLRHIDADTYYYDPTILIGTPSMIDYLR
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEEECCHHHHHHH
AVSGFNSELKTIIIGGASCPFRLFENLCDSDLKVYNIYGTTETSGCVGVNELYDGSYTLF
HHHCCCCCEEEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHCCCEEEEE
DKDAVTIAEDGEILVKGPCVMKGYYKDDEANNKVLKDGVYHTGDYGRINNAGRLVLLQRN
ECCEEEEECCCCEEEECCEEEECCCCCCCCCCCCHHCCCEECCCCCCCCCCCEEEEEECC
PDIILLPTGEKISRVRTNEQITAINGVAEGFITFYNNRLTAIIVPIDKGATEDIFKRRID
CCEEEEECCCHHHHHCCCCEEEEEHHHHHHHHEEECCCEEEEEEECCCCCHHHHHHHHHH
KYNEKKGYRWEIQKIVLRKEPLPRNADGTVDEDAVCEFIEKIK
HHHCCCCCEEEEEEHEECCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TDKNTFYNMLKNNAQKHPDAVAVVYDTMKVTYAKLFDDVTKKALHFQKFDGERIAIFGQ
CCCHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
ASYRWIVNMFGTIVAGKDLVLVDFFLPHDSRVDLLKKTEVNYTLTSTNQYILSDENSIII
CCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEECCCCEEEECCCEEEEECCCEEEE
SSAEKDDVEGLIYDENTTEGDIIMFTATAGECDKPVVLSVDNILNTATEISNRVECTEDD
ECCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCC
IVLAQIPLHNEFGLIYSLIWPLCCGAMVCIGRGLRHIDADTYYYDPTILIGTPSMIDYLR
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEEECCHHHHHHH
AVSGFNSELKTIIIGGASCPFRLFENLCDSDLKVYNIYGTTETSGCVGVNELYDGSYTLF
HHHCCCCCEEEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHCCCEEEEE
DKDAVTIAEDGEILVKGPCVMKGYYKDDEANNKVLKDGVYHTGDYGRINNAGRLVLLQRN
ECCEEEEECCCCEEEECCEEEECCCCCCCCCCCCHHCCCEECCCCCCCCCCCEEEEEECC
PDIILLPTGEKISRVRTNEQITAINGVAEGFITFYNNRLTAIIVPIDKGATEDIFKRRID
CCEEEEECCCHHHHHCCCCEEEEEHHHHHHHHEEECCCEEEEEEECCCCCHHHHHHHHHH
KYNEKKGYRWEIQKIVLRKEPLPRNADGTVDEDAVCEFIEKIK
HHHCCCCCEEEEEEHEECCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA